Details for: SGPL1
Gene ID: 8879
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: SGPL1
Ensembl ID: ENSG00000166224
Description: sphingosine-1-phosphate lyase 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 13.88rCSI 11.22%PRS 75.7
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CSI 9.12rCSI 16.07%PRS 61.77
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CSI 7.77rCSI 11.49%PRS 70.52
-
CSI 7.01rCSI 10.7%PRS 80.2
-
CSI 6.38rCSI 10.28%PRS 54.7
-
CSI 5.61rCSI 12.43%PRS 63.31
-
CSI 5.3rCSI 7.79%PRS 58.41
-
CSI 5.2rCSI 16.25%PRS 50.7
-
CSI 4.43rCSI 9.89%PRS 72.99
-
CSI 4.19rCSI 9.55%PRS 61.19
-
CSI 3.95rCSI 4.13%PRS 68.68
-
CSI 3.91rCSI 3.85%PRS 67.93
-
CSI 3.82rCSI 5.23%PRS 58.19
-
CSI 3.74rCSI 7%PRS 53.33
-
CSI 3.61rCSI 7.94%PRS 77.06
-
CSI 3.56rCSI 4.57%PRS 69.93
-
CSI 3.56rCSI 10.55%PRS 74.95
-
CSI 3.15rCSI 3.8%PRS 74.02
-
CSI 3.15rCSI 2.42%PRS 66.08
-
CSI 3.03rCSI 6.93%PRS 65.3
-
CSI 3.02rCSI 3.68%PRS 72.72
-
CSI 2.86rCSI 4.81%PRS 46.61
-
CSI 2.82rCSI 17.59%PRS 56.9
-
CSI 2.81rCSI 9.98%PRS 73.07
-
CSI 2.77rCSI 3.04%PRS 68.97
-
CSI 2.68rCSI 6.81%PRS 59.16
-
CSI 2.64rCSI 3.99%PRS 69.8
-
CSI 2.63rCSI 4.54%PRS 55.41
-
CSI 2.58rCSI 3.09%PRS 63.31
-
CSI 2.52rCSI 1.95%PRS 67.9
-
CSI 2.51rCSI 1.86%PRS 57.88
-
CSI 2.48rCSI 2.59%PRS 65.59
-
CSI 2.47rCSI 6.27%PRS 54.68
-
CSI 2.46rCSI 4.94%PRS 54.21
-
CSI 2.42rCSI 1.92%PRS 52.06
-
CSI 2.41rCSI 9.04%PRS 57.08
-
CSI 2.4rCSI 5.39%PRS 81.42
-
CSI 2.39rCSI 4.27%PRS 64.5
-
CSI 2.35rCSI 4.77%PRS 44.05
-
CSI 2.32rCSI 2.14%PRS 66.82
-
CSI 2.31rCSI 4.12%PRS 78.05
-
CSI 2.28rCSI 5.11%PRS 47.28
-
CSI 2.27rCSI 3.33%PRS 76.65
-
CSI 2.14rCSI 2.29%PRS 65.1
-
CSI 2.08rCSI 2.98%PRS 68.13
-
CSI 2.07rCSI 3.03%PRS 70.27
-
CSI 2.06rCSI 1.71%PRS 64.7
-
CSI 2.03rCSI 2.13%PRS 61.61
-
CSI 2rCSI 2.65%PRS 71.58
-
CSI 1.98rCSI 3.19%PRS 67.93
-
CSI 1.98rCSI 3.02%PRS 74.39
-
CSI 1.92rCSI 4.43%PRS 53.84
-
CSI 1.91rCSI 1.99%PRS 63.13
-
CSI 1.89rCSI 1.72%PRS 79.46
-
CSI 1.86rCSI 4.45%PRS 52.21
-
CSI 1.85rCSI 1.85%PRS 58.66
-
CSI 1.84rCSI 2.51%PRS 56.74
-
CSI 1.84rCSI 1.69%PRS 74.22
-
CSI 1.8rCSI 2.91%PRS 61.51
-
CSI 1.79rCSI 2.23%PRS 44.77
-
CSI 1.79rCSI 2.29%PRS 57.38
-
CSI 1.77rCSI 4.62%PRS 65.03
-
CSI 1.77rCSI 2.42%PRS 66.51
-
CSI 1.75rCSI 2.48%PRS 61.63
-
CSI 1.74rCSI 4.5%PRS 60.23
-
CSI 1.71rCSI 3%PRS 57.32
-
CSI 1.71rCSI 2.24%PRS 78.54
-
CSI 1.69rCSI 2.7%PRS 57.53
-
CSI 1.69rCSI 2.35%PRS 63.68
-
CSI 1.69rCSI 1.48%PRS 53.11
-
CSI 1.67rCSI 1.61%PRS 56.17
-
CSI 1.64rCSI 13.32%PRS 58.64
-
CSI 1.6rCSI 1.54%PRS 64.99
-
CSI 1.56rCSI 3.7%PRS 68.48
-
CSI 1.53rCSI 3.8%PRS 63.78
-
CSI 1.53rCSI 2.2%PRS 54.72
-
CSI 1.53rCSI 1.76%PRS 58.06
-
CSI 1.49rCSI 1.92%PRS 47.88
-
CSI 1.48rCSI 5.74%PRS 78.93
-
CSI 1.47rCSI 2.15%PRS 60.63
-
CSI 1.47rCSI 7.02%PRS 65.19
-
CSI 1.45rCSI 1.73%PRS 46.39
-
CSI 1.44rCSI 2.31%PRS 48.56
-
CSI 1.42rCSI 3.45%PRS 45.09
-
CSI 1.39rCSI 3.08%PRS 51.15
-
CSI 1.38rCSI 2.19%PRS 57.64
-
CSI 1.34rCSI 1.72%PRS 62.11
-
CSI 1.25rCSI 2.39%PRS 83.7
-
CSI 1.22rCSI 3.89%PRS 62.36
-
CSI 1.13rCSI 1.17%PRS 71.05
-
CSI 1.13rCSI 2.13%PRS 75.59
-
CSI 1.04rCSI 1.2%PRS 55.62
-
CSI 0.97rCSI 1.72%PRS 45.7
-
CSI 0.92rCSI 1.89%PRS 54.97
-
CSI 0.91rCSI 3.45%PRS 55.8
-
CSI 0.88rCSI 1.72%PRS 68.21
-
CSI 0.73rCSI 2.63%PRS 44.92
-
CSI 0.71rCSI 2.23%PRS 48.3
-
CSI 0.7rCSI 16.75%PRS 45.66
-
CSI 0.66rCSI 2.92%PRS 65.11
-
CSI 0.3rCSI 2.1%PRS 51.7%
-
CSI 0.3rCSI 1.7%PRS 79.2%
-
CSI 0.4rCSI 1.7%PRS 82.7%
-
CSI 0.4rCSI 2.3%PRS 47.8%
-
CSI 0.4rCSI 9.5%PRS 46.4%
-
CSI 0.6rCSI 2.4%PRS 47.3%
-
CSI 0.7rCSI 2.9%PRS 65.1%
-
CSI 0.7rCSI 16.8%PRS 45.7%
-
CSI 0.7rCSI 2.2%PRS 48.3%
-
CSI 0.7rCSI 2.6%PRS 44.9%
-
CSI 0.9rCSI 1.7%PRS 68.2%
-
CSI 0.9rCSI 3.5%PRS 55.8%
-
CSI 0.9rCSI 1.9%PRS 55.0%
-
CSI 1.0rCSI 1.7%PRS 45.7%
-
CSI 1.0rCSI 1.2%PRS 55.6%
-
CSI 1.1rCSI 2.1%PRS 75.6%
-
CSI 1.1rCSI 1.2%PRS 71.1%
-
CSI 1.2rCSI 3.9%PRS 62.4%
-
CSI 1.3rCSI 2.4%PRS 83.7%
-
CSI 1.3rCSI 1.7%PRS 62.1%
-
CSI 1.4rCSI 2.2%PRS 57.6%
-
CSI 1.4rCSI 3.1%PRS 51.2%
-
CSI 1.4rCSI 3.5%PRS 45.1%
-
CSI 1.4rCSI 2.3%PRS 48.6%
-
CSI 1.5rCSI 1.7%PRS 46.4%
-
CSI 1.5rCSI 7.0%PRS 65.2%
-
CSI 1.5rCSI 2.2%PRS 60.6%
-
CSI 1.5rCSI 5.7%PRS 78.9%
-
CSI 1.5rCSI 1.9%PRS 47.9%
-
CSI 1.5rCSI 1.8%PRS 58.1%
-
CSI 1.5rCSI 2.2%PRS 54.7%
-
CSI 1.5rCSI 3.8%PRS 63.8%
-
CSI 1.6rCSI 3.7%PRS 68.5%
-
CSI 1.6rCSI 1.5%PRS 65.0%
-
CSI 1.6rCSI 13.3%PRS 58.6%
-
CSI 1.7rCSI 1.6%PRS 56.2%
-
CSI 1.7rCSI 1.5%PRS 53.1%
-
CSI 1.7rCSI 2.4%PRS 63.7%
-
CSI 1.7rCSI 2.7%PRS 57.5%
-
CSI 1.7rCSI 2.2%PRS 78.5%
-
CSI 1.7rCSI 3.0%PRS 57.3%
-
CSI 1.7rCSI 4.5%PRS 60.2%
-
CSI 1.8rCSI 2.5%PRS 61.6%
-
CSI 1.8rCSI 2.4%PRS 66.5%
-
CSI 1.8rCSI 4.6%PRS 65.0%
-
CSI 1.8rCSI 2.3%PRS 57.4%
-
CSI 1.8rCSI 2.2%PRS 44.8%
-
CSI 1.8rCSI 2.9%PRS 61.5%
-
CSI 1.8rCSI 1.7%PRS 74.2%
-
CSI 1.8rCSI 2.5%PRS 56.7%
-
CSI 1.9rCSI 1.9%PRS 58.7%
-
CSI 1.9rCSI 4.5%PRS 52.2%
-
CSI 1.9rCSI 1.7%PRS 79.5%
-
CSI 1.9rCSI 2.0%PRS 63.1%
-
CSI 1.9rCSI 4.4%PRS 53.8%
-
CSI 2.0rCSI 3.0%PRS 74.4%
-
CSI 2.0rCSI 3.2%PRS 67.9%
-
CSI 2.0rCSI 2.7%PRS 71.6%
-
CSI 2.0rCSI 2.1%PRS 61.6%
-
CSI 2.1rCSI 1.7%PRS 64.7%
-
CSI 2.1rCSI 3.0%PRS 70.3%
-
CSI 2.1rCSI 3.0%PRS 68.1%
-
CSI 2.1rCSI 2.3%PRS 65.1%
-
CSI 2.3rCSI 3.3%PRS 76.7%
-
CSI 2.3rCSI 5.1%PRS 47.3%
-
CSI 2.3rCSI 4.1%PRS 78.1%
-
CSI 2.3rCSI 2.1%PRS 66.8%
-
CSI 2.4rCSI 4.8%PRS 44.1%
-
CSI 2.4rCSI 4.3%PRS 64.5%
-
CSI 2.4rCSI 5.4%PRS 81.4%
-
CSI 2.4rCSI 9.0%PRS 57.1%
-
CSI 2.4rCSI 1.9%PRS 52.1%
-
CSI 2.5rCSI 4.9%PRS 54.2%
-
CSI 2.5rCSI 6.3%PRS 54.7%
-
CSI 2.5rCSI 2.6%PRS 65.6%
-
CSI 2.5rCSI 1.9%PRS 57.9%
-
CSI 2.5rCSI 2.0%PRS 67.9%
-
CSI 2.6rCSI 3.1%PRS 63.3%
-
CSI 2.6rCSI 4.5%PRS 55.4%
-
CSI 2.6rCSI 4.0%PRS 69.8%
-
CSI 2.7rCSI 6.8%PRS 59.2%
-
CSI 2.8rCSI 3.0%PRS 69.0%
-
CSI 2.8rCSI 10.0%PRS 73.1%
-
CSI 2.8rCSI 17.6%PRS 56.9%
-
CSI 2.9rCSI 4.8%PRS 46.6%
-
CSI 3.0rCSI 3.7%PRS 72.7%
-
CSI 3.0rCSI 6.9%PRS 65.3%
-
CSI 3.2rCSI 2.4%PRS 66.1%
-
CSI 3.2rCSI 3.8%PRS 74.0%
-
CSI 3.6rCSI 10.6%PRS 75.0%
-
CSI 3.6rCSI 4.6%PRS 69.9%
-
CSI 3.6rCSI 7.9%PRS 77.1%
-
CSI 3.7rCSI 7.0%PRS 53.3%
-
CSI 3.8rCSI 5.2%PRS 58.2%
-
CSI 3.9rCSI 3.9%PRS 67.9%
-
CSI 4.0rCSI 4.1%PRS 68.7%
-
CSI 4.2rCSI 9.6%PRS 61.2%
-
CSI 4.4rCSI 9.9%PRS 73.0%
-
CSI 5.2rCSI 16.3%PRS 50.7%
-
CSI 5.3rCSI 7.8%PRS 58.4%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3766308736
Symbol: SGPL1_HUMAN
Name: Sphingosine-1-phosphate aldolase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11018465
Title: Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22.
PubMed ID: 11018465
PubMed ID: 14570870
Title: Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis.
PubMed ID: 14570870
PubMed ID: 10574462
Title: Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10574462
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 16777052
Title: Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry.
PubMed ID: 16777052
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22784711
Title: First evidence of sphingosine 1-phosphate lyase protein expression and activity downregulation in human neoplasm: implication for resistance to therapeutics in prostate cancer.
PubMed ID: 22784711
PubMed ID: 24809814
Title: Orally active 7-substituted (4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as active-site inhibitors of sphingosine 1-phosphate lyase for the treatment of multiple sclerosis.
PubMed ID: 24809814
DOI: 10.1021/jm500338n
PubMed ID: 28181337
Title: Deficiency of the sphingosine-1-phosphate lyase SGPL1 is associated with congenital nephrotic syndrome and congenital adrenal calcifications.
PubMed ID: 28181337
DOI: 10.1002/humu.23192
PubMed ID: 28165339
Title: Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency.
PubMed ID: 28165339
DOI: 10.1172/jci89626
PubMed ID: 28165343
Title: Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome.
PubMed ID: 28165343
DOI: 10.1172/jci90171
PubMed ID: 30090628
Title: Nephrotic syndrome and adrenal insufficiency caused by a variant in SGPL1.
PubMed ID: 30090628
DOI: 10.1093/ckj/sfx130
PubMed ID: 28077491
Title: Sphingosine 1-phosphate lyase deficiency causes Charcot-Marie-Tooth neuropathy.
PubMed ID: 28077491
PubMed ID: 30517686
Title: SGPL1 Deficiency: A Rare Cause of Primary Adrenal Insufficiency.
PubMed ID: 30517686
PubMed ID: 30635364
Title: Fifty years of lyase and a moment of truth: Sphingosine phosphate lyase from discovery to disease.
PubMed ID: 30635364
DOI: 10.1194/jlr.s091181
Sequence Information:
- Length: 568
- Mass: 63524
- Checksum: 3B16FDEFC4B2FDB6
- Sequence:
MPSTDLLMLK AFEPYLEILE VYSTKAKNYV NGHCTKYEPW QLIAWSVVWT LLIVWGYEFV FQPESLWSRF KKKCFKLTRK MPIIGRKIQD KLNKTKDDIS KNMSFLKVDK EYVKALPSQG LSSSAVLEKL KEYSSMDAFW QEGRASGTVY SGEEKLTELL VKAYGDFAWS NPLHPDIFPG LRKIEAEIVR IACSLFNGGP DSCGCVTSGG TESILMACKA YRDLAFEKGI KTPEIVAPQS AHAAFNKAAS YFGMKIVRVP LTKMMEVDVR AMRRAISRNT AMLVCSTPQF PHGVIDPVPE VAKLAVKYKI PLHVDACLGG FLIVFMEKAG YPLEHPFDFR VKGVTSISAD THKYGYAPKG SSLVLYSDKK YRNYQFFVDT DWQGGIYASP TIAGSRPGGI SAACWAALMH FGENGYVEAT KQIIKTARFL KSELENIKGI FVFGNPQLSV IALGSRDFDI YRLSNLMTAK GWNLNQLQFP PSIHFCITLL HARKRVAIQF LKDIRESVTQ IMKNPKAKTT GMGAIYGMAQ TTVDRNMVAE LSSVFLDSLY STDTVTQGSQ MNGSPKPH
Genular Protein ID: 1081875448
Symbol: A0A8V8TN35_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15164054
Title: The DNA sequence and comparative analysis of human chromosome 10.
PubMed ID: 15164054
DOI: 10.1038/nature02462
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
Sequence Information:
- Length: 488
- Mass: 53872
- Checksum: 48FDD3AB4151703A
- Sequence:
MPIIGRKIQD KLNKTKDDIS KNMSFLKVDK EYVKALPSQG LSSSAVLEKL KEYSSMDAFW QEGRASGTVY SGEEKLTELL VKAYGDFAWS NPLHPDIFPG LRKIEAEIVR IACSLFNGGP DSCGCVTSGG TESILMACKA YRDLAFEKGI KTPEIVAPQS AHAAFNKAAS YFGMKIVRVP LTKMMEVDVR AMRRAISRNT AMLVCSTPQF PHGVIDPVPE VAKLAVKYKI PLHVDACLGG FLIVFMEKAG YPLEHPFDFR VKGVTSISAD THKYGYAPKG SSLVLYSDKK YRNYQFFVDT DWQGGIYASP TIAGSRPGGI SAACWAALMH FGENGYVEAT KQIIKTARFL KSELENIKGI FVFGNPQLSV IALGSRDFDI YRLSNLMTAK GWNLNQLQFP PSIHFCITLL HARKRVAIQF LKDIRESVTQ IMKNPKAKTT GMGAIYGMAQ TTVDRNMVAE LSSVFLDSLY STDTVTQGSQ MNGSPKPH