Details for: RHOBTB2
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: pneumocyte (CL0000322)
Fold Change: 1.86
Marker Score: 2,984 - Cell Name: type II pneumocyte (CL0002063)
Fold Change: 1.84
Marker Score: 12,005 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.75
Marker Score: 510 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.58
Marker Score: 97,089 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.38
Marker Score: 5,771 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.36
Marker Score: 2,104 - Cell Name: type I pneumocyte (CL0002062)
Fold Change: 1.35
Marker Score: 1,632 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.31
Marker Score: 21,034 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.31
Marker Score: 20,440 - Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 1.24
Marker Score: 558 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.17
Marker Score: 11,154 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 1.12
Marker Score: 381 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.11
Marker Score: 10,474 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.06
Marker Score: 1,225 - Cell Name: granulosa cell (CL0000501)
Fold Change: 1.01
Marker Score: 10,203 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1
Marker Score: 4,140 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,794 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,019 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.99
Marker Score: 2,325 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.98
Marker Score: 8,451 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,405 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.96
Marker Score: 497 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.95
Marker Score: 450 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,411 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.92
Marker Score: 1,867 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,732 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.9
Marker Score: 5,157 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.88
Marker Score: 317 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.88
Marker Score: 13,118 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,295 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.84
Marker Score: 264 - Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.82
Marker Score: 4,298 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.8
Marker Score: 482 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.78
Marker Score: 28,864 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,261 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.77
Marker Score: 1,039 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.77
Marker Score: 585 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.76
Marker Score: 5,829 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.75
Marker Score: 360 - Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.75
Marker Score: 4,470 - Cell Name: brush cell (CL0002204)
Fold Change: 0.75
Marker Score: 684 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.75
Marker Score: 386 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.75
Marker Score: 240 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.73
Marker Score: 3,049 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.72
Marker Score: 289 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.69
Marker Score: 7,162 - Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.68
Marker Score: 1,846 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.67
Marker Score: 172 - Cell Name: Leydig cell (CL0000178)
Fold Change: 0.65
Marker Score: 697 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.64
Marker Score: 3,860 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.64
Marker Score: 13,639 - Cell Name: follicular B cell (CL0000843)
Fold Change: 0.63
Marker Score: 680 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.61
Marker Score: 12,195 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.6
Marker Score: 22,928 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.6
Marker Score: 252 - Cell Name: astrocyte (CL0000127)
Fold Change: 0.6
Marker Score: 516 - Cell Name: neuron (CL0000540)
Fold Change: 0.58
Marker Score: 2,365 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 438 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.55
Marker Score: 349 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.54
Marker Score: 2,083 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.54
Marker Score: 266 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.54
Marker Score: 594 - Cell Name: podocyte (CL0000653)
Fold Change: 0.54
Marker Score: 198 - Cell Name: enterocyte of colon (CL1000347)
Fold Change: 0.53
Marker Score: 820 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.51
Marker Score: 1,121 - Cell Name: Unknown (CL0002371)
Fold Change: 0.51
Marker Score: 539 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.49
Marker Score: 135 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.49
Marker Score: 286 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 0.48
Marker Score: 280 - Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.48
Marker Score: 124 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.47
Marker Score: 567 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.46
Marker Score: 1,805 - Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.44
Marker Score: 197 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 0.44
Marker Score: 1,576 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.44
Marker Score: 1,313 - Cell Name: epithelial cell (CL0000066)
Fold Change: 0.44
Marker Score: 699 - Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.44
Marker Score: 289 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.44
Marker Score: 2,843 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.43
Marker Score: 342 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 0.42
Marker Score: 9,424 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.42
Marker Score: 133 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.4
Marker Score: 219 - Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.4
Marker Score: 326 - Cell Name: ionocyte (CL0005006)
Fold Change: 0.4
Marker Score: 120 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.39
Marker Score: 577 - Cell Name: mesangial cell (CL0000650)
Fold Change: 0.38
Marker Score: 460 - Cell Name: secretory cell (CL0000151)
Fold Change: 0.38
Marker Score: 685 - Cell Name: memory B cell (CL0000787)
Fold Change: 0.37
Marker Score: 279 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.36
Marker Score: 359 - Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 0.35
Marker Score: 112 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.35
Marker Score: 238 - Cell Name: interneuron (CL0000099)
Fold Change: 0.35
Marker Score: 158 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.34
Marker Score: 1,584 - Cell Name: malignant cell (CL0001064)
Fold Change: 0.34
Marker Score: 4,540 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.33
Marker Score: 666 - Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.33
Marker Score: 66 - Cell Name: keratocyte (CL0002363)
Fold Change: 0.33
Marker Score: 75 - Cell Name: germ cell (CL0000586)
Fold Change: 0.33
Marker Score: 568 - Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.32
Marker Score: 86 - Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.32
Marker Score: 492
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3815896268
Symbol: RHBT2_HUMAN
Name: Rho-related BTB domain-containing protein 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 12426103
Title: Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse.
PubMed ID: 12426103
PubMed ID: 9872452
Title: Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 9872452
PubMed ID: 12168954
Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
PubMed ID: 12168954
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16421571
Title: DNA sequence and analysis of human chromosome 8.
PubMed ID: 16421571
DOI: 10.1038/nature04406
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 26517842
Title: Client proteins and small molecule inhibitors display distinct binding preferences for constitutive and stress-induced HSP90 isoforms and their conformationally restricted mutants.
PubMed ID: 26517842
PubMed ID: 26740508
Title: Identification of novel genetic causes of Rett syndrome-like phenotypes.
PubMed ID: 26740508
PubMed ID: 29276004
Title: Missense variants in RHOBTB2 cause a developmental and epileptic encephalopathy in humans, and altered levels cause neurological defects in Drosophila.
PubMed ID: 29276004
PubMed ID: 29768694
Title: De novo variants in RHOBTB2, an atypical Rho GTPase gene, cause epileptic encephalopathy.
PubMed ID: 29768694
DOI: 10.1002/humu.23550
Sequence Information:
- Length: 727
- Mass: 82626
- Checksum: 25C7493B2894A1B3
- Sequence:
MDSDMDYERP NVETIKCVVV GDNAVGKTRL ICARACNATL TQYQLLATHV PTVWAIDQYR VCQEVLERSR DVVDDVSVSL RLWDTFGDHH KDRRFAYGRS DVVVLCFSIA NPNSLHHVKT MWYPEIKHFC PRAPVILVGC QLDLRYADLE AVNRARRPLA RPIKPNEILP PEKGREVAKE LGIPYYETSV VAQFGIKDVF DNAIRAALIS RRHLQFWKSH LRNVQRPLLQ APFLPPKPPP PIIVVPDPPS SSEECPAHLL EDPLCADVIL VLQERVRIFA HKIYLSTSSS KFYDLFLMDL SEGELGGPSE PGGTHPEDHQ GHSDQHHHHH HHHHGRDFLL RAASFDVCES VDEAGGSGPA GLRASTSDGI LRGNGTGYLP GRGRVLSSWS RAFVSIQEEM AEDPLTYKSR LMVVVKMDSS IQPGPFRAVL KYLYTGELDE NERDLMHIAH IAELLEVFDL RMMVANILNN EAFMNQEITK AFHVRRTNRV KECLAKGTFS DVTFILDDGT ISAHKPLLIS SCDWMAAMFG GPFVESSTRE VVFPYTSKSC MRAVLEYLYT GMFTSSPDLD DMKLIILANR LCLPHLVALT EQYTVTGLME ATQMMVDIDG DVLVFLELAQ FHCAYQLADW CLHHICTNYN NVCRKFPRDM KAMSPENQEY FEKHRWPPVW YLKEEDHYQR ARKEREKEDY LHLKRQPKRR WLFWNSPSSP SSSAASSSSP SSSSAVV
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.