Details for: TRND

Gene ID: 4555

Symbol: TRND

Ensembl ID: ENSG00000210154

Description: tRNA-Asp

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 22.3448
    Cell Significance Index: 171.9100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 5.9687
    Cell Significance Index: 270.5400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 4.0903
    Cell Significance Index: 61.2900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 3.6475
    Cell Significance Index: 91.1000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.7287
    Cell Significance Index: 80.6000
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.4007
    Cell Significance Index: 15.1800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.3638
    Cell Significance Index: 23.5100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1863
    Cell Significance Index: 34.1800
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.9377
    Cell Significance Index: 12.5000
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.4198
    Cell Significance Index: 3.8900
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.3862
    Cell Significance Index: 4.9900
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.3500
    Cell Significance Index: 3.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3409
    Cell Significance Index: 17.7100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.2607
    Cell Significance Index: 2.7500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.1382
    Cell Significance Index: 1.4300
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.1179
    Cell Significance Index: 1.6300
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.1156
    Cell Significance Index: 1.4500
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.0595
    Cell Significance Index: 0.7000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0041
    Cell Significance Index: -0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0083
    Cell Significance Index: -15.6800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0129
    Cell Significance Index: -3.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0205
    Cell Significance Index: -13.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0353
    Cell Significance Index: -16.0200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0548
    Cell Significance Index: -0.7600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0620
    Cell Significance Index: -3.9100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0621
    Cell Significance Index: -10.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0732
    Cell Significance Index: -8.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0931
    Cell Significance Index: -18.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1052
    Cell Significance Index: -15.2900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1161
    Cell Significance Index: -3.1600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1412
    Cell Significance Index: -2.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2027
    Cell Significance Index: -12.4300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.2783
    Cell Significance Index: -2.7900
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.2807
    Cell Significance Index: -2.9100
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.2843
    Cell Significance Index: -2.7500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2902
    Cell Significance Index: -3.9600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2919
    Cell Significance Index: -4.9900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3005
    Cell Significance Index: -10.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3591
    Cell Significance Index: -7.7800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3636
    Cell Significance Index: -5.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3737
    Cell Significance Index: -11.9700
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.4188
    Cell Significance Index: -5.2000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.4240
    Cell Significance Index: -5.1400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.4802
    Cell Significance Index: -12.2400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4970
    Cell Significance Index: -10.3100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.4980
    Cell Significance Index: -7.9000
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.5092
    Cell Significance Index: -5.5700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.5347
    Cell Significance Index: -6.6800
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.5681
    Cell Significance Index: -6.7600
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.5836
    Cell Significance Index: -6.7800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5889
    Cell Significance Index: -19.2800
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.5954
    Cell Significance Index: -5.6600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6035
    Cell Significance Index: -19.2200
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.6112
    Cell Significance Index: -6.3900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.6327
    Cell Significance Index: -6.8500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.6430
    Cell Significance Index: -16.0400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.6500
    Cell Significance Index: -11.0400
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.7200
    Cell Significance Index: -9.2500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7273
    Cell Significance Index: -15.4900
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.7685
    Cell Significance Index: -7.8500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.8035
    Cell Significance Index: -15.7100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.8081
    Cell Significance Index: -6.6700
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.8389
    Cell Significance Index: -10.3300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.8600
    Cell Significance Index: -8.7800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.8669
    Cell Significance Index: -18.7300
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.9129
    Cell Significance Index: -9.5300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.9196
    Cell Significance Index: -12.5100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.9469
    Cell Significance Index: -11.1800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -1.0096
    Cell Significance Index: -12.4100
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -1.0096
    Cell Significance Index: -10.9600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.0125
    Cell Significance Index: -12.0700
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -1.0127
    Cell Significance Index: -10.7600
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -1.0259
    Cell Significance Index: -7.6400
  • Cell Name: pericyte (CL0000669)
    Fold Change: -1.0558
    Cell Significance Index: -12.6600
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -1.0562
    Cell Significance Index: -12.7400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.0606
    Cell Significance Index: -22.5100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -1.0652
    Cell Significance Index: -13.9300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -1.0767
    Cell Significance Index: -12.6600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.0856
    Cell Significance Index: -18.7700
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -1.0987
    Cell Significance Index: -9.6800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.1018
    Cell Significance Index: -22.1200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -1.1098
    Cell Significance Index: -12.7700
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -1.1171
    Cell Significance Index: -15.1900
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -1.1187
    Cell Significance Index: -14.6000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.1187
    Cell Significance Index: -22.1200
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -1.1207
    Cell Significance Index: -13.5500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -1.1694
    Cell Significance Index: -15.5400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -1.1709
    Cell Significance Index: -16.0800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -1.1930
    Cell Significance Index: -11.2000
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -1.1993
    Cell Significance Index: -15.0200
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -1.2034
    Cell Significance Index: -10.9400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -1.2200
    Cell Significance Index: -16.0100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -1.2346
    Cell Significance Index: -14.1300
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -1.2450
    Cell Significance Index: -13.0500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -1.2546
    Cell Significance Index: -16.5100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -1.2554
    Cell Significance Index: -7.4500
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -1.2563
    Cell Significance Index: -16.4000
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -1.2647
    Cell Significance Index: -19.2400
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -1.2705
    Cell Significance Index: -16.6400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -1.2791
    Cell Significance Index: -14.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** tRNA-Asp is a small, non-coding RNA molecule that is essential for the translation of aspartic acid-containing proteins. Its expression is not limited to immune cells, as it is also found in enterocytes, goblet cells, Paneth cells, and intestinal crypt stem cells. Notably, tRNA-Asp is significantly expressed in CD4-positive and CD8-positive alpha-beta thymocytes, suggesting its involvement in thymocyte development and selection. This gene is also highly expressed in B cells, absorptive cells, and intestinal crypt stem cells, indicating its role in maintaining immune homeostasis and intestinal barrier function. **Pathways and Functions:** The tRNA-Asp gene is involved in several key pathways, including: 1. **Translation regulation:** tRNA-Asp ensures the accurate translation of aspartic acid-containing proteins by recognizing and binding to aspartic acid-tRNA. 2. **Thymocyte development:** tRNA-Asp plays a crucial role in thymocyte development and selection, particularly in the context of alpha-beta T cell receptor (TCR) expression. 3. **B cell function:** tRNA-Asp is essential for B cell development and function, as it regulates the expression of aspartic acid-containing proteins that are involved in B cell receptor (BCR) maturation and function. 4. **Intestinal homeostasis:** tRNA-Asp maintains intestinal homeostasis by regulating the expression of aspartic acid-containing proteins in enterocytes, goblet cells, and Paneth cells, which are essential for maintaining the intestinal barrier function. **Clinical Significance:** Dysregulation of tRNA-Asp has been implicated in various diseases, including: 1. **Autoimmune disorders:** Alterations in tRNA-Asp expression have been linked to autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis, where dysregulation of immune homeostasis is a key pathogenic mechanism. 2. **Cancer:** Abnormal expression of tRNA-Asp has been observed in certain types of cancer, including colorectal cancer, where it is thought to contribute to tumorigenesis and metastasis. 3. **Gastrointestinal disorders:** Dysregulation of tRNA-Asp has been implicated in gastrointestinal disorders, such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), where it is thought to contribute to intestinal barrier dysfunction and inflammation. In conclusion, tRNA-Asp is a critical gene that plays a pivotal role in immune regulation, particularly in the context of thymocyte development, B cell function, and intestinal homeostasis. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying tRNA-Asp function and its clinical significance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.