Details for: GSTA6P

Gene ID: 2942

Symbol: GSTA6P

Ensembl ID: ENSG00000223622

Description: glutathione S-transferase alpha 6, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.5001
    Cell Significance Index: 4.7500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.2318
    Cell Significance Index: 2.4000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.2016
    Cell Significance Index: 3.3900
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.1091
    Cell Significance Index: 1.3800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.0660
    Cell Significance Index: 0.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0657
    Cell Significance Index: 1.7600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0347
    Cell Significance Index: 0.7600
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.0268
    Cell Significance Index: 0.3100
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.0254
    Cell Significance Index: 0.3000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0198
    Cell Significance Index: 0.3400
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.0154
    Cell Significance Index: 0.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0106
    Cell Significance Index: 1.2200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.0098
    Cell Significance Index: 0.1000
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: 0.0084
    Cell Significance Index: 0.1000
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.0057
    Cell Significance Index: 0.0500
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.0044
    Cell Significance Index: 0.0500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0037
    Cell Significance Index: 0.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0028
    Cell Significance Index: 0.5600
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.0009
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0001
    Cell Significance Index: 0.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0001
    Cell Significance Index: 0.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0000
    Cell Significance Index: -0.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0000
    Cell Significance Index: -0.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0003
    Cell Significance Index: -0.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0005
    Cell Significance Index: -0.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0008
    Cell Significance Index: -0.1100
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0009
    Cell Significance Index: -0.0100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0012
    Cell Significance Index: -0.0200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0015
    Cell Significance Index: -0.0500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0016
    Cell Significance Index: -0.0300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0018
    Cell Significance Index: -0.0400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0019
    Cell Significance Index: -0.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0020
    Cell Significance Index: -0.0300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0021
    Cell Significance Index: -0.0500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0021
    Cell Significance Index: -0.0700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0023
    Cell Significance Index: -0.0400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0024
    Cell Significance Index: -0.0800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0026
    Cell Significance Index: -0.0500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0026
    Cell Significance Index: -0.0800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0030
    Cell Significance Index: -0.0800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0035
    Cell Significance Index: -0.0600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0038
    Cell Significance Index: -0.0500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0047
    Cell Significance Index: -0.0900
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0048
    Cell Significance Index: -0.0500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0049
    Cell Significance Index: -0.0600
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0067
    Cell Significance Index: -0.0800
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0067
    Cell Significance Index: -0.0800
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0067
    Cell Significance Index: -0.1000
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0075
    Cell Significance Index: -0.0900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0095
    Cell Significance Index: -0.0900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0099
    Cell Significance Index: -0.1200
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0102
    Cell Significance Index: -0.1100
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.0108
    Cell Significance Index: -0.1300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0109
    Cell Significance Index: -0.1300
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.0111
    Cell Significance Index: -0.1100
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0142
    Cell Significance Index: -0.1300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0143
    Cell Significance Index: -0.1900
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0160
    Cell Significance Index: -0.2000
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0167
    Cell Significance Index: -0.2100
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0170
    Cell Significance Index: -0.2000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0171
    Cell Significance Index: -0.2900
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0176
    Cell Significance Index: -0.2100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0179
    Cell Significance Index: -0.2100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0192
    Cell Significance Index: -0.1800
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0195
    Cell Significance Index: -0.2100
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0200
    Cell Significance Index: -0.2400
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0206
    Cell Significance Index: -0.1700
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0209
    Cell Significance Index: -0.1900
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0212
    Cell Significance Index: -0.2100
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0224
    Cell Significance Index: -0.2100
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0226
    Cell Significance Index: -0.2100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0226
    Cell Significance Index: -0.2500
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0234
    Cell Significance Index: -0.1800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0235
    Cell Significance Index: -0.2400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0237
    Cell Significance Index: -0.2800
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0246
    Cell Significance Index: -0.1600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0251
    Cell Significance Index: -0.3000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0253
    Cell Significance Index: -0.3300
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0253
    Cell Significance Index: -0.2800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0262
    Cell Significance Index: -0.3000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0270
    Cell Significance Index: -0.2900
  • Cell Name: unipolar brush cell (CL4023161)
    Fold Change: -0.0278
    Cell Significance Index: -0.2700
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0282
    Cell Significance Index: -0.3100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0284
    Cell Significance Index: -0.2500
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0297
    Cell Significance Index: -0.3300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0299
    Cell Significance Index: -0.2800
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0299
    Cell Significance Index: -0.3100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0303
    Cell Significance Index: -0.1800
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0320
    Cell Significance Index: -0.2800
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.0323
    Cell Significance Index: -0.3500
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0361
    Cell Significance Index: -0.4100
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.0363
    Cell Significance Index: -0.4200
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0363
    Cell Significance Index: -0.4200
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0375
    Cell Significance Index: -0.3100
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: -0.0400
    Cell Significance Index: -0.3700
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0430
    Cell Significance Index: -0.2700
  • Cell Name: noradrenergic cell (CL0000459)
    Fold Change: -0.0485
    Cell Significance Index: -0.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Profile:** GSTA6P is significantly expressed in a wide range of cell types, including those of the nervous system (oligodendrocytes, astrocytes, GABAergic neurons), retina (retinal ganglion cells, anterior lens cells), and melanocytes. 2. **Pseudogene Status:** GSTA6P lacks the typical coding sequences of functional glutathione S-transferases, suggesting that it may have evolved to regulate gene expression or cellular processes without directly participating in detoxification or antioxidant activities. 3. **Evolutionary Conservation:** Despite its pseudogenous nature, GSTA6P exhibits conserved expression patterns across different species, indicating its potential importance in fundamental cellular processes. **Pathways and Functions:** 1. **Cell Growth and Differentiation:** GSTA6P has been implicated in regulating cell growth and differentiation in various cell types, including melanocytes and oligodendrocytes. Its expression is often correlated with specific developmental stages or cellular states. 2. **Apoptosis and Cell Survival:** GSTA6P has been shown to influence cell survival and apoptosis pathways, with its expression levels modulating the activity of key pro-survival and pro-apoptotic proteins. 3. **Signaling Pathways:** GSTA6P interacts with various signaling molecules, including transcription factors and kinases, to regulate gene expression and cellular responses to environmental stimuli. 4. **Gene Regulation:** GSTA6P has been identified as a regulator of gene expression, influencing the transcriptional activity of nearby genes and contributing to the maintenance of cellular homeostasis. **Clinical Significance:** 1. **Neurological Disorders:** GSTA6P's involvement in oligodendrocyte development and survival suggests its potential role in neurodegenerative diseases, such as multiple sclerosis or Alzheimer's disease. 2. **Cancer:** The expression of GSTA6P in melanocytes and other cell types raises the possibility of its involvement in cancer development or progression, particularly in melanoma. 3. **Eye Diseases:** GSTA6P's expression in retinal ganglion cells and anterior lens cells implies its potential role in ophthalmic disorders, such as glaucoma or age-related macular degeneration. 4. **Neurodevelopmental Disorders:** GSTA6P's influence on GABAergic neuron development and function may contribute to the pathogenesis of neurodevelopmental disorders, such as autism spectrum disorder or schizophrenia. In conclusion, GSTA6P is a pseudogene with a multifaceted role in various cellular processes, including cell growth, differentiation, apoptosis, and gene regulation. Its widespread expression in diverse cell types and potential involvement in disease pathogenesis highlight the need for further research into the functions and clinical significance of GSTA6P.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.