Details for: IGHV3 20

Gene ID: 28445

Symbol: IGHV3 20

Ensembl ID: ENSG00000211946

Description: immunoglobulin heavy variable 3-20

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 12.2
    Marker Score: 10,937
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.63
    Marker Score: 10,811
  • Cell Name: monocyte (CL0000576)
    Fold Change: 1.51
    Marker Score: 1,962
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 874
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7,577
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3,650
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32,729
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,819
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,401
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4,913
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 735
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,258
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.56
    Marker Score: 589
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 435
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.52
    Marker Score: 1,614
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.34
    Marker Score: 398
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.33
    Marker Score: 259
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.28
    Marker Score: 77
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.19
    Marker Score: 259
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.19
    Marker Score: 389
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.14
    Marker Score: 193
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.14
    Marker Score: 36
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.12
    Marker Score: 77
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.1
    Marker Score: 117
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.1
    Marker Score: 48
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.09
    Marker Score: 33
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.09
    Marker Score: 40
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.09
    Marker Score: 83
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.09
    Marker Score: 78
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.09
    Marker Score: 57
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.09
    Marker Score: 65
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.08
    Marker Score: 67
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.08
    Marker Score: 46
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.08
    Marker Score: 35
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.08
    Marker Score: 98
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.07
    Marker Score: 33
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.07
    Marker Score: 50
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.07
    Marker Score: 70
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 133
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.06
    Marker Score: 39
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.06
    Marker Score: 63
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.06
    Marker Score: 169
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.06
    Marker Score: 716
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.06
    Marker Score: 100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.06
    Marker Score: 32
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.06
    Marker Score: 137
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.06
    Marker Score: 69
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.05
    Marker Score: 133
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.05
    Marker Score: 30
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.05
    Marker Score: 90
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.05
    Marker Score: 55
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.05
    Marker Score: 33
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.05
    Marker Score: 31
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.04
    Marker Score: 44
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.04
    Marker Score: 9
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.03
    Marker Score: 32
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.03
    Marker Score: 30
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.03
    Marker Score: 126
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.03
    Marker Score: 30
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.03
    Marker Score: 107
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.02
    Marker Score: 40
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.02
    Marker Score: 51
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.02
    Marker Score: 28
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.02
    Marker Score: 14

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene Location and Structure:** The IGHV3-20 gene is located on the immunoglobulin heavy chain locus, a region of the genome that encodes for the heavy chains of immunoglobulins (antibodies). 2. **Gene Expression:** The IGHV3-20 gene is expressed in multiple cell types, including those involved in the innate and adaptive immune responses, such as endothelial cells, goblet cells, monocytes, and granulocytes. 3. **Cellular Localization:** The gene is primarily localized to the plasma membrane, where it is involved in the recognition and binding of antigens. 4. **Gene Function:** The IGHV3-20 gene plays a critical role in the development and maturation of B cells, enabling them to recognize and respond to specific antigens. **Pathways and Functions:** 1. **Antigen Binding:** The IGHV3-20 gene is involved in the binding of antigens to the surface of B cells, a critical step in the activation of immune responses. 2. **Immunoglobulin Complex Formation:** The gene is part of the immunoglobulin complex, which is composed of multiple chains (heavy, light, and alpha chains) that work together to recognize and bind to specific antigens. 3. **Immunoglobulin Mediated Immune Response:** The IGHV3-20 gene is essential for the production of antibodies, which are crucial for the clearance of pathogens and the prevention of disease. 4. **Cell Signaling:** The gene is involved in cell signaling pathways, including those that regulate B cell activation, proliferation, and differentiation. **Clinical Significance:** 1. **Immunodeficiency Disorders:** Mutations or deletions of the IGHV3-20 gene can lead to immunodeficiency disorders, such as X-linked agammaglobulinemia (XLA), a condition characterized by impaired antibody production. 2. **Cancer:** Aberrant expression of the IGHV3-20 gene has been linked to the development of certain types of cancer, including lymphomas and leukemias. 3. **Autoimmune Diseases:** The IGHV3-20 gene may also play a role in the development of autoimmune diseases, such as rheumatoid arthritis and lupus, where the immune system mistakenly attacks healthy tissues. 4. **Vaccine Development:** Understanding the function and expression of the IGHV3-20 gene is crucial for the development of effective vaccines, which rely on the production of antibodies to induce immune responses. In conclusion, the IGHV3-20 gene is a vital component of the human immune system, playing a critical role in the development and function of B cells. Its expression in various cell types and involvement in antigen binding, immunoglobulin complex formation, and cell signaling pathways make it a crucial gene in the context of immune responses. Further research is necessary to fully elucidate the clinical significance of the IGHV3-20 gene and its potential applications in the prevention and treatment of immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.