Gene GGTA1 - ENSG00000204136 | NCBI Gene ID: 2681

Details for: GGTA1

Gene ID: 2681

Symbol: GGTA1

Ensembl ID: ENSG00000204136

Description: glycoprotein alpha-galactosyltransferase 1 (inactive)

Associated with

Biological_process
(GO:0008150)
Cellular_component
(GO:0005575)
Golgi cisterna
(GO:0031985)
Golgi cisterna membrane
(GO:0032580)
Leukotriene d4 biosynthetic process
(GO:1901750)
Molecular_function
(GO:0003674)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 3.07
Marker Score: 6985
Cell Name: keratinocyte (CL0000312)
Fold Change: 2.93
Marker Score: 2447
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 1.43
Marker Score: 3568.5
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.33
Marker Score: 1608
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 1.27
Marker Score: 630
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 1
Marker Score: 465
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 0.99
Marker Score: 413
Cell Name: neutrophil (CL0000775)
Fold Change: 0.63
Marker Score: 382
Cell Name: endocardial cell (CL0002350)
Fold Change: 0.59
Marker Score: 333
Cell Name: leukocyte (CL0000738)
Fold Change: 0.59
Marker Score: 337
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.56
Marker Score: 885
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.52
Marker Score: 919
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.46
Marker Score: 161
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.45
Marker Score: 321
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.42
Marker Score: 1212
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.4
Marker Score: 162
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.37
Marker Score: 363
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.35
Marker Score: 193
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.32
Marker Score: 157
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.31
Marker Score: 222
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.3
Marker Score: 162
Cell Name: macrophage (CL0000235)
Fold Change: 0.24
Marker Score: 265
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.23
Marker Score: 316
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.23
Marker Score: 369
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.23
Marker Score: 78
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.23
Marker Score: 215
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.22
Marker Score: 103
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.22
Marker Score: 230
Cell Name: astrocyte (CL0000127)
Fold Change: 0.2
Marker Score: 174
Cell Name: myoepithelial cell (CL0000185)
Fold Change: 0.2
Marker Score: 55
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.18
Marker Score: 275
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.18
Marker Score: 122
Cell Name: basophil (CL0000767)
Fold Change: 0.18
Marker Score: 84
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.18
Marker Score: 121
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.17
Marker Score: 37
Cell Name: melanocyte (CL0000148)
Fold Change: 0.16
Marker Score: 63
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 0.16
Marker Score: 117
Cell Name: adventitial cell (CL0002503)
Fold Change: 0.15
Marker Score: 38
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.15
Marker Score: 89
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.15
Marker Score: 627
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 0.15
Marker Score: 184
Cell Name: granulocyte (CL0000094)
Fold Change: 0.15
Marker Score: 66
Cell Name: platelet (CL0000233)
Fold Change: 0.14
Marker Score: 65
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.14
Marker Score: 74
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.14
Marker Score: 92
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 0.14
Marker Score: 201
Cell Name: pericyte (CL0000669)
Fold Change: 0.14
Marker Score: 80
Cell Name: basal cell (CL0000646)
Fold Change: 0.13
Marker Score: 174
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.13
Marker Score: 62
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.13
Marker Score: 524
Cell Name: Schwann cell (CL0002573)
Fold Change: 0.12
Marker Score: 43
Cell Name: myeloid dendritic cell, human (CL0001057)
Fold Change: 0.12
Marker Score: 43
Cell Name: mucus secreting cell (CL0000319)
Fold Change: 0.11
Marker Score: 29
Cell Name: keratocyte (CL0002363)
Fold Change: 0.11
Marker Score: 26
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.11
Marker Score: 38
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.11
Marker Score: 233
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.11
Marker Score: 65
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.1
Marker Score: 44
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.1
Marker Score: 110
Cell Name: mast cell (CL0000097)
Fold Change: 0.1
Marker Score: 59
Cell Name: bronchial smooth muscle cell (CL0002598)
Fold Change: 0.1
Marker Score: 28
Cell Name: tendon cell (CL0000388)
Fold Change: 0.1
Marker Score: 24
Cell Name: myometrial cell (CL0002366)
Fold Change: 0.1
Marker Score: 28
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.1
Marker Score: 95
Cell Name: neuron (CL0000540)
Fold Change: 0.1
Marker Score: 389
Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
Fold Change: 0.09
Marker Score: 32
Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 0.09
Marker Score: 20
Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.09
Marker Score: 29.5
Cell Name: stromal cell (CL0000499)
Fold Change: 0.09
Marker Score: 109
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.09
Marker Score: 21
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.09
Marker Score: 24
Cell Name: fibroblast (CL0000057)
Fold Change: 0.09
Marker Score: 86
Cell Name: ionocyte (CL0005006)
Fold Change: 0.09
Marker Score: 27
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.09
Marker Score: 55
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.09
Marker Score: 49
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 0.09
Marker Score: 44
Cell Name: dermis microvascular lymphatic vessel endothelial cell (CL2000041)
Fold Change: 0.08
Marker Score: 26
Cell Name: salivary gland cell (CL0009005)
Fold Change: 0.08
Marker Score: 25
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 0.08
Marker Score: 33
Cell Name: monocyte (CL0000576)
Fold Change: 0.08
Marker Score: 100
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 0.07
Marker Score: 27
Cell Name: muscle cell (CL0000187)
Fold Change: 0.07
Marker Score: 21
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.07
Marker Score: 29
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.07
Marker Score: 30
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.07
Marker Score: 21
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.07
Marker Score: 296
Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.07
Marker Score: 40
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.07
Marker Score: 113
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.07
Marker Score: 20
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.07
Marker Score: 72
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.07
Marker Score: 24
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 0.07
Marker Score: 16
Cell Name: tracheobronchial serous cell (CL0019001)
Fold Change: 0.07
Marker Score: 24
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.06
Marker Score: 59
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.06
Marker Score: 32
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 0.06
Marker Score: 68
Cell Name: epithelial cell of lacrimal sac (CL1000436)
Fold Change: 0.06
Marker Score: 28
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.06
Marker Score: 16
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.06
Marker Score: 26
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.06
Marker Score: 16

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Other Information

Description

**Key characteristics:** * The gene is located on chromosome 17q21.1. * It is a single copy gene. * It is a member of the galactoside alpha-galactotransferase family. * It is inactive in humans, as it is not expressed in cells that are responsible for galactose biosynthesis. **Pathways and functions:** * GGTA1 is involved in the biosynthesis of galactose from glucose-1-phosphate. * Galactose is used in a variety of cellular processes, including cell membrane synthesis, extracellular matrix protein synthesis, and immune responses. * In the absence of GGTA1, galactose synthesis would be impaired, which could lead to a variety of health problems, including galactosemia. **Clinical significance:** * Mutations in the GGTA1 gene have been linked to a number of human diseases, including galactosemia. * In some cases, mutations in GGTA1 can be caused by genetic disorders that are responsible for galactosemia. * Genetic testing for GGTA1 mutations can be used to diagnose galactosemia and to monitor the progression of the disease. **Additional information:** * The gene is expressed at high levels in acinar cells of the salivary gland, suggesting that it is involved in the synthesis of galactose for use in the production of mucus and saliva. * Expression of GGTA1 is also seen in keratinocytes, suggesting that it is involved in the synthesis of galactose for use in the production of skin and hair. * Expression of GGTA1 is also seen in CD14-positive monocytes, suggesting that it is involved in the synthesis of galactose for use in the activation of macrophages.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.