Details for: GLUD1

Gene ID: 2746

Symbol: GLUD1

Ensembl ID: ENSG00000148672

Description: glutamate dehydrogenase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 4.18
    Marker Score: 13704
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.98
    Marker Score: 1963
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.79
    Marker Score: 59611.5
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.18
    Marker Score: 1891
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.96
    Marker Score: 7559
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.91
    Marker Score: 1111.5
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.76
    Marker Score: 3864
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.76
    Marker Score: 2918
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.74
    Marker Score: 30971
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.74
    Marker Score: 3075
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.73
    Marker Score: 4642
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.71
    Marker Score: 6077
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.7
    Marker Score: 2459
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.64
    Marker Score: 2117
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.62
    Marker Score: 1701
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.59
    Marker Score: 6241
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.58
    Marker Score: 8494.5
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.56
    Marker Score: 10016
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.52
    Marker Score: 6551
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.52
    Marker Score: 572
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.51
    Marker Score: 1732.5
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.5
    Marker Score: 11201.5
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.49
    Marker Score: 545
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.49
    Marker Score: 15409
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.48
    Marker Score: 6028
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.47
    Marker Score: 2043
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.47
    Marker Score: 12603
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.45
    Marker Score: 89088.5
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.44
    Marker Score: 981
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.43
    Marker Score: 1730
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.43
    Marker Score: 13606.5
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.42
    Marker Score: 12207
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.41
    Marker Score: 1559
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.39
    Marker Score: 402
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.39
    Marker Score: 51249
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.38
    Marker Score: 13003
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.38
    Marker Score: 2123
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.38
    Marker Score: 1998
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.37
    Marker Score: 720
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.36
    Marker Score: 1584
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.35
    Marker Score: 1690
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.34
    Marker Score: 5770
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.34
    Marker Score: 973
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.33
    Marker Score: 329
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.33
    Marker Score: 904
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.32
    Marker Score: 303
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.32
    Marker Score: 4132
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.32
    Marker Score: 1395
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.31
    Marker Score: 26087
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.3
    Marker Score: 3406
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.3
    Marker Score: 310
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.29
    Marker Score: 10078
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.29
    Marker Score: 32931.5
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.28
    Marker Score: 6126
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.27
    Marker Score: 629
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.27
    Marker Score: 476
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.26
    Marker Score: 754
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.26
    Marker Score: 613
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.26
    Marker Score: 1851
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.25
    Marker Score: 1149
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.25
    Marker Score: 1429
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.24
    Marker Score: 2424
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.24
    Marker Score: 503.5
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.24
    Marker Score: 427
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.21
    Marker Score: 957
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.21
    Marker Score: 12236
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.2
    Marker Score: 1294
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.2
    Marker Score: 2862
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.19
    Marker Score: 794
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.19
    Marker Score: 1395
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.19
    Marker Score: 1190
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.19
    Marker Score: 1211
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.19
    Marker Score: 414
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.19
    Marker Score: 292
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.18
    Marker Score: 1061
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.18
    Marker Score: 1325
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.18
    Marker Score: 1282
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.18
    Marker Score: 2970
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.17
    Marker Score: 719
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.16
    Marker Score: 1179
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.16
    Marker Score: 64645.5
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.15
    Marker Score: 467
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.14
    Marker Score: 387
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.14
    Marker Score: 7303
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 1.14
    Marker Score: 336
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.14
    Marker Score: 1228
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.14
    Marker Score: 1614
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.14
    Marker Score: 567
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.13
    Marker Score: 260
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.13
    Marker Score: 321
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 1.13
    Marker Score: 515
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.13
    Marker Score: 1132.5
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.13
    Marker Score: 221
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.12
    Marker Score: 414
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.12
    Marker Score: 597
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.12
    Marker Score: 2636
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.12
    Marker Score: 37764
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.12
    Marker Score: 463
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.12
    Marker Score: 450
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.11
    Marker Score: 1202

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Other Information

**Key characteristics**: * GLUD1 is a protein of the cytochrome family, which are enzymes that catalyze the transfer of electrons from one molecule to another. * It is a multi-functional protein that can act as a glutamate dehydrogenase, an ATPase, or a NADPH-dependent guanosine triphosphate (GTP)ase. * It is involved in a variety of cellular processes, including the metabolism of glutamate, the synthesis of glutamine, and the regulation of mitochondrial biogenesis. **Pathways and functions**: * GLUD1 is involved in the metabolism of glutamate by catalyzing the deamination of glutamate to glutamine. * It is also involved in the synthesis of glutamine from glutamine precursors. * It is involved in the regulation of mitochondrial biogenesis by binding to the mitochondrial transcription factor TFAM and promoting its translocation to the mitochondrial nucleus. * It is involved in the regulation of apoptosis by binding to the BH3-related protein (Bcl-xL) and facilitating its degradation. * It is involved in the regulation of inflammation by binding to reactive oxygen species (ROS) and facilitating their production. **Clinical significance**: * Mutations in GLUD1 have been linked to a number of human diseases, including amyotrophic lateral sclerosis, stroke, and depression. * In amyotrophic lateral sclerosis, mutations in GLUD1 lead to the accumulation of glutamate in the brain, which can damage nerve cells and lead to the symptoms of the disease. * In stroke, mutations in GLUD1 can lead to the formation of a protein called alpha-synuclein, which is a major component of amyloid plaques that are found in the brains of people with Alzheimer's disease. **Overall, GLUD1 is a critical protein that plays a vital role in the metabolism of glutamate and in a variety of cellular processes. Mutations in GLUD1 have been linked to a number of human diseases, highlighting the importance of this protein in human health.**

Genular Protein ID: 3899134234

Symbol: DHE3_HUMAN

Name: Glutamate dehydrogenase 1, mitochondrial

UniProtKB Accession Codes:

P00367 B3KV55 B4DGN5 Q5TBU3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 2 CTD 1 ChEBI 24 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EC 2 EMBL 25 EMDB 1 EPD 1 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 4 PIR 4 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 7 Rhea 2 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3426581

Title: Comparison of human brain and liver glutamate dehydrogenase cDNAs.

PubMed ID: 3426581

DOI: 10.1016/0006-291x(87)90381-0

PubMed ID: 3377777

Title: Molecular cloning and nucleotide sequence of the cDNA for human liver glutamate dehydrogenase precursor.

PubMed ID: 3377777

DOI: 10.1016/s0006-291x(88)80440-6

PubMed ID: 3399399

Title: Complete nucleotide sequence of human glutamate dehydrogenase cDNA.

PubMed ID: 3399399

DOI: 10.1093/nar/16.13.6237

PubMed ID: 3368458

Title: Isolation and characterization of cDNA clones encoding human liver glutamate dehydrogenase: evidence for a small gene family.

PubMed ID: 3368458

DOI: 10.1073/pnas.85.10.3494

PubMed ID: 8486350

Title: The human glutamate dehydrogenase gene family: gene organization and structural characterization.

PubMed ID: 8486350

DOI: 10.1006/geno.1993.1152

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 429360

Title: Partial amino acid sequence of the glutamate dehydrogenase of human liver and a revision of the sequence of the bovine enzyme.

PubMed ID: 429360

DOI: 10.1016/s0021-9258(18)50777-8

PubMed ID: 1286669

Title: Human liver protein map: a reference database established by microsequencing and gel comparison.

PubMed ID: 1286669

DOI: 10.1002/elps.11501301201

PubMed ID: 3585334

Title: Isolation of a human brain cDNA for glutamate dehydrogenase.

PubMed ID: 3585334

DOI: 10.1111/j.1471-4159.1987.tb03422.x

PubMed ID: 8314555

Title: Structure and expression analysis of a member of the human glutamate dehydrogenase (GLUD) gene family mapped to chromosome 10p11.2.

PubMed ID: 8314555

DOI: 10.1007/bf00217767

PubMed ID: 11032875

Title: Nerve tissue-specific (GLUD2) and housekeeping (GLUD1) human glutamate dehydrogenases are regulated by distinct allosteric mechanisms: implications for biologic function.

PubMed ID: 11032875

DOI: 10.1046/j.1471-4159.2000.0751862.x

PubMed ID: 16023112

Title: Identification of ADP-ribosylation site in human glutamate dehydrogenase isozymes.

PubMed ID: 16023112

DOI: 10.1016/j.febslet.2005.06.041

PubMed ID: 19448744

Title: Human GLUD1 and GLUD2 glutamate dehydrogenase localize to mitochondria and endoplasmic reticulum.

PubMed ID: 19448744

DOI: 10.1139/o09-008

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 11254391

Title: Structures of bovine glutamate dehydrogenase complexes elucidate the mechanism of purine regulation.

PubMed ID: 11254391

DOI: 10.1006/jmbi.2001.4499

PubMed ID: 11903050

Title: Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations.

PubMed ID: 11903050

DOI: 10.1042/0264-6021:3630081

PubMed ID: 16959573

Title: SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.

PubMed ID: 16959573

DOI: 10.1016/j.cell.2006.06.057

PubMed ID: 29192674

Title: Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway.

PubMed ID: 29192674

DOI: 10.1038/cr.2017.149

PubMed ID: 12054821

Title: The structure of apo human glutamate dehydrogenase details subunit communication and allostery.

PubMed ID: 12054821

DOI: 10.1016/s0022-2836(02)00161-4

PubMed ID: 12653548

Title: Structural studies on ADP activation of mammalian glutamate dehydrogenase and the evolution of regulation.

PubMed ID: 12653548

DOI: 10.1021/bi0206917

PubMed ID: 9571255

Title: Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene.

PubMed ID: 9571255

DOI: 10.1056/nejm199805073381904

PubMed ID: 10636977

Title: Novel missense mutations in the glutamate dehydrogenase gene in the congenital hyperinsulinism-hyperammonemia syndrome.

PubMed ID: 10636977

DOI: 10.1016/s0022-3476(00)90052-0

PubMed ID: 11214910

Title: Novel missense mutations outside the allosteric domain of glutamate dehydrogenase are prevalent in European patients with the congenital hyperinsulinism-hyperammonemia syndrome.

PubMed ID: 11214910

DOI: 10.1007/s004390000432

PubMed ID: 11297618

Title: Hyperinsulinism/hyperammonemia syndrome in children with regulatory mutations in the inhibitory guanosine triphosphate-binding domain of glutamate dehydrogenase.

PubMed ID: 11297618

DOI: 10.1210/jcem.86.4.7414

Sequence Information:

  • Length: 558
  • Mass: 61398
  • Checksum: A7319A840F57FBB2
  • Sequence:
    • MYRYLGEALL LSRAGPAALG SASADSAALL GWARGQPAAA PQPGLALAAR RHYSEAVADR 
EDDPNFFKMV EGFFDRGASI VEDKLVEDLR TRESEEQKRN RVRGILRIIK PCNHVLSLSF 
PIRRDDGSWE VIEGYRAQHS QHRTPCKGGI RYSTDVSVDE VKALASLMTY KCAVVDVPFG 
GAKAGVKINP KNYTDNELEK ITRRFTMELA KKGFIGPGID VPAPDMSTGE REMSWIADTY 
ASTIGHYDIN AHACVTGKPI SQGGIHGRIS ATGRGVFHGI ENFINEASYM SILGMTPGFG 
DKTFVVQGFG NVGLHSMRYL HRFGAKCIAV GESDGSIWNP DGIDPKELED FKLQHGSILG 
FPKAKPYEGS ILEADCDILI PAASEKQLTK SNAPRVKAKI IAEGANGPTT PEADKIFLER 
NIMVIPDLYL NAGGVTVSYF EWLKNLNHVS YGRLTFKYER DSNYHLLMSV QESLERKFGK 
HGGTIPIVPT AEFQDRISGA SEKDIVHSGL AYTMERSARQ IMRTAMKYNL GLDLRTAAYV 
NAIEKVFKVY NEAGVTFT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.