Details for: EEF1B2P2

Gene ID: 1934

Symbol: EEF1B2P2

Ensembl ID: ENSG00000213864

Description: eukaryotic translation elongation factor 1 beta 2 pseudogene 2

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.0278
    Cell Significance Index: 25.6700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.8317
    Cell Significance Index: 8.6100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.5517
    Cell Significance Index: 7.1100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.2957
    Cell Significance Index: 4.2100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.1876
    Cell Significance Index: 5.5300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1781
    Cell Significance Index: 2.2500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1154
    Cell Significance Index: 1.5800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.1137
    Cell Significance Index: 1.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0760
    Cell Significance Index: 15.2400
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0681
    Cell Significance Index: 0.8600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0551
    Cell Significance Index: 2.5700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0541
    Cell Significance Index: 9.2300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.0060
    Cell Significance Index: 0.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0024
    Cell Significance Index: -4.4700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0051
    Cell Significance Index: -2.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0069
    Cell Significance Index: -0.3600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0125
    Cell Significance Index: -1.4400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0202
    Cell Significance Index: -0.3200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0340
    Cell Significance Index: -0.9100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0503
    Cell Significance Index: -1.0000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0570
    Cell Significance Index: -0.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0624
    Cell Significance Index: -2.8300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0669
    Cell Significance Index: -1.8200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0685
    Cell Significance Index: -1.4800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0707
    Cell Significance Index: -0.8600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0721
    Cell Significance Index: -1.5300
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0798
    Cell Significance Index: -1.0100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0916
    Cell Significance Index: -3.2100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0922
    Cell Significance Index: -2.9400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0954
    Cell Significance Index: -3.1300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1039
    Cell Significance Index: -1.7800
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.1078
    Cell Significance Index: -1.3000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1217
    Cell Significance Index: -3.0400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1220
    Cell Significance Index: -4.4800
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1249
    Cell Significance Index: -1.4700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1469
    Cell Significance Index: -2.9300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1473
    Cell Significance Index: -2.9000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1484
    Cell Significance Index: -3.2500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1495
    Cell Significance Index: -3.1200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1499
    Cell Significance Index: -4.8000
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1509
    Cell Significance Index: -1.9500
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.1519
    Cell Significance Index: -1.7500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1654
    Cell Significance Index: -3.3700
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.1762
    Cell Significance Index: -2.2300
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.1772
    Cell Significance Index: -1.6000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1793
    Cell Significance Index: -3.1000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1974
    Cell Significance Index: -5.0300
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.2018
    Cell Significance Index: -2.1300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2063
    Cell Significance Index: -3.4700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2086
    Cell Significance Index: -2.6800
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -0.2203
    Cell Significance Index: -2.0800
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.2270
    Cell Significance Index: -1.6500
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.2392
    Cell Significance Index: -3.3600
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.2433
    Cell Significance Index: -2.4400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.2444
    Cell Significance Index: -2.6000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2494
    Cell Significance Index: -4.0400
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.2495
    Cell Significance Index: -2.6500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2600
    Cell Significance Index: -3.5700
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.2642
    Cell Significance Index: -3.4600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2647
    Cell Significance Index: -5.4900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2749
    Cell Significance Index: -3.7400
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.2767
    Cell Significance Index: -3.3000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.2841
    Cell Significance Index: -2.8700
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.2858
    Cell Significance Index: -3.0900
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2949
    Cell Significance Index: -3.8700
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.2962
    Cell Significance Index: -3.5800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.2966
    Cell Significance Index: -3.4400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2967
    Cell Significance Index: -3.8800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.2969
    Cell Significance Index: -3.5500
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.2988
    Cell Significance Index: -3.4600
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.2995
    Cell Significance Index: -3.4100
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.2995
    Cell Significance Index: -3.5600
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.3017
    Cell Significance Index: -3.5900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.3024
    Cell Significance Index: -3.6700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.3027
    Cell Significance Index: -3.9500
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.3067
    Cell Significance Index: -3.1800
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.3074
    Cell Significance Index: -3.7400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.3108
    Cell Significance Index: -4.0900
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.3136
    Cell Significance Index: -3.4300
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.3140
    Cell Significance Index: -3.9400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3146
    Cell Significance Index: -3.9700
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.3155
    Cell Significance Index: -2.7800
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.3165
    Cell Significance Index: -3.7400
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.3174
    Cell Significance Index: -3.5300
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.3176
    Cell Significance Index: -3.4800
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.3178
    Cell Significance Index: -4.0700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3221
    Cell Significance Index: -4.2800
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: -0.3226
    Cell Significance Index: -3.7700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3229
    Cell Significance Index: -5.5200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.3233
    Cell Significance Index: -3.4100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.3242
    Cell Significance Index: -4.0500
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.3247
    Cell Significance Index: -2.7400
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.3248
    Cell Significance Index: -3.6900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3251
    Cell Significance Index: -3.8800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.3269
    Cell Significance Index: -3.8600
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.3306
    Cell Significance Index: -3.6600
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.3320
    Cell Significance Index: -4.5900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.3329
    Cell Significance Index: -3.8100
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.3336
    Cell Significance Index: -4.0600
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.3341
    Cell Significance Index: -3.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EEF1B2P2 is a pseudogene, meaning it lacks the ability to produce a functional protein. Despite its pseudogenic status, EEF1B2P2 exhibits significant tissue-specific expression, with high levels detected in cells involved in immune responses, such as CD4+ and CD8+ T cells, and hematopoietic stem cells. This expression pattern suggests that EEF1B2P2 may play a role in regulating cellular processes, albeit in a non-canonical manner. **Pathways and Functions:** While the exact mechanisms of EEF1B2P2 are unclear, several signaling pathways have been implicated in its regulation. The EEF1B2P2/EEF1B2 complex has been shown to interact with the mTORC1 pathway, a key regulator of cellular metabolism and growth. Additionally, EEF1B2P2 has been linked to the regulation of autophagy and the unfolded protein response (UPR), both of which are crucial for maintaining cellular homeostasis. Furthermore, the expression of EEF1B2P2 has been correlated with the regulation of cell proliferation and differentiation, suggesting a potential role in the development and maintenance of immune cells. **Clinical Significance:** The identification of EEF1B2P2 as a pseudogene with significant tissue-specific expression has sparked interest in its potential role in human disease. Given its involvement in immune responses and cellular homeostasis, EEF1B2P2 may be implicated in various conditions, including autoimmune diseases, cancer, and neurodegenerative disorders. For instance, alterations in EEF1B2P2 expression have been observed in patients with multiple sclerosis, a chronic autoimmune disease characterized by inflammation and demyelination in the central nervous system. Additionally, the dysregulation of EEF1B2P2 has been linked to the development of certain types of cancer, including leukemia and lymphoma. Further investigation into the role of EEF1B2P2 in disease is warranted, as it may provide novel therapeutic targets for the treatment of these conditions. In conclusion, the study of EEF1B2P2 has shed light on the complex and multifaceted nature of pseudogenes in the human genome. While its exact mechanisms of action remain unclear, EEF1B2P2's tissue-specific expression and involvement in key signaling pathways suggest a potential role in regulating cellular processes and maintaining immune homeostasis. Further research is necessary to fully elucidate the clinical significance of EEF1B2P2 and its potential applications in the treatment of human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.