Details for: GLE1

Gene ID: 2733

Symbol: GLE1

Ensembl ID: ENSG00000119392

Description: GLE1 RNA export mediator

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.08
    Marker Score: 3633
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168527
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.23
    Marker Score: 1769
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1
    Marker Score: 1550
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71750
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47974
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30399
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.96
    Marker Score: 9035.5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.95
    Marker Score: 58532
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2404
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.94
    Marker Score: 8111
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.94
    Marker Score: 8926
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 484
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 439
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2716
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.88
    Marker Score: 704
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.88
    Marker Score: 3572
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4970
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.86
    Marker Score: 212
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.82
    Marker Score: 30404
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.78
    Marker Score: 3019
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.76
    Marker Score: 28886.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 577.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 302
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.73
    Marker Score: 7545
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 375
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.71
    Marker Score: 14197.5
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.71
    Marker Score: 5466
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.71
    Marker Score: 10629
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7
    Marker Score: 788
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2864.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 622
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.68
    Marker Score: 752
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.66
    Marker Score: 1807.5
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.66
    Marker Score: 2755
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.63
    Marker Score: 639
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.63
    Marker Score: 9830.5
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.63
    Marker Score: 2624
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.63
    Marker Score: 758
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.62
    Marker Score: 13264
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.62
    Marker Score: 835
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.62
    Marker Score: 259
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.62
    Marker Score: 612
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.62
    Marker Score: 360
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.6
    Marker Score: 801
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.56
    Marker Score: 162
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.56
    Marker Score: 699.5
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.55
    Marker Score: 400
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.55
    Marker Score: 191
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.54
    Marker Score: 587
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 434
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.54
    Marker Score: 284
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.52
    Marker Score: 346
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.51
    Marker Score: 328
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.51
    Marker Score: 382
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.51
    Marker Score: 1749
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.51
    Marker Score: 614
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.51
    Marker Score: 296
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.51
    Marker Score: 1996
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.51
    Marker Score: 246
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.5
    Marker Score: 435
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.5
    Marker Score: 312
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.5
    Marker Score: 458
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.5
    Marker Score: 207
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.49
    Marker Score: 131
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.49
    Marker Score: 334
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.49
    Marker Score: 2263
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.49
    Marker Score: 941
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.49
    Marker Score: 133
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.48
    Marker Score: 1428
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.48
    Marker Score: 2066
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.48
    Marker Score: 194
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.48
    Marker Score: 1690
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.47
    Marker Score: 192
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.47
    Marker Score: 175
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.46
    Marker Score: 279
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.46
    Marker Score: 657
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.46
    Marker Score: 598
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.46
    Marker Score: 533
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.46
    Marker Score: 2962
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.46
    Marker Score: 5328
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.45
    Marker Score: 435
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.45
    Marker Score: 224
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.45
    Marker Score: 250
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.45
    Marker Score: 1824
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.44
    Marker Score: 962
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.44
    Marker Score: 138
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.44
    Marker Score: 213.5
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.43
    Marker Score: 95
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.43
    Marker Score: 695
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.43
    Marker Score: 161
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.43
    Marker Score: 100
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.43
    Marker Score: 608
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.43
    Marker Score: 91
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.42
    Marker Score: 367

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Other Information

**Key characteristics:** - It is a nuclear transport protein that is expressed in a variety of cell types. - It is a multi-subunit protein that is composed of two transmembrane domains and a cytoplasmic domain. - It is a key regulator of nuclear mRNA export and plays a role in the regulation of gene expression. **Pathways and functions:** - It is involved in the transport of mature and pre-mRNA from the nucleus to the cytoplasm. - It is a key regulator of nuclear mRNA export and plays a role in the regulation of gene expression. - It is involved in the processing of capped intron-containing pre-mRNA. - It is involved in the transport of mature transcript to the cytoplasm. - It plays a role in the regulation of cell growth and differentiation. **Clinical significance:** - Mutations in GLE1 have been linked to a number of human diseases, including autism, schizophrenia, and cancer. - Targeting GLE1 has been shown to be a promising strategy for the treatment of these diseases.

Genular Protein ID: 1548657364

Symbol: GLE1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53GS7 O75458 Q53GT9 Q5VVU1 Q8NCP6 Q9UFL6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 2 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9618489

Title: The human homologue of Saccharomyces cerevisiae Gle1p is required for poly(A)+ RNA export.

PubMed ID: 9618489

DOI: 10.1073/pnas.95.12.6779

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12668658

Title: An essential role for hGle1 nucleocytoplasmic shuttling in mRNA export.

PubMed ID: 12668658

DOI: 10.1083/jcb.200211081

PubMed ID: 14645504

Title: The mRNA export factor human Gle1 interacts with the nuclear pore complex protein Nup155.

PubMed ID: 14645504

DOI: 10.1074/mcp.m300106-mcp200

PubMed ID: 16000379

Title: Interaction between the shuttling mRNA export factor Gle1 and the nucleoporin hCG1: a conserved mechanism in the export of Hsp70 mRNA.

PubMed ID: 16000379

DOI: 10.1091/mbc.e04-11-0998

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 18204449

Title: Mutations in mRNA export mediator GLE1 result in a fetal motoneuron disease.

PubMed ID: 18204449

DOI: 10.1038/ng.2007.65

Sequence Information:

  • Length: 698
  • Mass: 79836
  • Checksum: F9FC04683BCCDBB2
  • Sequence:
    • MPSEGRCWET LKALRSSDKG RLCYYRDWLL RREDVLEECM SLPKLSSYSG WVVEHVLPHM 
QENQPLSETS PSSTSASALD QPSFVPKSPD ASSAFSPASP ATPNGTKGKD ESQHTESMVL 
QSSRGIKVEG CVRMYELVHR MKGTEGLRLW QEEQERKVQA LSEMASEQLK RFDEWKELKQ 
HKEFQDLREV MEKSSREALG HQEKLKAEHR HRAKILNLKL REAEQQRVKQ AEQERLRKEE 
GQIRLRALYA LQEEMLQLSQ QLDASEQHKA LLKVDLAAFQ TRGNQLCSLI SGIIRASSES 
SYPTAESQAE AERALREMRD LLMNLGQEIT RACEDKRRQD EEEAQVKLQE AQMQQGPEAH 
KEPPAPSQGP GGKQNEDLQV KVQDITMQWY QQLQDASMQC VLTFEGLTNS KDSQAKKIKM 
DLQKAATIPV SQISTIAGSK LKEIFDKIHS LLSGKPVQSG GRSVSVTLNP QGLDFVQYKL 
AEKFVKQGEE EVASHHEAAF PIAVVASGIW ELHPRVGDLI LAHLHKKCPY SVPFYPTFKE 
GMALEDYQRM LGYQVKDSKV EQQDNFLKRM SGMIRLYAAI IQLRWPYGNR QEIHPHGLNH 
GWRWLAQILN MEPLSDVTAT LLFDFLEVCG NALMKQYQVQ FWKMLILIKE DYFPRIEAIT 
SSGQMGSFIR LKQFLEKCLQ HKDIPVPKGF LTSSFWRS

Genular Protein ID: 3047488385

Symbol: B3KMG0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KMG0

Database IDs:

ARBA 13 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 EPD 1 GO 3 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 2 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 ProteomicsDB 1 RefSeq 1 SAM 1 SMR 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 444
  • Mass: 50393
  • Checksum: CD28467BFD38370E
  • Sequence:
    • MLQLSQQLDA SEQHKALLKV DLAAFQTRGN QLCSLISGII RASSESSYPT AESQAEAERA 
LREMRDLLMN LGQEITRACE DKRRQDEEEA QVKLQEAQMQ QGPEAHKEPP APSQGPGGKQ 
NEDLQVKVQD ITMQWYQQLQ DASMQCVLTF EGLTNSKDSQ AKKIKMDLQK AATIPVSQIS 
TIAGSKLKEI FDKIHSLLSG KPVQSGGRSV SVTLNPQGLD FVQYKLAEKF VKQGEEEVAS 
HHEAAFPIAV VASGIWELHP RVGDLILAHL HKKCPYSVPF YPTFKEGMAL EDYQRMLGYQ 
VKDSKVEQQD NFLKRMSGMI RLYAAIIQLR WPYGNRQEIH PHGLNHGWRW LAQILNMEPL 
SDVTATLLFD FLEVCGNALM KQYQVQFWKM LILIKEDYFP RIEAITSSGQ MGSFIRLKQF 
LEKCLQHKDI PVPKGFLTSS FWRS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.