Details for: GALK2

Gene ID: 2585

Symbol: GALK2

Ensembl ID: ENSG00000156958

Description: galactokinase 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.85
    Marker Score: 1075
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.8
    Marker Score: 66494
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.75
    Marker Score: 16491
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.73
    Marker Score: 106437
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.72
    Marker Score: 13178
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.72
    Marker Score: 65146
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.71
    Marker Score: 16227
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.69
    Marker Score: 17461
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.68
    Marker Score: 25158
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.65
    Marker Score: 14152
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.63
    Marker Score: 32435
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.61
    Marker Score: 6206
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.58
    Marker Score: 6546
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.53
    Marker Score: 4377.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.53
    Marker Score: 2356
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.44
    Marker Score: 1795
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.43
    Marker Score: 3374
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.37
    Marker Score: 5564
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.36
    Marker Score: 2625
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.36
    Marker Score: 29085
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.33
    Marker Score: 1064
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.3
    Marker Score: 6010
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.29
    Marker Score: 2171
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.24
    Marker Score: 1428
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.2
    Marker Score: 548
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.13
    Marker Score: 1206
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.12
    Marker Score: 468
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.11
    Marker Score: 319
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.1
    Marker Score: 1216
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.09
    Marker Score: 653
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.08
    Marker Score: 16838
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.07
    Marker Score: 1157
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.07
    Marker Score: 17214
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.05
    Marker Score: 2502
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.04
    Marker Score: 1260
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.04
    Marker Score: 304
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.04
    Marker Score: 1398
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.02
    Marker Score: 4258.5
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1
    Marker Score: 22311
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71700
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47925
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.99
    Marker Score: 551
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.99
    Marker Score: 759
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.98
    Marker Score: 8520
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30391
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.98
    Marker Score: 2147
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.96
    Marker Score: 3411
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.96
    Marker Score: 6141
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.95
    Marker Score: 305
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2398
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 482
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.93
    Marker Score: 3317
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.93
    Marker Score: 31536
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.93
    Marker Score: 16503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 436
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.92
    Marker Score: 514
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.92
    Marker Score: 436
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.91
    Marker Score: 339
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.91
    Marker Score: 3907
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.9
    Marker Score: 1578
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2705
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.89
    Marker Score: 468
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.88
    Marker Score: 1436
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.88
    Marker Score: 326
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.88
    Marker Score: 515
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.88
    Marker Score: 1786.5
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.87
    Marker Score: 239
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.87
    Marker Score: 602
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.85
    Marker Score: 1210
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4856
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.84
    Marker Score: 745
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.84
    Marker Score: 504
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.84
    Marker Score: 1008
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.83
    Marker Score: 303
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.83
    Marker Score: 261
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.83
    Marker Score: 939
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.82
    Marker Score: 407
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.81
    Marker Score: 330
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.81
    Marker Score: 699
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.8
    Marker Score: 451
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.8
    Marker Score: 389
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.8
    Marker Score: 986
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.79
    Marker Score: 4742
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 600.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 311
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.78
    Marker Score: 739
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.77
    Marker Score: 4142
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.75
    Marker Score: 238
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.75
    Marker Score: 689
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.74
    Marker Score: 3097
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.74
    Marker Score: 234
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 375
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.72
    Marker Score: 962
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.72
    Marker Score: 764
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3004
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.7
    Marker Score: 182
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.7
    Marker Score: 264
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.7
    Marker Score: 337

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Other Information

**Key characteristics:** - GALK2 is a transmembrane protein with a molecular weight of approximately 150 kDa. - It is expressed in a variety of cell types, including corneal endothelial cells, pvalb GABAergic cortical interneurons, near-projecting glutamatergic cortical neuron, L2/3-6 intratelencephalic projecting glutamatergic neuron, sncg GABAergic cortical interneuron, vip GABAergic cortical interneuron, corticothalamic-projecting glutamatergic cortical neuron, dopaminergic neuron, lamp5 GABAergic cortical interneuron, and L6b glutamatergic cortical neuron. - It is a highly regulated protein, with its expression being controlled by a variety of factors, including growth factors, hormones, and cytokines. **Pathways and functions:** - GALK2 is involved in the regulation of the galactose metabolic process, which is responsible for the metabolism of galactose, a sugar that is found in milk and other dairy products. - It is a key enzyme in this process, and its activity is regulated by a variety of factors, including growth factors, hormones, and cytokines. - It is involved in the regulation of many cellular processes, including cell growth, differentiation, and migration. - It is also involved in the regulation of inflammation and cell death. **Clinical significance:** Mutations in the GALK2 gene have been linked to a number of human diseases, including galactosemia, a disorder that is caused by a deficiency of galactose in the diet. In galactosemia, the accumulation of galactose in the blood can lead to a number of clinical symptoms, including developmental delays, intellectual disabilities, and seizures.

Genular Protein ID: 2451788926

Symbol: GALK2_HUMAN

Name: N-acetylgalactosamine kinase

UniProtKB Accession Codes:

Q01415 Q7Z4Q4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 15 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 7 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 Rhea 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1438294

Title: Cloning of a human galactokinase gene (GK2) on chromosome 15 by complementation in yeast.

PubMed ID: 1438294

DOI: 10.1073/pnas.89.22.10887

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7542884

Title: Comparison of the enzymatic activities of human galactokinase GALK1 and a related human galactokinase protein GK2.

PubMed ID: 7542884

DOI: 10.1006/bbrc.1995.2023

PubMed ID: 8798585

Title: Identification of the GalNAc kinase amino acid sequence.

PubMed ID: 8798585

DOI: 10.1074/jbc.271.39.23653

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 16006554

Title: The molecular architecture of human N-acetylgalactosamine kinase.

PubMed ID: 16006554

DOI: 10.1074/jbc.m505730200

Sequence Information:

  • Length: 458
  • Mass: 50378
  • Checksum: 192B774938F32947
  • Sequence:
    • MATESPATRR VQVAEHPRLL KLKEMFNSKF GSIPKFYVRA PGRVNIIGEH IDYCGYSVLP 
MAVEQDVLIA VEPVKTYALQ LANTNPLYPD FSTSANNIQI DKTKPLWHNY FLCGLKGIQE 
HFGLSNLTGM NCLVDGNIPP SSGLSSSSAL VCCAGLVTLT VLGRNLSKVE LAEICAKSER 
YIGTEGGGMD QSISFLAEEG TAKLIEFSPL RATDVKLPSG AVFVIANSCV EMNKAATSHF 
NIRVMECRLA AKLLAKYKSL QWDKVLRLEE VQAKLGISLE EMLLVTEDAL HPEPYNPEEI 
CRCLGISLEE LRTQILSPNT QDVLIFKLYQ RAKHVYSEAA RVLQFKKICE EAPENMVQLL 
GELMNQSHMS CRDMYECSCP ELDQLVDICR KFGAQGSRLT GAGWGGCTVS MVPADKLPSF 
LANVHKAYYQ RSDGSLAPEK QSLFATKPGG GALVLLEA

Genular Protein ID: 989232510

Symbol: B7ZAX5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7ZAX5

Database IDs:

ARBA 5 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 5 EPD 1 Ensembl 4 GO 4 Gene3D 3 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 10 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 2 PROSITE 2 Pfam 6 Proteomes 2 ProteomicsDB 1 RefSeq 2 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 434
  • Mass: 47635
  • Checksum: 1A347D57A6D9CE46
  • Sequence:
    • MFNSKFGSIP KFYVRAPGRV NIIGEHIDYC GYSVLPMAVE QDVLIAVEPV KTYALQLANT 
NPLYPDFSTS ANNIQIDKTK PLWHNYFLCG LKGIQEHFGL SNLTGMNCLV DGNIPPSSGL 
SSSSALVCCA GLVTLTVLGR NLSKVELAEI CAKSERYIGT EGGGMDQSIS FLAEEGTAKL 
IEFSPLRATD VKLPSGAVFV IANSCVEMNK AATSHFNIRV MECRLAAKLL AKYKSLQWDK 
VLRLEEVQAK LGISLEEMLL VTEDALHPEP YNPEEICRCL GISLEELRTQ ILSPNTQDVL 
IFKLYQRAKH VYSEAARVLQ FKKICEEAPE NMVQLLGELM NQSHMSCRDM YECSCPELDQ 
LVDICRKFGA QGSRLTGAGW GGCTVSMVPA DKLPSFLANV HKAYYQRSDG SLAPEKQSLF 
ATKPGGGALV LLEA

Genular Protein ID: 944525559

Symbol: B4DW43_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DW43

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 4 Gene3D 3 GenomeRNAi 1 InterPro 10 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 2 PROSITE 2 PeptideAtlas 1 Pfam 6 RefSeq 1 SUPFAM 2

Sequence Information:

  • Length: 434
  • Mass: 47589
  • Checksum: F782A11FD30E9FDE
  • Sequence:
    • MFNSKFGSIP KFYVRAPGRV NIIGEHIDYC GYSVLPMAVE QDVLIAVEPV KTYALQLANT 
NPLYPDFSTS ANNIQIDKTK PLWHNYFLCG LKGIQEHFGL SNLTGMNCLV DGNIPPSSGL 
SSSSALVCCA GLVTLTVLGR NLSKVELAEI CAKSERYIGT EGGGMDQSIS FLAEEGTAKL 
IEFSPLRATD VKLPSGAVSL IANSCVEMNK AATSHFNIRV MECRLAAKLL AKYKSLQWDK 
VLRLEEVQAK LGISLEEMLL VTEDALHPEP YNPEEICRCL GISLEELRTQ ILSPNTQDVL 
IFKLYQRAKH VYSEAARVLQ FKKICEEAPE NMVQLLGELM NQSHMSCRDM YECSCPELDQ 
LVDICRKFGA QGSRLTGAGW GGCTVSMVPA DKLPSFLANV HKAYYQRSDG SLAPEKQSLF 
ATKPGGGALV LLEA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.