Details for: IGLV10 54

Gene ID: 28772

Symbol: IGLV10 54

Ensembl ID: ENSG00000211642

Description: immunoglobulin lambda variable 10-54

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 872
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,690
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 798
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.96
    Marker Score: 1,662
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,298
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,290
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.6
    Marker Score: 775
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 470
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.57
    Marker Score: 345
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.52
    Marker Score: 301
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.44
    Marker Score: 701
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.43
    Marker Score: 415
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 373
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.34
    Marker Score: 304
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.29
    Marker Score: 3,800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.24
    Marker Score: 236
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.24
    Marker Score: 372
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.23
    Marker Score: 130
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.22
    Marker Score: 91
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 118
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.2
    Marker Score: 232
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.19
    Marker Score: 177
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.18
    Marker Score: 75
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.18
    Marker Score: 741
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.17
    Marker Score: 102
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.16
    Marker Score: 987
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.16
    Marker Score: 94
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.16
    Marker Score: 264
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.16
    Marker Score: 489
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.15
    Marker Score: 170
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.14
    Marker Score: 73
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.14
    Marker Score: 596
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.13
    Marker Score: 324
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.13
    Marker Score: 41
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.13
    Marker Score: 283
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.12
    Marker Score: 43
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.12
    Marker Score: 60
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.12
    Marker Score: 83
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.12
    Marker Score: 84
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.11
    Marker Score: 29
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.11
    Marker Score: 400
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.11
    Marker Score: 64
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.11
    Marker Score: 74
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.11
    Marker Score: 144
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.11
    Marker Score: 29
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.1
    Marker Score: 81
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.1
    Marker Score: 52
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1
    Marker Score: 109
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.1
    Marker Score: 86
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.09
    Marker Score: 792
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.09
    Marker Score: 263
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.09
    Marker Score: 29
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.09
    Marker Score: 60
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.09
    Marker Score: 109
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.09
    Marker Score: 59
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.09
    Marker Score: 40
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.09
    Marker Score: 25
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.08
    Marker Score: 29
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.08
    Marker Score: 101
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.08
    Marker Score: 29
  • Cell Name: enucleated reticulocyte (CL0002422)
    Fold Change: 0.08
    Marker Score: 29
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.08
    Marker Score: 27
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.08
    Marker Score: 104
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.08
    Marker Score: 274
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.08
    Marker Score: 64
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.07
    Marker Score: 211
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.07
    Marker Score: 51
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.07
    Marker Score: 162
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.07
    Marker Score: 42
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.07
    Marker Score: 76
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.07
    Marker Score: 27
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.07
    Marker Score: 28
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.07
    Marker Score: 27
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.07
    Marker Score: 30
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.07
    Marker Score: 37
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.07
    Marker Score: 176
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.06
    Marker Score: 734
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.06
    Marker Score: 36
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.06
    Marker Score: 27
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.06
    Marker Score: 25
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.06
    Marker Score: 26
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.05
    Marker Score: 36
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.05
    Marker Score: 70
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.05
    Marker Score: 28

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Organization:** The IGLV10-54 gene is situated on the X chromosome, a characteristic shared by other immunoglobulin genes. Its organization consists of three exons (IGLV10-1, IGLV10-2, and IGLV10-3) that encode the variable region of the λ antibody. 2. **Immunoglobulin Lambda (λ) Antibody:** The IGLV10-54 gene produces a λ antibody, which differs from the more common IgM and IgG antibodies produced by other genes. λ antibodies are typically involved in the early stages of immune responses and are often associated with the activation of B cells. 3. **Diversity and Variability:** The IGLV10-54 gene exhibits a high degree of diversity and variability, allowing for the generation of a vast repertoire of antibodies. This diversity is crucial for the immune system to recognize and respond to a wide range of pathogens. **Pathways and Functions:** 1. **Adaptive Immune Response:** The IGLV10-54 gene plays a critical role in the adaptive immune response, which involves the activation of B cells and the production of antibodies. This process is essential for the elimination of pathogens and the prevention of disease. 2. **Immunoglobulin Production:** The IGLV10-54 gene is involved in the production of immunoglobulins, which are proteins that recognize and bind to specific antigens. This binding process triggers an immune response, leading to the activation of immune cells and the elimination of pathogens. 3. **Cellular Interactions:** The IGLV10-54 gene is expressed in various cell types, including granulocyte-monocyte progenitor cells, goblet cells, and intestinal epithelial cells. This expression suggests that the gene plays a role in the regulation of immune responses and the maintenance of tissue homeostasis. **Clinical Significance:** 1. **Immunodeficiency Disorders:** Abnormalities in the IGLV10-54 gene have been linked to immunodeficiency disorders, such as X-linked agammaglobulinemia (XLA). This condition is characterized by a reduced ability to produce immunoglobulins, making individuals more susceptible to infections. 2. **Cancer:** The IGLV10-54 gene has been implicated in the development of certain types of cancer, including lymphoma and leukemia. Abnormal expression of this gene may contribute to the progression of these diseases. 3. **Inflammatory Diseases:** The IGLV10-54 gene is also involved in the regulation of inflammatory responses. Dysregulation of this gene may contribute to the development of inflammatory diseases, such as rheumatoid arthritis and atherosclerosis. In conclusion, the IGLV10-54 gene is a vital component of the immune system, playing a critical role in the adaptive immune response and the production of immunoglobulins. Further research into this gene's structure, function, and expression patterns will provide valuable insights into the diagnosis and treatment of immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.