Details for: TRNK

Gene ID: 4566

Symbol: TRNK

Ensembl ID: ENSG00000210156

Description: tRNA-Lys

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: 5.0004
    Cell Significance Index: 41.3600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 4.4051
    Cell Significance Index: 199.6700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 3.7612
    Cell Significance Index: 93.9400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.9365
    Cell Significance Index: 44.0000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.5975
    Cell Significance Index: 74.8400
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 2.3953
    Cell Significance Index: 31.9300
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.5465
    Cell Significance Index: 19.9800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0252
    Cell Significance Index: 47.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0147
    Cell Significance Index: 52.7100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.4494
    Cell Significance Index: 6.6400
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.4494
    Cell Significance Index: 4.8700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2543
    Cell Significance Index: 3.4700
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.2300
    Cell Significance Index: 2.3800
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.1976
    Cell Significance Index: 2.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0755
    Cell Significance Index: 8.6500
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.0606
    Cell Significance Index: 0.7600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0495
    Cell Significance Index: 8.4500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0360
    Cell Significance Index: 0.9800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0131
    Cell Significance Index: -24.6800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0134
    Cell Significance Index: -24.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0149
    Cell Significance Index: -8.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0160
    Cell Significance Index: -24.5600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0350
    Cell Significance Index: -22.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0523
    Cell Significance Index: -23.7500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0690
    Cell Significance Index: -4.3500
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0858
    Cell Significance Index: -0.8300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1216
    Cell Significance Index: -24.4000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1451
    Cell Significance Index: -21.0900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1631
    Cell Significance Index: -1.7200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1634
    Cell Significance Index: -5.7400
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.2324
    Cell Significance Index: -2.3300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2359
    Cell Significance Index: -5.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2381
    Cell Significance Index: -14.6000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2704
    Cell Significance Index: -8.6600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3260
    Cell Significance Index: -4.6400
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.3380
    Cell Significance Index: -3.5900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3596
    Cell Significance Index: -7.4600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.3605
    Cell Significance Index: -5.0000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3776
    Cell Significance Index: -9.6200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3838
    Cell Significance Index: -5.5200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3869
    Cell Significance Index: -8.3600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3894
    Cell Significance Index: -11.4700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.3908
    Cell Significance Index: -5.0200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3941
    Cell Significance Index: -13.8100
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.3985
    Cell Significance Index: -3.7100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.4004
    Cell Significance Index: -7.8800
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.4022
    Cell Significance Index: -4.1700
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.4345
    Cell Significance Index: -4.1300
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.4870
    Cell Significance Index: -5.3700
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.5380
    Cell Significance Index: -6.6800
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.5602
    Cell Significance Index: -7.0600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.5623
    Cell Significance Index: -7.3400
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.6256
    Cell Significance Index: -8.6800
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.6381
    Cell Significance Index: -6.9800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.6488
    Cell Significance Index: -11.0900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6611
    Cell Significance Index: -14.0800
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.6704
    Cell Significance Index: -9.2700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.6791
    Cell Significance Index: -7.0900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.6826
    Cell Significance Index: -10.8300
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.6879
    Cell Significance Index: -7.5000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.6944
    Cell Significance Index: -11.9700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.7240
    Cell Significance Index: -14.7300
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.7383
    Cell Significance Index: -5.6800
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.7600
    Cell Significance Index: -6.8600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7691
    Cell Significance Index: -25.1800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.7787
    Cell Significance Index: -24.6300
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.7876
    Cell Significance Index: -8.7200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7894
    Cell Significance Index: -25.1400
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.7931
    Cell Significance Index: -7.2100
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.7932
    Cell Significance Index: -7.3900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.7944
    Cell Significance Index: -9.6300
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.8259
    Cell Significance Index: -6.9700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.8348
    Cell Significance Index: -10.7500
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: -0.8556
    Cell Significance Index: -7.4800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.8586
    Cell Significance Index: -12.3300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.8612
    Cell Significance Index: -11.2400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.8862
    Cell Significance Index: -15.3200
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.8901
    Cell Significance Index: -9.6700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.8976
    Cell Significance Index: -18.0200
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.9302
    Cell Significance Index: -11.2200
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.9410
    Cell Significance Index: -10.3300
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.9452
    Cell Significance Index: -9.7500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.9602
    Cell Significance Index: -10.9900
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.9622
    Cell Significance Index: -10.0600
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.9748
    Cell Significance Index: -11.6000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.9812
    Cell Significance Index: -10.5200
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.9864
    Cell Significance Index: -9.6500
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.9876
    Cell Significance Index: -9.7800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.9890
    Cell Significance Index: -11.3800
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.9920
    Cell Significance Index: -10.7400
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.9939
    Cell Significance Index: -7.8000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.9948
    Cell Significance Index: -13.0600
  • Cell Name: DN4 thymocyte (CL0000808)
    Fold Change: -0.9981
    Cell Significance Index: -7.5200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -1.0142
    Cell Significance Index: -12.6700
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -1.0293
    Cell Significance Index: -10.9500
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -1.0380
    Cell Significance Index: -12.0600
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -1.0405
    Cell Significance Index: -11.2500
  • Cell Name: pericyte (CL0000669)
    Fold Change: -1.0558
    Cell Significance Index: -12.6600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -1.0566
    Cell Significance Index: -14.0400
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -1.0737
    Cell Significance Index: -10.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TRNK is a tRNA molecule that is specifically charged with the amino acid lysine. The tRNA-Lys molecule plays a critical role in the translation of proteins, particularly those involved in immune responses and cell growth. The unique expression pattern of TRNK in the gastrointestinal tract, particularly in cells associated with the immune system, highlights its potential importance in the regulation of immune responses. **Pathways and Functions** TRNK is involved in the translation of proteins that are essential for the maintenance of gut homeostasis and immune responses. The tRNA-Lys molecule is involved in the synthesis of proteins that are involved in the regulation of immune cell function, including the activation and proliferation of immune cells such as T cells and B cells. Additionally, TRNK is involved in the synthesis of proteins that are involved in the maintenance of the epithelial barrier function, including the production of antimicrobial peptides and the regulation of tight junction proteins. The signaling pathways that regulate TRNK expression and function are not fully understood, but it is likely that TRNK plays a role in the regulation of the Wnt/β-catenin pathway, which is involved in the regulation of intestinal stem cell self-renewal and differentiation. TRNK may also interact with other signaling pathways, including the PI3K/AKT pathway, which is involved in the regulation of cell growth and survival. **Clinical Significance** The elevated expression of TRNK in various cell types found in the colon and large intestine suggests its potential involvement in the development of various gastrointestinal disorders, including inflammatory bowel disease (IBD) and cancer. TRNK may play a role in the regulation of immune responses and the maintenance of gut homeostasis, and its dysregulation may contribute to the development of these disorders. Furthermore, TRNK may be used as a biomarker for the diagnosis and monitoring of gastrointestinal disorders. The expression of TRNK in various cell types may be used to identify individuals at risk of developing these disorders, and its levels may be used to monitor the effectiveness of treatment. In addition, TRNK may have potential therapeutic applications in the treatment of gastrointestinal disorders. TRNK may be targeted to regulate immune responses and maintain gut homeostasis, and its inhibition or overexpression may be used to treat various gastrointestinal disorders. In conclusion, TRNK is a critical component of the translational machinery within cells, particularly in the context of the immune system and gastrointestinal tract. Its unique expression pattern and potential involvement in the regulation of immune responses and gut homeostasis make it a promising area of research for the diagnosis and treatment of various gastrointestinal disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.