Details for: RN7SL1

Gene ID: 6029

Symbol: RN7SL1

Ensembl ID: ENSG00000276168

Description: RNA component of signal recognition particle 7SL1

Associated with

  • Signal recognition particle, endoplasmic reticulum targeting
    (GO:0005786)
  • Srp-dependent cotranslational protein targeting to membrane, signal sequence recognition
    (GO:0006617)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 12.0798
    Cell Significance Index: 178.3400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.6637
    Cell Significance Index: -20.5300
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.7305
    Cell Significance Index: 36.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.4958
    Cell Significance Index: 100.7200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.3801
    Cell Significance Index: 107.8800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 2.1407
    Cell Significance Index: 29.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2270
    Cell Significance Index: 63.7400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.1319
    Cell Significance Index: 16.9600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.0398
    Cell Significance Index: 14.2800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.9741
    Cell Significance Index: 24.3300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.6313
    Cell Significance Index: 9.0800
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.6111
    Cell Significance Index: 6.3800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3136
    Cell Significance Index: 11.0200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.2702
    Cell Significance Index: 3.4800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2237
    Cell Significance Index: 10.4300
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.1742
    Cell Significance Index: 2.2500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1641
    Cell Significance Index: 10.3400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1554
    Cell Significance Index: 4.2300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.1356
    Cell Significance Index: 1.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0043
    Cell Significance Index: -0.8700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0090
    Cell Significance Index: -16.5900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0111
    Cell Significance Index: -20.8600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0111
    Cell Significance Index: -15.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0122
    Cell Significance Index: -18.8200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0257
    Cell Significance Index: -16.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0273
    Cell Significance Index: -20.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0349
    Cell Significance Index: -19.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0508
    Cell Significance Index: -8.6800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0579
    Cell Significance Index: -26.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0782
    Cell Significance Index: -22.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1025
    Cell Significance Index: -21.5900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1105
    Cell Significance Index: -12.6600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1413
    Cell Significance Index: -20.5400
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.1691
    Cell Significance Index: -2.0400
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.1864
    Cell Significance Index: -2.0200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1934
    Cell Significance Index: -4.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2088
    Cell Significance Index: -21.7400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2673
    Cell Significance Index: -16.3900
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.2719
    Cell Significance Index: -1.7100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3877
    Cell Significance Index: -5.2900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4552
    Cell Significance Index: -14.5800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4573
    Cell Significance Index: -13.4700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4850
    Cell Significance Index: -10.0600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.5021
    Cell Significance Index: -15.8800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5078
    Cell Significance Index: -17.7900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5567
    Cell Significance Index: -17.7300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5654
    Cell Significance Index: -18.5100
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.5777
    Cell Significance Index: -5.9900
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.5975
    Cell Significance Index: -8.2900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.6098
    Cell Significance Index: -9.6800
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.6146
    Cell Significance Index: -7.7200
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.6196
    Cell Significance Index: -7.2900
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.7092
    Cell Significance Index: -6.2400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.7324
    Cell Significance Index: -18.2700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.7614
    Cell Significance Index: -19.4000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.8099
    Cell Significance Index: -17.1900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.8170
    Cell Significance Index: -11.6300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.8183
    Cell Significance Index: -16.1800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.8389
    Cell Significance Index: -17.0700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.8500
    Cell Significance Index: -10.9200
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: -0.8676
    Cell Significance Index: -7.5900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.8734
    Cell Significance Index: -18.8700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.8966
    Cell Significance Index: -18.0000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.8995
    Cell Significance Index: -9.1900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.9562
    Cell Significance Index: -18.8200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.9717
    Cell Significance Index: -20.2800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.9875
    Cell Significance Index: -5.8600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.0015
    Cell Significance Index: -21.3300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -1.0080
    Cell Significance Index: -20.1000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -1.0314
    Cell Significance Index: -17.6300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.0382
    Cell Significance Index: -17.9500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -1.0516
    Cell Significance Index: -10.6700
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: -1.0824
    Cell Significance Index: -9.3800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -1.0940
    Cell Significance Index: -15.7100
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -1.1294
    Cell Significance Index: -15.0600
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -1.1423
    Cell Significance Index: -17.0900
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -1.1451
    Cell Significance Index: -7.4500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.1512
    Cell Significance Index: -9.6700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.2253
    Cell Significance Index: -20.6400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -1.2696
    Cell Significance Index: -17.5600
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -1.3265
    Cell Significance Index: -12.6100
  • Cell Name: neuron (CL0000540)
    Fold Change: -1.3556
    Cell Significance Index: -12.8500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -1.3565
    Cell Significance Index: -17.1400
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -1.3798
    Cell Significance Index: -13.4500
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -1.3875
    Cell Significance Index: -15.9800
  • Cell Name: mural cell (CL0008034)
    Fold Change: -1.4408
    Cell Significance Index: -17.5400
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -1.4563
    Cell Significance Index: -18.3400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -1.4683
    Cell Significance Index: -15.2000
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -1.4728
    Cell Significance Index: -16.1100
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -1.5038
    Cell Significance Index: -16.0000
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -1.5259
    Cell Significance Index: -15.1100
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -1.5331
    Cell Significance Index: -16.3100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -1.5384
    Cell Significance Index: -18.9100
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -1.5425
    Cell Significance Index: -20.9800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -1.5499
    Cell Significance Index: -16.3500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -1.5930
    Cell Significance Index: -19.3100
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -1.6005
    Cell Significance Index: -16.9700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -1.6118
    Cell Significance Index: -19.1800
  • Cell Name: pericyte (CL0000669)
    Fold Change: -1.6254
    Cell Significance Index: -19.4900
  • Cell Name: T cell (CL0000084)
    Fold Change: -1.6254
    Cell Significance Index: -19.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RN7SL1 is a small RNA molecule that forms the core of the signal recognition particle (SRP). It is approximately 170 nucleotides in length and is highly conserved across species. The RN7SL1 molecule is composed of two subunits, RN7SL1-A and RN7SL1-B, which are linked by a disulfide bond. This RNA component is essential for the recognition and targeting of proteins containing signal sequences to the ER. RN7SL1 is also involved in the regulation of protein synthesis and is required for the proper folding and secretion of proteins. **Pathways and Functions:** The RN7SL1 molecule plays a central role in the SRP-mediated targeting of proteins to the ER. The SRP-RN7SL1 complex binds to the ribosome-associated SRP receptor (SRβ) and recruits the ribosome to the ER membrane, where it facilitates the recognition and targeting of proteins containing signal sequences. This process involves the binding of RN7SL1 to the signal sequence, which triggers a conformational change in the SRP complex, allowing it to interact with the ribosome. The SRP-RN7SL1 complex then mediates the transfer of the ribosome to the ER membrane, where the protein is folded and secreted. RN7SL1 is also involved in the regulation of protein synthesis and is required for the proper folding and secretion of proteins. It plays a key role in the cotranslational targeting of proteins to the ER, where it interacts with the ribosome and the SRβ receptor to facilitate the recognition and targeting of proteins containing signal sequences. **Clinical Significance:** Dysregulation of RN7SL1 has been implicated in various diseases, including cancer and neurodegenerative disorders. For example, aberrant expression of RN7SL1 has been observed in certain types of cancer, including breast and lung cancer. Additionally, RN7SL1 has been shown to play a role in the development of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. Furthermore, RN7SL1 has been shown to have potential therapeutic applications in the treatment of various diseases, including cancer and cardiovascular disease. For example, RN7SL1 has been shown to inhibit the growth of cancer cells by targeting the ER and inducing apoptosis. Additionally, RN7SL1 has been shown to have anti-inflammatory properties and may have potential therapeutic applications in the treatment of cardiovascular disease. In conclusion, RN7SL1 is a critical component of the signal recognition particle (SRP) complex, which plays a pivotal role in the targeting of proteins to the endoplasmic reticulum (ER) for proper folding and secretion. The RN7SL1 molecule is highly conserved across species and is involved in the regulation of protein synthesis and the proper folding and secretion of proteins. Dysregulation of RN7SL1 has been implicated in various diseases, including cancer and neurodegenerative disorders, and has potential therapeutic applications in the treatment of these diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.