Details for: IGHV3 20

Gene ID: 28445

Symbol: IGHV3 20

Ensembl ID: ENSG00000211946

Description: immunoglobulin heavy variable 3-20

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.3077
    Cell Significance Index: 4.7600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0166
    Cell Significance Index: 0.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0082
    Cell Significance Index: -6.1900
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0110
    Cell Significance Index: -0.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0488
    Cell Significance Index: -4.9800
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0591
    Cell Significance Index: -0.6600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1028
    Cell Significance Index: -6.6300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1219
    Cell Significance Index: -1.7700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1630
    Cell Significance Index: -4.3600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1789
    Cell Significance Index: -4.5700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2236
    Cell Significance Index: -2.2900
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.2514
    Cell Significance Index: -3.0400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2607
    Cell Significance Index: -6.3200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2797
    Cell Significance Index: -4.1300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3037
    Cell Significance Index: -4.3600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3284
    Cell Significance Index: -6.4200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.3460
    Cell Significance Index: -4.2800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3580
    Cell Significance Index: -6.1200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3636
    Cell Significance Index: -6.7200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.3714
    Cell Significance Index: -5.0900
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.3763
    Cell Significance Index: -3.8200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.3931
    Cell Significance Index: -6.3700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.4091
    Cell Significance Index: -5.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4264
    Cell Significance Index: -19.8800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.4282
    Cell Significance Index: -10.9100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4331
    Cell Significance Index: -6.4900
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.4338
    Cell Significance Index: -5.1500
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.4437
    Cell Significance Index: -5.2200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.4442
    Cell Significance Index: -5.2500
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.4528
    Cell Significance Index: -5.2100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.4571
    Cell Significance Index: -5.9200
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.4640
    Cell Significance Index: -3.0900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4706
    Cell Significance Index: -11.7500
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.4741
    Cell Significance Index: -4.2700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.4782
    Cell Significance Index: -5.0800
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.5042
    Cell Significance Index: -5.3600
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.5047
    Cell Significance Index: -5.5300
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.5064
    Cell Significance Index: -4.1800
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.5385
    Cell Significance Index: -5.8900
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.5446
    Cell Significance Index: -6.1700
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.5486
    Cell Significance Index: -5.5700
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.5646
    Cell Significance Index: -5.4200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.5662
    Cell Significance Index: -6.3800
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.5669
    Cell Significance Index: -6.0600
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.5676
    Cell Significance Index: -6.1200
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.5799
    Cell Significance Index: -6.4200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.5863
    Cell Significance Index: -6.5500
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.5881
    Cell Significance Index: -6.0500
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.6008
    Cell Significance Index: -6.4600
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.6034
    Cell Significance Index: -6.1600
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.6049
    Cell Significance Index: -7.1900
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.6093
    Cell Significance Index: -6.4200
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.6242
    Cell Significance Index: -5.3200
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.6306
    Cell Significance Index: -6.2200
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.6319
    Cell Significance Index: -6.1300
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.6329
    Cell Significance Index: -7.1900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.6466
    Cell Significance Index: -6.0700
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.6509
    Cell Significance Index: -6.3500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.6509
    Cell Significance Index: -8.6500
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.6520
    Cell Significance Index: -5.2400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6583
    Cell Significance Index: -15.2100
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.6637
    Cell Significance Index: -6.2800
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.6659
    Cell Significance Index: -6.9000
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.6676
    Cell Significance Index: -5.9600
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: -0.6766
    Cell Significance Index: -6.2400
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.6842
    Cell Significance Index: -6.3700
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.6871
    Cell Significance Index: -7.3100
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.6893
    Cell Significance Index: -6.8000
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.6895
    Cell Significance Index: -6.1600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.6925
    Cell Significance Index: -9.0400
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.6999
    Cell Significance Index: -5.3500
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.7000
    Cell Significance Index: -8.7500
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.7001
    Cell Significance Index: -6.3600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.7049
    Cell Significance Index: -6.1700
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.7079
    Cell Significance Index: -6.5700
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: -0.7089
    Cell Significance Index: -6.3500
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -0.7125
    Cell Significance Index: -6.2600
  • Cell Name: brush cell of tracheobronchial tree (CL0002075)
    Fold Change: -0.7145
    Cell Significance Index: -6.4300
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.7166
    Cell Significance Index: -6.3800
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.7191
    Cell Significance Index: -6.2400
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.7305
    Cell Significance Index: -8.7600
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.7356
    Cell Significance Index: -6.6400
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.7357
    Cell Significance Index: -7.6200
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.7424
    Cell Significance Index: -7.4100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.7509
    Cell Significance Index: -8.7100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.7584
    Cell Significance Index: -7.7000
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.7659
    Cell Significance Index: -9.0500
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.7665
    Cell Significance Index: -6.6800
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.7757
    Cell Significance Index: -7.8200
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.7773
    Cell Significance Index: -5.4700
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.7775
    Cell Significance Index: -7.8600
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.7777
    Cell Significance Index: -8.9500
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.7801
    Cell Significance Index: -7.1700
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.7872
    Cell Significance Index: -6.4600
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.7875
    Cell Significance Index: -8.3500
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.7891
    Cell Significance Index: -6.3900
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.7952
    Cell Significance Index: -7.4800
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.7954
    Cell Significance Index: -8.8100
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.7955
    Cell Significance Index: -6.0700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.7963
    Cell Significance Index: -6.2000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene Location and Structure:** The IGHV3-20 gene is located on the immunoglobulin heavy chain locus, a region of the genome that encodes for the heavy chains of immunoglobulins (antibodies). 2. **Gene Expression:** The IGHV3-20 gene is expressed in multiple cell types, including those involved in the innate and adaptive immune responses, such as endothelial cells, goblet cells, monocytes, and granulocytes. 3. **Cellular Localization:** The gene is primarily localized to the plasma membrane, where it is involved in the recognition and binding of antigens. 4. **Gene Function:** The IGHV3-20 gene plays a critical role in the development and maturation of B cells, enabling them to recognize and respond to specific antigens. **Pathways and Functions:** 1. **Antigen Binding:** The IGHV3-20 gene is involved in the binding of antigens to the surface of B cells, a critical step in the activation of immune responses. 2. **Immunoglobulin Complex Formation:** The gene is part of the immunoglobulin complex, which is composed of multiple chains (heavy, light, and alpha chains) that work together to recognize and bind to specific antigens. 3. **Immunoglobulin Mediated Immune Response:** The IGHV3-20 gene is essential for the production of antibodies, which are crucial for the clearance of pathogens and the prevention of disease. 4. **Cell Signaling:** The gene is involved in cell signaling pathways, including those that regulate B cell activation, proliferation, and differentiation. **Clinical Significance:** 1. **Immunodeficiency Disorders:** Mutations or deletions of the IGHV3-20 gene can lead to immunodeficiency disorders, such as X-linked agammaglobulinemia (XLA), a condition characterized by impaired antibody production. 2. **Cancer:** Aberrant expression of the IGHV3-20 gene has been linked to the development of certain types of cancer, including lymphomas and leukemias. 3. **Autoimmune Diseases:** The IGHV3-20 gene may also play a role in the development of autoimmune diseases, such as rheumatoid arthritis and lupus, where the immune system mistakenly attacks healthy tissues. 4. **Vaccine Development:** Understanding the function and expression of the IGHV3-20 gene is crucial for the development of effective vaccines, which rely on the production of antibodies to induce immune responses. In conclusion, the IGHV3-20 gene is a vital component of the human immune system, playing a critical role in the development and function of B cells. Its expression in various cell types and involvement in antigen binding, immunoglobulin complex formation, and cell signaling pathways make it a crucial gene in the context of immune responses. Further research is necessary to fully elucidate the clinical significance of the IGHV3-20 gene and its potential applications in the prevention and treatment of immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.