Details for: GNA12

Gene ID: 2768

Symbol: GNA12

Ensembl ID: ENSG00000146535

Description: G protein subunit alpha 12

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 4.44
    Marker Score: 3644
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.31
    Marker Score: 49388
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.9
    Marker Score: 7937
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.86
    Marker Score: 2501
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.72
    Marker Score: 65316
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.71
    Marker Score: 17294
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.68
    Marker Score: 25096
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.67
    Marker Score: 12810
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.64
    Marker Score: 15457
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.63
    Marker Score: 6321
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.61
    Marker Score: 6566
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.61
    Marker Score: 1947
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.54
    Marker Score: 857
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.52
    Marker Score: 15744
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.51
    Marker Score: 472
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.51
    Marker Score: 55551
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.5
    Marker Score: 14229
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.47
    Marker Score: 90272
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.46
    Marker Score: 1686
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.46
    Marker Score: 12567
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.44
    Marker Score: 463
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.37
    Marker Score: 7172.5
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.36
    Marker Score: 5641
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.33
    Marker Score: 2054
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.31
    Marker Score: 3088
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.29
    Marker Score: 5087
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.29
    Marker Score: 20172
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.24
    Marker Score: 2527
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.23
    Marker Score: 2365
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.21
    Marker Score: 24020
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.19
    Marker Score: 696
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.16
    Marker Score: 1431
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.1
    Marker Score: 661
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.04
    Marker Score: 6255
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.03
    Marker Score: 1010
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.02
    Marker Score: 1707
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71735
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47959.5
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.99
    Marker Score: 654
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.98
    Marker Score: 2800
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30398
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.97
    Marker Score: 365
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.96
    Marker Score: 5180
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.96
    Marker Score: 303
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2404
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.94
    Marker Score: 2070.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 485
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.93
    Marker Score: 522
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 440
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.92
    Marker Score: 876
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2717
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.89
    Marker Score: 281
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.88
    Marker Score: 760
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.88
    Marker Score: 256
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4975
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.87
    Marker Score: 415
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.86
    Marker Score: 1396
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.86
    Marker Score: 512
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.85
    Marker Score: 6420
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.85
    Marker Score: 15034
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.85
    Marker Score: 1055
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.84
    Marker Score: 3895
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.84
    Marker Score: 469
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.82
    Marker Score: 216
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.82
    Marker Score: 801
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.82
    Marker Score: 516
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.81
    Marker Score: 339
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.81
    Marker Score: 18032
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.81
    Marker Score: 391
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.81
    Marker Score: 232
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.8
    Marker Score: 867
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.8
    Marker Score: 324
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8
    Marker Score: 27315
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.8
    Marker Score: 464
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.79
    Marker Score: 6908
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.78
    Marker Score: 288
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 311.5
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.78
    Marker Score: 384
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.78
    Marker Score: 2871
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.77
    Marker Score: 3216.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 585
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.76
    Marker Score: 25715
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.76
    Marker Score: 12207
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.76
    Marker Score: 1808
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.74
    Marker Score: 899
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 378
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.73
    Marker Score: 439
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.72
    Marker Score: 781
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.72
    Marker Score: 252
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.72
    Marker Score: 165
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.72
    Marker Score: 247
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.71
    Marker Score: 485
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.7
    Marker Score: 368
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.69
    Marker Score: 156
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.69
    Marker Score: 1576
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.68
    Marker Score: 2855
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.68
    Marker Score: 263

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Other Information

**Key characteristics** * The GNA12 gene is located on chromosome 15q21.1. * It is a large gene, encoding for a protein of 1271 amino acids. * GNA12 is a member of the G protein-coupled receptor (GPCR) family of proteins. * It is a key regulator of the adenylate cyclase-modulating g protein-coupled receptor signaling pathway. **Pathways and functions** * GNA12 is involved in the regulation of cell signaling pathways, including the adenylate cyclase-modulating g protein-coupled receptor signaling pathway, the blood coagulation pathway, and the G protein-coupled receptor signaling pathway. * It is also involved in platelet activation, signaling, and aggregation. * GNA12 is a key regulator of the regulation of blood volume and blood pressure. **Clinical significance** Mutations in the GNA12 gene have been linked to a number of human diseases, including cerebral vascular disease, stroke, and heart failure. These mutations can lead to the dysfunction of GNA12 protein, resulting in abnormal cell signaling and cell death. **Additional information** * GNA12 is a relatively new gene, with the first known gene product being identified in 1999. * The protein is expressed in a variety of cell types, including neurons, astrocytes, and endothelial cells. * GNA12 is a well-characterized protein that has been extensively studied in research.

Genular Protein ID: 1459385298

Symbol: GNA12_HUMAN

Name: Guanine nucleotide-binding protein subunit alpha-12

UniProtKB Accession Codes:

Q03113 A4D204 B3KXS2 B7Z3F7 Q2T9L1 Q5PPR5 Q86UM8 Q8TD71 Q9UDU9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEBI 6 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 31 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8423800

Title: Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product.

PubMed ID: 8423800

DOI: 10.1128/mcb.13.2.762-768.1993

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10026210

Title: A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho.

PubMed ID: 10026210

DOI: 10.1074/jbc.274.9.5868

PubMed ID: 11094164

Title: Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho.

PubMed ID: 11094164

DOI: 10.1016/s0014-5793(00)02224-9

PubMed ID: 11976333

Title: Galpha12 and Galpha13 negatively regulate the adhesive functions of cadherin.

PubMed ID: 11976333

DOI: 10.1074/jbc.m201984200

PubMed ID: 12515866

Title: Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF.

PubMed ID: 12515866

DOI: 10.1073/pnas.0234057100

PubMed ID: 15525651

Title: Galpha12 directly interacts with PP2A: evidence for Galpha12-stimulated PP2A phosphatase activity and dephosphorylation of microtubule-associated protein, tau.

PubMed ID: 15525651

DOI: 10.1074/jbc.c400508200

PubMed ID: 15240885

Title: A role for Galpha12/Galpha13 in p120ctn regulation.

PubMed ID: 15240885

DOI: 10.1073/pnas.0401366101

PubMed ID: 16202387

Title: Socius, a novel binding partner of Galpha12/13, promotes the Galpha12-induced RhoA activation.

PubMed ID: 16202387

DOI: 10.1016/j.bbrc.2005.09.097

PubMed ID: 15980433

Title: G alpha12 interaction with alphaSNAP induces VE-cadherin localization at endothelial junctions and regulates barrier function.

PubMed ID: 15980433

DOI: 10.1074/jbc.m502844200

PubMed ID: 16787920

Title: A role for the G12 family of heterotrimeric G proteins in prostate cancer invasion.

PubMed ID: 16787920

DOI: 10.1074/jbc.m604376200

PubMed ID: 16705036

Title: The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis.

PubMed ID: 16705036

DOI: 10.1073/pnas.0510254103

PubMed ID: 17565996

Title: Galpha12 stimulates apoptosis in epithelial cells through JNK1-mediated Bcl-2 degradation and up-regulation of IkappaBalpha.

PubMed ID: 17565996

DOI: 10.1074/jbc.m702804200

PubMed ID: 18703424

Title: RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits.

PubMed ID: 18703424

DOI: 10.1095/biolreprod.107.067504

PubMed ID: 22609986

Title: PRR5L degradation promotes mTORC2-mediated PKC-delta phosphorylation and cell migration downstream of Galpha12.

PubMed ID: 22609986

DOI: 10.1038/ncb2507

PubMed ID: 23762476

Title: Galpha(1)(2) drives invasion of oral squamous cell carcinoma through up-regulation of proinflammatory cytokines.

PubMed ID: 23762476

DOI: 10.1371/journal.pone.0066133

PubMed ID: 27084452

Title: Galpha12/13 signaling promotes cervical cancer invasion through the RhoA/ROCK-JNK signaling axis.

PubMed ID: 27084452

DOI: 10.1016/j.bbrc.2016.04.048

Sequence Information:

  • Length: 381
  • Mass: 44279
  • Checksum: 04C3F12B29255F89
  • Sequence:
    • MSGVVRTLSR CLLPAEAGGA RERRAGSGAR DAEREARRRS RDIDALLARE RRAVRRLVKI 
LLLGAGESGK STFLKQMRII HGREFDQKAL LEFRDTIFDN ILKGSRVLVD ARDKLGIPWQ 
YSENEKHGMF LMAFENKAGL PVEPATFQLY VPALSALWRD SGIREAFSRR SEFQLGESVK 
YFLDNLDRIG QLNYFPSKQD ILLARKATKG IVEHDFVIKK IPFKMVDVGG QRSQRQKWFQ 
CFDGITSILF MVSSSEYDQV LMEDRRTNRL VESMNIFETI VNNKLFFNVS IILFLNKMDL 
LVEKVKTVSI KKHFPDFRGD PHRLEDVQRY LVQCFDRKRR NRSKPLFHHF TTAIDTENVR 
FVFHAVKDTI LQENLKDIML Q

Genular Protein ID: 2143526894

Symbol: Q6ZQV4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6ZQV4

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 5 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 2 SMART 1 SMR 1 SUPFAM 2

Sequence Information:

  • Length: 233
  • Mass: 27618
  • Checksum: 048B1571D245BCAD
  • Sequence:
    • MIYPLIVLPL CASWHWGLIR KGIVLFWGES VKYFLDNLDR IGQLNYFPSK QDILLARKAT 
KGIVEHDFVI KKIPFKMADV GGQRSQRQKW FQCFDGITSI LFMVSSSEYD QVLMEDRRTN 
RLVESMNIFE TIVNNKLFFN VSIILFLNKM DLLVEKVKTV SIKKHFPDFR GDPHRLEDVQ 
RYLVQCFDRK RRNRSKPLFH HFTTAIDTEN VRFVFHAVKD TILQENLKDI MLQ

Genular Protein ID: 2231536759

Symbol: E9PC54_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PC54

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 3 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMART 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

Sequence Information:

  • Length: 305
  • Mass: 35196
  • Checksum: 0A76CE1AD141672F
  • Sequence:
    • MAPRAGLGAG PLLLRSRADW VCGGWEAALS APPPFCTAWV ERTGLVHFLR EGGHGACFPL 
ALLHPGSVVS FQMIYPLIVL PLCASWHWGL IRKGIVLFWG ESVKYFLDNL DRIGQLNYFP 
SKQDILLARK ATKGIVEHDF VIKKIPFKMV DVGGQRSQRQ KWFQCFDGIT SILFMVSSSE 
YDQVLMEDRR TNRLVESMNI FETIVNNKLF FNVSIILFLN KMDLLVEKVK TVSIKKHFPD 
FRGDPHRLED VQRYLVQCFD RKRRNRSKPL FHHFTTAIDT ENVRFVFHAV KDTILQENLK 
DIMLQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.