Details for: FFAR1

Gene ID: 2864

Symbol: FFAR1

Ensembl ID: ENSG00000126266

Description: free fatty acid receptor 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: T cell (CL0000084)
    Fold Change: 2.44
    Marker Score: 4214
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1173
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 873
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 858
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7692
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4819
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 505
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71831
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48056
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.99
    Marker Score: 408.5
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 375
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.88
    Marker Score: 304
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.84
    Marker Score: 644.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.73
    Marker Score: 906
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 463
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.67
    Marker Score: 442
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 233
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.49
    Marker Score: 548
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.44
    Marker Score: 902
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.37
    Marker Score: 151
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.34
    Marker Score: 76
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.26
    Marker Score: 275
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.22
    Marker Score: 95
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.22
    Marker Score: 408
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.19
    Marker Score: 116
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.19
    Marker Score: 2983
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.19
    Marker Score: 384
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.18
    Marker Score: 91
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.17
    Marker Score: 171
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.16
    Marker Score: 40
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.15
    Marker Score: 50
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.15
    Marker Score: 46.5
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.14
    Marker Score: 84
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.13
    Marker Score: 97
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.13
    Marker Score: 67
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.12
    Marker Score: 44
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.12
    Marker Score: 123
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.12
    Marker Score: 195
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.12
    Marker Score: 39
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.11
    Marker Score: 65.5
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1
    Marker Score: 169
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.1
    Marker Score: 92.5
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.09
    Marker Score: 91
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.09
    Marker Score: 196
  • Cell Name: GIP cell (CL0002278)
    Fold Change: 0.09
    Marker Score: 29
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.09
    Marker Score: 84
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.09
    Marker Score: 51
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.09
    Marker Score: 86
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.08
    Marker Score: 175
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.08
    Marker Score: 242
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.08
    Marker Score: 46
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.08
    Marker Score: 210.5
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.08
    Marker Score: 78
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.08
    Marker Score: 45
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.08
    Marker Score: 18
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.07
    Marker Score: 27
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.07
    Marker Score: 65
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.07
    Marker Score: 29
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.07
    Marker Score: 170
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.07
    Marker Score: 61.5
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.07
    Marker Score: 33
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.07
    Marker Score: 65.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.06
    Marker Score: 31
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.06
    Marker Score: 44
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.06
    Marker Score: 68
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.06
    Marker Score: 46
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.06
    Marker Score: 40
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.06
    Marker Score: 72
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.06
    Marker Score: 67
  • Cell Name: type D enteroendocrine cell (CL0000502)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.05
    Marker Score: 34
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.05
    Marker Score: 546
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.05
    Marker Score: 35
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.05
    Marker Score: 39
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.05
    Marker Score: 303

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Other Information

**Key characteristics:** * FFAR1 is a single-pass membrane protein with a molecular weight of approximately 140 kDa. * It is a ligand-gated ion channel that is expressed in high levels in the plasma membrane of cells that are in close proximity to the pancreas. * It is a key regulator of insulin secretion by binding to free fatty acids and triggering the activation of the G alpha (q) signaling pathway. * It is also involved in the regulation of glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) secretion. **Pathways and functions:** * FFAR1 is a key regulator of insulin secretion. * It binds to free fatty acids, which are secreted by the beta cells of the pancreas. * Binding of FFAR1 to free fatty acids activates the G alpha (q) signaling pathway, which leads to the activation of the insulin receptor. * This results in the release of insulin from the beta cells, which lowers blood sugar levels. * FFAR1 is also involved in the regulation of glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) secretion. * It is expressed in the islet cells of the pancreas and is important for the regulation of blood sugar levels. **Clinical significance:** * Mutations in the FFAR1 gene have been linked to several human diseases, including type 2 diabetes, obesity, and metabolic syndrome. * Targeting FFAR1 with drugs is a promising therapeutic strategy for these diseases.

Genular Protein ID: 3687336251

Symbol: FFAR1_HUMAN

Name: Free fatty acid receptor 1

UniProtKB Accession Codes:

O14842 Q0VAS2 Q4VBL4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 3 Ensembl 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 7 PIR 1 PRINTS 3 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9344866

Title: A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1.

PubMed ID: 9344866

DOI: 10.1006/bbrc.1997.7513

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12496284

Title: The orphan G protein-coupled receptor GPR40 is activated by medium and long-chain fatty acids.

PubMed ID: 12496284

DOI: 10.1074/jbc.m211495200

PubMed ID: 16289108

Title: GPR40 gene expression in human pancreas and insulinoma.

PubMed ID: 16289108

DOI: 10.1016/j.bbrc.2005.10.161

PubMed ID: 17699519

Title: Identification of residues important for agonist recognition and activation in GPR40.

PubMed ID: 17699519

DOI: 10.1074/jbc.m705077200

PubMed ID: 19068482

Title: Two arginine-glutamate ionic locks near the extracellular surface of FFAR1 gate receptor activation.

PubMed ID: 19068482

DOI: 10.1074/jbc.m806987200

PubMed ID: 21570468

Title: Phytanic acid and pristanic acid, branched-chain fatty acids associated with Refsum disease and other inherited peroxisomal disorders, mediate intracellular Ca2+ signaling through activation of free fatty acid receptor GPR40.

PubMed ID: 21570468

DOI: 10.1016/j.nbd.2011.04.020

PubMed ID: 23809162

Title: Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation.

PubMed ID: 23809162

DOI: 10.1016/j.immuni.2013.05.015

PubMed ID: 24130766

Title: A novel antidiabetic drug, fasiglifam/TAK-875, acts as an ago-allosteric modulator of FFAR1.

PubMed ID: 24130766

DOI: 10.1371/journal.pone.0076280

PubMed ID: 24742677

Title: Alteration of the glucagon axis in GPR120 (FFAR4) knockout mice: a role for GPR120 in glucagon secretion.

PubMed ID: 24742677

DOI: 10.1074/jbc.m114.568683

PubMed ID: 25043059

Title: High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875.

PubMed ID: 25043059

DOI: 10.1038/nature13494

PubMed ID: 29695780

Title: Structural basis for GPR40 allosteric agonism and incretin stimulation.

PubMed ID: 29695780

DOI: 10.1038/s41467-017-01240-w

Sequence Information:

  • Length: 300
  • Mass: 31457
  • Checksum: 77EF27DACD93E80B
  • Sequence:
    • MDLPPQLSFG LYVAAFALGF PLNVLAIRGA TAHARLRLTP SLVYALNLGC SDLLLTVSLP 
LKAVEALASG AWPLPASLCP VFAVAHFFPL YAGGGFLAAL SAGRYLGAAF PLGYQAFRRP 
CYSWGVCAAI WALVLCHLGL VFGLEAPGGW LDHSNTSLGI NTPVNGSPVC LEAWDPASAG 
PARFSLSLLL FFLPLAITAF CYVGCLRALA RSGLTHRRKL RAAWVAGGAL LTLLLCVGPY 
NASNVASFLY PNLGGSWRKL GLITGAWSVV LNPLVTGYLG RGPGLKTVCA ARTQGGKSQK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.