Details for: ROBO1

Gene ID: 6091

Symbol: ROBO1

Ensembl ID: ENSG00000169855

Description: roundabout guidance receptor 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granule cell (CL0000120)
    Fold Change: 11.19
    Marker Score: 84400
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 9.29
    Marker Score: 21350
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 8.43
    Marker Score: 2785
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 8.02
    Marker Score: 42100
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 5.71
    Marker Score: 8039
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 5.54
    Marker Score: 29734
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 4.8
    Marker Score: 15720
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.62
    Marker Score: 82068
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 4.42
    Marker Score: 3068.5
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 4.35
    Marker Score: 2422
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 3.89
    Marker Score: 2658
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 3.45
    Marker Score: 3059
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 3.02
    Marker Score: 7237
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 3.01
    Marker Score: 13929
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.91
    Marker Score: 57928
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.9
    Marker Score: 6371
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.83
    Marker Score: 1089
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.83
    Marker Score: 3203
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 2.75
    Marker Score: 1423
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.7
    Marker Score: 102676
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.68
    Marker Score: 20553
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.67
    Marker Score: 11185
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.55
    Marker Score: 1429
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.52
    Marker Score: 1246.5
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.42
    Marker Score: 765
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.38
    Marker Score: 3995
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.36
    Marker Score: 2861
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.35
    Marker Score: 9086
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.15
    Marker Score: 2892
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.09
    Marker Score: 664
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.07
    Marker Score: 21376
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.05
    Marker Score: 1767
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.01
    Marker Score: 3876
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.99
    Marker Score: 1112
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.96
    Marker Score: 2251
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.96
    Marker Score: 7963
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.93
    Marker Score: 1131
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.89
    Marker Score: 17959
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.84
    Marker Score: 772
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.81
    Marker Score: 38613
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.79
    Marker Score: 66193
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.79
    Marker Score: 15344
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.78
    Marker Score: 60023
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.75
    Marker Score: 2162
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.75
    Marker Score: 3551.5
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.71
    Marker Score: 5750
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.63
    Marker Score: 978
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.6
    Marker Score: 1698
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.59
    Marker Score: 14993
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.59
    Marker Score: 1756
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.57
    Marker Score: 3938
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.56
    Marker Score: 425
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.55
    Marker Score: 842
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.55
    Marker Score: 23126
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.48
    Marker Score: 383
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.47
    Marker Score: 967
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.47
    Marker Score: 553
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.47
    Marker Score: 3992
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167656
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.43
    Marker Score: 5964
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.41
    Marker Score: 441
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.4
    Marker Score: 14085
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.4
    Marker Score: 1333
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.4
    Marker Score: 610
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.38
    Marker Score: 502
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.38
    Marker Score: 3939
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.37
    Marker Score: 1480
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.36
    Marker Score: 792
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.36
    Marker Score: 1700
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.34
    Marker Score: 3150.5
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.33
    Marker Score: 7904
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.33
    Marker Score: 492
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1.33
    Marker Score: 403
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.31
    Marker Score: 2025
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.29
    Marker Score: 625
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.29
    Marker Score: 1056
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.28
    Marker Score: 375
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.27
    Marker Score: 2083.5
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.26
    Marker Score: 843
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.23
    Marker Score: 590
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.21
    Marker Score: 15959
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.2
    Marker Score: 18822
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.19
    Marker Score: 895.5
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.18
    Marker Score: 777
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.17
    Marker Score: 4898
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.17
    Marker Score: 1620
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.15
    Marker Score: 1215
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.14
    Marker Score: 7444
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.11
    Marker Score: 250
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.11
    Marker Score: 6673
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.11
    Marker Score: 17801
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.08
    Marker Score: 369
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.08
    Marker Score: 1300
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.06
    Marker Score: 270
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 1.04
    Marker Score: 313
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.03
    Marker Score: 3804
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 1.02
    Marker Score: 288
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.02
    Marker Score: 62579
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1
    Marker Score: 1378
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71774

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Other Information

**Key Characteristics:** ROBO1 is a member of the immunoglobulin superfamily and is characterized by its ability to bind to netrin-1, a secreted protein that guides axons during development. The ROBO1 gene is highly expressed in various cell types, including granule cells, macroglial cells, sympathetic neurons, and chromaffin cells. The protein is composed of an extracellular ligand-binding domain, a transmembrane domain, and an intracellular signaling domain. **Pathways and Functions:** ROBO1 plays a critical role in various signaling pathways, including: 1. **Axon Guidance:** ROBO1 is essential for axon guidance and repulsion, particularly during the development of the nervous system. It interacts with netrin-1 to regulate axon pathfinding and branching. 2. **Cell Migration:** ROBO1 is involved in cell migration and sprouting angiogenesis, which is essential for tissue development and repair. 3. **Immune Regulation:** ROBO1 is expressed in immune cells, such as macrophages and T cells, and regulates immune responses by modulating the activity of various signaling pathways. 4. **Developmental Biology:** ROBO1 is involved in the development of various organs, including the heart, lungs, and kidneys. **Key Signaling Pathways:** 1. **Netrin-1 Signaling:** ROBO1 binds to netrin-1, which regulates axon guidance and repulsion. 2. **Rho Protein Signaling:** ROBO1 regulates the activity of Rho proteins, which are involved in cell migration and cytoskeletal dynamics. 3. **Notch Signaling:** ROBO1 interacts with Notch receptors to regulate cell fate decisions and development. 4. **MAPK Signaling:** ROBO1 regulates the activity of MAPK kinases, which are involved in cell proliferation and differentiation. **Clinical Significance:** Dysregulation of ROBO1 has been implicated in various diseases, including: 1. **Neurodevelopmental Disorders:** ROBO1 mutations have been associated with neurodevelopmental disorders, such as autism and cerebral palsy. 2. **Cancer:** ROBO1 is overexpressed in certain types of cancer, including lung and breast cancer, and is associated with poor prognosis. 3. **Autoimmune Diseases:** ROBO1 is involved in the regulation of immune responses and is implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. In conclusion, ROBO1 is a critical regulator of axon guidance, cell migration, and immune responses. Understanding the complex functions of ROBO1 is essential for the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 291596331

Symbol: ROBO1_HUMAN

Name: Roundabout homolog 1

UniProtKB Accession Codes:

Q9Y6N7 B2RXI1 D3DU36 E9PD49 Q1RMC7 Q7Z300 Q9BUS7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 6 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 22 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 36 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 25 PDBsum 12 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 Pumba 1 RNAct 1 Reactome 9 RefSeq 5 SAM 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9458045

Title: Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors.

PubMed ID: 9458045

DOI: 10.1016/s0092-8674(00)80915-0

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 10102268

Title: Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance.

PubMed ID: 10102268

DOI: 10.1016/s0092-8674(00)80590-5

PubMed ID: 9608531

Title: The DUTT1 gene, a novel NCAM family member is expressed in developing murine neural tissues and has an unusually broad pattern of expression.

PubMed ID: 9608531

DOI: 10.1006/mcne.1998.0672

PubMed ID: 9796701

Title: Homozygous deletions at 3p12 in breast and lung cancer.

PubMed ID: 9796701

DOI: 10.1038/sj.onc.1202103

PubMed ID: 10892742

Title: Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor.

PubMed ID: 10892742

DOI: 10.1016/s0092-8674(00)80883-1

PubMed ID: 11404413

Title: Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance.

PubMed ID: 11404413

DOI: 10.1523/jneurosci.21-12-04281.2001

PubMed ID: 12082532

Title: Tumour specific promoter region methylation of the human homologue of the Drosophila Roundabout gene DUTT1 (ROBO1) in human cancers.

PubMed ID: 12082532

DOI: 10.1038/sj.onc.1205421

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24673457

Title: Roundabout 1 exists predominantly as a basal dimeric complex and this is unaffected by binding of the ligand Slit2.

PubMed ID: 24673457

DOI: 10.1042/bj20140190

PubMed ID: 24560577

Title: FLRT3 is a Robo1-interacting protein that determines Netrin-1 attraction in developing axons.

PubMed ID: 24560577

DOI: 10.1016/j.cub.2014.01.042

PubMed ID: 26529257

Title: Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression.

PubMed ID: 26529257

DOI: 10.1172/jci81673

PubMed ID: 17848514

Title: Structural insights into the Slit-Robo complex.

PubMed ID: 17848514

DOI: 10.1073/pnas.0705310104

PubMed ID: 28402530

Title: Mutations in the human ROBO1 Gene in pituitary stalk interruption syndrome.

PubMed ID: 28402530

DOI: 10.1210/jc.2016-1095

PubMed ID: 29194579

Title: Targeted gene sequencing and whole-exome sequencing in autopsied fetuses with prenatally diagnosed kidney anomalies.

PubMed ID: 29194579

DOI: 10.1111/cge.13185

PubMed ID: 31448886

Title: A novel missense mutation in human receptor roundabout-1 (ROBO1) gene associated with pituitary stalk interruption syndrome.

PubMed ID: 31448886

DOI: 10.4274/jcrpe.galenos.2019.2018.0309

PubMed ID: 35348658

Title: Novel dominant and recessive variants in human ROBO1 cause distinct neurodevelopmental defects through different mechanisms.

PubMed ID: 35348658

DOI: 10.1093/hmg/ddac070

PubMed ID: 35227688

Title: Biallelic pathogenic variants in roundabout guidance receptor 1 associate with syndromic congenital anomalies of the kidney and urinary tract.

PubMed ID: 35227688

DOI: 10.1016/j.kint.2022.01.028

Sequence Information:

  • Length: 1651
  • Mass: 180930
  • Checksum: 9D98CD7CAB73074D
  • Sequence:
    • MKWKHVPFLV MISLLSLSPN HLFLAQLIPD PEDVERGNDH GTPIPTSDND DNSLGYTGSR 
LRQEDFPPRI VEHPSDLIVS KGEPATLNCK AEGRPTPTIE WYKGGERVET DKDDPRSHRM 
LLPSGSLFFL RIVHGRKSRP DEGVYVCVAR NYLGEAVSHN ASLEVAILRD DFRQNPSDVM 
VAVGEPAVME CQPPRGHPEP TISWKKDGSP LDDKDERITI RGGKLMITYT RKSDAGKYVC 
VGTNMVGERE SEVAELTVLE RPSFVKRPSN LAVTVDDSAE FKCEARGDPV PTVRWRKDDG 
ELPKSRYEIR DDHTLKIRKV TAGDMGSYTC VAENMVGKAE ASATLTVQEP PHFVVKPRDQ 
VVALGRTVTF QCEATGNPQP AIFWRREGSQ NLLFSYQPPQ SSSRFSVSQT GDLTITNVQR 
SDVGYYICQT LNVAGSIITK AYLEVTDVIA DRPPPVIRQG PVNQTVAVDG TFVLSCVATG 
SPVPTILWRK DGVLVSTQDS RIKQLENGVL QIRYAKLGDT GRYTCIASTP SGEATWSAYI 
EVQEFGVPVQ PPRPTDPNLI PSAPSKPEVT DVSRNTVTLS WQPNLNSGAT PTSYIIEAFS 
HASGSSWQTV AENVKTETSA IKGLKPNAIY LFLVRAANAY GISDPSQISD PVKTQDVLPT 
SQGVDHKQVQ RELGNAVLHL HNPTVLSSSS IEVHWTVDQQ SQYIQGYKIL YRPSGANHGE 
SDWLVFEVRT PAKNSVVIPD LRKGVNYEIK ARPFFNEFQG ADSEIKFAKT LEEAPSAPPQ 
GVTVSKNDGN GTAILVSWQP PPEDTQNGMV QEYKVWCLGN ETRYHINKTV DGSTFSVVIP 
FLVPGIRYSV EVAASTGAGS GVKSEPQFIQ LDAHGNPVSP EDQVSLAQQI SDVVKQPAFI 
AGIGAACWII LMVFSIWLYR HRKKRNGLTS TYAGIRKVPS FTFTPTVTYQ RGGEAVSSGG 
RPGLLNISEP AAQPWLADTW PNTGNNHNDC SISCCTAGNG NSDSNLTTYS RPADCIANYN 
NQLDNKQTNL MLPESTVYGD VDLSNKINEM KTFNSPNLKD GRFVNPSGQP TPYATTQLIQ 
SNLSNNMNNG SGDSGEKHWK PLGQQKQEVA PVQYNIVEQN KLNKDYRAND TVPPTIPYNQ 
SYDQNTGGSY NSSDRGSSTS GSQGHKKGAR TPKVPKQGGM NWADLLPPPP AHPPPHSNSE 
EYNISVDESY DQEMPCPVPP ARMYLQQDEL EEEEDERGPT PPVRGAASSP AAVSYSHQST 
ATLTPSPQEE LQPMLQDCPE ETGHMQHQPD RRRQPVSPPP PPRPISPPHT YGYISGPLVS 
DMDTDAPEEE EDEADMEVAK MQTRRLLLRG LEQTPASSVG DLESSVTGSM INGWGSASEE 
DNISSGRSSV SSSDGSFFTD ADFAQAVAAA AEYAGLKVAR RQMQDAAGRR HFHASQCPRP 
TSPVSTDSNM SAAVMQKTRP AKKLKHQPGH LRRETYTDDL PPPPVPPPAI KSPTAQSKTQ 
LEVRPVVVPK LPSMDARTDR SSDRKGSSYK GREVLDGRQV VDMRTNPGDP REAQEQQNDG 
KGRGNKAAKR DLPPAKTHLI QEDILPYCRP TFPTSNNPRD PSSSSSMSSR GSGSRQREQA 
NVGRRNIAEM QVLGGYERGE DNNEELEETE S

Genular Protein ID: 817981094

Symbol: Q1RMC8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q1RMC8

Database IDs:

ARBA 2 BioGRID-ORCS 1 CDD 6 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 Genevisible 1 GenomeRNAi 1 IntAct 1 InterPro 10 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 1 SAM 1 SMART 4 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1606
  • Mass: 175830
  • Checksum: 1A4D020697BA9AD3
  • Sequence:
    • MIAEPAHFYL FGLICLCSGS RLRQEDFPPR IVEHPSDLIV SKGEPATLNC KAEGRPTPTI 
EWYKGGERVE TDKDDPRSHR MLLPSGSLFF LRIVHGRKSR PDEGVYVCVA RNYLGEAVSH 
NASLEVAILR DDFRQNPSDV MVAVGEPAVM ECQPPRGHPE PTISWKKDGS PLDDKDERIT 
IRGGKLMITY TRKSDAGKYV CVGTNMVGER ESEVAELTVL ERPSFVKRPS NLAVTVDDSA 
EFKCEARGDP VPTVRWRKDD GELPKSRYEI RDDHTLKIRK VTAGDMGSYT CVAENMVGKA 
EASATLTVQV GSEPPHFVVK PRDQVVALGR TVTFQCEATG NPQPAIFWRR EGSQNLLFSY 
QPPQSSSRFS VSQTGDLTIT NVQRSDVGYY ICQTLNVAGS IITKAYLEVT DVIADRPPPV 
IRQGPVNQTV AVDGTFVLSC VATGSPVPTI LWRKDGVLVS TQDSRIKQLE NGVLQIRYAK 
LGDTGRYTCI ASTPSGEATW SAYIEVQEFG VPVQPPRPTD PNLIPSAPSK PEVTDVSRNT 
VTLSWQPNLN SGATPTSYII EAFSHASGSS WQTVAENVKT ETSAIKGLKP NAIYLFLVRA 
ANAYGISDPS QISDPVKTQD VLPTSQGVDH KQVQRELGNA VLHLHNPTVL SPSSIEVHWT 
VDQQSQYIQG YKILYRPSGA NHGESDWLVF EVRTPAKNSV VIPDLRKGVN YEIKARPFFN 
EFQGADSEIK FAKTLEEAPS APPQGVTVSK NDGNGTAILV SWQPPPEDTQ NGMVQEYKVW 
CLGNETRYHI NKTVDGSTFS VVIPFLVPGI RYSVEVAAST GAGSGVKSEP QFIQLDAHGN 
PVSPEDQVSL AQQISDVVKQ PAFIAGIGAA CWIILMVFSI WLYRHRKKRN GLTSTYAGIR 
KVTYQRGGEA VSSGGRPGLL NISEPAAQPW LADTWPNTGN NHNDCSISCC TAGNGNSDSN 
LTTYSRPADC IANYNNQLDN KQTNLMLPES TVYGDVDLSN KINEMKTFNS PNLKDGRFVN 
PSGQPTPYAT TQLIQSNLSN NMNNGSGDSG EKHWKPLGQQ KQEVAPVQYN IVEQNKLNKD 
YRANDTVPPT IPYNQSYDQN TGGSYNSSDR GSSTSGSQGH KKGARTPKVP KQGGMNWADP 
LPPPPAHPPP HSNSEEYNIS VDESYDQEMP CPVPPARMYL QQDELEEEED ERGPTPPVRG 
AASSPAAVSY SHQSTATLTP SPQEELQPML QDCPEETGHM QHQPDRRRQP VSPPPPPRPI 
SPPHTYGYIS GPLVSDMDTD APEEEEDEAD MEVAKMQTRR LLLRGLEQTP ASSVGDLESS 
VTGSMINGWG SASEEDNISS GRSSVSSSDG SFFTDADFAQ AVAAAAEYAG LKVARRQMQD 
AAGRRHFHAS QCPRPTSPVS TDSNMSAAVM QKTRPAKKLK HQPGHLRRET YTDDLPPPPV 
PPPAIKSPTA QSKTQLEVRP VVVPKLPSMD ARTDRSSDRK GSSYKGREVL DGRQVVDMRT 
NPGDPREAQE QQNDGKGRGN KAAKRDLPPA KTHLIQEDIL PYCRPTFPTS NNPRDPSSSS 
SMSSRGSGSR QREQANVGRR NIAEMQVLGG YERGEDNNEE LEETES

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.