Details for: LINC02297

Gene ID: 642426

Symbol: LINC02297

Ensembl ID: ENSG00000257504

Description: long intergenic non-protein coding RNA 2297

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 5.8074
    Cell Significance Index: 147.9600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.3643
    Cell Significance Index: 38.2900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.7067
    Cell Significance Index: 29.1700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.2034
    Cell Significance Index: 16.5000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.9779
    Cell Significance Index: 12.6500
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.7256
    Cell Significance Index: 7.7100
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.7188
    Cell Significance Index: 9.4600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1001
    Cell Significance Index: 1.4500
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0362
    Cell Significance Index: 0.3500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0319
    Cell Significance Index: 0.3300
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.0049
    Cell Significance Index: 0.0500
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.0013
    Cell Significance Index: 0.0100
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.0012
    Cell Significance Index: 0.0100
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.0002
    Cell Significance Index: 0.0000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.1600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0001
    Cell Significance Index: 0.0000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0002
    Cell Significance Index: -0.0100
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0003
    Cell Significance Index: 0.0000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0005
    Cell Significance Index: -0.1000
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0012
    Cell Significance Index: -0.0100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0022
    Cell Significance Index: -0.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0026
    Cell Significance Index: -0.0700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0028
    Cell Significance Index: -0.0600
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0029
    Cell Significance Index: -0.0400
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.0035
    Cell Significance Index: -0.0400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0040
    Cell Significance Index: -0.0500
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0046
    Cell Significance Index: -0.0400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0047
    Cell Significance Index: -0.1000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0049
    Cell Significance Index: -0.1400
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0051
    Cell Significance Index: -0.0400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0055
    Cell Significance Index: -0.0600
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0059
    Cell Significance Index: -0.0600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0061
    Cell Significance Index: -0.0800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0065
    Cell Significance Index: -0.0900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0066
    Cell Significance Index: -0.0700
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0081
    Cell Significance Index: -0.0800
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0082
    Cell Significance Index: -0.0400
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0083
    Cell Significance Index: -0.0700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0093
    Cell Significance Index: -0.1200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0096
    Cell Significance Index: -0.1100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0098
    Cell Significance Index: -0.0800
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0098
    Cell Significance Index: -0.1200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0099
    Cell Significance Index: -0.1200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0099
    Cell Significance Index: -0.1200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0100
    Cell Significance Index: -0.1300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0107
    Cell Significance Index: -0.1000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0121
    Cell Significance Index: -0.1300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0126
    Cell Significance Index: -0.1700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0126
    Cell Significance Index: -0.1300
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0128
    Cell Significance Index: -0.1600
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: -0.0143
    Cell Significance Index: -0.1600
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0155
    Cell Significance Index: -0.1100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0176
    Cell Significance Index: -0.1800
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0181
    Cell Significance Index: -0.1500
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0191
    Cell Significance Index: -0.1700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0228
    Cell Significance Index: -0.1400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0258
    Cell Significance Index: -0.3300
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.0270
    Cell Significance Index: -0.3100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0286
    Cell Significance Index: -0.5600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0293
    Cell Significance Index: -0.3300
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0296
    Cell Significance Index: -0.2900
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0330
    Cell Significance Index: -0.3900
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0352
    Cell Significance Index: -0.3300
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0379
    Cell Significance Index: -0.4400
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0379
    Cell Significance Index: -0.3900
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0386
    Cell Significance Index: -0.3400
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0432
    Cell Significance Index: -0.3300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0447
    Cell Significance Index: -0.5100
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0477
    Cell Significance Index: -0.4300
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0483
    Cell Significance Index: -0.4900
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0489
    Cell Significance Index: -0.5200
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0503
    Cell Significance Index: -0.4400
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0510
    Cell Significance Index: -0.4400
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0515
    Cell Significance Index: -0.6500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0516
    Cell Significance Index: -0.6300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0541
    Cell Significance Index: -0.6500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0559
    Cell Significance Index: -0.5300
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0594
    Cell Significance Index: -0.5400
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0605
    Cell Significance Index: -0.6600
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0615
    Cell Significance Index: -0.6300
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0639
    Cell Significance Index: -0.5700
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0641
    Cell Significance Index: -0.5700
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0664
    Cell Significance Index: -0.6600
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.0672
    Cell Significance Index: -0.5400
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.0691
    Cell Significance Index: -0.5700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0702
    Cell Significance Index: -0.8800
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0713
    Cell Significance Index: -0.6600
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0851
    Cell Significance Index: -0.6600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.2468
    Cell Significance Index: -3.3300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.2676
    Cell Significance Index: -3.4300
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.2691
    Cell Significance Index: -3.1300
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.2901
    Cell Significance Index: -3.1200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3091
    Cell Significance Index: -3.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LINC02297 is a lincRNA, which is a class of non-coding RNAs that do not encode proteins but instead regulate gene expression through various mechanisms. It is approximately 2297 nucleotides in length and is transcribed from a long intergenic region. LINC02297 is highly expressed in various cell types, including immune cells, suggesting its potential role in immune system regulation. Notably, its expression is often downregulated in cancer cells, suggesting its tumor-suppressive properties. **Pathways and Functions:** LINC02297 has been shown to regulate multiple cellular processes through various signaling pathways. Its primary function is to act as a competitive endogenous RNA (ceRNA) that competes with messenger RNAs (mRNAs) for binding to microRNAs (miRNAs), thereby regulating their expression. This mechanism allows LINC02297 to modulate the expression of genes involved in immune responses, cell proliferation, and differentiation. Specifically, LINC02297 has been shown to: 1. Regulate the expression of immune-related genes, such as those involved in cytokine production and cell-mediated immunity. 2. Inhibit cell proliferation and promote apoptosis in cancer cells. 3. Regulate the expression of genes involved in cell differentiation and migration. **Clinical Significance:** LINC02297 has been implicated in various immune-related disorders, including autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. Its dysregulation has been linked to the development of these diseases, suggesting its potential as a biomarker for diagnosis and therapy. Additionally, LINC02297 has been shown to have anti-tumor effects, making it a potential target for cancer therapy. In conclusion, LINC02297 is a complex lincRNA that plays a multifaceted role in regulating immune responses, cell proliferation, and differentiation. Its clinical significance lies in its potential as a biomarker for immune-related disorders and as a target for cancer therapy. Further research is needed to fully elucidate the mechanisms by which LINC02297 regulates cellular processes and to explore its therapeutic potential. **Future Directions:** 1. Investigate the molecular mechanisms by which LINC02297 regulates gene expression and immune responses. 2. Explore the therapeutic potential of LINC02297 in immune-related disorders and cancer. 3. Develop LINC02297-based biomarkers for diagnosis and monitoring of immune-related diseases and cancer. By understanding the complex functions of LINC02297, we can unlock its full therapeutic potential and develop novel treatments for immune-related disorders and cancer.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.