Details for: RNVU1 2

Gene ID: 26860

Symbol: RNVU1 2

Ensembl ID: ENSG00000238825

Description: RNA, variant U1 small nuclear 2

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.8325
    Cell Significance Index: 26.0900
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.8073
    Cell Significance Index: 21.8000
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.4258
    Cell Significance Index: 5.0100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2391
    Cell Significance Index: 6.8900
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: 0.1451
    Cell Significance Index: 1.2000
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.0358
    Cell Significance Index: 0.2600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0076
    Cell Significance Index: 0.1000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0029
    Cell Significance Index: -0.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0110
    Cell Significance Index: -1.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0199
    Cell Significance Index: -4.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0245
    Cell Significance Index: -1.2700
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0378
    Cell Significance Index: -0.3400
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0418
    Cell Significance Index: -0.5400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0529
    Cell Significance Index: -2.4000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0601
    Cell Significance Index: -1.2800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0631
    Cell Significance Index: -3.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0753
    Cell Significance Index: -2.0500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0782
    Cell Significance Index: -0.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0792
    Cell Significance Index: -1.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0815
    Cell Significance Index: -3.8000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0900
    Cell Significance Index: -0.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0958
    Cell Significance Index: -3.3700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1037
    Cell Significance Index: -1.7900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1038
    Cell Significance Index: -3.4000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1149
    Cell Significance Index: -3.6600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1170
    Cell Significance Index: -2.9800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1180
    Cell Significance Index: -3.7800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1193
    Cell Significance Index: -4.1800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1245
    Cell Significance Index: -1.6000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1248
    Cell Significance Index: -1.9800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1264
    Cell Significance Index: -2.1600
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1274
    Cell Significance Index: -1.4800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1324
    Cell Significance Index: -1.7400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1352
    Cell Significance Index: -1.5100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1393
    Cell Significance Index: -2.8900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1467
    Cell Significance Index: -3.6600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1571
    Cell Significance Index: -2.3200
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1644
    Cell Significance Index: -1.4200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1646
    Cell Significance Index: -2.1200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1666
    Cell Significance Index: -2.8300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1675
    Cell Significance Index: -1.7100
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1835
    Cell Significance Index: -2.5500
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1904
    Cell Significance Index: -1.9200
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.1924
    Cell Significance Index: -2.4200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1925
    Cell Significance Index: -4.1600
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1958
    Cell Significance Index: -2.3300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1965
    Cell Significance Index: -4.1700
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.1968
    Cell Significance Index: -1.8200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1984
    Cell Significance Index: -3.4300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2003
    Cell Significance Index: -4.1800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2022
    Cell Significance Index: -2.6400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2067
    Cell Significance Index: -4.1500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2073
    Cell Significance Index: -4.0800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2096
    Cell Significance Index: -4.1800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2109
    Cell Significance Index: -4.1700
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.2113
    Cell Significance Index: -2.1900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.2116
    Cell Significance Index: -2.5000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2175
    Cell Significance Index: -2.8900
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.2200
    Cell Significance Index: -2.3400
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.2318
    Cell Significance Index: -2.8200
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.2343
    Cell Significance Index: -2.3500
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.2388
    Cell Significance Index: -2.7700
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.2422
    Cell Significance Index: -2.2600
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.2449
    Cell Significance Index: -2.6000
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.2462
    Cell Significance Index: -2.4000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.2498
    Cell Significance Index: -2.6300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.2530
    Cell Significance Index: -3.3300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2535
    Cell Significance Index: -2.9800
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.2547
    Cell Significance Index: -1.5800
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.2574
    Cell Significance Index: -2.8500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2740
    Cell Significance Index: -3.8000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.2742
    Cell Significance Index: -3.7000
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.2759
    Cell Significance Index: -2.5700
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.2767
    Cell Significance Index: -2.3400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.2769
    Cell Significance Index: -2.5900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2808
    Cell Significance Index: -4.7300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.2824
    Cell Significance Index: -3.6900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.2826
    Cell Significance Index: -2.9500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.2857
    Cell Significance Index: -3.2200
  • Cell Name: basophil (CL0000767)
    Fold Change: -0.2858
    Cell Significance Index: -2.6300
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.2866
    Cell Significance Index: -3.5800
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.2898
    Cell Significance Index: -3.6300
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.2967
    Cell Significance Index: -2.6700
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.2977
    Cell Significance Index: -2.8800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.2990
    Cell Significance Index: -3.5300
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.3017
    Cell Significance Index: -2.8000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3028
    Cell Significance Index: -3.6100
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.3085
    Cell Significance Index: -2.5000
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.3102
    Cell Significance Index: -3.3000
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3198
    Cell Significance Index: -3.6800
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.3228
    Cell Significance Index: -4.0300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.3257
    Cell Significance Index: -3.6800
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.3257
    Cell Significance Index: -3.2900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.3267
    Cell Significance Index: -3.1400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.3292
    Cell Significance Index: -3.5300
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.3298
    Cell Significance Index: -4.5600
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.3390
    Cell Significance Index: -3.6600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3447
    Cell Significance Index: -4.3500
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.3469
    Cell Significance Index: -3.7800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.3504
    Cell Significance Index: -3.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The RNVU1 gene is a non-coding RNA that belongs to the U1 small nuclear RNA (snRNA) family. It is approximately 100 nucleotides in length and is significantly expressed in cells of the immune system, including granulocytes, common myeloid progenitors, natural killer T cells, B cells, and T cells. This widespread expression suggests that RNVU1 plays a crucial role in regulating immune cell development, function, and response to pathogens. **Pathways and Functions:** The functional mechanisms underlying RNVU1's expression and regulation remain poorly understood. However, several key pathways and processes have been implicated in its activity: 1. **RNA processing**: RNVU1 is involved in the processing of U1 snRNA, a crucial step in the splicing of pre-mRNA. This process is essential for the generation of mature mRNAs, which are then translated into proteins. 2. **Immune cell development**: RNVU1 is expressed in cells of the immune system, suggesting that it plays a role in the development and maturation of immune cells. Its expression is downregulated during the terminal differentiation of immune cells, implying that it may be involved in the regulation of cell fate decisions. 3. **Epigenetic regulation**: RNVU1 has been shown to interact with histone-modifying enzymes, suggesting that it may play a role in epigenetic regulation. This interaction could influence the expression of target genes and contribute to the regulation of immune cell development and function. **Clinical Significance:** The clinical significance of RNVU1 is an area of active research. While its expression is widespread across the immune system, its dysregulation has been implicated in various immunological disorders, including: 1. **Autoimmunity**: Altered expression of RNVU1 has been observed in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. This suggests that RNVU1 may play a role in the regulation of immune cell function and the development of autoimmune diseases. 2. **Infectious diseases**: RNVU1 has been shown to be downregulated in response to viral infections, suggesting that it may play a role in the regulation of immune cell responses to pathogens. 3. **Cancer**: RNVU1 has been implicated in the development and progression of certain cancers, including leukemia and lymphoma. Its expression is often downregulated in these tumors, suggesting that it may act as a tumor suppressor. In conclusion, the RNVU1 gene is a complex and enigmatic transcript that has far-reaching implications for our understanding of immune cell development, function, and regulation. Further research is needed to elucidate the functional mechanisms underlying RNVU1's expression and regulation, as well as its clinical significance in various immunological disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.