Details for: GUCY1A2

Gene ID: 2977

Symbol: GUCY1A2

Ensembl ID: ENSG00000152402

Description: guanylate cyclase 1 soluble subunit alpha 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.86
    Marker Score: 1551
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.74
    Marker Score: 14713
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.53
    Marker Score: 85617
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.3
    Marker Score: 6569
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.25
    Marker Score: 9314
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.22
    Marker Score: 10264
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.14
    Marker Score: 78975
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.14
    Marker Score: 20135
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.14
    Marker Score: 823
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.11
    Marker Score: 16163
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.03
    Marker Score: 76963
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.02
    Marker Score: 3398
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.02
    Marker Score: 3881
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.95
    Marker Score: 7558
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.94
    Marker Score: 38628
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.91
    Marker Score: 7788
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.91
    Marker Score: 18140
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.9
    Marker Score: 28466
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.9
    Marker Score: 4160
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.86
    Marker Score: 15954
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.83
    Marker Score: 1060
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.81
    Marker Score: 1448
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.75
    Marker Score: 9198
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.68
    Marker Score: 103381
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.65
    Marker Score: 1245
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.65
    Marker Score: 524
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.63
    Marker Score: 2510
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.57
    Marker Score: 5256
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.57
    Marker Score: 3603
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.48
    Marker Score: 1996
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 168043
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.4
    Marker Score: 1736
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.39
    Marker Score: 2824
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 861
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.35
    Marker Score: 1555
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.34
    Marker Score: 601
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.26
    Marker Score: 2366
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.25
    Marker Score: 754
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.22
    Marker Score: 633
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.22
    Marker Score: 684
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.21
    Marker Score: 457
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.19
    Marker Score: 1133
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.17
    Marker Score: 8838
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.12
    Marker Score: 471
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.07
    Marker Score: 1114
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.03
    Marker Score: 16109
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.02
    Marker Score: 1577
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1
    Marker Score: 303
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71782
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48007
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1
    Marker Score: 272
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.97
    Marker Score: 10050
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.97
    Marker Score: 568
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.95
    Marker Score: 1181
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5296
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2735
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.88
    Marker Score: 5304
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5279
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.87
    Marker Score: 414
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.87
    Marker Score: 1579
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.85
    Marker Score: 649
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.85
    Marker Score: 1377
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.84
    Marker Score: 14957
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.81
    Marker Score: 1640
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 696
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.76
    Marker Score: 244
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.75
    Marker Score: 3129
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.75
    Marker Score: 686
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.72
    Marker Score: 4784
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.71
    Marker Score: 504
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.71
    Marker Score: 241
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.7
    Marker Score: 337
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.69
    Marker Score: 218
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.68
    Marker Score: 353
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.67
    Marker Score: 393
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.64
    Marker Score: 772
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.63
    Marker Score: 7148
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.63
    Marker Score: 598
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.63
    Marker Score: 547.5
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.61
    Marker Score: 736
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.61
    Marker Score: 1147
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.6
    Marker Score: 741.5
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.59
    Marker Score: 394
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.59
    Marker Score: 715
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.59
    Marker Score: 345
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.59
    Marker Score: 766
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.57
    Marker Score: 148
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.57
    Marker Score: 317
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.57
    Marker Score: 1331
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.55
    Marker Score: 2306.5
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.55
    Marker Score: 613
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.53
    Marker Score: 167
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.53
    Marker Score: 11360
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.52
    Marker Score: 506

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Other Information

**Key characteristics** * GUCY1A2 is a type of guanylate cyclase that is expressed in the cytoplasm of cells. * It is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is a glycoprotein that is highly conserved in evolution. **Pathways and functions** GUCY1A2 is involved in a variety of signaling pathways, including the cGMP-mediated signaling pathway, the nitric oxide-mediated signal transduction pathway, and the platelet homeostasis pathway. It is also involved in the regulation of muscle contraction, and it plays a role in the maintenance of blood pressure and blood volume. **Clinical significance** Mutations in GUCY1A2 have been linked to a number of neurological disorders, including schizophrenia, autism, and epilepsy. These disorders are characterized by abnormal levels of nitric oxide in the brain, which can lead to a variety of symptoms, including cognitive impairment, seizures, and muscle spasms. GUCY1A2 is a promising target for the treatment of these disorders.

Genular Protein ID: 2830619397

Symbol: GCYA2_HUMAN

Name: Guanylate cyclase soluble subunit alpha-2

UniProtKB Accession Codes:

P33402 A1L4C4 B7ZLT5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEBI 3 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 9 DrugCentral 1 EC 2 EMBL 10 Ensembl 3 GO 10 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 Rhea 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1683630

Title: Molecular cloning and expression of a new alpha-subunit of soluble guanylyl cyclase. Interchangeability of the alpha-subunits of the enzyme.

PubMed ID: 1683630

DOI: 10.1016/0014-5793(91)80871-y

PubMed ID: 7673142

Title: A variant of the alpha 2 subunit of soluble guanylyl cyclase contains an insert homologous to a region within adenylyl cyclases and functions as a dominant negative protein.

PubMed ID: 7673142

DOI: 10.1074/jbc.270.36.21109

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 732
  • Mass: 81750
  • Checksum: 79465A7D3FE52DB7
  • Sequence:
    • MSRRKISSES FSSLGSDYLE TSPEEEGECP LSRLCWNGSR SPPGPLEPSP AAAAAAAAPA 
PTPAASAAAA AATAGARRVQ RRRRVNLDSL GESISRLTAP SPQTIQQTLK RTLQYYEHQV 
IGYRDAEKNF HNISNRCSYA DHSNKEEIED VSGILQCTAN ILGLKFEEIQ KRFGEEFFNI 
CFHENERVLR AVGGTLQDFF NGFDALLEHI RTSFGKQATL ESPSFLCKEL PEGTLMLHYF 
HPHHIVGFAM LGMIKAAGKK IYRLDVEVEQ VANEKLCSDV SNPGNCSCLT FLIKECENTN 
IMKNLPQGTS QVPADLRISI NTFCRAFPFH LMFDPSMSVL QLGEGLRKQL RCDTHKVLKF 
EDCFEIVSPK VNATFERVLL RLSTPFVIRT KPEASGSENK DKVMEVKGQM IHVPESNSIL 
FLGSPCVDKL DELMGRGLHL SDIPIHDATR DVILVGEQAK AQDGLKKRMD KLKATLERTH 
QALEEEKKKT VDLLYSIFPG DVAQQLWQGQ QVQARKFDDV TMLFSDIVGF TAICAQCTPM 
QVISMLNELY TRFDHQCGFL DIYKVETIGD AYCVAAGLHR KSLCHAKPIA LMALKMMELS 
EEVLTPDGRP IQMRIGIHSG SVLAGVVGVR MPRYCLFGNN VTLASKFESG SHPRRINVSP 
TTYQLLKREE SFTFIPRSRE ELPDNFPKEI PGICYFLEVR TGPKPPKPSL SSSRIKKVSY 
NIGTMFLRET SL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.