Details for: XPO6

Gene ID: 23214

Symbol: XPO6

Ensembl ID: ENSG00000169180

Description: exportin 6

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.93
    Marker Score: 2,132
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.7
    Marker Score: 62,593
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.69
    Marker Score: 6,870
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.69
    Marker Score: 17,421
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.64
    Marker Score: 100,622
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.63
    Marker Score: 15,487
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.63
    Marker Score: 61,775
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.58
    Marker Score: 31,339
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.57
    Marker Score: 6,079
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.56
    Marker Score: 14,687
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.53
    Marker Score: 6,340
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.5
    Marker Score: 630
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.5
    Marker Score: 12,873
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.47
    Marker Score: 22,009
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.43
    Marker Score: 2,503
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.42
    Marker Score: 10,892
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.33
    Marker Score: 2,060
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.31
    Marker Score: 788
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.3
    Marker Score: 761
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.3
    Marker Score: 2,846
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.28
    Marker Score: 27,251
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.22
    Marker Score: 334
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.21
    Marker Score: 5,613
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.21
    Marker Score: 18,918
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.15
    Marker Score: 1,325
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.14
    Marker Score: 368
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.14
    Marker Score: 665
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1.08
    Marker Score: 387
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.07
    Marker Score: 2,067
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.07
    Marker Score: 534
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.06
    Marker Score: 1,203
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.06
    Marker Score: 2,158
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.06
    Marker Score: 2,595
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.05
    Marker Score: 331
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.03
    Marker Score: 1,736
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.02
    Marker Score: 2,465
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.01
    Marker Score: 1,065
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1
    Marker Score: 2,398
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,670
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,894
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.99
    Marker Score: 1,334
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.99
    Marker Score: 285
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.98
    Marker Score: 4,123
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,387
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.98
    Marker Score: 310
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.98
    Marker Score: 583
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.97
    Marker Score: 1,205
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.97
    Marker Score: 750
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.97
    Marker Score: 964
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.96
    Marker Score: 1,036
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.95
    Marker Score: 16,828
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,397
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.93
    Marker Score: 31,490
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 434
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.92
    Marker Score: 622
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.9
    Marker Score: 783
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.9
    Marker Score: 505
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,698
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.9
    Marker Score: 2,556
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.89
    Marker Score: 444
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.89
    Marker Score: 1,254
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.88
    Marker Score: 338
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.88
    Marker Score: 1,063
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.88
    Marker Score: 272
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,293
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.87
    Marker Score: 276
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.87
    Marker Score: 374
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.87
    Marker Score: 1,045
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.86
    Marker Score: 1,040
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.86
    Marker Score: 2,024
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.86
    Marker Score: 1,392
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4,842
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.85
    Marker Score: 341
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.84
    Marker Score: 406
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.83
    Marker Score: 337
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.83
    Marker Score: 306
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.81
    Marker Score: 4,874
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.81
    Marker Score: 1,045
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.81
    Marker Score: 808
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.8
    Marker Score: 737
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.8
    Marker Score: 998
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 605
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 316
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.79
    Marker Score: 1,144
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.79
    Marker Score: 273
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.78
    Marker Score: 282
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.78
    Marker Score: 294
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.77
    Marker Score: 518
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.77
    Marker Score: 407
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.77
    Marker Score: 736
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.77
    Marker Score: 469
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.77
    Marker Score: 478
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.76
    Marker Score: 656
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.76
    Marker Score: 804
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.76
    Marker Score: 883
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.76
    Marker Score: 670
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.75
    Marker Score: 11,976
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.74
    Marker Score: 163

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** XPO6 is a 76-kDa protein that belongs to the exportin family, which is characterized by its ability to recognize and bind to specific nuclear export sequences (NES) on target proteins. XPO6 is widely expressed in various tissues, including the brain, where it is highly abundant in neurons and interneurons. Its expression is also observed in corneal epithelial cells, indicating its role in maintaining cellular homeostasis in different tissues. **Pathways and Functions:** XPO6 is involved in multiple cellular processes, including: 1. **Nuclear Export:** XPO6 recognizes and binds to NES on target proteins, facilitating their export from the nucleus to the cytoplasm. This process is crucial for regulating gene expression, cell growth, and differentiation. 2. **Protein Degradation:** XPO6 is involved in the regulation of protein degradation pathways, including the ubiquitin-proteasome system. Its interaction with ubiquitin ligases and proteasomes modulates protein degradation rates and cellular homeostasis. 3. **Cell Signaling:** XPO6 interacts with various signaling molecules, including kinases, phosphatases, and transcription factors, influencing cell signaling pathways and cellular responses to environmental cues. 4. **Cell Cycle Regulation:** XPO6 is involved in the regulation of the cell cycle, particularly in the G2/M phase, where it modulates the activity of cyclin-dependent kinases and other cell cycle regulators. **Clinical Significance:** Dysregulation of XPO6 has been implicated in various diseases, including: 1. **Neurodegenerative Disorders:** XPO6 dysfunction has been linked to neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, where it contributes to the degradation of neuronal proteins and the disruption of cellular homeostasis. 2. **Cancer:** XPO6 overexpression has been observed in various types of cancer, including breast, lung, and colon cancer, where it promotes tumor growth, metastasis, and resistance to chemotherapy. 3. **Neuropsychiatric Disorders:** XPO6 has been implicated in the pathogenesis of neuropsychiatric disorders, such as schizophrenia and bipolar disorder, where it influences cellular homeostasis and neuronal function. In conclusion, XPO6 is a multifunctional protein that plays a critical role in regulating cellular processes, including nuclear export, protein degradation, and cell signaling. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its mechanisms of action and potential therapeutic targets.

Genular Protein ID: 814380679

Symbol: XPO6_HUMAN

Name: Exportin-6

UniProtKB Accession Codes:

Q96QU8 A1L3W4 D3DWF9 Q2YDX3 Q53G88 Q68G50 Q76N88 Q96CP8 Q9BT21

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 CarbonylDB 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14592989

Title: Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes.

PubMed ID: 14592989

DOI: 10.1093/emboj/cdg565

PubMed ID: 9205841

Title: Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9205841

DOI: 10.1093/dnares/4.2.141

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 1125
  • Mass: 128883
  • Checksum: 753D5F815EC110A2
  • Sequence:
    • MASEEASLRA LESLMTEFFH DCTTNERKRE IEELLNNFAQ QIGAWRFCLY FLSSTRNDYV 
MMYSLTVFEN LINKMWLGVP SQDKMEIRSC LPKLLLAHHK TLPYFIRNKL CKVIVDIGRQ 
DWPMFYHDFF TNILQLIQSP VTTPLGLIML KTTSEELACP REDLSVARKE ELRKLLLDQV 
QTVLGLLTGI LETVWDKHSV TAATPPPSPT SGESGDLLSN LLQSPSSAKL LNQPIPILDV 
ESEYICSLAL ECLAHLFSWI PLSASITPSL LTTIFHFARF GCDIRARKMA SVNGSSQNCV 
SGQERGRLGV LAMSCINELM SKNCVPMEFE EYLLRMFQQT FYLLQKITKD NNAHTVKSRL 
EELDESYIEK FTDFLRLFVS VHLRRIESYS QFPVVEFLTL LFKYTFHQPT HEGYFSCLDI 
WTLFLDYLTS KIKSRLGDKE AVLNRYEDAL VLLLTEVLNR IQFRYNQAQL EELDDETLDD 
DQQTEWQRYL RQSLEVVAKV MELLPTHAFS TLFPVLQDNL EVYLGLQQFI VTSGSGHRLN 
ITAENDCRRL HCSLRDLSSL LQAVGRLAEY FIGDVFAARF NDALTVVERL VKVTLYGSQI 
KLYNIETAVP SVLKPDLIDV HAQSLAALQA YSHWLAQYCS EVHRQNTQQF VTLISTTMDA 
ITPLISTKVQ DKLLLSACHL LVSLATTVRP VFLISIPAVQ KVFNRITDAS ALRLVDKAQV 
LVCRALSNIL LLPWPNLPEN EQQWPVRSIN HASLISALSR DYRNLKPSAV APQRKMPLDD 
TKLIIHQTLS VLEDIVENIS GESTKSRQIC YQSLQESVQV SLALFPAFIH QSDVTDEMLS 
FFLTLFRGLR VQMGVPFTEQ IIQTFLNMFT REQLAESILH EGSTGCRVVE KFLKILQVVV 
QEPGQVFKPF LPSIIALCME QVYPIIAERP SPDVKAELFE LLFRTLHHNW RYFFKSTVLA 
SVQRGIAEEQ MENEPQFSAI MQAFGQSFLQ PDIHLFKQNL FYLETLNTKQ KLYHKKIFRT 
AMLFQFVNVL LQVLVHKSHD LLQEEIGIAI YNMASVDFDG FFAAFLPEFL TSCDGVDANQ 
KSVLGRNFKM DRDLPSFTQN VHRLVNDLRY YRLCNDSLPP GTVKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.