Details for: UBL3

Gene ID: 5412

Symbol: UBL3

Ensembl ID: ENSG00000122042

Description: ubiquitin like 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2.54
    Marker Score: 1325
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.39
    Marker Score: 42384
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.25
    Marker Score: 76428
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.15
    Marker Score: 13730
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.15
    Marker Score: 1131
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.11
    Marker Score: 2537
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.96
    Marker Score: 8127
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.94
    Marker Score: 2040
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.93
    Marker Score: 71190
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.93
    Marker Score: 8927
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.93
    Marker Score: 1313
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.86
    Marker Score: 3084
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.86
    Marker Score: 4449
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.86
    Marker Score: 1981
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.85
    Marker Score: 2233
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.84
    Marker Score: 15974
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.81
    Marker Score: 1706
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.81
    Marker Score: 68635
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.73
    Marker Score: 7055
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.73
    Marker Score: 723
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.72
    Marker Score: 2533
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.72
    Marker Score: 17710
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.7
    Marker Score: 6579.5
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.68
    Marker Score: 837
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.67
    Marker Score: 3795.5
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.67
    Marker Score: 1305
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.66
    Marker Score: 32986
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.64
    Marker Score: 15402
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.62
    Marker Score: 13896
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.62
    Marker Score: 1245
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.59
    Marker Score: 4022
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.59
    Marker Score: 15086
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.58
    Marker Score: 1348
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.57
    Marker Score: 23482.5
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.56
    Marker Score: 2969
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.55
    Marker Score: 3142
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.55
    Marker Score: 6446
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.52
    Marker Score: 24391
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.5
    Marker Score: 32082
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.48
    Marker Score: 5102
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.48
    Marker Score: 334
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.46
    Marker Score: 2257
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.46
    Marker Score: 89709
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.45
    Marker Score: 690
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.44
    Marker Score: 11012
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.42
    Marker Score: 12277.5
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.42
    Marker Score: 530
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.4
    Marker Score: 347
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.4
    Marker Score: 581
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.37
    Marker Score: 3128
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.37
    Marker Score: 315
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.37
    Marker Score: 1766
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.36
    Marker Score: 961
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.36
    Marker Score: 3648
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.36
    Marker Score: 1640
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.35
    Marker Score: 1674
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.35
    Marker Score: 403
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.34
    Marker Score: 1565.5
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.34
    Marker Score: 1156.5
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.34
    Marker Score: 1893
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.34
    Marker Score: 1852
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1.33
    Marker Score: 293
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.33
    Marker Score: 384
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.33
    Marker Score: 2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.32
    Marker Score: 2899
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 1.31
    Marker Score: 297
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.31
    Marker Score: 531
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.3
    Marker Score: 1405
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.3
    Marker Score: 1491
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.29
    Marker Score: 770
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.29
    Marker Score: 812
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.27
    Marker Score: 303
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.26
    Marker Score: 1312
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.26
    Marker Score: 565
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.26
    Marker Score: 1088
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.25
    Marker Score: 1331
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.25
    Marker Score: 504
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.24
    Marker Score: 453
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.23
    Marker Score: 1231
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.23
    Marker Score: 460
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.22
    Marker Score: 713
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.22
    Marker Score: 963
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.22
    Marker Score: 631
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.22
    Marker Score: 2977.5
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.22
    Marker Score: 1346
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.22
    Marker Score: 5095
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.21
    Marker Score: 384
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.21
    Marker Score: 1110
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.21
    Marker Score: 348
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.21
    Marker Score: 383
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.2
    Marker Score: 285
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.19
    Marker Score: 274
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.19
    Marker Score: 2167
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.19
    Marker Score: 292
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 1.18
    Marker Score: 283
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.18
    Marker Score: 436
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.16
    Marker Score: 253
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.16
    Marker Score: 287
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.16
    Marker Score: 254
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.16
    Marker Score: 1260

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Other Information

**Key Characteristics:** UBL3, also known as ubiquitin-like protein 3, is a small protein that belongs to the ubiquitin-like protein family. It shares a high degree of sequence similarity with ubiquitin, the classical ubiquitin-like protein, and is characterized by its ability to interact with other proteins and regulate cellular processes. UBL3 is significantly expressed in various cell types, including rod bipolar cells, cortical cells of the adrenal gland, fibroblasts of the mammary gland, and foveolar cells of the stomach, among others. **Pathways and Functions:** UBL3 is involved in several cellular pathways, including: 1. **Extracellular exosome regulation:** UBL3 is associated with the regulation of exosome formation and function. Exosomes are small extracellular vesicles that play a crucial role in intercellular communication, and UBL3 is thought to be involved in the targeting and sorting of proteins and lipids to exosomes. 2. **Protein binding:** UBL3 interacts with other proteins, including ubiquitin and ubiquitin-like proteins, to regulate protein degradation, protein-protein interactions, and protein localization. 3. **Cell signaling:** UBL3 is involved in various signaling pathways, including those involved in cell growth, differentiation, and survival. **Clinical Significance:** UBL3 plays a significant role in maintaining cellular homeostasis and regulating various cellular processes. Dysregulation of UBL3 has been implicated in several diseases, including: 1. **Neurodegenerative diseases:** UBL3 has been shown to be involved in the regulation of protein aggregation and clearance in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 2. **Cancer:** UBL3 has been implicated in the regulation of cell growth, differentiation, and survival in various types of cancer, including breast cancer and lung cancer. 3. **Inflammatory diseases:** UBL3 has been shown to play a role in the regulation of immune responses and inflammation in diseases such as rheumatoid arthritis and atherosclerosis. In conclusion, UBL3 is a ubiquitin-like protein that plays a crucial role in regulating cellular processes, including exosomal regulation, protein binding, and cell signaling. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and mechanisms of UBL3. **Recommendations:** 1. Further research is needed to elucidate the mechanisms of UBL3 in regulating exosomal formation and function. 2. The role of UBL3 in various disease states, including neurodegenerative diseases, cancer, and inflammatory diseases, should be further investigated. 3. The potential therapeutic applications of UBL3 as a target for disease treatment should be explored. By continuing to study UBL3, we can gain a deeper understanding of its functions and mechanisms, ultimately leading to the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 3879388164

Symbol: UBL3_HUMAN

Name: Ubiquitin-like protein 3

UniProtKB Accession Codes:

O95164 B2R4J1 Q5RL72 Q5VZS0 Q6FIG8 Q96SG7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 10 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10375635

Title: Cloning, mapping and expression of UBL3, a novel ubiquitin-like gene.

PubMed ID: 10375635

DOI: 10.1016/s0378-1119(99)00138-9

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16831869

Title: MUBS: a family of ubiquitin-fold proteins that are plasma membrane-anchored by prenylation.

PubMed ID: 16831869

DOI: 10.1074/jbc.m602283200

PubMed ID: 17567738

Title: Solution structure of a membrane-anchored ubiquitin-fold (MUB) protein from Homo sapiens.

PubMed ID: 17567738

DOI: 10.1110/ps.072834007

Sequence Information:

  • Length: 117
  • Mass: 13157
  • Checksum: 4EB1375D9C0B029F
  • Sequence:
    • MSSNVPADMI NLRLILVSGK TKEFLFSPND SASDIAKHVY DNWPMDWEEE QVSSPNILRL 
IYQGRFLHGN VTLGALKLPF GKTTVMHLVA RETLPEPNSQ GQRNREKTGE SNCCVIL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.