Details for: MTFR1

Gene ID: 9650

Symbol: MTFR1

Ensembl ID: ENSG00000066855

Description: mitochondrial fission regulator 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.47
    Marker Score: 29,362
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.16
    Marker Score: 3,830
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.94
    Marker Score: 7,361
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.93
    Marker Score: 65,574
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.52
    Marker Score: 3,390
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.43
    Marker Score: 8,623
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.89
    Marker Score: 1,108
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.71
    Marker Score: 4,892
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.61
    Marker Score: 481
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.45
    Marker Score: 3,426
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.27
    Marker Score: 19,833
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.03
    Marker Score: 1,187
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.02
    Marker Score: 1,577
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.02
    Marker Score: 322
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,756
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,981
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.98
    Marker Score: 6,276
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.97
    Marker Score: 543
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.96
    Marker Score: 4,143
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 490
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.95
    Marker Score: 1,930
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 444
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.92
    Marker Score: 2,017
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.91
    Marker Score: 33,679
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,721
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4,985
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 314
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.87
    Marker Score: 253
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.86
    Marker Score: 953
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.86
    Marker Score: 52,668
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.85
    Marker Score: 3,577
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.85
    Marker Score: 1,066
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.84
    Marker Score: 3,432
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.83
    Marker Score: 31,361
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.83
    Marker Score: 4,436
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.82
    Marker Score: 1,177
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.82
    Marker Score: 454
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.8
    Marker Score: 6,868
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.8
    Marker Score: 1,912
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.8
    Marker Score: 861
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 610
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.8
    Marker Score: 791
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.79
    Marker Score: 253
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.78
    Marker Score: 976
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.78
    Marker Score: 544
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,268
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.77
    Marker Score: 11,517
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.77
    Marker Score: 3,189
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.77
    Marker Score: 682
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 306
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.76
    Marker Score: 319
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.75
    Marker Score: 365
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.75
    Marker Score: 451
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.75
    Marker Score: 2,887
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.74
    Marker Score: 444
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.74
    Marker Score: 5,661
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.74
    Marker Score: 1,556
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 380
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.73
    Marker Score: 6,924
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.72
    Marker Score: 7,385
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.71
    Marker Score: 2,796
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2,972
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 639
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.7
    Marker Score: 4,178
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.69
    Marker Score: 456
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.69
    Marker Score: 2,444
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.69
    Marker Score: 888
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.67
    Marker Score: 194
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.67
    Marker Score: 14,358
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.67
    Marker Score: 1,285
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.66
    Marker Score: 6,174
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.65
    Marker Score: 11,623
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.65
    Marker Score: 339
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.65
    Marker Score: 195
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.63
    Marker Score: 226
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.63
    Marker Score: 235
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.62
    Marker Score: 2,033
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.61
    Marker Score: 161
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.61
    Marker Score: 5,231
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.61
    Marker Score: 190
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.6
    Marker Score: 11,976
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.6
    Marker Score: 408
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.6
    Marker Score: 1,057
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.6
    Marker Score: 844
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.59
    Marker Score: 201
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.59
    Marker Score: 631
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.59
    Marker Score: 622
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.59
    Marker Score: 309
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.59
    Marker Score: 441
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.58
    Marker Score: 9,377
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.58
    Marker Score: 326
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.58
    Marker Score: 19,619
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.58
    Marker Score: 1,054
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.58
    Marker Score: 201
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.58
    Marker Score: 672
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.57
    Marker Score: 457

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MTFR1 is a mitochondrial protein that regulates mitochondrial fission, a process that involves the dynamic remodeling of the mitochondrial network. Unlike other mitochondrial fission regulators, MTFR1 is specifically involved in the regulation of mitochondrial fission, rather than fusion or dynamics. MTFR1 is a member of the PH domain leucine-rich repeat protein family, which is known for its involvement in various cellular processes, including cell signaling and protein-protein interactions. **Pathways and Functions:** MTFR1 is involved in the following pathways: 1. **Aerobic Respiration:** MTFR1 regulates mitochondrial fission, which is essential for maintaining mitochondrial homeostasis and efficient aerobic respiration. 2. **Mitochondrial Fission:** MTFR1 specifically regulates mitochondrial fission, a process that involves the dynamic remodeling of the mitochondrial network. 3. **Mitochondrion Organization:** MTFR1 plays a critical role in maintaining mitochondrial organization and structure, which is essential for cellular homeostasis. 4. **Protein Binding:** MTFR1 interacts with various proteins, including mitochondrial proteins and cytosolic proteins, to regulate mitochondrial fission and dynamics. **Functions:** MTFR1 has several functions, including: 1. **Regulation of Mitochondrial Fission:** MTFR1 regulates mitochondrial fission by interacting with other mitochondrial proteins and modulating the dynamics of the mitochondrial network. 2. **Maintenance of Mitochondrial Homeostasis:** MTFR1 helps maintain mitochondrial homeostasis by regulating mitochondrial fission and dynamics, which is essential for maintaining cellular health. 3. **Regulation of Cellular Stress Response:** MTFR1 has been implicated in the regulation of the cellular stress response, including the response to oxidative stress and DNA damage. **Clinical Significance:** Dysregulation of MTFR1 has been implicated in various diseases, including: 1. **Mitochondrial Diseases:** MTFR1 dysfunction has been linked to various mitochondrial diseases, including Leber hereditary optic neuropathy and Kearns-Sayre syndrome. 2. **Neurodegenerative Diseases:** MTFR1 has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 3. **Cardiovascular Diseases:** MTFR1 has been linked to cardiovascular diseases, including heart failure and arrhythmias. 4. **Cancer:** MTFR1 has been implicated in cancer, including colorectal cancer and breast cancer. In conclusion, the MTFR1 gene is a critical component of the mitochondrial dynamics machinery, playing a vital role in regulating mitochondrial fission and maintaining cellular homeostasis. Dysregulation of MTFR1 has been implicated in various diseases, underscoring its significance as a therapeutic target. Further research is needed to fully elucidate the functions and mechanisms of MTFR1, as well as its potential as a therapeutic target for various diseases.

Genular Protein ID: 650045659

Symbol: MTFR1_HUMAN

Name: Mitochondrial fission regulator 1

UniProtKB Accession Codes:

Q15390 E7EP84 Q6IB94 Q7Z669 Q86XH5 Q8IVD7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 EMBL 6 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 6 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 7584026

Title: Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.

PubMed ID: 7584026

DOI: 10.1093/dnares/1.1.27

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 333
  • Mass: 37000
  • Checksum: ED8025FCF1B44827
  • Sequence:
    • MLGWIKRLIR MVFQQVGVSM QSVLWSRKPY GSSRSIVRKI GTNLSLIQCP RVQFQINSHA 
TEWSPSHPGE DAVASFADVG WVAKEEGECS ARLRTEVRSR PPLQDDLLFF EKAPSRQISL 
PDLSQEEPQL KTPALANEEA LQKICALENE LAALRAQIAK IVTQQEQQNL TAGDLDSTTF 
GTIPPHPPPP PPPLPPPALG LHQSTSAVDL IKERREKRAN AGKTLVKNNP KKPEMPNMLE 
ILKEMNSVKL RSVKRSEQDV KPKPVDATDP AALIAEALKK KFAYRYRSDS QDEVEKGIPK 
SESEATSERV LFGPHMLKPT GKMKALIENV SDS

Genular Protein ID: 1617124363

Symbol: B4E3G8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E3G8

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 3 Genevisible 1 GenomeRNAi 1 InterPro 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1

Sequence Information:

  • Length: 348
  • Mass: 38715
  • Checksum: 71FE4256C60FE015
  • Sequence:
    • MLGWIKRLIR MVFQQVGVSM QSVLWSRKPY GSSRSIVRKI GTNLSLIQCP RVQFQINSHA 
TEWSPSHPGE DAVASFADVG WVAKEEGECS ARLRTEVRSR PPLQDDLLFF EKAPSRQISL 
PDLSQEEPQL KTPALANEEA LQKICALENE LAALRAQIAK IVTQQEQQNL TAGDLDSTTF 
GTIPPHPPPP PPPLPPPALG LHQSTSAVDL IKERREKRAN AGKTLVKNNP KKPEMPNMLE 
ILKEMNSVKL RSVKRSEQDV KPKPVDATDP AALIAEALKK KFAYRYRSDS QDEVEKGIPK 
SESEATSERV LVSYLPRFLS CYVEIHPIAK HLHFASDSPV SSVSSKGR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.