Details for: ZNF365

Gene ID: 22891

Symbol: ZNF365

Ensembl ID: ENSG00000138311

Description: zinc finger protein 365

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.31
    Marker Score: 2,326
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.73
    Marker Score: 16,460
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.63
    Marker Score: 100,026
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.58
    Marker Score: 508
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.52
    Marker Score: 2,345
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.52
    Marker Score: 13,015
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,942
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.25
    Marker Score: 11,769
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.22
    Marker Score: 644
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.2
    Marker Score: 7,223
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.16
    Marker Score: 1,955
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.16
    Marker Score: 366
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.1
    Marker Score: 4,543
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,820
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,045
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1
    Marker Score: 2,531
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.95
    Marker Score: 9,804
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,356
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,742
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.9
    Marker Score: 2,569
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,288
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.85
    Marker Score: 5,665
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.85
    Marker Score: 354
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.84
    Marker Score: 30,981
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.83
    Marker Score: 1,104
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,266
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.76
    Marker Score: 11,292
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.73
    Marker Score: 256
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.73
    Marker Score: 27,804
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.72
    Marker Score: 14,292
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.71
    Marker Score: 373
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.71
    Marker Score: 359
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.68
    Marker Score: 1,609
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.63
    Marker Score: 550
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.63
    Marker Score: 486
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6
    Marker Score: 2,322
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.59
    Marker Score: 767
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.58
    Marker Score: 720
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.57
    Marker Score: 179
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 452
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.56
    Marker Score: 370
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.55
    Marker Score: 485
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.54
    Marker Score: 1,296
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.52
    Marker Score: 3,995
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.51
    Marker Score: 921
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.5
    Marker Score: 719
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.48
    Marker Score: 477
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.47
    Marker Score: 10,045
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.46
    Marker Score: 191
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.45
    Marker Score: 206
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.44
    Marker Score: 294
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.44
    Marker Score: 114
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.43
    Marker Score: 285
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.39
    Marker Score: 1,403
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.35
    Marker Score: 160
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.34
    Marker Score: 444
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.32
    Marker Score: 360
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.29
    Marker Score: 263
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.26
    Marker Score: 245
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.26
    Marker Score: 2,205
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.25
    Marker Score: 506
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.25
    Marker Score: 68
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.25
    Marker Score: 103
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.24
    Marker Score: 88
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.23
    Marker Score: 160
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.23
    Marker Score: 73
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.22
    Marker Score: 210
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.22
    Marker Score: 7,491
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.22
    Marker Score: 924
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.22
    Marker Score: 252
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.22
    Marker Score: 267
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.21
    Marker Score: 62
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.21
    Marker Score: 181
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2
    Marker Score: 245
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.2
    Marker Score: 108
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.2
    Marker Score: 77
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.2
    Marker Score: 278
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.19
    Marker Score: 334
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.19
    Marker Score: 188
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.19
    Marker Score: 184
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.19
    Marker Score: 82
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.19
    Marker Score: 300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.18
    Marker Score: 822
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.17
    Marker Score: 103
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.17
    Marker Score: 63
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.17
    Marker Score: 38
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.17
    Marker Score: 97
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.17
    Marker Score: 4,246
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.16
    Marker Score: 33
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.16
    Marker Score: 74
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.16
    Marker Score: 42
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.15
    Marker Score: 124
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.15
    Marker Score: 105
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.15
    Marker Score: 67
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.15
    Marker Score: 84
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.15
    Marker Score: 167
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.15
    Marker Score: 214

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZNF365 is a member of the zinc finger protein family, characterized by its ability to bind to DNA and regulate gene expression. The protein is specifically expressed in various cell types, including blood vessel endothelial cells, neurons, and hematopoietic stem cells. Its expression pattern suggests a diverse range of cellular functions, including regulation of neuronal projection development, oligodendrocyte differentiation, and metal ion binding. **Pathways and Functions:** ZNF365 is involved in multiple cellular pathways, including: 1. **Centrosome and Cerebellar Molecular Layer Morphogenesis:** ZNF365 regulates the organization of centrosomes, which are crucial for maintaining cell polarity and morphogenesis. 2. **Dendrite Arborization and Dendritic Spine Morphogenesis:** ZNF365 influences the development of dendrites and dendritic spines, which are essential for neuronal connectivity and synaptic plasticity. 3. **Regulation of Neuron Projection Development:** ZNF365 modulates the extension and branching of neuronal projections, which is critical for neuronal connectivity and circuit formation. 4. **Positive Regulation of Oligodendrocyte Differentiation:** ZNF365 promotes the differentiation of oligodendrocytes, which are responsible for myelination and neuronal function. 5. **Regulation of DNA Strand Resection Involved in Replication Fork Processing:** ZNF365 regulates the repair of DNA strand breaks during replication and repair, ensuring genome stability. **Clinical Significance:** The dysregulation of ZNF365 has been implicated in various neurological disorders, including: 1. **Neurodevelopmental Disorders:** ZNF365 mutations have been associated with neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 2. **Neurodegenerative Diseases:** ZNF365 has been linked to neurodegenerative diseases, including Alzheimer's disease and amyotrophic lateral sclerosis (ALS). 3. **Cerebellar Disorders:** ZNF365 is involved in cerebellar function and dysfunction, which can lead to cerebellar disorders, such as ataxia and dysarthria. In conclusion, ZNF365 is a multifunctional protein that plays a critical role in regulating neuronal development and oligodendrocyte differentiation. Its dysregulation has been implicated in various neurological disorders, highlighting the importance of further research into the molecular mechanisms underlying these diseases.

Genular Protein ID: 2146347579

Symbol: ZN365_HUMAN

Name: Protein ZNF365

UniProtKB Accession Codes:

Q70YC5 A8K0F0 O94930 Q05D75 Q5HYE6 Q68SG8 Q6NSK2 Q6P9D4 Q70YC6 Q70YC7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 2 ExpressionAtlas 1 GO 13 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 RefSeq 3 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12740763

Title: Identification of a novel gene and a common variant associated with uric acid nephrolithiasis in a Sardinian genetic isolate.

PubMed ID: 12740763

DOI: 10.1086/375628

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15363853

Title: Emergence of talanin protein associated with human uric acid nephrolithiasis in the hominidae lineage.

PubMed ID: 15363853

DOI: 10.1016/j.gene.2004.06.030

PubMed ID: 16682949

Title: Centrosomal proteins Nde1 and Su48 form a complex regulated by phosphorylation.

PubMed ID: 16682949

DOI: 10.1038/sj.onc.1209637

PubMed ID: 16617106

Title: Characterization of Su48, a centrosome protein essential for cell division.

PubMed ID: 16617106

DOI: 10.1073/pnas.0601682103

PubMed ID: 17389905

Title: A novel DISC1-interacting partner DISC1-binding zinc-finger protein: implication in the modulation of DISC1-dependent neurite outgrowth.

PubMed ID: 17389905

DOI: 10.1038/sj.mp.4001945

PubMed ID: 23776040

Title: ZNF365 promotes stability of fragile sites and telomeres.

PubMed ID: 23776040

DOI: 10.1158/2159-8290.cd-12-0536

PubMed ID: 23966166

Title: ZNF365 promotes stalled replication forks recovery to maintain genome stability.

PubMed ID: 23966166

DOI: 10.4161/cc.25882

Sequence Information:

  • Length: 407
  • Mass: 46542
  • Checksum: CC3C25AF6A753E64
  • Sequence:
    • MQQKAFEESR YPWQESFENV AVCLPLRCPR CGDHTRFRSL SSLRAHLEFS HSYEERTLLT 
KCSLFPSLKD TDLVTSSELL KPGKLQSSGN VVKQKPSYVN LYSISHEHSK DRKPFEVVAE 
RPVSYVQTYT AMDLHADSLD GTRSGPGLPT SDTKASFEAH VREKFNRMVE AVDRTIEKRI 
DKLTKELAQK TAELLEVRAA FVQLTQKKQE VQRRERALNR QVDVAVEMIA VLRQRLTESE 
EELLRKEEEV VTFNHFLEAA AEKEVQGKAR LQDFIENLLQ RVELAEKQLE YYQSQQASGF 
VRDLSGHVLT DISSNRKPKC LSRGHPHSVC NHPDLKAHFH PKGRNHLKKA KDDRASMQPA 
KAIHEQAESS RDLCRPPKKG ELLGFGRKGN IRPKMAKKKP TAIVNII

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.