Details for: TRBV12 4

Gene ID: 28576

Symbol: TRBV12 4

Ensembl ID: ENSG00000276953

Description: T cell receptor beta variable 12-4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.3613
    Cell Significance Index: 1.9700
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.0645
    Cell Significance Index: 0.6300
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.0469
    Cell Significance Index: 0.3800
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.0133
    Cell Significance Index: 0.1100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0041
    Cell Significance Index: -0.1000
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0249
    Cell Significance Index: -0.2700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0509
    Cell Significance Index: -0.6100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0682
    Cell Significance Index: -1.1500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0873
    Cell Significance Index: -1.2400
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.1245
    Cell Significance Index: -1.1200
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.1245
    Cell Significance Index: -1.2800
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1282
    Cell Significance Index: -1.3000
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1294
    Cell Significance Index: -1.4000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1311
    Cell Significance Index: -3.3400
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1313
    Cell Significance Index: -1.1100
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1401
    Cell Significance Index: -1.4800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1464
    Cell Significance Index: -3.9100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1464
    Cell Significance Index: -1.6000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1480
    Cell Significance Index: -3.7800
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.1507
    Cell Significance Index: -1.5600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1573
    Cell Significance Index: -1.9800
  • Cell Name: group 3 innate lymphoid cell, human (CL0001078)
    Fold Change: -0.1647
    Cell Significance Index: -1.5400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1656
    Cell Significance Index: -2.3000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1664
    Cell Significance Index: -4.0300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1705
    Cell Significance Index: -2.9400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1709
    Cell Significance Index: -2.3300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1712
    Cell Significance Index: -2.0800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1796
    Cell Significance Index: -2.1200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1959
    Cell Significance Index: -3.8300
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1979
    Cell Significance Index: -1.6700
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.2002
    Cell Significance Index: -1.8800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.2020
    Cell Significance Index: -1.8900
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.2025
    Cell Significance Index: -1.9200
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.2030
    Cell Significance Index: -2.4500
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.2052
    Cell Significance Index: -1.6200
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2059
    Cell Significance Index: -3.3100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2078
    Cell Significance Index: -3.8400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.2091
    Cell Significance Index: -2.0100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2153
    Cell Significance Index: -3.2700
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.2164
    Cell Significance Index: -1.6100
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.2175
    Cell Significance Index: -2.1300
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.2185
    Cell Significance Index: -2.0000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2194
    Cell Significance Index: -3.7500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.2198
    Cell Significance Index: -2.2300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2224
    Cell Significance Index: -2.8100
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.2249
    Cell Significance Index: -1.4600
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.2274
    Cell Significance Index: -2.7000
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.2311
    Cell Significance Index: -2.4500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2316
    Cell Significance Index: -3.1800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2320
    Cell Significance Index: -3.7600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.2362
    Cell Significance Index: -2.4500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2376
    Cell Significance Index: -3.3300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2466
    Cell Significance Index: -3.5800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.2474
    Cell Significance Index: -2.8700
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.2489
    Cell Significance Index: -2.1200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.2571
    Cell Significance Index: -3.0600
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.2573
    Cell Significance Index: -2.2200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2596
    Cell Significance Index: -3.5600
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.2610
    Cell Significance Index: -1.5000
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.2622
    Cell Significance Index: -3.1900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2628
    Cell Significance Index: -3.8300
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.2675
    Cell Significance Index: -1.8400
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.2686
    Cell Significance Index: -2.3100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2701
    Cell Significance Index: -3.5000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.2729
    Cell Significance Index: -2.7500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2738
    Cell Significance Index: -4.6500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.2758
    Cell Significance Index: -3.6300
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2775
    Cell Significance Index: -3.5700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2863
    Cell Significance Index: -3.7600
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.2864
    Cell Significance Index: -3.3700
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.2903
    Cell Significance Index: -2.8300
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.2945
    Cell Significance Index: -3.4800
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.2962
    Cell Significance Index: -3.3100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2964
    Cell Significance Index: -3.4100
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.2967
    Cell Significance Index: -2.8700
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.3003
    Cell Significance Index: -3.5700
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.3028
    Cell Significance Index: -3.4900
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.3030
    Cell Significance Index: -3.4300
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.3046
    Cell Significance Index: -3.6000
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.3073
    Cell Significance Index: -3.1200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.3079
    Cell Significance Index: -4.0200
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.3087
    Cell Significance Index: -2.5800
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.3090
    Cell Significance Index: -3.8600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.3100
    Cell Significance Index: -3.8100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.3103
    Cell Significance Index: -2.4800
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.3115
    Cell Significance Index: -3.4500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.3132
    Cell Significance Index: -3.5300
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.3168
    Cell Significance Index: -2.9300
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.3172
    Cell Significance Index: -3.6500
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.3181
    Cell Significance Index: -3.4200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.3193
    Cell Significance Index: -3.2600
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.3204
    Cell Significance Index: -3.5100
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.3209
    Cell Significance Index: -3.4600
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.3264
    Cell Significance Index: -3.5700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.3326
    Cell Significance Index: -3.9300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.3330
    Cell Significance Index: -3.7200
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.3350
    Cell Significance Index: -3.4200
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.3393
    Cell Significance Index: -3.4500
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.3416
    Cell Significance Index: -3.4900
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.3431
    Cell Significance Index: -3.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **TCR beta family member**: TRBV12.4 is a member of the TCR beta family, which consists of over 40 beta chains that contribute to the diversity of the TCR repertoire. 2. **Effector CD8-positive T cells**: TRBV12.4 is predominantly expressed in effector CD8-positive, alpha-beta T cells, which are crucial for the recognition and elimination of infected cells or tumor cells. 3. **Central memory CD4-positive T cells**: TRBV12.4 is also expressed in central memory CD4-positive, alpha-beta T cells, which play a key role in the regulation of immune responses and tissue homeostasis. 4. **Mature NK T cells**: TRBV12.4 is expressed in mature NK T cells, which are involved in the recognition and elimination of tumor cells and virus-infected cells. **Pathways and Functions:** 1. **Adaptive immune response**: TRBV12.4 plays a critical role in the adaptive immune response by recognizing and binding to antigens presented by MHC molecules on antigen-presenting cells. 2. **TCR signaling pathway**: TRBV12.4 contributes to the signaling pathway that activates T cells upon antigen recognition, leading to the activation of downstream signaling pathways. 3. **Cell surface receptor signaling pathway**: TRBV12.4 is a cell surface receptor that interacts with MHC molecules, leading to the activation of downstream signaling pathways. 4. **Regulation of immune responses**: TRBV12.4 is involved in the regulation of immune responses, including the activation and regulation of effector T cells and the maintenance of immune homeostasis. **Clinical Significance:** 1. **Cancer immunotherapy**: TRBV12.4 can be a potential target for cancer immunotherapy, as it is expressed on effector CD8-positive T cells that recognize tumor cells. 2. **Autoimmune diseases**: TRBV12.4 may play a role in the pathogenesis of autoimmune diseases, such as multiple sclerosis, where T cells are dysregulated and contribute to tissue damage. 3. **Infectious diseases**: TRBV12.4 may contribute to the recognition and elimination of virus-infected cells, making it a potential target for the treatment of infectious diseases. 4. **Immunodeficiency disorders**: TRBV12.4 may be involved in the regulation of immune responses in immunodeficiency disorders, such as HIV/AIDS, where T cells are compromised and contribute to the progression of the disease. In conclusion, TRBV12.4 is a critical component of the adaptive immune response, and its dysregulation can contribute to various diseases. Further research is needed to elucidate the functional significance of TRBV12.4 and its potential applications in cancer immunotherapy, autoimmune diseases, infectious diseases, and immunodeficiency disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.