Details for: SLC7A6

Gene ID: 9057

Symbol: SLC7A6

Ensembl ID: ENSG00000103064

Description: solute carrier family 7 member 6

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 4.45
    Marker Score: 1,627
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.73
    Marker Score: 9,349
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 3.34
    Marker Score: 74,646
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 3.14
    Marker Score: 11,157
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.97
    Marker Score: 12,439
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.61
    Marker Score: 824
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.59
    Marker Score: 757
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.59
    Marker Score: 1,702
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.36
    Marker Score: 1,319
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.86
    Marker Score: 2,502
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.68
    Marker Score: 1,853
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.57
    Marker Score: 6,385
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.51
    Marker Score: 886
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.49
    Marker Score: 55,008
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.48
    Marker Score: 14,080
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,230
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.46
    Marker Score: 15,037
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.44
    Marker Score: 88,865
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.41
    Marker Score: 2,182
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.41
    Marker Score: 12,082
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.41
    Marker Score: 13,218
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.39
    Marker Score: 3,043
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.38
    Marker Score: 687
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.37
    Marker Score: 1,662
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.36
    Marker Score: 5,618
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.34
    Marker Score: 50,774
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.26
    Marker Score: 733
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.23
    Marker Score: 1,007
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.22
    Marker Score: 9,386
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.19
    Marker Score: 18,583
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.17
    Marker Score: 400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.15
    Marker Score: 22,915
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.12
    Marker Score: 545
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.12
    Marker Score: 16,742
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.11
    Marker Score: 291
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.08
    Marker Score: 2,069
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.06
    Marker Score: 4,083
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.01
    Marker Score: 1,432
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.01
    Marker Score: 423
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,729
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,954
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.99
    Marker Score: 315
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,397
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.98
    Marker Score: 249
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.96
    Marker Score: 1,002
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.95
    Marker Score: 15,248
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,402
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.94
    Marker Score: 339
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 483
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,713
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.88
    Marker Score: 4,059
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4,932
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.83
    Marker Score: 890
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.83
    Marker Score: 249
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.81
    Marker Score: 485
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 311
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 588
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.77
    Marker Score: 1,285
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.76
    Marker Score: 1,335
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.75
    Marker Score: 186
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.75
    Marker Score: 205
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.75
    Marker Score: 227
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.75
    Marker Score: 1,214
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.74
    Marker Score: 574
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.74
    Marker Score: 370
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.73
    Marker Score: 38,763
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.73
    Marker Score: 881
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.73
    Marker Score: 253
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.72
    Marker Score: 331
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 375
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.72
    Marker Score: 430
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.71
    Marker Score: 183
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2,940
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.7
    Marker Score: 1,993
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.69
    Marker Score: 2,718
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.69
    Marker Score: 250
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 622
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.67
    Marker Score: 1,360
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.66
    Marker Score: 520
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.65
    Marker Score: 1,122
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.64
    Marker Score: 148
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.64
    Marker Score: 732
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.64
    Marker Score: 551
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.63
    Marker Score: 200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.63
    Marker Score: 13,484
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.63
    Marker Score: 203
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.63
    Marker Score: 1,121
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.62
    Marker Score: 572
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.62
    Marker Score: 1,075
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.61
    Marker Score: 2,109
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.61
    Marker Score: 248
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.61
    Marker Score: 274
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.61
    Marker Score: 1,105
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.6
    Marker Score: 651
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.6
    Marker Score: 187
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.59
    Marker Score: 155

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SLC7A6 is a transmembrane protein that belongs to the SLC7 family of solute carriers. It is characterized by its ability to transport cationic amino acids, such as arginine, lysine, and leucine, across cell membranes. The protein is also involved in the transport of other small molecules, including inorganic cations and oligopeptides. SLC7A6 is expressed in various tissues, including those involved in metabolism, cardiovascular function, and immune responses. **Pathways and Functions** SLC7A6 is involved in several biological pathways, including amino acid transmembrane transport, amino acid transmembrane transporter activity, and neutral amino acid transport. The protein plays a crucial role in maintaining the balance of amino acids across cell membranes, which is essential for various cellular processes, such as protein synthesis, degradation, and signaling. SLC7A6 is also involved in the regulation of blood pressure and cardiovascular function through the transport of arginine, a precursor to nitric oxide, which is a key molecule in vascular relaxation. **Clinical Significance** SLC7A6 has been implicated in several diseases, including cardiovascular diseases, metabolic disorders, and cancer. Mutations in the SLC7A6 gene have been associated with various conditions, such as hypertension, atherosclerosis, and kidney disease. The protein's role in amino acid transport also makes it a potential target for the treatment of amino acid-related disorders, such as hyperammonemia and hyperargininemia. In addition, SLC7A6 has been shown to play a role in the regulation of immune responses, particularly in the context of inflammation and tissue repair. The protein's interaction with other molecules, such as basigin, has been implicated in the regulation of cell surface interactions and the modulation of immune responses. **Conclusion** In conclusion, SLC7A6 is a multifunctional protein that plays a crucial role in amino acid transport and other cellular processes. Its involvement in various biological pathways, including cardiovascular function and immune responses, makes it an important target for the treatment of various diseases. Further research is needed to fully elucidate the role of SLC7A6 in human health and disease. **References** * [Insert references to relevant studies and reviews] **Future Directions** * Investigate the role of SLC7A6 in the regulation of cardiovascular function and immune responses in different disease models. * Explore the potential therapeutic applications of SLC7A6 inhibitors or activators in the treatment of amino acid-related disorders and cardiovascular diseases. * Elucidate the molecular mechanisms underlying the interaction between SLC7A6 and other molecules, such as basigin, and their implications for immune responses and tissue repair.

Genular Protein ID: 3330108271

Symbol: YLAT2_HUMAN

Name: Cationic amino acid transporter, y+ system

UniProtKB Accession Codes:

Q92536 Q68DS4 Q7L1N3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 17 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 7 EMDB 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 5 Rhea 6 SABIO-RK 1 SAM 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9039502

Title: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.

PubMed ID: 9039502

DOI: 10.1093/dnares/3.5.321

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9829974

Title: Identification and characterization of a membrane protein (y+L amino acid transporter-1) that associates with 4F2hc to encode the amino acid transport activity y+L. A candidate gene for lysinuric protein intolerance.

PubMed ID: 9829974

DOI: 10.1074/jbc.273.49.32437

PubMed ID: 11078698

Title: Arginine transport through system y(+)L in cultured human fibroblasts: normal phenotype of cells from LPI subjects.

PubMed ID: 11078698

DOI: 10.1152/ajpcell.2000.279.6.c1829

PubMed ID: 10903140

Title: The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine.

PubMed ID: 10903140

DOI: 10.1042/bj3490787

PubMed ID: 11311135

Title: Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2 requires different domains.

PubMed ID: 11311135

DOI: 10.1042/bj3550725

PubMed ID: 11742806

Title: Two-way arginine transport in human endothelial cells: TNF-alpha stimulation is restricted to system y(+).

PubMed ID: 11742806

DOI: 10.1152/ajpcell.2002.282.1.c134

PubMed ID: 14603368

Title: Nitric oxide synthesis requires activity of the cationic and neutral amino acid transport system y+L in human umbilical vein endothelium.

PubMed ID: 14603368

DOI: 10.1113/eph8802647

PubMed ID: 15280038

Title: INFgamma stimulates arginine transport through system y+L in human monocytes.

PubMed ID: 15280038

DOI: 10.1016/j.febslet.2004.06.086

PubMed ID: 15756301

Title: A y(+)LAT-1 mutant protein interferes with y(+)LAT-2 activity: implications for the molecular pathogenesis of lysinuric protein intolerance.

PubMed ID: 15756301

DOI: 10.1038/sj.ejhg.5201376

PubMed ID: 16785209

Title: Mutation of the 4F2 heavy-chain carboxy terminus causes y+ LAT2 light-chain dysfunction.

PubMed ID: 16785209

DOI: 10.1080/09687860600652968

PubMed ID: 17329401

Title: Activation of classical protein kinase C decreases transport via systems y+ and y+L.

PubMed ID: 17329401

DOI: 10.1152/ajpcell.00323.2006

PubMed ID: 17197568

Title: Ornithine transport via cationic amino acid transporter-1 is involved in ornithine cytotoxicity in retinal pigment epithelial cells.

PubMed ID: 17197568

DOI: 10.1167/iovs.06-0398

PubMed ID: 19562367

Title: Arginine transport in human erythroid cells: discrimination of CAT1 and 4F2hc/y+LAT2 roles.

PubMed ID: 19562367

DOI: 10.1007/s00424-009-0692-9

PubMed ID: 31705628

Title: y+LAT1 and y+LAT2 contribution to arginine uptake in different human cell models: Implications in the pathophysiology of Lysinuric Protein Intolerance.

PubMed ID: 31705628

DOI: 10.1111/jcmm.14801

Sequence Information:

  • Length: 515
  • Mass: 56828
  • Checksum: 4E92F6E1972351A9
  • Sequence:
    • MEAREPGRPT PTYHLVPNTS QSQVEEDVSS PPQRSSETMQ LKKEISLLNG VSLVVGNMIG 
SGIFVSPKGV LVHTASYGMS LIVWAIGGLF SVVGALCYAE LGTTITKSGA SYAYILEAFG 
GFIAFIRLWV SLLVVEPTGQ AIIAITFANY IIQPSFPSCD PPYLACRLLA AACICLLTFV 
NCAYVKWGTR VQDTFTYAKV VALIAIIVMG LVKLCQGHSE HFQDAFEGSS WDMGNLSLAL 
YSALFSYSGW DTLNFVTEEI KNPERNLPLA IGISMPIVTL IYILTNVAYY TVLNISDVLS 
SDAVAVTFAD QTFGMFSWTI PIAVALSCFG GLNASIFASS RLFFVGSREG HLPDLLSMIH 
IERFTPIPAL LFNCTMALIY LIVEDVFQLI NYFSFSYWFF VGLSVVGQLY LRWKEPKRPR 
PLKLSVFFPI VFCICSVFLV IVPLFTDTIN SLIGIGIALS GVPFYFMGVY LPESRRPLFI 
RNVLAAITRG TQQLCFCVLT ELDVAEEKKD ERKTD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.