Details for: KRT18P11

Gene ID: 3876

Symbol: KRT18P11

Ensembl ID: ENSG00000215089

Description: keratin 18 pseudogene 11

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.6291
    Cell Significance Index: 5.9800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.2694
    Cell Significance Index: 2.9400
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.1764
    Cell Significance Index: 2.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0958
    Cell Significance Index: 4.9800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0309
    Cell Significance Index: 0.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0045
    Cell Significance Index: 0.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0102
    Cell Significance Index: -1.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0130
    Cell Significance Index: -7.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0288
    Cell Significance Index: -3.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0519
    Cell Significance Index: -7.5400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0616
    Cell Significance Index: -0.8400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0827
    Cell Significance Index: -3.7500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0830
    Cell Significance Index: -2.2600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1317
    Cell Significance Index: -8.0700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1745
    Cell Significance Index: -5.5900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1859
    Cell Significance Index: -4.0700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1959
    Cell Significance Index: -7.1900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2333
    Cell Significance Index: -8.2000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2402
    Cell Significance Index: -6.4400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2509
    Cell Significance Index: -3.4800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2557
    Cell Significance Index: -4.0600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2601
    Cell Significance Index: -3.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2670
    Cell Significance Index: -7.6900
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.2698
    Cell Significance Index: -3.0000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2934
    Cell Significance Index: -3.1000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3131
    Cell Significance Index: -6.6700
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.3133
    Cell Significance Index: -3.9400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3416
    Cell Significance Index: -4.3100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3544
    Cell Significance Index: -5.3100
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.3553
    Cell Significance Index: -4.2600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.3620
    Cell Significance Index: -5.3000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3676
    Cell Significance Index: -7.6300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3752
    Cell Significance Index: -6.3100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3768
    Cell Significance Index: -8.1600
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.3772
    Cell Significance Index: -3.1200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3985
    Cell Significance Index: -4.1300
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.4016
    Cell Significance Index: -3.0900
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.4615
    Cell Significance Index: -5.9100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.4690
    Cell Significance Index: -5.6900
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.4696
    Cell Significance Index: -4.6500
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.4719
    Cell Significance Index: -5.1800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.4736
    Cell Significance Index: -5.4200
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.4795
    Cell Significance Index: -5.7000
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.4806
    Cell Significance Index: -6.6000
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.4809
    Cell Significance Index: -5.1100
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.4828
    Cell Significance Index: -4.9800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.4833
    Cell Significance Index: -5.7800
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.4837
    Cell Significance Index: -5.3000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.4902
    Cell Significance Index: -6.9800
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.4931
    Cell Significance Index: -5.9600
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.4941
    Cell Significance Index: -6.2000
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.5027
    Cell Significance Index: -5.8400
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.5032
    Cell Significance Index: -6.3000
  • Cell Name: brush cell (CL0002204)
    Fold Change: -0.5138
    Cell Significance Index: -4.7100
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.5183
    Cell Significance Index: -6.3000
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.5189
    Cell Significance Index: -6.4400
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.5193
    Cell Significance Index: -6.5700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.5195
    Cell Significance Index: -5.5700
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.5244
    Cell Significance Index: -5.9700
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.5268
    Cell Significance Index: -6.1000
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: -0.5272
    Cell Significance Index: -6.1600
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.5288
    Cell Significance Index: -5.8700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.5290
    Cell Significance Index: -6.3000
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.5310
    Cell Significance Index: -6.0300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.5314
    Cell Significance Index: -6.2800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.5369
    Cell Significance Index: -6.6000
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.5425
    Cell Significance Index: -5.9100
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.5480
    Cell Significance Index: -6.3700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5503
    Cell Significance Index: -6.5600
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.5571
    Cell Significance Index: -6.0400
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.5579
    Cell Significance Index: -6.9700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.5607
    Cell Significance Index: -6.2600
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.5630
    Cell Significance Index: -6.1100
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.5667
    Cell Significance Index: -6.1000
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.5700
    Cell Significance Index: -6.4800
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.5755
    Cell Significance Index: -5.6300
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.5784
    Cell Significance Index: -5.9100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.5876
    Cell Significance Index: -4.8500
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.5890
    Cell Significance Index: -6.3800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.5904
    Cell Significance Index: -8.1900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.5953
    Cell Significance Index: -7.6500
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.6006
    Cell Significance Index: -7.7600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.6032
    Cell Significance Index: -8.4600
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.6076
    Cell Significance Index: -5.4000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.6141
    Cell Significance Index: -8.1600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.6182
    Cell Significance Index: -5.8600
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.6204
    Cell Significance Index: -6.1200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.6254
    Cell Significance Index: -6.3900
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.6280
    Cell Significance Index: -5.6800
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.6327
    Cell Significance Index: -8.7500
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.6338
    Cell Significance Index: -7.1600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.6353
    Cell Significance Index: -3.7700
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.6371
    Cell Significance Index: -5.9600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.6444
    Cell Significance Index: -6.0500
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: -0.6444
    Cell Significance Index: -5.9800
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.6444
    Cell Significance Index: -7.0500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.6591
    Cell Significance Index: -7.3000
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.6641
    Cell Significance Index: -6.4300
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: -0.6652
    Cell Significance Index: -6.2000
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.6696
    Cell Significance Index: -6.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** KRT18P11 is significantly expressed in lung goblet cells, lung ciliated cells, astrocytes, club cells, type I pneumocytes, epithelial cells of the uterus, intestinal crypt stem cells, epithelial cells of the mammary gland, and bladder urothelial cells. This widespread expression suggests a conserved role in maintaining tissue homeostasis. 2. **Pseudogene Status:** KRT18P11 is a non-coding RNA, implying that it does not encode a functional protein. However, its expression and potential regulatory functions hint at a more complex role. 3. **Evolutionary Conservation:** The presence of KRT18P11 in various species, including humans, mice, and zebrafish, indicates that this pseudogene has been conserved across evolution, suggesting its importance in maintaining tissue function. **Pathways and Functions:** While KRT18P11 is a pseudogene, its expression and potential regulatory functions suggest involvement in various cellular processes. Some possible pathways and functions include: 1. **Cell Proliferation and Differentiation:** KRT18P11 may regulate cell proliferation and differentiation in various tissues, including the lung, mammary gland, and intestinal crypts. 2. **Epithelial-Mesenchymal Transition (EMT):** KRT18P11 may play a role in EMT, a process crucial for tissue development, repair, and disease progression. 3. **Stem Cell Maintenance:** KRT18P11 may be involved in maintaining stem cell populations, such as intestinal crypt stem cells, which are essential for tissue homeostasis. 4. **Tissue Repair and Regeneration:** KRT18P11 may contribute to tissue repair and regeneration by regulating the expression of genes involved in these processes. **Clinical Significance:** The clinical significance of KRT18P11 is an area of active research. Some potential implications include: 1. **Cancer Association:** KRT18P11 may be involved in cancer development and progression, particularly in tissues where it is highly expressed, such as the lung and mammary gland. 2. **Regenerative Medicine:** KRT18P11 may hold promise for regenerative medicine, particularly in the development of therapies for tissue repair and regeneration. 3. **Diagnostic Biomarkers:** KRT18P11 may serve as a diagnostic biomarker for various diseases, including cancer and tissue damage. 4. **Therapeutic Targets:** KRT18P11 may be a therapeutic target for the treatment of diseases involving tissue damage, cancer, and stem cell dysregulation. In conclusion, KRT18P11 is a pseudogene with significant expression levels in various tissues, suggesting a conserved role in maintaining tissue homeostasis. Further research is needed to elucidate the pathways and functions of KRT18P11 and its potential clinical significance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.