Gene GSTA6P - ENSG00000223622 | NCBI Gene ID: 2942

Details for: GSTA6P

Gene ID: 2942

Symbol: GSTA6P

Ensembl ID: ENSG00000223622

Description: glutathione S-transferase alpha 6, pseudogene

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Other Information

Description

**Key characteristics:** * GSTA6P is a pseudogene, meaning it is not expressed in humans. * It is located on chromosome 17. * It is involved in eye disorders. **Pathways and functions:** * GSTA6P is a glutathione S-transferase, which is an enzyme that helps to protect cells from damage caused by reactive oxygen species (ROS). * It is expressed in several cell types, including pigmented ciliary epithelial cells, oligodendrocytes, astrocytes, melanocytes, oligodendrocyte precursor cells, GABAergic neurons, fibroblasts, retinal ganglion cells, and anterior lens cells. * It helps to maintain cellular homeostasis and prevent oxidative stress. * It is involved in the regulation of inflammation and apoptosis. **Clinical significance:** * Mutations in GSTA6P have been linked to several eye disorders, including retinal dystrophy, age-related macular degeneration, and cataracts. * GSTA6P is a potential therapeutic target for these disorders. * Studies of GSTA6P knockout mice have shown that they have a reduced susceptibility to oxidative stress-induced cell damage, suggesting that it may be a potential therapeutic target for eye diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.