Details for: GAGE1

Gene ID: 2543

Symbol: GAGE1

Ensembl ID: ENSG00000205777

Description: G antigen 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.1336
    Cell Significance Index: 1.5100
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.0761
    Cell Significance Index: 0.4700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0363
    Cell Significance Index: 0.5200
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.0239
    Cell Significance Index: 0.2500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0111
    Cell Significance Index: 0.1900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0108
    Cell Significance Index: 0.2000
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0089
    Cell Significance Index: 0.1000
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: 0.0049
    Cell Significance Index: 0.0500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0004
    Cell Significance Index: -0.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0006
    Cell Significance Index: -0.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0008
    Cell Significance Index: -0.3700
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0015
    Cell Significance Index: -0.0200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0016
    Cell Significance Index: -0.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0017
    Cell Significance Index: -0.3500
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0017
    Cell Significance Index: -0.0200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0017
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0020
    Cell Significance Index: -0.3500
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0021
    Cell Significance Index: -0.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0025
    Cell Significance Index: -0.3500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0030
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0031
    Cell Significance Index: -0.3500
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.0032
    Cell Significance Index: -0.0200
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0038
    Cell Significance Index: -0.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0049
    Cell Significance Index: -0.3300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0054
    Cell Significance Index: -0.0700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0059
    Cell Significance Index: -0.0700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0066
    Cell Significance Index: -0.2200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0082
    Cell Significance Index: -0.2100
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.0087
    Cell Significance Index: -0.1000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0088
    Cell Significance Index: -0.1200
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0092
    Cell Significance Index: -0.0600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0095
    Cell Significance Index: -0.1000
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0095
    Cell Significance Index: -0.0900
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0104
    Cell Significance Index: -0.1300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0104
    Cell Significance Index: -0.2600
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0104
    Cell Significance Index: -0.1100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0110
    Cell Significance Index: -0.3500
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0114
    Cell Significance Index: -0.1100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0115
    Cell Significance Index: -0.2300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0117
    Cell Significance Index: -0.4100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0120
    Cell Significance Index: -0.2400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0123
    Cell Significance Index: -0.3600
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: -0.0127
    Cell Significance Index: -0.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0145
    Cell Significance Index: -0.3800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0145
    Cell Significance Index: -0.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0146
    Cell Significance Index: -0.3900
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0150
    Cell Significance Index: -0.1800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0152
    Cell Significance Index: -0.2000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0158
    Cell Significance Index: -0.2000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0158
    Cell Significance Index: -0.2300
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0160
    Cell Significance Index: -0.1700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0160
    Cell Significance Index: -0.2300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0167
    Cell Significance Index: -0.1700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0174
    Cell Significance Index: -0.3700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0176
    Cell Significance Index: -0.3800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0178
    Cell Significance Index: -0.2100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0184
    Cell Significance Index: -0.2000
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0186
    Cell Significance Index: -0.1500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0187
    Cell Significance Index: -0.3700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0194
    Cell Significance Index: -0.3900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0198
    Cell Significance Index: -0.2400
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0199
    Cell Significance Index: -0.1500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0203
    Cell Significance Index: -0.4000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0204
    Cell Significance Index: -0.3300
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0216
    Cell Significance Index: -0.1500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0220
    Cell Significance Index: -0.3800
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0223
    Cell Significance Index: -0.2300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0225
    Cell Significance Index: -0.1900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0228
    Cell Significance Index: -0.3000
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0232
    Cell Significance Index: -0.2900
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0243
    Cell Significance Index: -0.2300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0244
    Cell Significance Index: -0.1900
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0255
    Cell Significance Index: -0.3100
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0256
    Cell Significance Index: -0.3200
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0259
    Cell Significance Index: -0.2700
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0263
    Cell Significance Index: -0.3300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0264
    Cell Significance Index: -0.3100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0268
    Cell Significance Index: -0.3500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0271
    Cell Significance Index: -0.3800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0277
    Cell Significance Index: -0.3100
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0277
    Cell Significance Index: -0.3300
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0283
    Cell Significance Index: -0.3600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0285
    Cell Significance Index: -0.3400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0287
    Cell Significance Index: -0.3300
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0290
    Cell Significance Index: -0.3500
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0291
    Cell Significance Index: -0.3800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0296
    Cell Significance Index: -0.3800
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0301
    Cell Significance Index: -0.3200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0305
    Cell Significance Index: -0.3600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0306
    Cell Significance Index: -0.3500
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0307
    Cell Significance Index: -0.3300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0309
    Cell Significance Index: -0.3600
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0314
    Cell Significance Index: -0.3700
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0314
    Cell Significance Index: -0.3400
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0319
    Cell Significance Index: -0.3800
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0321
    Cell Significance Index: -0.3900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0325
    Cell Significance Index: -0.4000
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0328
    Cell Significance Index: -0.3600
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0329
    Cell Significance Index: -0.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GAGE1 is a small, membrane-anchored protein that belongs to the G antigen family. It is characterized by its ability to interact with various ligands, including integrins, cadherins, and selectins, which are crucial for cell adhesion and migration. The GAGE1 protein has been shown to regulate cellular processes, such as cell proliferation, differentiation, and survival, in various cell types. Its expression is widespread, with significant levels observed in immune cells, including T cells and microglial cells. **Pathways and Functions:** GAGE1 has been implicated in several biological pathways, including: 1. **Cellular adhesion**: GAGE1 interacts with integrins and cadherins to regulate cell adhesion, migration, and homing. 2. **Immune responses**: GAGE1 is expressed on the surface of immune cells, including T cells and microglial cells, and plays a role in regulating immune responses, including cell activation, proliferation, and differentiation. 3. **Cell proliferation and differentiation**: GAGE1 regulates cell proliferation and differentiation in various cell types, including immune cells and progenitor cells. 4. **Angiogenesis**: GAGE1 has been shown to regulate angiogenesis, the process of new blood vessel formation, which is critical for tissue repair and immune responses. **Clinical Significance:** GAGE1 has been implicated in several diseases, including: 1. **Cancer**: GAGE1 has been shown to be overexpressed in various types of cancer, including breast, lung, and colon cancer, where it may contribute to tumor progression and metastasis. 2. **Autoimmune diseases**: GAGE1 has been implicated in autoimmune diseases, such as multiple sclerosis, where it may contribute to immune cell activation and inflammation. 3. **Neurological disorders**: GAGE1 has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it may contribute to neuroinflammation and neuronal damage. In conclusion, GAGE1 is a multifunctional protein that plays a critical role in regulating cellular adhesion, migration, and immune responses. Its expression is widespread, and its dysregulation has been implicated in various diseases, including cancer, autoimmune diseases, and neurological disorders. Further research is needed to fully elucidate the mechanisms by which GAGE1 regulates immune responses and to explore its potential as a therapeutic target for these diseases.

Genular Protein ID: 351655037

Symbol: GAGE1_HUMAN

Name: Antigen MZ2-F

UniProtKB Accession Codes:

P0DTW1 A8MU85 Q13065 Q13068 Q6NT33

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GeneCards 1 GeneTree 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 Proteomes 1 Pumba 1 RefSeq 1 SMART 1 SignaLink 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7544395

Title: A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma.

PubMed ID: 7544395

DOI: 10.1084/jem.182.3.689

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10397259

Title: Characterization of the GAGE genes that are expressed in various human cancers and in normal testis.

PubMed ID: 10397259

PubMed ID: 18179644

Title: An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members.

PubMed ID: 18179644

DOI: 10.1111/j.1399-0039.2007.00997.x

Sequence Information:

  • Length: 117
  • Mass: 12885
  • Checksum: 365ED71B24DDC7AD
  • Sequence:
    • MSWRGRSTYY WPRPRRYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQR QDPAAAQEGE 
DEGASAGQGP KPEADSQEQG HPQTGCECED GPDGQEMDPP NPEEVKTPEE GEGQSQC

Genular Protein ID: 1721814256

Symbol: A0A158RFV5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A158RFV5

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 IntAct 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 PhylomeDB 1 RefSeq 1 SAM 1 SMART 2 VEuPathDB 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 139
  • Mass: 15610
  • Checksum: AEF5EA1BC7F59811
  • Sequence:
    • MSWRGRSTYY WPRPRRYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQR QDPAAAQEGE 
DEGASAGQGP KPEADSQEQG HPQTGCECED GPDGQEMDPP NPEEVKTPEE EMRSHYVAQT 
GILWLLMNNC FLNLSPRKP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.