Details for: MTA1
Gene ID: 9112
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: MTA1
Ensembl ID: ENSG00000182979
Description: metastasis associated 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 12.54rCSI 10.19%PRS 50.9
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CSI 7.92rCSI 13.97%PRS 58.7
-
CSI 7.08rCSI 9.68%PRS 52.84
-
CSI 4.36rCSI 3.38%PRS 51.05
-
CSI 4.31rCSI 5.9%PRS 45.56
-
CSI 3.44rCSI 7.61%PRS 47.97
-
CSI 3.03rCSI 4.44%PRS 53.78
-
CSI 2.99rCSI 4.38%PRS 61.85
-
CSI 2.91rCSI 4.63%PRS 61.31
-
CSI 2.9rCSI 2.4%PRS 51.8
-
CSI 2.9rCSI 2.85%PRS 52.98
-
CSI 2.88rCSI 12.24%PRS 45.81
-
CSI 2.83rCSI 5%PRS 32.76
-
CSI 2.79rCSI 5.61%PRS 39.89
-
CSI 2.69rCSI 2%PRS 43.38
-
CSI 2.59rCSI 2.28%PRS 55.72
-
CSI 2.57rCSI 1.52%PRS 66.81
-
CSI 2.53rCSI 2.63%PRS 50.86
-
CSI 2.36rCSI 3.49%PRS 55.75
-
CSI 2.35rCSI 4.07%PRS 40.78
-
CSI 2.34rCSI 1.74%PRS 64
-
CSI 2.27rCSI 5.88%PRS 46.01
-
CSI 2.26rCSI 4.11%PRS 66.72
-
CSI 2.25rCSI 2.73%PRS 58.2
-
CSI 2.24rCSI 1.96%PRS 60.39
-
CSI 2.16rCSI 6.97%PRS 49.2
-
CSI 2.15rCSI 3.83%PRS 65.55
-
CSI 2.15rCSI 2.58%PRS 48.29
-
CSI 2.12rCSI 5.37%PRS 58.65
-
CSI 2.1rCSI 2.87%PRS 55.61
-
CSI 2.09rCSI 1.46%PRS 52.62
-
CSI 2.08rCSI 1.57%PRS 54.57
-
CSI 2.07rCSI 2.63%PRS 56.1
-
CSI 2.07rCSI 1.82%PRS 39.1
-
CSI 2.06rCSI 3.66%PRS 30.01
-
CSI 2.03rCSI 2.91%PRS 56.63
-
CSI 1.98rCSI 1.64%PRS 49.1
-
CSI 1.97rCSI 3.02%PRS 55.08
-
CSI 1.96rCSI 1.55%PRS 37.7
-
CSI 1.95rCSI 1.31%PRS 62.08
-
CSI 1.91rCSI 3.43%PRS 43.64
-
CSI 1.9rCSI 2.9%PRS 46.91
-
CSI 1.82rCSI 1.95%PRS 48.64
-
CSI 1.81rCSI 1.46%PRS 51.23
-
CSI 1.76rCSI 3.57%PRS 31.8
-
CSI 1.74rCSI 2.08%PRS 33.55
-
CSI 1.73rCSI 1.67%PRS 40.93
-
CSI 1.72rCSI 2.66%PRS 48.17
-
CSI 1.72rCSI 3.21%PRS 39.53
-
CSI 1.72rCSI 1.65%PRS 50.67
-
CSI 1.71rCSI 1.81%PRS 63.93
-
CSI 1.68rCSI 2.82%PRS 33.66
-
CSI 1.67rCSI 3.04%PRS 43.31
-
CSI 1.67rCSI 2.66%PRS 42.98
-
CSI 1.66rCSI 2.07%PRS 32
-
CSI 1.63rCSI 1.7%PRS 47.25
-
CSI 1.61rCSI 2.32%PRS 60.3
-
CSI 1.6rCSI 1.67%PRS 49.3
-
CSI 1.58rCSI 1.58%PRS 44.29
-
CSI 1.57rCSI 2.22%PRS 46.88
-
CSI 1.56rCSI 1.8%PRS 44.44
-
CSI 1.53rCSI 2.05%PRS 73.08
-
CSI 1.53rCSI 1.38%PRS 47.15
-
CSI 1.51rCSI 2.05%PRS 43.2
-
CSI 1.5rCSI 2.08%PRS 49.75
-
CSI 1.5rCSI 2.13%PRS 52.87
-
CSI 1.48rCSI 2.4%PRS 48.25
-
CSI 1.47rCSI 1.7%PRS 40.36
-
CSI 1.45rCSI 1.86%PRS 48.24
-
CSI 1.45rCSI 1.7%PRS 53.51
-
CSI 1.44rCSI 1.24%PRS 54.68
-
CSI 1.43rCSI 4.23%PRS 54.4
-
CSI 1.38rCSI 2.48%PRS 48.87
-
CSI 1.35rCSI 1.19%PRS 48.89
-
CSI 1.32rCSI 5.8%PRS 42.88
-
CSI 1.32rCSI 1.65%PRS 60.47
-
CSI 1.31rCSI 3.32%PRS 45.66
-
CSI 1.2rCSI 1.49%PRS 46.15
-
CSI 1.19rCSI 2.67%PRS 34.48
-
CSI 1.19rCSI 12.93%PRS 69.14
-
CSI 1.19rCSI 3.38%PRS 64.31
-
CSI 1.14rCSI 2.52%PRS 54.43
-
CSI 1.14rCSI 3.7%PRS 52.59
-
CSI 1.13rCSI 1.65%PRS 48.73
-
CSI 1.09rCSI 4.24%PRS 57.98
-
CSI 1.09rCSI 1.74%PRS 43.88
-
CSI 1.08rCSI 2.36%PRS 68.3
-
CSI 1.06rCSI 2.01%PRS 71.94
-
CSI 1.04rCSI 1.2%PRS 59.98
-
CSI 0.97rCSI 3.86%PRS 70.24
-
CSI 0.93rCSI 2.31%PRS 48.24
-
CSI 0.89rCSI 2.03%PRS 48.19
-
CSI 0.8rCSI 2.02%PRS 40.29
-
CSI 0.75rCSI 0.65%PRS 60.61
-
CSI 0.74rCSI 2.52%PRS 58.05
-
CSI 0.71rCSI 1.01%PRS 40.92
-
CSI 0.68rCSI 4.28%PRS 42.54
-
CSI 0.65rCSI 2.04%PRS 35.05
-
CSI 0.65rCSI 2.28%PRS 65.01
-
CSI 0.64rCSI 2.43%PRS 42.57
-
CSI 0.2rCSI 1.5%PRS 37.5%
-
CSI 0.2rCSI 4.0%PRS 72.4%
-
CSI 0.2rCSI 5.4%PRS 73.3%
-
CSI 0.3rCSI 5.9%PRS 83.2%
-
CSI 0.3rCSI 1.2%PRS 32.4%
-
CSI 0.3rCSI 2.0%PRS 35.1%
-
CSI 0.4rCSI 1.6%PRS 34.5%
-
CSI 0.5rCSI 2.3%PRS 66.0%
-
CSI 0.6rCSI 0.8%PRS 34.7%
-
CSI 0.6rCSI 2.7%PRS 49.3%
-
CSI 0.6rCSI 1.5%PRS 32.6%
-
CSI 0.6rCSI 3.5%PRS 36.2%
-
CSI 0.6rCSI 2.4%PRS 42.6%
-
CSI 0.7rCSI 2.3%PRS 65.0%
-
CSI 0.7rCSI 2.0%PRS 35.1%
-
CSI 0.7rCSI 4.3%PRS 42.5%
-
CSI 0.7rCSI 1.0%PRS 40.9%
-
CSI 0.7rCSI 2.5%PRS 58.1%
-
CSI 0.8rCSI 0.7%PRS 60.6%
-
CSI 0.8rCSI 2.0%PRS 40.3%
-
CSI 0.9rCSI 2.0%PRS 48.2%
-
CSI 0.9rCSI 2.3%PRS 48.2%
-
CSI 1.0rCSI 3.9%PRS 70.2%
-
CSI 1.0rCSI 1.2%PRS 60.0%
-
CSI 1.1rCSI 2.0%PRS 71.9%
-
CSI 1.1rCSI 2.4%PRS 68.3%
-
CSI 1.1rCSI 1.7%PRS 43.9%
-
CSI 1.1rCSI 4.2%PRS 58.0%
-
CSI 1.1rCSI 1.7%PRS 48.7%
-
CSI 1.1rCSI 3.7%PRS 52.6%
-
CSI 1.1rCSI 2.5%PRS 54.4%
-
CSI 1.2rCSI 3.4%PRS 64.3%
-
CSI 1.2rCSI 12.9%PRS 69.1%
-
CSI 1.2rCSI 2.7%PRS 34.5%
-
CSI 1.2rCSI 1.5%PRS 46.2%
-
CSI 1.3rCSI 3.3%PRS 45.7%
-
CSI 1.3rCSI 1.7%PRS 60.5%
-
CSI 1.3rCSI 5.8%PRS 42.9%
-
CSI 1.4rCSI 1.2%PRS 48.9%
-
CSI 1.4rCSI 2.5%PRS 48.9%
-
CSI 1.4rCSI 4.2%PRS 54.4%
-
CSI 1.4rCSI 1.2%PRS 54.7%
-
CSI 1.5rCSI 1.7%PRS 53.5%
-
CSI 1.5rCSI 1.9%PRS 48.2%
-
CSI 1.5rCSI 1.7%PRS 40.4%
-
CSI 1.5rCSI 2.4%PRS 48.3%
-
CSI 1.5rCSI 2.1%PRS 52.9%
-
CSI 1.5rCSI 2.1%PRS 49.8%
-
CSI 1.5rCSI 2.1%PRS 43.2%
-
CSI 1.5rCSI 1.4%PRS 47.2%
-
CSI 1.5rCSI 2.1%PRS 73.1%
-
CSI 1.6rCSI 1.8%PRS 44.4%
-
CSI 1.6rCSI 2.2%PRS 46.9%
-
CSI 1.6rCSI 1.6%PRS 44.3%
-
CSI 1.6rCSI 1.7%PRS 49.3%
-
CSI 1.6rCSI 2.3%PRS 60.3%
-
CSI 1.6rCSI 1.7%PRS 47.3%
-
CSI 1.7rCSI 2.1%PRS 32.0%
-
CSI 1.7rCSI 2.7%PRS 43.0%
-
CSI 1.7rCSI 3.0%PRS 43.3%
-
CSI 1.7rCSI 2.8%PRS 33.7%
-
CSI 1.7rCSI 1.8%PRS 63.9%
-
CSI 1.7rCSI 1.7%PRS 50.7%
-
CSI 1.7rCSI 3.2%PRS 39.5%
-
CSI 1.7rCSI 2.7%PRS 48.2%
-
CSI 1.7rCSI 1.7%PRS 40.9%
-
CSI 1.7rCSI 2.1%PRS 33.6%
-
CSI 1.8rCSI 3.6%PRS 31.8%
-
CSI 1.8rCSI 1.5%PRS 51.2%
-
CSI 1.8rCSI 2.0%PRS 48.6%
-
CSI 1.9rCSI 2.9%PRS 46.9%
-
CSI 1.9rCSI 3.4%PRS 43.6%
-
CSI 2.0rCSI 1.3%PRS 62.1%
-
CSI 2.0rCSI 1.6%PRS 37.7%
-
CSI 2.0rCSI 3.0%PRS 55.1%
-
CSI 2.0rCSI 1.6%PRS 49.1%
-
CSI 2.0rCSI 2.9%PRS 56.6%
-
CSI 2.1rCSI 3.7%PRS 30.0%
-
CSI 2.1rCSI 1.8%PRS 39.1%
-
CSI 2.1rCSI 2.6%PRS 56.1%
-
CSI 2.1rCSI 1.6%PRS 54.6%
-
CSI 2.1rCSI 1.5%PRS 52.6%
-
CSI 2.1rCSI 2.9%PRS 55.6%
-
CSI 2.1rCSI 5.4%PRS 58.7%
-
CSI 2.2rCSI 2.6%PRS 48.3%
-
CSI 2.2rCSI 3.8%PRS 65.6%
-
CSI 2.2rCSI 7.0%PRS 49.2%
-
CSI 2.2rCSI 2.0%PRS 60.4%
-
CSI 2.3rCSI 2.7%PRS 58.2%
-
CSI 2.3rCSI 4.1%PRS 66.7%
-
CSI 2.3rCSI 5.9%PRS 46.0%
-
CSI 2.3rCSI 1.7%PRS 64.0%
-
CSI 2.4rCSI 4.1%PRS 40.8%
-
CSI 2.4rCSI 3.5%PRS 55.8%
-
CSI 2.5rCSI 2.6%PRS 50.9%
-
CSI 2.6rCSI 1.5%PRS 66.8%
-
CSI 2.6rCSI 2.3%PRS 55.7%
-
CSI 2.7rCSI 2.0%PRS 43.4%
-
CSI 2.8rCSI 5.6%PRS 39.9%
-
CSI 2.8rCSI 5.0%PRS 32.8%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2839155052
Symbol: MTA1_HUMAN
Name: Metastasis-associated protein MTA1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8083195
Title: A novel candidate metastasis-associated gene, mta1, differentially expressed in highly metastatic mammary adenocarcinoma cell lines. cDNA cloning, expression, and protein analyses.
PubMed ID: 8083195
PubMed ID: 7607577
Title: Analysis of the complete sequence of the novel metastasis-associated candidate gene, mta1, differentially expressed in mammary adenocarcinoma and breast cancer cell lines.
PubMed ID: 7607577
PubMed ID: 12167865
Title: A naturally occurring MTA1 variant sequesters oestrogen receptor-alpha in the cytoplasm.
PubMed ID: 12167865
DOI: 10.1038/nature00889
PubMed ID: 12508121
Title: The DNA sequence and analysis of human chromosome 14.
PubMed ID: 12508121
DOI: 10.1038/nature01348
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9885572
Title: NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities.
PubMed ID: 9885572
PubMed ID: 15254226
Title: Metastasis-associated protein 1 interacts with NRIF3, an estrogen-inducible nuclear receptor coregulator.
PubMed ID: 15254226
PubMed ID: 15077195
Title: Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase.
PubMed ID: 15077195
PubMed ID: 15701600
Title: MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing.
PubMed ID: 15701600
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 16617102
Title: MTA1, a transcriptional activator of breast cancer amplified sequence 3.
PubMed ID: 16617102
PubMed ID: 16428440
Title: MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties.
PubMed ID: 16428440
PubMed ID: 17671180
Title: Identification of Pax5 as a target of MTA1 in B-cell lymphomas.
PubMed ID: 17671180
PubMed ID: 25948590
PubMed ID: 18220336
Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
PubMed ID: 18220336
DOI: 10.1021/pr0705441
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 17922032
Title: MTA1-mediated transcriptional repression of BRCA1 tumor suppressor gene.
PubMed ID: 17922032
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19837670
Title: MTA1 coregulator regulates p53 stability and function.
PubMed ID: 19837670
PubMed ID: 19805145
Title: E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1.
PubMed ID: 19805145
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20682799
Title: Metastasis-associated protein 1 and its short form variant stimulates Wnt1 transcription through promoting its derepression from Six3 corepressor.
PubMed ID: 20682799
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21965678
Title: SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function.
PubMed ID: 21965678
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22253283
Title: Metastasis-associated protein 1/nucleosome remodeling and histone deacetylase complex in cancer.
PubMed ID: 22253283
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 22926524
Title: RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene.
PubMed ID: 22926524
DOI: 10.1038/onc.2012.386
PubMed ID: 24413532
Title: Differential regulation of estrogen receptor alpha expression in breast cancer cells by metastasis-associated protein 1.
PubMed ID: 24413532
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24970816
Title: The subcellular distribution and function of MTA1 in cancer differentiation.
PubMed ID: 24970816
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 28977666
Title: CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.
PubMed ID: 28977666
DOI: 10.1093/nar/gkx711
PubMed ID: 30327463
Title: PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex.
PubMed ID: 30327463
PubMed ID: 33283408
Title: Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.
PubMed ID: 33283408
DOI: 10.1111/febs.15650
PubMed ID: 24920672
Title: Insight into the architecture of the NuRD complex: structure of the RbAp48-MTA1 subcomplex.
PubMed ID: 24920672
Sequence Information:
- Length: 715
- Mass: 80786
- Checksum: 2D5330F0489AE62E
- Sequence:
MAANMYRVGD YVYFENSSSN PYLIRRIEEL NKTANGNVEA KVVCFYRRRD ISSTLIALAD KHATLSVCYK AGPGADNGEE GEIEEEMENP EMVDLPEKLK HQLRHRELFL SRQLESLPAT HIRGKCSVTL LNETESLKSY LEREDFFFYS LVYDPQQKTL LADKGEIRVG NRYQADITDL LKEGEEDGRD QSRLETQVWE AHNPLTDKQI DQFLVVARSV GTFARALDCS SSVRQPSLHM SAAAASRDIT LFHAMDTLHK NIYDISKAIS ALVPQGGPVL CRDEMEEWSA SEANLFEEAL EKYGKDFTDI QQDFLPWKSL TSIIEYYYMW KTTDRYVQQK RLKAAEAESK LKQVYIPNYN KPNPNQISVN NVKAGVVNGT GAPGQSPGAG RACESCYTTQ SYQWYSWGPP NMQCRLCASC WTYWKKYGGL KMPTRLDGER PGPNRSNMSP HGLPARSSGS PKFAMKTRQA FYLHTTKLTR IARRLCREIL RPWHAARHPY LPINSAAIKA ECTARLPEAS QSPLVLKQAV RKPLEAVLRY LETHPRPPKP DPVKSVSSVL SSLTPAKVAP VINNGSPTIL GKRSYEQHNG VDGNMKKRLL MPSRGLANHG QARHMGPSRN LLLNGKSYPT KVRLIRGGSL PPVKRRRMNW IDAPDDVFYM ATEETRKIRK LLSSSETKRA ARRPYKPIAL RQSQALPPRP PPPAPVNDEP IVIED
Genular Protein ID: 547721089
Symbol: Q9BRL8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 255
- Mass: 28706
- Checksum: 9E640D1DA92429A9
- Sequence:
MKTRQAFYLH TTKLTRIARR LCREILRPWH AARHPYLPIN SAAIKAECTA RLPEASQSPL VLKQAVRKPL EAVLRYLETH PRPPKPDPVK SVSSVLSSLT PAKVAPVINN GSPTILGKRS YEQHNGVDGN MKKRLLMPSR GTYLGLANHG QTRHMGPSRN LLLNGKSYPT KVRLIRGGSL PPVKRRRMNW IDAPDDVFYM ATEETRKIRK LLSSSETKRA ARRPYKPIAL RQSQALPPRP PPPAPVNDEP IVIED