Gene GNG4 - ENSG00000168243 | NCBI Gene ID: 2786

Details for: GNG4

Gene ID: 2786

Symbol: GNG4

Ensembl ID: ENSG00000168243

Description: G protein subunit gamma 4

Associated with

Activation of gabab receptors
(R-HSA-991365)
Activation of g protein gated potassium channels
(R-HSA-1296041)
Activation of kainate receptors upon glutamate binding
(R-HSA-451326)
Adora2b mediated anti-inflammatory cytokines production
(R-HSA-9660821)
Adp signalling through p2y purinoceptor 1
(R-HSA-418592)
Adp signalling through p2y purinoceptor 12
(R-HSA-392170)
Adrenaline,noradrenaline inhibits insulin secretion
(R-HSA-400042)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Aquaporin-mediated transport
(R-HSA-445717)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
Ca2+ pathway
(R-HSA-4086398)
Chaperonin-mediated protein folding
(R-HSA-390466)
Class b/2 (secretin family receptors)
(R-HSA-373080)
Cooperation of pdcl (phlp1) and tric/cct in g-protein beta folding
(R-HSA-6814122)
Disease
(R-HSA-1643685)
Esr-mediated signaling
(R-HSA-8939211)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
G-protein activation
(R-HSA-202040)
G-protein beta:gamma signalling
(R-HSA-397795)
Gaba b receptor activation
(R-HSA-977444)
Gaba receptor activation
(R-HSA-977443)
G alpha (12/13) signalling events
(R-HSA-416482)
G alpha (i) signalling events
(R-HSA-418594)
G alpha (q) signalling events
(R-HSA-416476)
G alpha (s) signalling events
(R-HSA-418555)
G alpha (z) signalling events
(R-HSA-418597)
G beta:gamma signalling through btk
(R-HSA-8964315)
G beta:gamma signalling through cdc42
(R-HSA-8964616)
G beta:gamma signalling through pi3kgamma
(R-HSA-392451)
G beta:gamma signalling through plc beta
(R-HSA-418217)
Glucagon-like peptide-1 (glp1) regulates insulin secretion
(R-HSA-381676)
Glucagon-type ligand receptors
(R-HSA-420092)
Glucagon signaling in metabolic regulation
(R-HSA-163359)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Gper1 signaling
(R-HSA-9634597)
G protein gated potassium channels
(R-HSA-1296059)
Hemostasis
(R-HSA-109582)
Infectious disease
(R-HSA-5663205)
Inhibition of voltage gated ca2+ channels via gbeta/gamma subunits
(R-HSA-997272)
Integration of energy metabolism
(R-HSA-163685)
Inwardly rectifying k+ channels
(R-HSA-1296065)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Metabolism
(R-HSA-1430728)
Metabolism of proteins
(R-HSA-392499)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Opioid signalling
(R-HSA-111885)
Parasitic infection pathways
(R-HSA-9824443)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet homeostasis
(R-HSA-418346)
Potassium channels
(R-HSA-1296071)
Presynaptic function of kainate receptors
(R-HSA-500657)
Prostacyclin signalling through prostacyclin receptor
(R-HSA-392851)
Protein folding
(R-HSA-391251)
Regulation of insulin secretion
(R-HSA-422356)
Signal amplification
(R-HSA-392518)
Signaling by gpcr
(R-HSA-372790)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Thrombin signalling through proteinase activated receptors (pars)
(R-HSA-456926)
Thromboxane signalling through tp receptor
(R-HSA-428930)
Transmission across chemical synapses
(R-HSA-112315)
Transport of small molecules
(R-HSA-382551)
Vasopressin regulates renal water homeostasis via aquaporins
(R-HSA-432040)
Extracellular exosome
(GO:0070062)
G-protein beta-subunit binding
(GO:0031681)
G protein-coupled receptor signaling pathway
(GO:0007186)
Heterotrimeric g-protein complex
(GO:0005834)
Negative regulation of cell growth
(GO:0030308)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Regulation of g protein-coupled receptor signaling pathway
(GO:0008277)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 2.01
Marker Score: 8319
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.88
Marker Score: 2277
Cell Name: chromaffin cell (CL0000166)
Fold Change: 1.87
Marker Score: 2627
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.86
Marker Score: 27825
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 1.8
Marker Score: 5073
Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.75
Marker Score: 59121
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 1.72
Marker Score: 695
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 1.7
Marker Score: 3528.5
Cell Name: stellate neuron (CL0000122)
Fold Change: 1.62
Marker Score: 8679
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 1.58
Marker Score: 8305
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.55
Marker Score: 5978
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.48
Marker Score: 29432
Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 169071
Cell Name: endocrine cell (CL0000163)
Fold Change: 1.42
Marker Score: 735
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 1.4
Marker Score: 784
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.36
Marker Score: 865
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 1.3
Marker Score: 583
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 1.12
Marker Score: 1582
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.11
Marker Score: 1718
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.1
Marker Score: 1239
Cell Name: decidual cell (CL2000002)
Fold Change: 1.08
Marker Score: 4678
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.08
Marker Score: 626
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 1.06
Marker Score: 367
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251793
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 1.03
Marker Score: 346
Cell Name: neural cell (CL0002319)
Fold Change: 1.01
Marker Score: 486
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 1
Marker Score: 4648
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71812
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48036
Cell Name: PP cell (CL0000696)
Fold Change: 0.99
Marker Score: 223
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 505
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.97
Marker Score: 408
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 458
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.93
Marker Score: 1515
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.93
Marker Score: 3588.5
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.92
Marker Score: 3839
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2740
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.91
Marker Score: 5165
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 324
Cell Name: CNS interneuron (CL0000402)
Fold Change: 0.88
Marker Score: 422
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5296
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 0.83
Marker Score: 956
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.82
Marker Score: 317
Cell Name: sympathetic neuron (CL0011103)
Fold Change: 0.8
Marker Score: 263
Cell Name: interneuron (CL0000099)
Fold Change: 0.79
Marker Score: 363
Cell Name: neuronal brush cell (CL0000555)
Fold Change: 0.78
Marker Score: 2603
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.77
Marker Score: 3241.5
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.76
Marker Score: 306.5
Cell Name: brush cell (CL0002204)
Fold Change: 0.76
Marker Score: 697
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 0.76
Marker Score: 283
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 393
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.76
Marker Score: 577
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.75
Marker Score: 13285
Cell Name: macroglial cell (CL0000126)
Fold Change: 0.72
Marker Score: 1660
Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 0.72
Marker Score: 338
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 0.71
Marker Score: 415
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 178
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.69
Marker Score: 435
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 0.66
Marker Score: 625
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.65
Marker Score: 779
Cell Name: granule cell (CL0000120)
Fold Change: 0.63
Marker Score: 4784
Cell Name: neuron (CL0000540)
Fold Change: 0.63
Marker Score: 2576
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.63
Marker Score: 4847
Cell Name: neural crest cell (CL0011012)
Fold Change: 0.61
Marker Score: 657
Cell Name: hepatoblast (CL0005026)
Fold Change: 0.61
Marker Score: 2008
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 0.61
Marker Score: 1021
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 0.6
Marker Score: 570
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 0.59
Marker Score: 342
Cell Name: preosteoblast (CL0007010)
Fold Change: 0.57
Marker Score: 162
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.57
Marker Score: 362.5
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 439
Cell Name: osteoblast (CL0000062)
Fold Change: 0.55
Marker Score: 295.5
Cell Name: motor neuron (CL0000100)
Fold Change: 0.55
Marker Score: 325
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.54
Marker Score: 20418
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.53
Marker Score: 5503
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 0.53
Marker Score: 275
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.53
Marker Score: 168
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.51
Marker Score: 136
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.5
Marker Score: 5588
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.49
Marker Score: 295
Cell Name: paneth cell (CL0000510)
Fold Change: 0.49
Marker Score: 338
Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 0.49
Marker Score: 154
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.46
Marker Score: 307
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.46
Marker Score: 125
Cell Name: visceromotor neuron (CL0005025)
Fold Change: 0.45
Marker Score: 132
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.45
Marker Score: 187
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.45
Marker Score: 551
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.44
Marker Score: 428
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.42
Marker Score: 862
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.41
Marker Score: 402
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.4
Marker Score: 1662
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.4
Marker Score: 125
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.39
Marker Score: 162
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.38
Marker Score: 517
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: 0.38
Marker Score: 161
Cell Name: type L enteroendocrine cell (CL0002279)
Fold Change: 0.38
Marker Score: 104
Cell Name: glial cell (CL0000125)
Fold Change: 0.38
Marker Score: 417
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.37
Marker Score: 163

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**Key characteristics:** - GNG4 is a transmembrane protein that is expressed in the plasma membrane of cells. - It is a member of the G protein family of signaling molecules. - GNG4 is a heterotrimer, meaning that it is composed of four subunits that come together to form a functional protein. - Each subunit of GNG4 is responsible for a specific signaling pathway. **Pathways and functions:** - GNG4 is involved in the aquaporin-mediated transport pathway, which is responsible for the transport of water across cell membranes. - It is also involved in the disease pathway, which is responsible for the regulation of inflammation and cell death. - GNG4 is also involved in the regulation of blood clotting, and it is a key regulator of hemostasis. - It is also involved in the regulation of energy metabolism, protein metabolism, and neuronal function. **Clinical significance:** GNG4 mutations have been linked to a number of human diseases, including Alzheimer's disease, Parkinson's disease, and glaucoma. These diseases are characterized by a variety of symptoms that are thought to be caused by defects in GNG4. **Additional information:** - GNG4 is a highly conserved protein, with a similar sequence found in organisms from yeast to humans. - It is a well-characterized protein that has been extensively studied in model systems. - GNG4 is a promising target for the treatment of human diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4

Genular Protein ID: 2944389185

Symbol: GBG4_HUMAN

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4

UniProtKB Accession Codes:

P50150

Database IDs:

Citations:

PubMed ID: 7665596

Title: Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits.

PubMed ID: 7665596

DOI: 10.1074/jbc.270.37.21765

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 75
Mass: 8389
Checksum: 42FAEF4728F83FF5
Sequence:

MKEGMSNNST TSISQARKAV EQLKMEACMD RVKVSQAAAD LLAYCEAHVR EDPLIIPVPA 
SENPFREKKF FCTIL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.