H2BC12L | ENSG00000234289 | NCBI 54145

Details for: H2BC12L

Gene ID: 54145

Symbol: H2BC12L

Ensembl ID: ENSG00000234289

Description: H2B clustered histone 12 like

Associated with

Activated pkn1 stimulates transcription of ar (androgen receptor) regulated genes klk2 and klk3
(R-HSA-5625886)
Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromosome maintenance
(R-HSA-73886)
Cleavage of the damaged purine
(R-HSA-110331)
Cleavage of the damaged pyrimidine
(R-HSA-110329)
Condensation of prophase chromosomes
(R-HSA-2299718)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna double-strand break repair
(R-HSA-5693532)
Dna double strand break response
(R-HSA-5693606)
Dna methylation
(R-HSA-5334118)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of adipogenesis genes by mll3 and mll4 complexes
(R-HSA-9851695)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Meiotic synapsis
(R-HSA-1221632)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
Mll4 and mll3 complexes regulate expression of pparg target genes in adipogenesis and hepatic steatosis
(R-HSA-9841922)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Nonhomologous end-joining (nhej)
(R-HSA-5693571)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Packaging of telomere ends
(R-HSA-171306)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Processing of dna double-strand break ends
(R-HSA-5693607)
Recognition and association of dna glycosylase with site containing an affected purine
(R-HSA-110330)
Recognition and association of dna glycosylase with site containing an affected pyrimidine
(R-HSA-110328)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-HSA-5693565)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by piwi-interacting rnas (pirnas)
(R-HSA-9845323)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Replacement of protamines by nucleosomes in the male pronucleus
(R-HSA-9821993)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate pkns
(R-HSA-5625740)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-HSA-8936459)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-HSA-8939236)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.5030
Cell Significance Index: 6.3700
Cell Name: thymocyte (CL0000893)
Fold Change: 0.1448
Cell Significance Index: 1.8300
Cell Name: decidual cell (CL2000002)
Fold Change: 0.1119
Cell Significance Index: 1.8000
Cell Name: theca cell (CL0000503)
Fold Change: 0.0732
Cell Significance Index: 0.4300
Cell Name: kidney cell (CL1000497)
Fold Change: 0.0576
Cell Significance Index: 0.4600
Cell Name: stromal cell (CL0000499)
Fold Change: 0.0440
Cell Significance Index: 0.4500
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.0256
Cell Significance Index: 0.1600
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0218
Cell Significance Index: 4.3800
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.0192
Cell Significance Index: 1.9600
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.0145
Cell Significance Index: 0.1500
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.0050
Cell Significance Index: 0.0400
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0031
Cell Significance Index: 1.6700
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.0016
Cell Significance Index: 0.0100
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0000
Cell Significance Index: -0.0200
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0007
Cell Significance Index: -0.0200
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: -0.0016
Cell Significance Index: -0.0100
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0021
Cell Significance Index: -0.0900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0026
Cell Significance Index: -0.3600
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0035
Cell Significance Index: -0.1300
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0037
Cell Significance Index: -0.1000
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: -0.0090
Cell Significance Index: -0.1200
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0129
Cell Significance Index: -0.3800
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: -0.0147
Cell Significance Index: -0.1300
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: -0.0155
Cell Significance Index: -0.1500
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: -0.0159
Cell Significance Index: -0.1400
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.0164
Cell Significance Index: -0.4100
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0178
Cell Significance Index: -1.0900
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0203
Cell Significance Index: -0.9500
Cell Name: basal cell (CL0000646)
Fold Change: -0.0235
Cell Significance Index: -0.2800
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0238
Cell Significance Index: -1.2500
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0251
Cell Significance Index: -0.6400
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0263
Cell Significance Index: -0.4400
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0270
Cell Significance Index: -0.7100
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0279
Cell Significance Index: -0.9700
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0330
Cell Significance Index: -0.8400
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: -0.0337
Cell Significance Index: -0.3200
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.0339
Cell Significance Index: -0.4700
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0371
Cell Significance Index: -1.1800
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: -0.0383
Cell Significance Index: -0.3600
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.0398
Cell Significance Index: -0.6700
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0404
Cell Significance Index: -1.9000
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0408
Cell Significance Index: -1.0200
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: -0.0408
Cell Significance Index: -0.4400
Cell Name: epithelial cell (CL0000066)
Fold Change: -0.0417
Cell Significance Index: -0.4400
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0452
Cell Significance Index: -1.4800
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0470
Cell Significance Index: -0.9300
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0477
Cell Significance Index: -1.0300
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0477
Cell Significance Index: -1.1900
Cell Name: podocyte (CL0000653)
Fold Change: -0.0479
Cell Significance Index: -0.5500
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.0486
Cell Significance Index: -0.9500
Cell Name: fibroblast of lung (CL0002553)
Fold Change: -0.0488
Cell Significance Index: -0.5800
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0488
Cell Significance Index: -0.9800
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.0556
Cell Significance Index: -0.9000
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.0563
Cell Significance Index: -1.0400
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0570
Cell Significance Index: -1.2100
Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.0602
Cell Significance Index: -1.2000
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.0609
Cell Significance Index: -1.2400
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.0610
Cell Significance Index: -1.2000
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.0627
Cell Significance Index: -0.7100
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.0634
Cell Significance Index: -0.8200
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: -0.0636
Cell Significance Index: -0.6100
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0640
Cell Significance Index: -1.5500
Cell Name: leukocyte (CL0000738)
Fold Change: -0.0651
Cell Significance Index: -1.1100
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.0654
Cell Significance Index: -1.1300
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: -0.0665
Cell Significance Index: -0.5500
Cell Name: T cell (CL0000084)
Fold Change: -0.0669
Cell Significance Index: -0.7900
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.0684
Cell Significance Index: -1.0000
Cell Name: myeloid cell (CL0000763)
Fold Change: -0.0692
Cell Significance Index: -0.9200
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.0700
Cell Significance Index: -1.4600
Cell Name: pulmonary alveolar type 1 cell (CL0002062)
Fold Change: -0.0701
Cell Significance Index: -0.7700
Cell Name: enterocyte (CL0000584)
Fold Change: -0.0709
Cell Significance Index: -0.4400
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.0718
Cell Significance Index: -0.6100
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.0720
Cell Significance Index: -1.0500
Cell Name: B cell (CL0000236)
Fold Change: -0.0736
Cell Significance Index: -0.8700
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: -0.0745
Cell Significance Index: -0.6300
Cell Name: dendritic cell (CL0000451)
Fold Change: -0.0749
Cell Significance Index: -0.9800
Cell Name: mature NK T cell (CL0000814)
Fold Change: -0.0754
Cell Significance Index: -0.8500
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: -0.0759
Cell Significance Index: -0.5800
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: -0.0765
Cell Significance Index: -0.7800
Cell Name: endothelial cell (CL0000115)
Fold Change: -0.0765
Cell Significance Index: -0.9400
Cell Name: glial cell (CL0000125)
Fold Change: -0.0767
Cell Significance Index: -0.8400
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.0770
Cell Significance Index: -1.0100
Cell Name: mast cell (CL0000097)
Fold Change: -0.0786
Cell Significance Index: -1.0400
Cell Name: progenitor cell (CL0011026)
Fold Change: -0.0791
Cell Significance Index: -0.8400
Cell Name: myofibroblast cell (CL0000186)
Fold Change: -0.0792
Cell Significance Index: -0.8300
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.0792
Cell Significance Index: -1.1700
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.0796
Cell Significance Index: -1.3600
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: -0.0797
Cell Significance Index: -0.9700
Cell Name: mature microglial cell (CL0002629)
Fold Change: -0.0797
Cell Significance Index: -0.8700
Cell Name: smooth muscle cell (CL0000192)
Fold Change: -0.0800
Cell Significance Index: -0.9300
Cell Name: cholangiocyte (CL1000488)
Fold Change: -0.0801
Cell Significance Index: -0.7900
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.0802
Cell Significance Index: -1.1000
Cell Name: macrophage (CL0000235)
Fold Change: -0.0803
Cell Significance Index: -0.8200
Cell Name: acinar cell (CL0000622)
Fold Change: -0.0804
Cell Significance Index: -1.0100
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: -0.0805
Cell Significance Index: -0.8800
Cell Name: mesothelial cell (CL0000077)
Fold Change: -0.0806
Cell Significance Index: -0.9800
Cell Name: club cell (CL0000158)
Fold Change: -0.0808
Cell Significance Index: -0.8800
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: -0.0822
Cell Significance Index: -0.7000
Cell Name: microglial cell (CL0000129)
Fold Change: -0.0825
Cell Significance Index: -0.9700
Cell Name: chondrocyte (CL0000138)
Fold Change: -0.0833
Cell Significance Index: -0.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** 1. **Histone protein**: H2BC12L is a member of the H2B family of histone proteins, which are essential for chromatin structure and gene regulation. 2. **DNA repair**: H2BC12L is involved in the repair of DNA double-strand breaks, highlighting its role in maintaining genome stability. 3. **Transcriptional regulation**: The gene regulates transcription of various genes, including those involved in immune responses and neuronal function. 4. **Cell cycle regulation**: H2BC12L is involved in the regulation of the cell cycle, particularly in the G2/M phase transition. 5. **Expression in diverse cell types**: H2BC12L is expressed in a range of cell types, including neurons, glial cells, immune cells, and stem cells, highlighting its importance in different cellular contexts. **Pathways and Functions** 1. **DNA repair pathways**: H2BC12L is involved in the repair of DNA double-strand breaks through homologous recombination (HRR) and non-homologous end-joining (NHEJ) pathways. 2. **Transcriptional regulation**: The gene regulates transcription of various genes, including those involved in immune responses (e.g., antimicrobial peptide production) and neuronal function (e.g., androgen receptor regulation). 3. **Cell cycle regulation**: H2BC12L is involved in the regulation of the cell cycle, particularly in the G2/M phase transition, ensuring proper cell division and preventing genomic instability. 4. **Chromatin modification**: The gene is involved in chromatin modification, including the assembly of nucleosomes and the regulation of histone methylation and acetylation. 5. **Developmental processes**: H2BC12L is involved in developmental processes, such as embryogenesis and meiosis, ensuring proper genome stability and cellular differentiation. **Clinical Significance** 1. **Cancer**: Alterations in H2BC12L expression have been implicated in various cancers, including leukemia and lymphoma, highlighting its potential as a therapeutic target. 2. **Neurological disorders**: The gene's involvement in neuronal function and development suggests its potential role in neurological disorders, such as neurodegenerative diseases and autism spectrum disorder. 3. **Immune system disorders**: H2BC12L's involvement in immune responses and DNA repair pathways suggests its potential role in immune system disorders, such as autoimmune diseases and immunodeficiency syndromes. 4. **Genetic instability**: The gene's involvement in DNA repair pathways highlights its potential role in genetic instability and genomic instability, which can contribute to various diseases. In conclusion, H2BC12L is a complex gene involved in various cellular processes, including DNA repair, transcriptional regulation, and cell cycle regulation. Its expression in diverse cell types and involvement in developmental processes highlight its importance in maintaining genome stability and proper cellular differentiation. The gene's potential role in cancer, neurological disorders, immune system disorders, and genetic instability underscores its significance in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.