Details for: GABBR1

Gene ID: 2550

Symbol: GABBR1

Ensembl ID: ENSG00000204681

Description: gamma-aminobutyric acid type B receptor subunit 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.58
    Marker Score: 55066
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.17
    Marker Score: 1272
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.89
    Marker Score: 8731
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.86
    Marker Score: 70481
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.82
    Marker Score: 7563
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.81
    Marker Score: 2080
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.77
    Marker Score: 3895
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.76
    Marker Score: 15120
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.76
    Marker Score: 34951
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.7
    Marker Score: 1118
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.7
    Marker Score: 6568
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.68
    Marker Score: 16008
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.67
    Marker Score: 102919
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.66
    Marker Score: 61210
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.65
    Marker Score: 12681
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.65
    Marker Score: 24688
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.62
    Marker Score: 3296
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.59
    Marker Score: 14971
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.52
    Marker Score: 1837
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.51
    Marker Score: 2327
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.36
    Marker Score: 522
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.23
    Marker Score: 691
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.22
    Marker Score: 5106
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.21
    Marker Score: 702
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.19
    Marker Score: 691
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.16
    Marker Score: 1939.5
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.14
    Marker Score: 1535.5
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.11
    Marker Score: 1382
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.11
    Marker Score: 2133
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.09
    Marker Score: 368
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.09
    Marker Score: 319
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.09
    Marker Score: 872
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.08
    Marker Score: 536
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.05
    Marker Score: 1003
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.05
    Marker Score: 1161
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.05
    Marker Score: 331
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1
    Marker Score: 417
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.99
    Marker Score: 2827
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.95
    Marker Score: 1072
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 491
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 446
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.93
    Marker Score: 1124
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.93
    Marker Score: 446
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2735
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.91
    Marker Score: 789
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5098
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5272
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 312
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.83
    Marker Score: 786.5
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.83
    Marker Score: 226
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.81
    Marker Score: 10747
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1257
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.75
    Marker Score: 3670
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.74
    Marker Score: 361
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.74
    Marker Score: 3100.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 292
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 551
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 653
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.7
    Marker Score: 391
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.68
    Marker Score: 302
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.67
    Marker Score: 473
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.66
    Marker Score: 168
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.66
    Marker Score: 7425
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.66
    Marker Score: 268
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.64
    Marker Score: 232
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.63
    Marker Score: 2563
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.63
    Marker Score: 340
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.62
    Marker Score: 331
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.62
    Marker Score: 350
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6
    Marker Score: 683
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.6
    Marker Score: 20270
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.58
    Marker Score: 151
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.57
    Marker Score: 211
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.57
    Marker Score: 183
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.56
    Marker Score: 31400
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.56
    Marker Score: 270
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.55
    Marker Score: 586
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.55
    Marker Score: 687.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 436
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.55
    Marker Score: 589
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.54
    Marker Score: 414
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.53
    Marker Score: 2217
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.53
    Marker Score: 221
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.53
    Marker Score: 379
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.53
    Marker Score: 349
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.52
    Marker Score: 343
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.52
    Marker Score: 164
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.52
    Marker Score: 458
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.51
    Marker Score: 117
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.5
    Marker Score: 2085
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.49
    Marker Score: 484
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.49
    Marker Score: 135
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.49
    Marker Score: 953
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.49
    Marker Score: 166
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.48
    Marker Score: 150
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.48
    Marker Score: 4806.5
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.47
    Marker Score: 507

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Other Information

**Key characteristics**: * It is a member of the G protein-coupled receptor family of ion channels. * It is expressed in high levels in astrocytes, which are star-shaped cells that are found in the brain and spinal cord. * It is also expressed in other cell types, including neurons, interneurons, and vascular cells. * It is a ligand for the G protein-coupled receptor alpha (Galpha) subunit. **Pathways and functions**: * Activation of GABBR1 by Galpha leads to the opening of G protein-coupled potassium channels, which hyperpolarize the cell. * This increase in intracellular potassium concentration inhibits voltage-gated calcium channels, which leads to a decrease in neuronal excitability. * GABBR1 also acts as a receptor for the neurotransmitter gamma-aminobutyric acid (GABA). * When GABA binds to GABBR1, it blocks the action of Galpha and inhibits GABA-mediated excitatory signaling. **Clinical significance**: Mutations in the GABBR1 gene have been linked to a number of neurological disorders, including autism, schizophrenia, and epilepsy. These disorders are characterized by abnormal brain function and synaptic abnormalities. **Additional notes**: * GABBR1 is a highly conserved gene, with a similar sequence found in mammals, birds, and reptiles. * It is a key target for therapeutic interventions in neurological disorders that are characterized by abnormal synaptic transmission, such as autism and epilepsy.

Genular Protein ID: 1129257026

Symbol: GABR1_HUMAN

Name: Gamma-aminobutyric acid type B receptor subunit 1

UniProtKB Accession Codes:

Q9UBS5 B0UXY7 O95375 O95468 O95975 O96022 Q5STL4 Q5SUJ8 Q5SUL3 Q71SG6 Q86W60 Q9UQQ0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 3 CORUM 1 CTD 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 11 DrugCentral 1 EMBL 45 EMDB 13 Ensembl 35 ExpressionAtlas 1 GO 35 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 40 PDBsum 24 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 5 RefSeq 4 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9844003

Title: Human gamma-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channels.

PubMed ID: 9844003

DOI: 10.1073/pnas.95.25.14991

PubMed ID: 9872316

Title: Heterodimerization is required for the formation of a functional GABA(B) receptor.

PubMed ID: 9872316

DOI: 10.1038/25354

PubMed ID: 9753614

Title: GABA (gamma-amino-butyric acid) neurotransmission: identification and fine mapping of the human GABAB receptor gene.

PubMed ID: 9753614

DOI: 10.1006/bbrc.1998.9296

PubMed ID: 9798068

Title: Human gamma-aminobutyric acid B receptor gene: complementary DNA cloning, expression, chromosomal location, and genomic organization.

PubMed ID: 9798068

DOI: 10.1016/s0006-3223(98)00244-3

PubMed ID: 9933300

Title: Mapping, genomic structure, and polymorphisms of the human GABABR1 receptor gene: evaluation of its involvement in idiopathic generalized epilepsy.

PubMed ID: 9933300

DOI: 10.1007/s100480050051

PubMed ID: 9889352

Title: Molecular cloning of human GABABR1 and its tissue distribution.

PubMed ID: 9889352

DOI: 10.1016/s0169-328x(98)00316-7

PubMed ID: 10906333

Title: Characterization of gamma-aminobutyric acid receptor GABAB(1e), a GABAB(1) splice variant encoding a truncated receptor.

PubMed ID: 10906333

DOI: 10.1074/jbc.m005333200

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 10773016

Title: Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor.

PubMed ID: 10773016

PubMed ID: 10075644

Title: Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity.

PubMed ID: 10075644

DOI: 10.1074/jbc.274.12.7607

PubMed ID: 9872744

Title: Role of heteromer formation in GABAB receptor function.

PubMed ID: 9872744

DOI: 10.1126/science.283.5398.74

PubMed ID: 14718537

Title: Marlin-1, a novel RNA-binding protein associates with GABA receptors.

PubMed ID: 14718537

DOI: 10.1074/jbc.m311737200

PubMed ID: 15617512

Title: Subcellular distribution of GABA(B) receptor homo- and hetero-dimers.

PubMed ID: 15617512

DOI: 10.1042/bj20041435

PubMed ID: 18165688

Title: Direct detection of the interaction between recombinant soluble extracellular regions in the heterodimeric metabotropic gamma-aminobutyric acid receptor.

PubMed ID: 18165688

DOI: 10.1074/jbc.m705202200

PubMed ID: 22660477

Title: Structure and functional interaction of the extracellular domain of human GABA(B) receptor GBR2.

PubMed ID: 22660477

DOI: 10.1038/nn.3133

PubMed ID: 24305054

Title: Structural mechanism of ligand activation in human GABA(B) receptor.

PubMed ID: 24305054

DOI: 10.1038/nature12725

PubMed ID: 10402495

Title: Association analysis of exonic variants of the gene encoding the GABAB receptor and idiopathic generalized epilepsy.

PubMed ID: 10402495

DOI: 10.1002/(sici)1096-8628(19990820)88:4<305::aid-ajmg5>3.0.co;2-x

Sequence Information:

  • Length: 961
  • Mass: 108320
  • Checksum: 54E7349CD02B633F
  • Sequence:
    • MLLLLLLAPL FLRPPGAGGA QTPNATSEGC QIIHPPWEGG IRYRGLTRDQ VKAINFLPVD 
YEIEYVCRGE REVVGPKVRK CLANGSWTDM DTPSRCVRIC SKSYLTLENG KVFLTGGDLP 
ALDGARVDFR CDPDFHLVGS SRSICSQGQW STPKPHCQVN RTPHSERRAV YIGALFPMSG 
GWPGGQACQP AVEMALEDVN SRRDILPDYE LKLIHHDSKC DPGQATKYLY ELLYNDPIKI 
ILMPGCSSVS TLVAEAARMW NLIVLSYGSS SPALSNRQRF PTFFRTHPSA TLHNPTRVKL 
FEKWGWKKIA TIQQTTEVFT STLDDLEERV KEAGIEITFR QSFFSDPAVP VKNLKRQDAR 
IIVGLFYETE ARKVFCEVYK ERLFGKKYVW FLIGWYADNW FKIYDPSINC TVDEMTEAVE 
GHITTEIVML NPANTRSISN MTSQEFVEKL TKRLKRHPEE TGGFQEAPLA YDAIWALALA 
LNKTSGGGGR SGVRLEDFNY NNQTITDQIY RAMNSSSFEG VSGHVVFDAS GSRMAWTLIE 
QLQGGSYKKI GYYDSTKDDL SWSKTDKWIG GSPPADQTLV IKTFRFLSQK LFISVSVLSS 
LGIVLAVVCL SFNIYNSHVR YIQNSQPNLN NLTAVGCSLA LAAVFPLGLD GYHIGRNQFP 
FVCQARLWLL GLGFSLGYGS MFTKIWWVHT VFTKKEEKKE WRKTLEPWKL YATVGLLVGM 
DVLTLAIWQI VDPLHRTIET FAKEEPKEDI DVSILPQLEH CSSRKMNTWL GIFYGYKGLL 
LLLGIFLAYE TKSVSTEKIN DHRAVGMAIY NVAVLCLITA PVTMILSSQQ DAAFAFASLA 
IVFSSYITLV VLFVPKMRRL ITRGEWQSEA QDTMKTGSST NNNEEEKSRL LEKENRELEK 
IIAEKEERVS ELRHQLQSRQ QLRSRRHPPT PPEPSGGLPR GPPEPPDRLS CDGSRVHLLY 
K

Genular Protein ID: 3744952289

Symbol: C9J342_HUMAN

Name: N/A

UniProtKB Accession Codes:

C9J342

Database IDs:

ARBA 13 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 3 ChiTaRS 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 7 MassIVE 1 NCBI Taxonomy 1 PANTHER 2 PRINTS 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 3 SMART 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

Sequence Information:

  • Length: 966
  • Mass: 108863
  • Checksum: 0B6698E6BD1EABA2
  • Sequence:
    • MPGAWMLLLL LLAPLFLRPP GAGGAQTPNA TSEGCQIIHP PWEGGIRYRG LTRDQVKAIN 
FLPVDYEIEY VCRGEREVVG PKVRKCLANG SWTDMDTPSR CVRICSKSYL TLENGKVFLT 
GGDLPALDGA RVDFRCDPDF HLVGSSRSIC SQGQWSTPKP HCQVNRTPHS ERRAVYIGAL 
FPMSGGWPGG QACQPAVEMA LEDVNSRRDI LPDYELKLIH HDSKCDPGQA TKYLYELLYN 
DPIKIILMPG CSSVSTLVAE AARMWNLIVL SYGSSSPALS NRQRFPTFFR THPSATLHNP 
TRVKLFEKWG WKKIATIQQT TEVFTSTLDD LEERVKEAGI EITFRQSFFS DPAVPVKNLK 
RQDARIIVGL FYETEARKVF CEVYKERLFG KKYVWFLIGW YADNWFKIYD PSINCTVDEM 
TEAVEGHITT EIVMLNPANT RSISNMTSQE FVEKLTKRLK RHPEETGGFQ EAPLAYDAIW 
ALALALNKTS GGGGRSGVRL EDFNYNNQTI TDQIYRAMNS SSFEGVSGHV VFDASGSRMA 
WTLIEQLQGG SYKKIGYYDS TKDDLSWSKT DKWIGGSPPA DQTLVIKTFR FLSQKLFISV 
SVLSSLGIVL AVVCLSFNIY NSHVRYIQNS QPNLNNLTAV GCSLALAAVF PLGLDGYHIG 
RNQFPFVCQA RLWLLGLGFS LGYGSMFTKI WWVHTVFTKK EEKKEWRKTL EPWKLYATVG 
LLVGMDVLTL AIWQIVDPLH RTIETFAKEE PKEDIDVSIL PQLEHCSSRK MNTWLGIFYG 
YKGLLLLLGI FLAYETKSVS TEKINDHRAV GMAIYNVAVL CLITAPVTMI LSSQQDAAFA 
FASLAIVFSS YITLVVLFVP KMRRLITRGE WQSEAQDTMK TGSSTNNNEE EKSRLLEKEN 
RELEKIIAEK EERVSELRHQ LQSRQQLRSR RHPPTPPEPS GGLPRGPPEP PDRLSCDGSR 
VHLLYK

Genular Protein ID: 2392711273

Symbol: Q8IW08_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8IW08

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 3 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 844
  • Mass: 95132
  • Checksum: 1E35BA65E468BBC9
  • Sequence:
    • MGPGAPFARV GWPLPLLVVM AAGVAPVWAS HSPHLPRPHS RVPPHPSSER RAVYIGALFP 
MSGGWPGGQA SQPAVEMALE DVNSRRDILP DYELKLIHHD SKCDPGQATK YLYELLYNDP 
IKIILMPGCS SVSTLVAEAA RMWNLIVLSY GSSSPALSNR QRFPTFFRTH PSATLHNPTR 
VKLFEKWGWK KIATIQQTTE VFTSTLDDLE ERVKEAGIEI TFRQSFFSDP AVPVKNLKRQ 
DARIIVGLFY ETEARKVFCE VYKERLFGKK YVWFLIGWYA DNWFKIYDPS INCTVDEMTE 
AVEGHITTEI VMLNPANTRS ISNMTSQEFV EKLTKRLKRH PEETGGFQEA PLAYDAIWAL 
ALALNKTSGG GGRSGVRLED FNYNNQTITD QIYRAMNSSS FEGVSGHVVF DASGSRMAWT 
LIEQLQGGSY KKIGYYDSTK DDLSWSKTDK WIGGSPPADQ TLVIKTFRFL SQKLFISVSV 
LSSLGIVLAV VCLSFNIYNS HVRYIQNSQP NLNNLTAVGC SLALAAVFPL GLDGYHIGRN 
QFPFVCQARL WLLGLGFSLG YGSMFTKIWW VHTVFTKKEE KKEWRKTLEP WKLYATVGLL 
VGMDVLTLAI WQIVDPLHRT IETFAKEEPK EDIDVSILPQ LEHCSSRKMN TWLGIFYGYK 
GLLLLLGIFL AYETKSVSTE KINDHRAVGM AIYNVAVLCL ITAPVTMILS SQQDAAFAFA 
SLAIVFSSYI TLVVLFVPKM RRLITRGEWQ SEAQDTMKTG SSTNNNEEEK SRLLEKENRE 
LEKIIAEKEE RVSELRHQLQ SRQQLRSRRH PPTPPEPSGG LPRGPPEPPD RLSCDGSRVH 
LLYK

Genular Protein ID: 2354386445

Symbol: Q59HG8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59HG8

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 2 PeptideAtlas 1 Pfam 2 RefSeq 3 SAM 2 SUPFAM 1

Sequence Information:

  • Length: 808
  • Mass: 91486
  • Checksum: 9DC1F94FD39AFC55
  • Sequence:
    • PRLPSVNRTP HSERRAVYIG ALFPMSGGWP GGQACQPAVE MALEDVNSRR DILPDYELKL 
IHHDSKCDPG QATKYLYELL YNDPIKIILM PGCSSVSTLV AEAARMWNLI VLSYGSSSPA 
LSNRQRFPTF FRTHPSATLH NPTRVKLFEK WGWKKIATIQ QTTEVFTSTL DDLEERVKEA 
GIEITFRQSF FSDPAVPVKN LKRQDARIIV GLFYETEARK VFCEVYKERL FGKKYVWFLI 
GWYADNWFKI YDPSINCTVD EMTEAVEGHI TTEIVMLNPA NTRSISNMTS QEFVEKLTKR 
LKRHPEETGG FQEAPLAYDA IWALALALNK TSGGGGRSGV RLEDFNYNNQ TITDQIYRAM 
NSSSFEGVSG HVVFDASGSR MAWTLIEQLQ GGSYKKIGYY DSTKDDLSWS KTDKWIGGSP 
PADQTLVIKT FRFLSQKLFI SVSVLSSLGI VLAVVCLSFN IYNSHVRYIQ NSQPNLNNLT 
AVGCSLALAA VFPLGLDGYH IGRNQFPFVC QARLWLLGLG FSLGYGSMFT KIWWVHTVFT 
KKEEKKEWRK TLEPWKLYAT VGLLVGMDVL TLAIWQIVDP LHRTIETFAK EEPKEDIDVS 
ILPQLEHCSS RKMNTWLGIF YGYKGLLLLL GIFLAYETKS VSTEKINDHR AVGMAIYNVA 
VLCLITAPVT MILSSQQDAA FAFASLAIVF SSYITLVVLF VPKMRRLITR GEWQSEAQDT 
MKTGSSTNNN EEEKSRLLEK ENRELEKIIA EKEERVSELR HQLQSRQQLR SRRHPPTPPE 
PSGGLPRGPP EPPDRLSCDG SRVHLLYK

Genular Protein ID: 952980854

Symbol: Q5SUJ9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5SUJ9

Database IDs:

ARBA 11 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 6 ExpressionAtlas 1 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 2 Pfam 2 PharmGKB 1 RefSeq 1 SAM 3 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 844
  • Mass: 95148
  • Checksum: D926376823699485
  • Sequence:
    • MGPGAPFARV GWPLPLLVVM AAGVAPVWAS HSPHLPRPHS RVPPHPSSER RAVYIGALFP 
MSGGWPGGQA CQPAVEMALE DVNSRRDILP DYELKLIHHD SKCDPGQATK YLYELLYNDP 
IKIILMPGCS SVSTLVAEAA RMWNLIVLSY GSSSPALSNR QRFPTFFRTH PSATLHNPTR 
VKLFEKWGWK KIATIQQTTE VFTSTLDDLE ERVKEAGIEI TFRQSFFSDP AVPVKNLKRQ 
DARIIVGLFY ETEARKVFCE VYKERLFGKK YVWFLIGWYA DNWFKIYDPS INCTVDEMTE 
AVEGHITTEI VMLNPANTRS ISNMTSQEFV EKLTKRLKRH PEETGGFQEA PLAYDAIWAL 
ALALNKTSGG GGRSGVRLED FNYNNQTITD QIYRAMNSSS FEGVSGHVVF DASGSRMAWT 
LIEQLQGGSY KKIGYYDSTK DDLSWSKTDK WIGGSPPADQ TLVIKTFRFL SQKLFISVSV 
LSSLGIVLAV VCLSFNIYNS HVRYIQNSQP NLNNLTAVGC SLALAAVFPL GLDGYHIGRN 
QFPFVCQARL WLLGLGFSLG YGSMFTKIWW VHTVFTKKEE KKEWRKTLEP WKLYATVGLL 
VGMDVLTLAI WQIVDPLHRT IETFAKEEPK EDIDVSILPQ LEHCSSRKMN TWLGIFYGYK 
GLLLLLGIFL AYETKSVSTE KINDHRAVGM AIYNVAVLCL ITAPVTMILS SQQDAAFAFA 
SLAIVFSSYI TLVVLFVPKM RRLITRGEWQ SEAQDTMKTG SSTNNNEEEK SRLLEKENRE 
LEKIIAEKEE RVSELRHQLQ SRQQLRSRRH PPTPPEPSGG LPRGPPEPPD RLSCDGSRVH 
LLYK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.