Details for: GK3

Gene ID: 2713

Symbol: GK3

Ensembl ID: ENSG00000229894

Description: glycerol kinase 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 2.59
    Marker Score: 1770
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.01
    Marker Score: 2003
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1178
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 862
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.19
    Marker Score: 493
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7686
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4825
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.13
    Marker Score: 15077
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.11
    Marker Score: 508
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 514
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 468
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.95
    Marker Score: 379
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5354
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.92
    Marker Score: 331
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2744
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 713
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 468
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.63
    Marker Score: 499
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 177
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.49
    Marker Score: 786
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.23
    Marker Score: 824
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.19
    Marker Score: 336
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.17
    Marker Score: 992
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.15
    Marker Score: 3262
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.12
    Marker Score: 327
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.1
    Marker Score: 101
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.09
    Marker Score: 331
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.09
    Marker Score: 33
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.09
    Marker Score: 144
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.08
    Marker Score: 91
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.08
    Marker Score: 47
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.08
    Marker Score: 53
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.08
    Marker Score: 118
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.08
    Marker Score: 156.5
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.07
    Marker Score: 43
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.07
    Marker Score: 35
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.07
    Marker Score: 49
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.07
    Marker Score: 23
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.07
    Marker Score: 35
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.07
    Marker Score: 73
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.07
    Marker Score: 38
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.06
    Marker Score: 78
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.06
    Marker Score: 48
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.06
    Marker Score: 31
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.05
    Marker Score: 56
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.05
    Marker Score: 34
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.04
    Marker Score: 38
  • Cell Name: type D enteroendocrine cell (CL0000502)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.04
    Marker Score: 35
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.04
    Marker Score: 66
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.04
    Marker Score: 40
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.04
    Marker Score: 41
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.04
    Marker Score: 66
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.04
    Marker Score: 42
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.04
    Marker Score: 84
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.03
    Marker Score: 38
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.03
    Marker Score: 72
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.03
    Marker Score: 27
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.03
    Marker Score: 27
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.03
    Marker Score: 28
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.03
    Marker Score: 12.5
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.03
    Marker Score: 36
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.02
    Marker Score: 13

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Other Information

**Key characteristics:** - The GK3 gene is a member of the GK family of kinases, which are involved in the regulation of lipid metabolism. - It is expressed in a variety of cell types, including hepatocytes, enterocytes, and intestinal cells. - The protein encoded by the GK3 gene is a catalytic subunit of the glycerol kinase enzyme. - The enzyme is responsible for the phosphorylation of glycerol to glyceraldehyde-3-phosphate (G3P), which is a key intermediate in lipid metabolism. **Pathways and functions:** - The GK3 gene is involved in the regulation of lipid synthesis, degradation, and metabolism. - It is a key regulator of the synthesis of very low-density lipoprotein (VLDL), a protein that is responsible for the transport of cholesterol and fat to peripheral tissues. - The gene is also involved in the regulation of the uptake of cholesterol and fatty acids into cells. - It is a key regulator of the degradation of glycerol and other lipids. **Clinical significance:** - Mutations in the GK3 gene have been linked to a number of human diseases, including hyperlipidemia, atherosclerosis, and obesity. - These diseases are characterized by high levels of cholesterol and triglycerides in the blood. - Targeting the GK3 gene has been shown to be a potential therapeutic strategy for these diseases. **Additional information:** - The GK3 gene is located on chromosome 15q21.1. - It is a highly conserved gene, with a similar gene found in humans, mice, and rats. - The protein encoded by the GK3 gene is a transmembrane protein that is found in the endoplasmic reticulum. - The enzyme is a heterodimer, meaning that it consists of two subunits that are held together by a linker peptide. - The GK3a and GK3b subunits are both catalytic subunits of the enzyme.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.