Details for: LRRFIP2

Gene ID: 9209

Symbol: LRRFIP2

Ensembl ID: ENSG00000093167

Description: LRR binding FLII interacting protein 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 4.42
    Marker Score: 11,072
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 4.35
    Marker Score: 97,303
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.93
    Marker Score: 6,426
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.88
    Marker Score: 10,239
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.74
    Marker Score: 11,467
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.68
    Marker Score: 1,488
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.62
    Marker Score: 1,523
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.57
    Marker Score: 38,407
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.56
    Marker Score: 3,450
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.41
    Marker Score: 18,452
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.28
    Marker Score: 10,570
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.27
    Marker Score: 45,111
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.26
    Marker Score: 2,733
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.25
    Marker Score: 85,599
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.25
    Marker Score: 48,030
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.23
    Marker Score: 1,758
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.23
    Marker Score: 75,325
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.22
    Marker Score: 5,425
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.16
    Marker Score: 1,172
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.15
    Marker Score: 2,268
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.15
    Marker Score: 678
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.14
    Marker Score: 8,249
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.13
    Marker Score: 78,498
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.12
    Marker Score: 620
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.12
    Marker Score: 2,266
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.12
    Marker Score: 1,876
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.11
    Marker Score: 5,048
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.08
    Marker Score: 8,621
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.07
    Marker Score: 2,284
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.06
    Marker Score: 1,085
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.02
    Marker Score: 7,800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.01
    Marker Score: 1,178
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.01
    Marker Score: 1,394
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.99
    Marker Score: 2,255
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.97
    Marker Score: 2,270
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.97
    Marker Score: 825
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.93
    Marker Score: 3,427
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.92
    Marker Score: 118,378
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.91
    Marker Score: 1,115
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.9
    Marker Score: 2,046
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.89
    Marker Score: 30,357
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.86
    Marker Score: 3,576
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.81
    Marker Score: 5,688
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.81
    Marker Score: 17,209
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.8
    Marker Score: 2,246
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.8
    Marker Score: 16,885
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.78
    Marker Score: 454
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.77
    Marker Score: 7,193
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.75
    Marker Score: 15,021
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.75
    Marker Score: 5,726
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.74
    Marker Score: 18,000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.71
    Marker Score: 58,120
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.67
    Marker Score: 1,444
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.66
    Marker Score: 2,407
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.65
    Marker Score: 586
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.64
    Marker Score: 2,362
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 1.64
    Marker Score: 494
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.63
    Marker Score: 610
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.63
    Marker Score: 1,553
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.62
    Marker Score: 789
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.61
    Marker Score: 1,240
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.6
    Marker Score: 544
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.59
    Marker Score: 457
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.58
    Marker Score: 432
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.58
    Marker Score: 941
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.57
    Marker Score: 452
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.57
    Marker Score: 10,070
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.54
    Marker Score: 2,377
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.54
    Marker Score: 847
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.52
    Marker Score: 1,963
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.51
    Marker Score: 1,871
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.5
    Marker Score: 1,751
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.5
    Marker Score: 83,637
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.48
    Marker Score: 7,961
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.47
    Marker Score: 12,674
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.46
    Marker Score: 815
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.46
    Marker Score: 6,282
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.46
    Marker Score: 538
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.45
    Marker Score: 11,301
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.43
    Marker Score: 1,195
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.43
    Marker Score: 538
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.42
    Marker Score: 6,955
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.42
    Marker Score: 350
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.42
    Marker Score: 449
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.41
    Marker Score: 2,002
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.39
    Marker Score: 5,811
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.38
    Marker Score: 1,660
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.37
    Marker Score: 441
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.35
    Marker Score: 845
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.35
    Marker Score: 1,242
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.34
    Marker Score: 1,424
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.34
    Marker Score: 971
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.34
    Marker Score: 6,412
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.34
    Marker Score: 1,439
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.33
    Marker Score: 452
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.33
    Marker Score: 1,965
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.33
    Marker Score: 483
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.32
    Marker Score: 1,658
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.32
    Marker Score: 1,314
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.31
    Marker Score: 3,751

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural Features:** LRRFIP2 contains leucine-rich repeats (LRRs), which are conserved domains found in various proteins involved in cell signaling and protein-protein interactions. 2. **Cellular Expression:** LRRFIP2 is expressed in multiple cell types, including skeletal muscle fibers, cardiac myocytes, epithelial cells, and neural cells. 3. **Protein Interactions:** LRRFIP2 interacts with other proteins, such as LRRF1, to regulate transcriptional processes and modulate signaling pathways. 4. **Signaling Pathways:** LRRFIP2 is involved in the regulation of DNA-templated transcription and the Wnt signaling pathway, which are critical for cellular development and homeostasis. **Pathways and Functions:** 1. **DNA-templated Transcription:** LRRFIP2 interacts with transcription factors and co-activators to regulate the expression of target genes involved in cellular development and homeostasis. 2. **Wnt Signaling Pathway:** LRRFIP2 modulates the Wnt signaling pathway, which is involved in cell proliferation, differentiation, and survival. 3. **Cellular Homeostasis:** LRRFIP2 plays a role in maintaining cellular homeostasis by regulating the expression of genes involved in cell growth, differentiation, and survival. 4. **Regulation of Gene Expression:** LRRFIP2 regulates the expression of genes involved in various cellular processes, including cell signaling, transcriptional regulation, and protein-protein interactions. **Clinical Significance:** 1. **Cancer:** Alterations in LRRFIP2 expression have been linked to various cancers, including breast, lung, and colon cancer. 2. **Neurological Disorders:** LRRFIP2 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cardiovascular Disease:** LRRFIP2 plays a role in regulating cardiac function and has been linked to cardiovascular disease. 4. **Immunological Disorders:** LRRFIP2 has been implicated in the regulation of immune responses and has been linked to immunological disorders, such as autoimmune diseases. In conclusion, LRRFIP2 is a multifunctional gene that plays a critical role in various cellular processes, including transcriptional regulation, cell signaling, and cellular homeostasis. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, cardiovascular disease, and immunological disorders. Further research is needed to fully elucidate the role of LRRFIP2 in human health and disease.

Genular Protein ID: 1430588016

Symbol: LRRF2_HUMAN

Name: Leucine-rich repeat flightless-interacting protein 2

UniProtKB Accession Codes:

Q9Y608 A8K649 A8MXR0 B4DY63 Q68CV3 Q9NXH5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 5 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 RefSeq 12 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10366446

Title: Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system.

PubMed ID: 10366446

DOI: 10.1006/geno.1999.5817

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21220426

Title: Unambiguous characterization of site-specific phosphorylation of leucine-rich repeat Fli-I-interacting protein 2 (LRRFIP2) in Toll-like receptor 4 (TLR4)-mediated signaling.

PubMed ID: 21220426

DOI: 10.1074/jbc.m110.168179

PubMed ID: 15677333

Title: Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis.

PubMed ID: 15677333

DOI: 10.1073/pnas.0409472102

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17693683

Title: Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.

PubMed ID: 17693683

DOI: 10.1074/mcp.m700120-mcp200

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19265123

Title: Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins.

PubMed ID: 19265123

DOI: 10.4049/jimmunol.0802260

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 721
  • Mass: 82171
  • Checksum: 94B18B274656CB0B
  • Sequence:
    • MGTPASGRKR TPVKDRFSAE DEALSNIARE AEARLAAKRA ARAEARDIRM RELERQQKEY 
SLHSFDRKWG QIQKWLEDSE RARYSHRSSH HRPYLGVEDA LSIRSVGSHR YDMFKDRSSR 
LSSLNHSYSH SHGMKKRSSD SHKDLLSGLY FDQRNYSSLR HSKPTSAYYT RQSSSLYSDP 
LATYKSDRAS PTANSGLLRS ASLASLYNGG LYNPYGPRTP SECSYYSSRI SSARSSPGFT 
NDDTASIVSS DRASRGRRES VVSAADYFSR SNRRGSVVSE VDDISIPDLS SLDEKSDKQY 
AENYTRPSSR NSASATTPLS GNSSRRGSGD TSSLIDPDTS LSELRDIYDL KDQIQDVEGR 
YMQGLKELKE SLSEVEEKYK KAMVSNAQLD NEKNNLIYQV DTLKDVIEEQ EEQMAEFYRE 
NEEKSKELER QKHMCSVLQH KMEELKEGLR QRDELIEEKQ RMQQKIDTMT KEVFDLQETL 
LWKDKKIGAL EKQKEYIACL RNERDMLREE LADLQETVKT GEKHGLVIIP DGTPNGDVSH 
EPVAGAITVV SQEAAQVLES AGEGPLDVRL RKLAGEKEEL LSQIRKLKLQ LEEERQKCSR 
NDGTVGDLAG LQNGSDLQFI EMQRDANRQI SEYKFKLSKA EQDITTLEQS ISRLEGQVLR 
YKTAAENAEK VEDELKAEKR KLQRELRTAL DKIEEMEMTN SHLAKRLEKM KANRTALLAQ 
Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.