Details for: UTS2R

Gene ID: 2837

Symbol: UTS2R

Ensembl ID: ENSG00000181408

Description: urotensin 2 receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0998
    Cell Significance Index: 1.9900
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.0815
    Cell Significance Index: 0.9600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: 0.0385
    Cell Significance Index: 0.5200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0007
    Cell Significance Index: -1.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0008
    Cell Significance Index: -1.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0009
    Cell Significance Index: -1.4000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0011
    Cell Significance Index: -1.4700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0023
    Cell Significance Index: -1.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0026
    Cell Significance Index: -1.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0054
    Cell Significance Index: -1.0800
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0085
    Cell Significance Index: -0.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0109
    Cell Significance Index: -1.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0169
    Cell Significance Index: -0.9500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0227
    Cell Significance Index: -0.2700
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.0256
    Cell Significance Index: -0.2700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0295
    Cell Significance Index: -0.2800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0411
    Cell Significance Index: -1.3100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0412
    Cell Significance Index: -0.5900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0414
    Cell Significance Index: -1.0100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0426
    Cell Significance Index: -1.2200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0478
    Cell Significance Index: -0.9400
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0577
    Cell Significance Index: -0.4000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0594
    Cell Significance Index: -1.2600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0608
    Cell Significance Index: -0.9900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0628
    Cell Significance Index: -1.3100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0635
    Cell Significance Index: -1.2800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0647
    Cell Significance Index: -1.2800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0664
    Cell Significance Index: -1.9500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0677
    Cell Significance Index: -1.7800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0701
    Cell Significance Index: -0.9400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0705
    Cell Significance Index: -0.9500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0742
    Cell Significance Index: -1.1100
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0743
    Cell Significance Index: -1.0100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0753
    Cell Significance Index: -0.9500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0753
    Cell Significance Index: -1.3000
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0767
    Cell Significance Index: -0.9600
  • Cell Name: ON parasol ganglion cell (CL4033052)
    Fold Change: -0.0771
    Cell Significance Index: -0.9600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0774
    Cell Significance Index: -0.9600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0789
    Cell Significance Index: -1.9100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0790
    Cell Significance Index: -1.7300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0792
    Cell Significance Index: -0.9500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0811
    Cell Significance Index: -1.0600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0813
    Cell Significance Index: -1.2000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0836
    Cell Significance Index: -1.1900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0863
    Cell Significance Index: -0.9400
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0867
    Cell Significance Index: -1.1100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0875
    Cell Significance Index: -1.2800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0904
    Cell Significance Index: -1.2400
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0924
    Cell Significance Index: -1.1100
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0944
    Cell Significance Index: -1.1400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0962
    Cell Significance Index: -1.8800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0971
    Cell Significance Index: -1.2900
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0975
    Cell Significance Index: -1.2500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0975
    Cell Significance Index: -1.0000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0986
    Cell Significance Index: -1.2500
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.1011
    Cell Significance Index: -1.0600
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.1013
    Cell Significance Index: -1.1100
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1032
    Cell Significance Index: -1.1100
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1035
    Cell Significance Index: -1.0800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1061
    Cell Significance Index: -1.1900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1088
    Cell Significance Index: -1.4800
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.1125
    Cell Significance Index: -1.1100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1135
    Cell Significance Index: -1.4900
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.1147
    Cell Significance Index: -1.0000
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.1147
    Cell Significance Index: -1.1100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1153
    Cell Significance Index: -1.9300
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1164
    Cell Significance Index: -0.9900
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1165
    Cell Significance Index: -1.5200
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.1177
    Cell Significance Index: -0.7400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1182
    Cell Significance Index: -1.5300
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.1184
    Cell Significance Index: -1.5000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1196
    Cell Significance Index: -1.4700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1213
    Cell Significance Index: -1.2800
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1223
    Cell Significance Index: -1.2100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1242
    Cell Significance Index: -1.2600
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1289
    Cell Significance Index: -1.5300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1302
    Cell Significance Index: -1.5100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1319
    Cell Significance Index: -1.5100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1321
    Cell Significance Index: -1.5800
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1343
    Cell Significance Index: -1.2500
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1347
    Cell Significance Index: -1.4300
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.1366
    Cell Significance Index: -1.2800
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.1366
    Cell Significance Index: -1.4600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1372
    Cell Significance Index: -1.6200
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.1378
    Cell Significance Index: -1.6400
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1380
    Cell Significance Index: -1.5100
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.1382
    Cell Significance Index: -1.3000
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1401
    Cell Significance Index: -1.5100
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.1405
    Cell Significance Index: -1.6700
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.1415
    Cell Significance Index: -1.7200
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1415
    Cell Significance Index: -1.3600
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.1417
    Cell Significance Index: -1.3100
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1439
    Cell Significance Index: -1.4700
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: -0.1445
    Cell Significance Index: -1.5200
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.1481
    Cell Significance Index: -1.7900
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1489
    Cell Significance Index: -1.7600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1489
    Cell Significance Index: -1.7600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1491
    Cell Significance Index: -1.4000
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.1503
    Cell Significance Index: -1.6500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1511
    Cell Significance Index: -1.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** UTS2R is a seven-transmembrane GPCR, which is characterized by its rhodopsin-like extracellular domain and a cytoplasmic tail with a G-protein-coupled receptor kinase (GRK) domain. 2. **Ligand:** The primary ligand of UTS2R is urotensin II (UT-II), a potent vasoconstrictor peptide. 3. **Signaling:** UTS2R activates Gq-protein-coupled signaling events, leading to increased intracellular calcium levels, phospholipase C activation, and subsequent vasoconstriction. 4. **Expression:** UTS2R is widely expressed in various tissues, including the cardiovascular system, nervous system, and intestinal epithelium. **Pathways and Functions:** 1. **Blood Pressure Regulation:** UTS2R is involved in regulating blood pressure through vasoconstriction and vasodilation. Activation of UTS2R by UT-II leads to increased blood pressure in hypertension models. 2. **Neuropeptide Signaling:** UTS2R is also involved in neuropeptide signaling pathways, including the regulation of pain, inflammation, and stress responses. 3. **G-Protein Coupled Receptor Signaling:** UTS2R is a member of the GPCR family, which is involved in various cellular processes, including signaling, cell proliferation, and differentiation. 4. **Vascular Smooth Muscle Contraction:** UTS2R activation leads to the contraction of vascular smooth muscle cells, resulting in increased blood pressure and vasoconstriction. **Clinical Significance:** 1. **Hypertension:** UTS2R is a potential therapeutic target for the treatment of hypertension, as its inhibition can lead to reduced blood pressure. 2. **Cardiovascular Diseases:** UTS2R is also involved in the pathogenesis of cardiovascular diseases, including atherosclerosis and cardiac hypertrophy. 3. **Neurological Disorders:** UTS2R is implicated in various neurological disorders, including pain, inflammation, and stress responses. 4. **Cancer:** UTS2R is overexpressed in various types of cancer, including colon and breast cancer, suggesting its potential role in tumorigenesis. In conclusion, the Urotensin 2 Receptor (UTS2R) is a complex GPCR that plays a crucial role in regulating blood pressure, blood vessel diameter maintenance, and neuropeptide signaling pathways. Its dysregulation is implicated in various diseases, including hypertension, cardiovascular diseases, neurological disorders, and cancer. Further research is necessary to fully elucidate the functions and clinical significance of UTS2R, and its potential as a therapeutic target for the treatment of these diseases. **References:** 1. [Insert relevant references to support the discussion] 2. [Insert relevant references to support the discussion] **Note:** The above article is a hypothetical example of how an expert immunologist would discuss the UTS2R gene. The references provided are fictional and not based on actual scientific literature.

Genular Protein ID: 1423828392

Symbol: UR2R_HUMAN

Name: Urotensin-2 receptor

UniProtKB Accession Codes:

Q9UKP6 B2RMV8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 10499587

Title: Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14.

PubMed ID: 10499587

DOI: 10.1038/45809

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14550283

Title: Identification of urotensin II-related peptide as the urotensin II-immunoreactive molecule in the rat brain.

PubMed ID: 14550283

DOI: 10.1016/j.bbrc.2003.09.102

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 389
  • Mass: 42130
  • Checksum: 6D6A88DBF78400CE
  • Sequence:
    • MALTPESPSS FPGLAATGSS VPEPPGGPNA TLNSSWASPT EPSSLEDLVA TGTIGTLLSA 
MGVVGVVGNA YTLVVTCRSL RAVASMYVYV VNLALADLLY LLSIPFIVAT YVTKEWHFGD 
VGCRVLFGLD FLTMHASIFT LTVMSSERYA AVLRPLDTVQ RPKGYRKLLA LGTWLLALLL 
TLPVMLAMRL VRRGPKSLCL PAWGPRAHRA YLTLLFATSI AGPGLLIGLL YARLARAYRR 
SQRASFKRAR RPGARALRLV LGIVLLFWAC FLPFWLWQLL AQYHQAPLAP RTARIVNYLT 
TCLTYGNSCA NPFLYTLLTR NYRDHLRGRV RGPGSGGGRG PVPSLQPRAR FQRCSGRSLS 
SCSPQPTDSL VLAPAAPARP APEGPRAPA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.