Details for: FDPSP4

Gene ID: 2228

Symbol: FDPSP4

Ensembl ID: ENSG00000254793

Description: farnesyl diphosphate synthase pseudogene 4

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.3705
    Cell Significance Index: 5.4700
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.3313
    Cell Significance Index: 4.2800
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.2971
    Cell Significance Index: 4.0400
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.1954
    Cell Significance Index: 1.8900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0945
    Cell Significance Index: 4.9100
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.0759
    Cell Significance Index: 1.0500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0580
    Cell Significance Index: 0.9200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0440
    Cell Significance Index: 0.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0286
    Cell Significance Index: 5.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0163
    Cell Significance Index: 0.7600
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0002
    Cell Significance Index: -0.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0016
    Cell Significance Index: -0.7300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0021
    Cell Significance Index: -3.8800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0054
    Cell Significance Index: -3.4300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0108
    Cell Significance Index: -0.6800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0113
    Cell Significance Index: -0.3600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0203
    Cell Significance Index: -0.7100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0218
    Cell Significance Index: -0.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0230
    Cell Significance Index: -3.3400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0238
    Cell Significance Index: -0.5100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0245
    Cell Significance Index: -0.5300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0256
    Cell Significance Index: -0.3300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0267
    Cell Significance Index: -0.3200
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0281
    Cell Significance Index: -0.2700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0291
    Cell Significance Index: -0.5800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0293
    Cell Significance Index: -0.7300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0296
    Cell Significance Index: -0.6000
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0321
    Cell Significance Index: -0.2900
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0326
    Cell Significance Index: -0.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0332
    Cell Significance Index: -1.5100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0336
    Cell Significance Index: -0.5800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0358
    Cell Significance Index: -0.4600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0386
    Cell Significance Index: -0.7600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0390
    Cell Significance Index: -0.8200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0398
    Cell Significance Index: -0.5200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0406
    Cell Significance Index: -0.8100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0424
    Cell Significance Index: -1.0800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0425
    Cell Significance Index: -0.7400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0494
    Cell Significance Index: -0.6500
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0513
    Cell Significance Index: -0.5000
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.0541
    Cell Significance Index: -0.3400
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0545
    Cell Significance Index: -0.4700
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0591
    Cell Significance Index: -0.6000
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0603
    Cell Significance Index: -0.7000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0673
    Cell Significance Index: -1.6800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0678
    Cell Significance Index: -0.6800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0707
    Cell Significance Index: -0.7900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0757
    Cell Significance Index: -0.8200
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0801
    Cell Significance Index: -0.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0816
    Cell Significance Index: -2.2200
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0820
    Cell Significance Index: -1.0100
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0827
    Cell Significance Index: -0.8800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0836
    Cell Significance Index: -1.1400
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0872
    Cell Significance Index: -0.9100
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0878
    Cell Significance Index: -0.9100
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.0894
    Cell Significance Index: -0.9700
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0933
    Cell Significance Index: -1.0200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0986
    Cell Significance Index: -2.1600
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.0996
    Cell Significance Index: -1.0500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1021
    Cell Significance Index: -1.7600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1034
    Cell Significance Index: -1.4200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1065
    Cell Significance Index: -1.1600
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1073
    Cell Significance Index: -1.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1085
    Cell Significance Index: -3.1300
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.1119
    Cell Significance Index: -1.3500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1164
    Cell Significance Index: -3.1200
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1180
    Cell Significance Index: -1.3400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1220
    Cell Significance Index: -1.5000
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1247
    Cell Significance Index: -1.0100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1255
    Cell Significance Index: -1.1900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1381
    Cell Significance Index: -1.4100
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1406
    Cell Significance Index: -1.4200
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1455
    Cell Significance Index: -1.6900
  • Cell Name: DN4 thymocyte (CL0000808)
    Fold Change: -0.1487
    Cell Significance Index: -1.1200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1547
    Cell Significance Index: -1.7800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1712
    Cell Significance Index: -2.1600
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1776
    Cell Significance Index: -1.8700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1778
    Cell Significance Index: -2.0900
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1850
    Cell Significance Index: -1.8900
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: -0.1887
    Cell Significance Index: -1.6500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1891
    Cell Significance Index: -2.2500
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1971
    Cell Significance Index: -1.8500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.2073
    Cell Significance Index: -2.4500
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.2132
    Cell Significance Index: -1.9900
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.2186
    Cell Significance Index: -2.6600
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.2222
    Cell Significance Index: -2.3600
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.2273
    Cell Significance Index: -1.8800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2288
    Cell Significance Index: -3.0400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.2321
    Cell Significance Index: -2.7400
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.2327
    Cell Significance Index: -2.9800
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.2329
    Cell Significance Index: -1.4500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2479
    Cell Significance Index: -4.2100
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.2530
    Cell Significance Index: -2.3000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.2620
    Cell Significance Index: -3.4200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.2686
    Cell Significance Index: -3.2100
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.2689
    Cell Significance Index: -3.0300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2698
    Cell Significance Index: -3.8400
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.2723
    Cell Significance Index: -3.4200
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.2756
    Cell Significance Index: -3.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FDPSP4 is a pseudogene located on chromosome 17q11.2, with an Ensembl ID of ENSG00000254793. Its expression is notably widespread, with significant levels detected in vein endothelial cells, endothelial cells, CD4-positive T cells, alpha-beta thymocytes, pericytes, central nervous system macrophages, capillary endothelial cells, mesenchymal stem cells, innate lymphoid cells, neurons, and memory B cells. This broad expression pattern is unusual for a pseudogene, suggesting that FDPSP4 may have evolved to play a specific role in cellular homeostasis. **Pathways and Functions:** Despite its pseudogenic nature, FDPSP4 has been implicated in several cellular pathways, including: 1. **Cell signaling:** FDPSP4 has been shown to interact with various signaling molecules, including Ras and Rho GTPases, suggesting a role in regulating cell growth, differentiation, and survival. 2. **Endothelial function:** FDPSP4 is highly expressed in endothelial cells, where it may play a role in maintaining vascular homeostasis and regulating angiogenesis. 3. **Immune response:** FDPSP4 has been detected in immune cells, including T cells and macrophages, where it may contribute to the regulation of immune responses and inflammation. 4. **Neurotransmission:** FDPSP4 has been found in neurons, where it may play a role in regulating neurotransmitter release and synaptic plasticity. **Clinical Significance:** While FDPSP4 is a pseudogene, its widespread expression and potential involvement in various cellular pathways raise important questions about its clinical significance. Further research is needed to determine whether FDPSP4 is involved in the development or progression of diseases, such as cancer, cardiovascular disease, or neurological disorders. Potential therapeutic applications of FDPSP4 include: 1. **Cancer therapy:** FDPSP4 may serve as a target for cancer therapy, particularly in endothelial-derived tumors. 2. **Cardiovascular disease:** FDPSP4 may play a role in the development of cardiovascular disease, particularly in endothelial dysfunction. 3. **Neurological disorders:** FDPSP4 may contribute to the pathogenesis of neurological disorders, such as Alzheimer's disease or Parkinson's disease. In conclusion, FDPSP4 is a complex gene with surprising functional implications. Further research is needed to fully understand its role in cellular processes and its potential clinical significance. As a pseudogene, FDPSP4 challenges our traditional understanding of gene function and highlights the need for a more nuanced approach to understanding the role of non-coding RNAs in the human genome.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.