Details for: TRNN

Gene ID: 4570

Symbol: TRNN

Ensembl ID: ENSG00000210135

Description: tRNA-Asn

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 34.6083
    Cell Significance Index: 266.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.4364
    Cell Significance Index: 160.2200
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 3.3563
    Cell Significance Index: 44.7400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.3177
    Cell Significance Index: 150.3800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.4059
    Cell Significance Index: 60.0900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.3448
    Cell Significance Index: 20.1500
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.3315
    Cell Significance Index: 18.4100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1324
    Cell Significance Index: 15.4500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0929
    Cell Significance Index: 31.4900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.7972
    Cell Significance Index: 8.2500
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.5650
    Cell Significance Index: 6.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5502
    Cell Significance Index: 28.5800
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.4660
    Cell Significance Index: 4.4300
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.4323
    Cell Significance Index: 4.5200
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.4226
    Cell Significance Index: 4.5800
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.2512
    Cell Significance Index: 2.4300
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.1511
    Cell Significance Index: 1.4500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0511
    Cell Significance Index: 1.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0216
    Cell Significance Index: -2.4800
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0310
    Cell Significance Index: -0.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0565
    Cell Significance Index: -9.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0571
    Cell Significance Index: -8.3100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0912
    Cell Significance Index: -5.7500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0927
    Cell Significance Index: -1.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1154
    Cell Significance Index: -23.1600
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1488
    Cell Significance Index: -1.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2222
    Cell Significance Index: -13.6200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2320
    Cell Significance Index: -7.4300
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2405
    Cell Significance Index: -3.0900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2648
    Cell Significance Index: -3.7700
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.2813
    Cell Significance Index: -3.4100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3278
    Cell Significance Index: -11.5200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3908
    Cell Significance Index: -5.7700
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.4043
    Cell Significance Index: -5.0200
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.4165
    Cell Significance Index: -4.9000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.4423
    Cell Significance Index: -7.5600
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.4789
    Cell Significance Index: -5.0200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.4996
    Cell Significance Index: -4.6900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5148
    Cell Significance Index: -10.6800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5273
    Cell Significance Index: -15.5300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.5617
    Cell Significance Index: -7.7900
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.5618
    Cell Significance Index: -4.9500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.5689
    Cell Significance Index: -6.7700
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.5814
    Cell Significance Index: -6.3600
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.5969
    Cell Significance Index: -7.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6001
    Cell Significance Index: -13.0000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.6040
    Cell Significance Index: -13.0500
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.6059
    Cell Significance Index: -6.0800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6139
    Cell Significance Index: -13.0300
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.6178
    Cell Significance Index: -7.7800
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.6385
    Cell Significance Index: -6.6200
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.6509
    Cell Significance Index: -7.5500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.6651
    Cell Significance Index: -13.0900
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.6766
    Cell Significance Index: -7.3500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.7148
    Cell Significance Index: -10.2800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.7186
    Cell Significance Index: -7.5800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7278
    Cell Significance Index: -23.1800
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.7316
    Cell Significance Index: -7.9100
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.7398
    Cell Significance Index: -8.0600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.7415
    Cell Significance Index: -9.6800
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.7497
    Cell Significance Index: -8.9900
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.7537
    Cell Significance Index: -8.3100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.7711
    Cell Significance Index: -19.6500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.8165
    Cell Significance Index: -9.6000
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.8362
    Cell Significance Index: -7.7900
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.8391
    Cell Significance Index: -6.9400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.8532
    Cell Significance Index: -18.1700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.8593
    Cell Significance Index: -12.3400
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.8735
    Cell Significance Index: -9.0100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.8846
    Cell Significance Index: -17.7600
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.8885
    Cell Significance Index: -8.0200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.8953
    Cell Significance Index: -9.1400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.8982
    Cell Significance Index: -17.7600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.9269
    Cell Significance Index: -12.8600
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.9485
    Cell Significance Index: -9.2800
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -1.0156
    Cell Significance Index: -7.9700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.0175
    Cell Significance Index: -17.5400
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -1.0188
    Cell Significance Index: -11.2800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -1.0471
    Cell Significance Index: -12.8700
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -1.0492
    Cell Significance Index: -12.1900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -1.0509
    Cell Significance Index: -13.8300
  • Cell Name: DN4 thymocyte (CL0000808)
    Fold Change: -1.0539
    Cell Significance Index: -7.9400
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -1.0627
    Cell Significance Index: -13.6100
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -1.0813
    Cell Significance Index: -11.8700
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: -1.0935
    Cell Significance Index: -9.5600
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -1.1007
    Cell Significance Index: -13.3800
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: -1.1156
    Cell Significance Index: -9.4400
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -1.1159
    Cell Significance Index: -14.3700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -1.1403
    Cell Significance Index: -22.3000
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -1.1578
    Cell Significance Index: -15.9000
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -1.1612
    Cell Significance Index: -17.3700
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -1.1704
    Cell Significance Index: -13.0000
  • Cell Name: stem cell (CL0000034)
    Fold Change: -1.1709
    Cell Significance Index: -8.5100
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -1.1725
    Cell Significance Index: -13.0400
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -1.1751
    Cell Significance Index: -10.2700
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -1.1780
    Cell Significance Index: -10.8200
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -1.1804
    Cell Significance Index: -14.3600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -1.1836
    Cell Significance Index: -9.7700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -1.1868
    Cell Significance Index: -12.3900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -1.1875
    Cell Significance Index: -15.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** tRNA-Asn is a 15-nt long, highly conserved snRNA that is specifically expressed in various cell types, including epithelial cells, stem cells, and neoplastic cells. Its expression is tightly regulated by post-transcriptional mechanisms, which ensure precise incorporation of Asn amino acids into proteins. The tRNA-Asn molecule is composed of a characteristic cloverleaf secondary structure, which enables its interaction with the aminoacyl-tRNA synthetase complex. This interaction is essential for the accurate loading of Asn amino acids onto the corresponding tRNA molecules. **Pathways and Functions:** tRNA-Asn plays a crucial role in regulating cellular homeostasis by modulating the expression of genes involved in differentiation, proliferation, and survival. Its dysregulation has been implicated in various diseases, including cancer, where aberrant tRNA-Asn expression can contribute to tumorigenesis and tumor progression. The tRNA-Asn molecule interacts with the aminoacyl-tRNA synthetase complex, which is responsible for the accurate incorporation of Asn amino acids into proteins. This interaction is essential for the regulation of protein expression and function. The tRNA-Asn molecule also interacts with other cellular proteins, including transcription factors and microRNAs, which regulate gene expression and cellular homeostasis. For example, tRNA-Asn has been shown to interact with the transcription factor NF-κB, which is involved in the regulation of inflammatory responses and immune cell function. Additionally, tRNA-Asn has been implicated in the regulation of microRNA expression, which plays a critical role in the regulation of gene expression and cellular homeostasis. **Clinical Significance:** The dysregulation of tRNA-Asn has been implicated in various diseases, including cancer, where aberrant tRNA-Asn expression can contribute to tumorigenesis and tumor progression. For example, studies have shown that tRNA-Asn expression is elevated in various types of cancer, including colon, breast, and lung cancer. This elevated expression has been associated with poor prognosis and reduced survival rates in cancer patients. Furthermore, tRNA-Asn has been implicated in the regulation of inflammatory responses and immune cell function. For example, studies have shown that tRNA-Asn interacts with the transcription factor NF-κB, which is involved in the regulation of inflammatory responses and immune cell function. This interaction has been implicated in the pathogenesis of various inflammatory diseases, including rheumatoid arthritis and atherosclerosis. In conclusion, tRNA-Asn is a critical component of the translational machinery that plays a pivotal role in regulating cellular homeostasis, differentiation, and proliferation. Its dysregulation has been implicated in various diseases, including cancer and inflammatory diseases. Further research is necessary to fully understand the molecular mechanisms underlying tRNA-Asn function and its role in disease pathogenesis.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.