Details for: RNU11

Gene ID: 26824

Symbol: RNU11

Ensembl ID: ENSG00000274978

Description: RNA, U11 small nuclear

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.6607
    Cell Significance Index: 7.9700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.1205
    Cell Significance Index: 3.0100
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.0671
    Cell Significance Index: 0.7900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0604
    Cell Significance Index: 0.7900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0507
    Cell Significance Index: 1.3800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0375
    Cell Significance Index: 1.0800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0235
    Cell Significance Index: 0.3200
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.0235
    Cell Significance Index: 0.1900
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.0084
    Cell Significance Index: 0.0800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0014
    Cell Significance Index: 0.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0004
    Cell Significance Index: 0.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0018
    Cell Significance Index: -0.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0042
    Cell Significance Index: -0.8500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0046
    Cell Significance Index: -0.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0065
    Cell Significance Index: -0.9500
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0072
    Cell Significance Index: -0.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0095
    Cell Significance Index: -0.4300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0132
    Cell Significance Index: -0.3900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0132
    Cell Significance Index: -0.4200
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0136
    Cell Significance Index: -0.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0142
    Cell Significance Index: -0.5000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0169
    Cell Significance Index: -0.3500
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0230
    Cell Significance Index: -0.2400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0243
    Cell Significance Index: -0.6200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0246
    Cell Significance Index: -0.5300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0271
    Cell Significance Index: -0.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0275
    Cell Significance Index: -0.8800
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0296
    Cell Significance Index: -0.3200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0301
    Cell Significance Index: -0.7500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0307
    Cell Significance Index: -0.4600
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0332
    Cell Significance Index: -0.2800
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -0.0337
    Cell Significance Index: -0.3200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0347
    Cell Significance Index: -1.1300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0353
    Cell Significance Index: -0.9000
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0353
    Cell Significance Index: -0.4600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0398
    Cell Significance Index: -0.6800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0403
    Cell Significance Index: -0.8100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0420
    Cell Significance Index: -0.3700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0421
    Cell Significance Index: -0.4300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0421
    Cell Significance Index: -0.7100
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0424
    Cell Significance Index: -0.4400
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0431
    Cell Significance Index: -0.4700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0431
    Cell Significance Index: -0.4700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0432
    Cell Significance Index: -0.5400
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0471
    Cell Significance Index: -0.5800
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0473
    Cell Significance Index: -0.4900
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0481
    Cell Significance Index: -0.4400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0483
    Cell Significance Index: -0.4900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0500
    Cell Significance Index: -0.8100
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.0504
    Cell Significance Index: -0.5300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0508
    Cell Significance Index: -0.6000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0510
    Cell Significance Index: -0.6000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0512
    Cell Significance Index: -0.8700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0515
    Cell Significance Index: -0.5700
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0537
    Cell Significance Index: -0.5200
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0541
    Cell Significance Index: -0.6800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0546
    Cell Significance Index: -1.0800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0548
    Cell Significance Index: -0.6300
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0559
    Cell Significance Index: -0.6500
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0564
    Cell Significance Index: -0.6300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0564
    Cell Significance Index: -0.7400
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: -0.0568
    Cell Significance Index: -0.4600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0570
    Cell Significance Index: -0.7500
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0572
    Cell Significance Index: -0.5000
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0573
    Cell Significance Index: -0.6100
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0576
    Cell Significance Index: -0.7400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0583
    Cell Significance Index: -0.8600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0586
    Cell Significance Index: -0.9900
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0591
    Cell Significance Index: -0.5500
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.0601
    Cell Significance Index: -0.6500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0610
    Cell Significance Index: -0.8300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0613
    Cell Significance Index: -0.8000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0617
    Cell Significance Index: -0.6500
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0626
    Cell Significance Index: -0.6200
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0631
    Cell Significance Index: -0.5900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0639
    Cell Significance Index: -0.7200
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0647
    Cell Significance Index: -0.7700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0647
    Cell Significance Index: -0.8600
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0650
    Cell Significance Index: -0.7200
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0655
    Cell Significance Index: -0.6600
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0658
    Cell Significance Index: -0.8000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0661
    Cell Significance Index: -0.7800
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0670
    Cell Significance Index: -0.6200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0675
    Cell Significance Index: -0.6400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0684
    Cell Significance Index: -1.0100
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0685
    Cell Significance Index: -0.8100
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0691
    Cell Significance Index: -0.8400
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0692
    Cell Significance Index: -0.7700
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0696
    Cell Significance Index: -0.7600
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0697
    Cell Significance Index: -0.6400
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.0702
    Cell Significance Index: -0.7800
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.0702
    Cell Significance Index: -0.7500
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0704
    Cell Significance Index: -0.8000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0705
    Cell Significance Index: -0.9200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0712
    Cell Significance Index: -0.8800
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0716
    Cell Significance Index: -0.8600
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0716
    Cell Significance Index: -0.7300
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0719
    Cell Significance Index: -0.7800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0719
    Cell Significance Index: -0.9100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0725
    Cell Significance Index: -0.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNU11 is a small nuclear RNA (snRNA) that belongs to the U11 family of snRNAs. It is approximately 50-60 nucleotides in length and is highly conserved across species. RNU11 is a component of the U11 snRNP complex, which plays a critical role in the recognition and processing of pre-mRNA 5'-splice sites. This complex is essential for the efficient splicing of pre-mRNAs, resulting in the production of mature mRNAs that encode proteins involved in various cellular processes, including immune responses. **Pathways and Functions:** The RNU11 gene is involved in several key pathways, including: 1. **Gene expression (transcription):** RNU11 is a crucial regulator of gene expression, influencing the transcriptional activity of RNA polymerase II (RNAPII). By binding to RNAPII, RNU11 modulates the recruitment of co-transcriptional factors, thereby controlling the expression of target genes. 2. **mRNA 5'-splice site recognition:** RNU11 is essential for the recognition and processing of pre-mRNA 5'-splice sites, ensuring the accurate splicing of pre-mRNAs and the production of mature mRNAs. 3. **Pre-mRNA 5'-splice site binding:** RNU11 binds to pre-mRNA 5'-splice sites, facilitating the recognition and processing of these sites by RNAPII and other co-transcriptional factors. 4. **RNA polymerase II transcription:** RNU11 is involved in the transcriptional regulation of RNAPII, modulating the activity of this enzyme and influencing the expression of target genes. 5. **U11 snRNP:** RNU11 is a component of the U11 snRNP complex, which plays a critical role in the recognition and processing of pre-mRNA 5'-splice sites. **Clinical Significance:** The RNU11 gene has been implicated in various diseases and disorders, including: 1. **Immune system disorders:** RNU11 has been linked to immune system disorders, such as autoimmune diseases and immunodeficiency syndromes, due to its role in regulating immune cell development and function. 2. **Cancer:** Altered expression of RNU11 has been observed in various types of cancer, suggesting its potential as a biomarker for cancer diagnosis and prognosis. 3. **Neurological disorders:** RNU11 has been implicated in neurological disorders, such as multiple sclerosis and Alzheimer's disease, due to its role in regulating gene expression and immune responses in the central nervous system. 4. **Cardiovascular disease:** RNU11 has been linked to cardiovascular disease, including atherosclerosis and cardiac dysfunction, due to its role in regulating gene expression and immune responses in cardiac tissue. In conclusion, the RNU11 gene is a critical regulator of gene expression and immune cell development, with significant implications for our understanding of immune system disorders, cancer, neurological disorders, and cardiovascular disease. Further research is needed to fully elucidate the functions and clinical significance of RNU11, but its importance in the immunological landscape is already clear.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.