Details for: LRP1

Gene ID: 4035

Symbol: LRP1

Ensembl ID: ENSG00000123384

Description: LDL receptor related protein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.11
    Marker Score: 105785
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 3.1
    Marker Score: 2039
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.87
    Marker Score: 3069
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 2.85
    Marker Score: 1043
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.8
    Marker Score: 7328
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.68
    Marker Score: 3084
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.54
    Marker Score: 1414
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.5
    Marker Score: 139975
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.43
    Marker Score: 15806
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.41
    Marker Score: 51405
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.35
    Marker Score: 540
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.33
    Marker Score: 1151
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.25
    Marker Score: 1281
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.2
    Marker Score: 1231
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.09
    Marker Score: 4025.5
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.06
    Marker Score: 584
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.03
    Marker Score: 527
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.01
    Marker Score: 6600
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.01
    Marker Score: 2762
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.98
    Marker Score: 50749
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.95
    Marker Score: 3796
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.87
    Marker Score: 2070.5
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.87
    Marker Score: 21053
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.86
    Marker Score: 2131
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.85
    Marker Score: 2237
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.83
    Marker Score: 1204
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.83
    Marker Score: 2261
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.81
    Marker Score: 752
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.78
    Marker Score: 1124
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.76
    Marker Score: 7176
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.76
    Marker Score: 66784
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.75
    Marker Score: 1021
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.72
    Marker Score: 424
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.71
    Marker Score: 1002
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.67
    Marker Score: 1612
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.66
    Marker Score: 3381
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.62
    Marker Score: 6260
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.6
    Marker Score: 928
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.6
    Marker Score: 12236
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.59
    Marker Score: 1355
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.56
    Marker Score: 1563
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.55
    Marker Score: 6087
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.54
    Marker Score: 1268
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.54
    Marker Score: 23002
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.53
    Marker Score: 30528
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.52
    Marker Score: 93769
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.52
    Marker Score: 1871
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.51
    Marker Score: 579
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.5
    Marker Score: 14287
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.49
    Marker Score: 12757
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.48
    Marker Score: 9001
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.47
    Marker Score: 2264
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.47
    Marker Score: 1584
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.47
    Marker Score: 1271
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.46
    Marker Score: 10897
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.46
    Marker Score: 6291
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.46
    Marker Score: 53784
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.45
    Marker Score: 2236
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.45
    Marker Score: 14952
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.44
    Marker Score: 7721
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.43
    Marker Score: 5933
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.42
    Marker Score: 13317
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.41
    Marker Score: 677
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.41
    Marker Score: 700
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.41
    Marker Score: 6075
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.39
    Marker Score: 8945
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.38
    Marker Score: 576
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.38
    Marker Score: 8183
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.38
    Marker Score: 7403
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.38
    Marker Score: 443
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.36
    Marker Score: 3386
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.36
    Marker Score: 435
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.33
    Marker Score: 5568
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.32
    Marker Score: 1600
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.32
    Marker Score: 538
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.3
    Marker Score: 6022
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.3
    Marker Score: 324
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.3
    Marker Score: 1523
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.29
    Marker Score: 324
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.27
    Marker Score: 16710
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.26
    Marker Score: 542
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.24
    Marker Score: 42009
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.24
    Marker Score: 448
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.23
    Marker Score: 1307
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.22
    Marker Score: 1362
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.22
    Marker Score: 685
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.21
    Marker Score: 319
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.2
    Marker Score: 13988
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.19
    Marker Score: 4924
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.18
    Marker Score: 774
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.17
    Marker Score: 18358
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.14
    Marker Score: 1157.5
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.13
    Marker Score: 8528
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.13
    Marker Score: 1520
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.13
    Marker Score: 411
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.11
    Marker Score: 1062
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.08
    Marker Score: 5651
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.08
    Marker Score: 242
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.06
    Marker Score: 1325
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.04
    Marker Score: 5010

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Other Information

**Key characteristics:** * LRP1 is a type I transmembrane protein with a molecular weight of approximately 120 kDa. * It is a glycoprotein that is expressed on the surface of cells. * LRP1 is a receptor for a number of ligands, including apolipoprotein E, amyloid-beta, and apolipoprotein A. * It is involved in the regulation of cholesterol and lipid metabolism. * It is also involved in the uptake of LDL particles by cells. **Pathways and functions:** * LRP1 is involved in the uptake of LDL particles from the bloodstream. * It is also involved in the regulation of cholesterol and lipid metabolism. * It is involved in the clearance of oxidized LDL particles from the blood. * It is also involved in the uptake of other ligands by cells. **Clinical significance:** * Mutations in the LRP1 gene have been linked to a number of diseases, including atherosclerosis, heart disease, and stroke. * LRP1 is a potential target for therapy in these diseases. * It is a promising target for the treatment of atherosclerosis, as it is expressed in high levels in the plaques that build up in the arteries of people with this condition. **Additional information:** * LRP1 is a protein that is expressed in very high levels in the liver. * It is also expressed in low levels in other tissues, such as muscle and fat cells. * LRP1 is a highly conserved protein, with similar sequences found in animals and humans.

Genular Protein ID: 1751859439

Symbol: LRP1_HUMAN

Name: Apolipoprotein E receptor

UniProtKB Accession Codes:

Q07954 Q2PP12 Q86SW0 Q8IVG8

Database IDs:

AGR 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CPTAC 3 CTD 1 CarbonylDB 1 ChEBI 18 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 ELM 1 EMBL 9 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 62 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 1 PDB 14 PDBsum 7 PIR 1 PRINTS 1 PRO 1 PROSITE 8 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3266596

Title: Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor.

PubMed ID: 3266596

DOI: 10.1002/j.1460-2075.1988.tb03306.x

PubMed ID: 7534747

Title: Structure of the gene (LRP1) coding for the human alpha 2-macroglobulin receptor lipoprotein receptor-related protein.

PubMed ID: 7534747

DOI: 10.1006/geno.1994.1584

PubMed ID: 9782078

Title: Strategy to sequence the 89 exons of the human LRP1 gene coding for the lipoprotein receptor related protein: identification of one expressed mutation among 48 polymorphisms.

PubMed ID: 9782078

DOI: 10.1006/geno.1998.5408

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2597675

Title: Structure of the low-density lipoprotein receptor-related protein (LRP) promoter.

PubMed ID: 2597675

DOI: 10.1016/0167-4781(89)90107-3

PubMed ID: 1698775

Title: Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor.

PubMed ID: 1698775

DOI: 10.1016/s0021-9258(18)38172-9

PubMed ID: 2112085

Title: Proteolytic processing of the 600 kd low density lipoprotein receptor-related protein (LRP) occurs in a trans-Golgi compartment.

PubMed ID: 2112085

DOI: 10.1002/j.1460-2075.1990.tb08301.x

PubMed ID: 1702392

Title: Evidence that the newly cloned low-density-lipoprotein receptor related protein (LRP) is the alpha 2-macroglobulin receptor.

PubMed ID: 1702392

DOI: 10.1016/0014-5793(90)80530-v

PubMed ID: 1618748

Title: The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A.

PubMed ID: 1618748

DOI: 10.1016/s0021-9258(18)42291-0

PubMed ID: 10772929

Title: LDL receptor-related protein as a component of the midkine receptor.

PubMed ID: 10772929

DOI: 10.1006/bbrc.2000.2549

PubMed ID: 11729193

Title: Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP).

PubMed ID: 11729193

DOI: 10.1074/jbc.m109336200

PubMed ID: 11854294

Title: Platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of the low density lipoprotein receptor-related protein (LRP). Evidence for integrated co-receptor function between LRP and the PDGF.

PubMed ID: 11854294

DOI: 10.1074/jbc.m200427200

PubMed ID: 11907044

Title: Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain.

PubMed ID: 11907044

DOI: 10.1074/jbc.m201979200

PubMed ID: 12888553

Title: The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65.

PubMed ID: 12888553

DOI: 10.1074/jbc.m306403200

PubMed ID: 12713657

Title: LDL receptor-related proteins in neurodevelopment.

PubMed ID: 12713657

DOI: 10.1034/j.1600-0854.2003.00086_4_5.x

PubMed ID: 15053742

Title: The mosaic receptor sorLA/LR11 binds components of the plasminogen-activating system and platelet-derived growth factor-BB similarly to LRP1 (low-density lipoprotein receptor-related protein), but mediates slow internalization of bound ligand.

PubMed ID: 15053742

DOI: 10.1042/bj20040149

PubMed ID: 14764453

Title: LR11, an LDL receptor gene family member, is a novel regulator of smooth muscle cell migration.

PubMed ID: 14764453

DOI: 10.1161/01.res.0000120862.79154.0f

PubMed ID: 15272003

Title: Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase Calpha regulates endocytosis and association with adaptor molecules.

PubMed ID: 15272003

DOI: 10.1074/jbc.m407592200

PubMed ID: 15769472

Title: Functions of sorting nexin 17 domains and recognition motif for P-selectin trafficking.

PubMed ID: 15769472

DOI: 10.1016/j.jmb.2005.02.004

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 17124247

Title: Identification of the ligands of protein interaction domains through a functional approach.

PubMed ID: 17124247

DOI: 10.1074/mcp.m600289-mcp200

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 32296178

Title: LRP1 is a master regulator of tau uptake and spread.

PubMed ID: 32296178

DOI: 10.1038/s41586-020-2156-5

PubMed ID: 34559985

Title: Lrp1 is a host entry factor for Rift Valley fever virus.

PubMed ID: 34559985

DOI: 10.1016/j.cell.2021.09.001

PubMed ID: 10318830

Title: NMR solution structure of complement-like repeat CR8 from the low density lipoprotein receptor-related protein.

PubMed ID: 10318830

DOI: 10.1074/jbc.274.20.14130

PubMed ID: 10652313

Title: NMR solution structure of complement-like repeat CR3 from the low density lipoprotein receptor-related protein. Evidence for specific binding to the receptor binding domain of human alpha(2)-macroglobulin.

PubMed ID: 10652313

DOI: 10.1074/jbc.275.5.3264

PubMed ID: 11735395

Title: Calcium coordination and pH dependence of the calcium affinity of ligand-binding repeat CR7 from the LRP. Comparison with related domains from the LRP and the LDL receptor.

PubMed ID: 11735395

DOI: 10.1021/bi015688m

PubMed ID: 16938309

Title: Binding site structure of one LRP-RAP complex: implications for a common ligand-receptor binding motif.

PubMed ID: 16938309

DOI: 10.1016/j.jmb.2006.07.013

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

PubMed ID: 26142438

Title: Whole exome sequencing identifies LRP1 as a pathogenic gene in autosomal recessive keratosis pilaris atrophicans.

PubMed ID: 26142438

DOI: 10.1136/jmedgenet-2014-102931

Sequence Information:

  • Length: 4544
  • Mass: 504606
  • Checksum: 5A11CC02FAB127BE
  • Sequence:
    • MLTPPLLLLL PLLSALVAAA IDAPKTCSPK QFACRDQITC ISKGWRCDGE RDCPDGSDEA 
PEICPQSKAQ RCQPNEHNCL GTELCVPMSR LCNGVQDCMD GSDEGPHCRE LQGNCSRLGC 
QHHCVPTLDG PTCYCNSSFQ LQADGKTCKD FDECSVYGTC SQLCTNTDGS FICGCVEGYL 
LQPDNRSCKA KNEPVDRPPV LLIANSQNIL ATYLSGAQVS TITPTSTRQT TAMDFSYANE 
TVCWVHVGDS AAQTQLKCAR MPGLKGFVDE HTINISLSLH HVEQMAIDWL TGNFYFVDDI 
DDRIFVCNRN GDTCVTLLDL ELYNPKGIAL DPAMGKVFFT DYGQIPKVER CDMDGQNRTK 
LVDSKIVFPH GITLDLVSRL VYWADAYLDY IEVVDYEGKG RQTIIQGILI EHLYGLTVFE 
NYLYATNSDN ANAQQKTSVI RVNRFNSTEY QVVTRVDKGG ALHIYHQRRQ PRVRSHACEN 
DQYGKPGGCS DICLLANSHK ARTCRCRSGF SLGSDGKSCK KPEHELFLVY GKGRPGIIRG 
MDMGAKVPDE HMIPIENLMN PRALDFHAET GFIYFADTTS YLIGRQKIDG TERETILKDG 
IHNVEGVAVD WMGDNLYWTD DGPKKTISVA RLEKAAQTRK TLIEGKMTHP RAIVVDPLNG 
WMYWTDWEED PKDSRRGRLE RAWMDGSHRD IFVTSKTVLW PNGLSLDIPA GRLYWVDAFY 
DRIETILLNG TDRKIVYEGP ELNHAFGLCH HGNYLFWTEY RSGSVYRLER GVGGAPPTVT 
LLRSERPPIF EIRMYDAQQQ QVGTNKCRVN NGGCSSLCLA TPGSRQCACA EDQVLDADGV 
TCLANPSYVP PPQCQPGEFA CANSRCIQER WKCDGDNDCL DNSDEAPALC HQHTCPSDRF 
KCENNRCIPN RWLCDGDNDC GNSEDESNAT CSARTCPPNQ FSCASGRCIP ISWTCDLDDD 
CGDRSDESAS CAYPTCFPLT QFTCNNGRCI NINWRCDNDN DCGDNSDEAG CSHSCSSTQF 
KCNSGRCIPE HWTCDGDNDC GDYSDETHAN CTNQATRPPG GCHTDEFQCR LDGLCIPLRW 
RCDGDTDCMD SSDEKSCEGV THVCDPSVKF GCKDSARCIS KAWVCDGDND CEDNSDEENC 
ESLACRPPSH PCANNTSVCL PPDKLCDGND DCGDGSDEGE LCDQCSLNNG GCSHNCSVAP 
GEGIVCSCPL GMELGPDNHT CQIQSYCAKH LKCSQKCDQN KFSVKCSCYE GWVLEPDGES 
CRSLDPFKPF IIFSNRHEIR RIDLHKGDYS VLVPGLRNTI ALDFHLSQSA LYWTDVVEDK 
IYRGKLLDNG ALTSFEVVIQ YGLATPEGLA VDWIAGNIYW VESNLDQIEV AKLDGTLRTT 
LLAGDIEHPR AIALDPRDGI LFWTDWDASL PRIEAASMSG AGRRTVHRET GSGGWPNGLT 
VDYLEKRILW IDARSDAIYS ARYDGSGHME VLRGHEFLSH PFAVTLYGGE VYWTDWRTNT 
LAKANKWTGH NVTVVQRTNT QPFDLQVYHP SRQPMAPNPC EANGGQGPCS HLCLINYNRT 
VSCACPHLMK LHKDNTTCYE FKKFLLYARQ MEIRGVDLDA PYYNYIISFT VPDIDNVTVL 
DYDAREQRVY WSDVRTQAIK RAFINGTGVE TVVSADLPNA HGLAVDWVSR NLFWTSYDTN 
KKQINVARLD GSFKNAVVQG LEQPHGLVVH PLRGKLYWTD GDNISMANMD GSNRTLLFSG 
QKGPVGLAID FPESKLYWIS SGNHTINRCN LDGSGLEVID AMRSQLGKAT ALAIMGDKLW 
WADQVSEKMG TCSKADGSGS VVLRNSTTLV MHMKVYDESI QLDHKGTNPC SVNNGDCSQL 
CLPTSETTRS CMCTAGYSLR SGQQACEGVG SFLLYSVHEG IRGIPLDPND KSDALVPVSG 
TSLAVGIDFH AENDTIYWVD MGLSTISRAK RDQTWREDVV TNGIGRVEGI AVDWIAGNIY 
WTDQGFDVIE VARLNGSFRY VVISQGLDKP RAITVHPEKG YLFWTEWGQY PRIERSRLDG 
TERVVLVNVS ISWPNGISVD YQDGKLYWCD ARTDKIERID LETGENREVV LSSNNMDMFS 
VSVFEDFIYW SDRTHANGSI KRGSKDNATD SVPLRTGIGV QLKDIKVFNR DRQKGTNVCA 
VANGGCQQLC LYRGRGQRAC ACAHGMLAED GASCREYAGY LLYSERTILK SIHLSDERNL 
NAPVQPFEDP EHMKNVIALA FDYRAGTSPG TPNRIFFSDI HFGNIQQIND DGSRRITIVE 
NVGSVEGLAY HRGWDTLYWT SYTTSTITRH TVDQTRPGAF ERETVITMSG DDHPRAFVLD 
ECQNLMFWTN WNEQHPSIMR AALSGANVLT LIEKDIRTPN GLAIDHRAEK LYFSDATLDK 
IERCEYDGSH RYVILKSEPV HPFGLAVYGE HIFWTDWVRR AVQRANKHVG SNMKLLRVDI 
PQQPMGIIAV ANDTNSCELS PCRINNGGCQ DLCLLTHQGH VNCSCRGGRI LQDDLTCRAV 
NSSCRAQDEF ECANGECINF SLTCDGVPHC KDKSDEKPSY CNSRRCKKTF RQCSNGRCVS 
NMLWCNGADD CGDGSDEIPC NKTACGVGEF RCRDGTCIGN SSRCNQFVDC EDASDEMNCS 
ATDCSSYFRL GVKGVLFQPC ERTSLCYAPS WVCDGANDCG DYSDERDCPG VKRPRCPLNY 
FACPSGRCIP MSWTCDKEDD CEHGEDETHC NKFCSEAQFE CQNHRCISKQ WLCDGSDDCG 
DGSDEAAHCE GKTCGPSSFS CPGTHVCVPE RWLCDGDKDC ADGADESIAA GCLYNSTCDD 
REFMCQNRQC IPKHFVCDHD RDCADGSDES PECEYPTCGP SEFRCANGRC LSSRQWECDG 
ENDCHDQSDE APKNPHCTSQ EHKCNASSQF LCSSGRCVAE ALLCNGQDDC GDSSDERGCH 
INECLSRKLS GCSQDCEDLK IGFKCRCRPG FRLKDDGRTC ADVDECSTTF PCSQRCINTH 
GSYKCLCVEG YAPRGGDPHS CKAVTDEEPF LIFANRYYLR KLNLDGSNYT LLKQGLNNAV 
ALDFDYREQM IYWTDVTTQG SMIRRMHLNG SNVQVLHRTG LSNPDGLAVD WVGGNLYWCD 
KGRDTIEVSK LNGAYRTVLV SSGLREPRAL VVDVQNGYLY WTDWGDHSLI GRIGMDGSSR 
SVIVDTKITW PNGLTLDYVT ERIYWADARE DYIEFASLDG SNRHVVLSQD IPHIFALTLF 
EDYVYWTDWE TKSINRAHKT TGTNKTLLIS TLHRPMDLHV FHALRQPDVP NHPCKVNNGG 
CSNLCLLSPG GGHKCACPTN FYLGSDGRTC VSNCTASQFV CKNDKCIPFW WKCDTEDDCG 
DHSDEPPDCP EFKCRPGQFQ CSTGICTNPA FICDGDNDCQ DNSDEANCDI HVCLPSQFKC 
TNTNRCIPGI FRCNGQDNCG DGEDERDCPE VTCAPNQFQC SITKRCIPRV WVCDRDNDCV 
DGSDEPANCT QMTCGVDEFR CKDSGRCIPA RWKCDGEDDC GDGSDEPKEE CDERTCEPYQ 
FRCKNNRCVP GRWQCDYDND CGDNSDEESC TPRPCSESEF SCANGRCIAG RWKCDGDHDC 
ADGSDEKDCT PRCDMDQFQC KSGHCIPLRW RCDADADCMD GSDEEACGTG VRTCPLDEFQ 
CNNTLCKPLA WKCDGEDDCG DNSDENPEEC ARFVCPPNRP FRCKNDRVCL WIGRQCDGTD 
NCGDGTDEED CEPPTAHTTH CKDKKEFLCR NQRCLSSSLR CNMFDDCGDG SDEEDCSIDP 
KLTSCATNAS ICGDEARCVR TEKAAYCACR SGFHTVPGQP GCQDINECLR FGTCSQLCNN 
TKGGHLCSCA RNFMKTHNTC KAEGSEYQVL YIADDNEIRS LFPGHPHSAY EQAFQGDESV 
RIDAMDVHVK AGRVYWTNWH TGTISYRSLP PAAPPTTSNR HRRQIDRGVT HLNISGLKMP 
RGIAIDWVAG NVYWTDSGRD VIEVAQMKGE NRKTLISGMI DEPHAIVVDP LRGTMYWSDW 
GNHPKIETAA MDGTLRETLV QDNIQWPTGL AVDYHNERLY WADAKLSVIG SIRLNGTDPI 
VAADSKRGLS HPFSIDVFED YIYGVTYINN RVFKIHKFGH SPLVNLTGGL SHASDVVLYH 
QHKQPEVTNP CDRKKCEWLC LLSPSGPVCT CPNGKRLDNG TCVPVPSPTP PPDAPRPGTC 
NLQCFNGGSC FLNARRQPKC RCQPRYTGDK CELDQCWEHC RNGGTCAASP SGMPTCRCPT 
GFTGPKCTQQ VCAGYCANNS TCTVNQGNQP QCRCLPGFLG DRCQYRQCSG YCENFGTCQM 
AADGSRQCRC TAYFEGSRCE VNKCSRCLEG ACVVNKQSGD VTCNCTDGRV APSCLTCVGH 
CSNGGSCTMN SKMMPECQCP PHMTGPRCEE HVFSQQQPGH IASILIPLLL LLLLVLVAGV 
VFWYKRRVQG AKGFQHQRMT NGAMNVEIGN PTYKMYEGGE PDDVGGLLDA DFALDPDKPT 
NFTNPVYATL YMGGHGSRHS LASTDEKREL LGRGPEDEIG DPLA

Genular Protein ID: 2924846801

Symbol: Q59FG2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59FG2

Database IDs:

ARBA 11 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 3 Genevisible 1 GenomeRNAi 1 InterPro 12 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 9 PROSITE-ProRule 3 PeptideAtlas 1 Pfam 6 RefSeq 1 SAM 1 SMART 4 SUPFAM 4

Sequence Information:

  • Length: 2359
  • Mass: 262019
  • Checksum: 2588B2908EA320B6
  • Sequence:
    • VCFVCLSHLL PPDSVYLLYS ERTILKSIHL SDERNLNAPV QPFEDPEHMK NVIALAFDYR 
AGTSPGTPNR IFFSDIHFGN IQQINDDGSR RITIVENVGS VEGLAYHRGW DTLYWTSYTT 
STITRHTVDQ TRPGAFERET VITMSGDDHP RAFVLDECQN LMFWTNWNEQ HPSIMRAALS 
GANVLTLIEK DIRTPNGLAI DHRAEKLYFS DATLDKIERC EYDGSHRYVI LKSEPVHPFG 
LAVYGEHIFW TDWVRRAVQR ANKHVGSNMK LLRVDIPQQP MGIIAVANDT NSCELSPCRI 
NNGGCQDLCL LTHQGHVNCS CRGGRILQDD LTCRAVNSSC RAQDEFECAN GECINFSLTC 
DGVPHCKDKS DEKPSYCNSR RCKKTFRQCS NGRCVSNMLW CNGADDCGDG SDEIPCNKTA 
CGVGEFRCRD GTCIGNSSRC NQFVDCEDAS DEMNCSATDC SSYFRLGVKG VLFQPCERTS 
LCYAPSWVCD GANDCGDYSD ERDCPGVKRP RCPLNYFACP SGRCIPMSWT CDKEDDCEHG 
EDETHCNKFC SEAQFECQNH RCISKQWLCD GSDDCGDGSD EAAHCEGKTC GPSSFSCPGT 
HVCVPERWLC DGDKDCADGA DESIAAGCLY NSTCDDREFM CQNRQCIPKH FVCDHDRDCA 
DGSDESPECE YPTCGPSEFR CANGRCLSSR QWECDGENDC HDQSDEAPKN PHCTSPEHKC 
NASSQFLCSS GRCVAEALLC NGQDDCGDSS DERGCHINEC LSRKLSGCSQ DCEDLKIGFK 
CRCRPGFRLK DDGRTCADVD ECSTTFPCSQ RCINTHGSYK CLCVEGYAPR GGDPHSCKAV 
TDEEPFLIFA NRYYLRKLNL DGSNYTLLKQ GLNNAVALDF DYREQMIYWT DVTTQGSMIR 
RMHLNGSNVQ VLHRTGLSNP DGLAVDWVGG NLYWCDKGRD TIEVSKLNGA YRTVLVSSGL 
REPRALVVDV QNGYLYWTDW GDHSLIGRIG MDGSSRSVIV DTKITWPNGL TLDYVTERIY 
WADAREDYIE FASLDGSNRH VVLSQDIPHI FALTLFEDYV YWTDWETKSI NRAHKTTGTN 
KTLLISTLHR PMDLHVFHAL RQPDVPNHPC KVNNGGCSNL CLLSPGGGHK CACPTNFYLG 
SDGRTCVSNC TASQFVCKND KCIPFWWKCD TEDDCGDHSD EPPDCPEFKC RPGQFQCSTG 
ICTNPAFICD GDNDCQDNSD EANCDIHVCL PSQFKCTNTN RCIPGIFRCN GQDNCGDGED 
ERDCPEVTCA PNQFQCSITK RCIPRVWVCD RDNDCVDGSD EPANCTQMTC GVDEFRCKDS 
GRCIPARWKC DGEDDCGDGS DEPKEECDER TCEPYQFRCK NNRCVPGRWQ CDYDNDCGDN 
SDEESCTPRP CSESEFSCAN GRCIAGRWKC DGDHDCADGS DEKDCTPRCD MDQFQCKSGH 
CIPLRWRCDA DADCMDGSDE EACGTGVRTC PLDEFQCNNT LCKPLAWKCD GEDDCGDNSD 
ENPEECARFV CPPNRPFRCK NDRVCLWIGR QCDGTDNCGD GTDEEDCEPP TAHTTHCKDK 
KEFLCRNQRC LSSLRCNMFD DCGDGSDEED CSIDPKLTSC ATNASICGDE ARCVRTEKAA 
YCACRSGFHT VPGQPGCQDI NECLRFGTCS QLCNNTKGGH LCSCARNFMK THNTCKAEGS 
EYQVLYIADD NEIRSLFPGH PHSAYEQAFQ GDESVRIDAM DVHVKAGRVY WTNWHTGTIS 
YRSLPPAAPP TTSNRHRRQI DRGVTHLNIS GLKMPRGIAI DWVAGNVYWT DSGRDVIEVA 
QMKGENRKTL ISGMIDEPHA IVVDPLRGTM YWSDWGNHPK IETAAMDGTL RETLVQDNIQ 
WPTGLAVDYH NERLYWADAK LSVIGSIRLN GTDPIVAADS KRGLSHPFSI DVFEDYIYGV 
TYINNRVFKI HKFGHSPLVN LTGGLSHASD VVLYHQHKQP EVTNPCDRKK CEWLCLLSPS 
GPVCTCPNGK RLDNGTCVPV PSPTPPPDAP RPGTCNLQCF NGGSCFLNAR RQPKCRCQPR 
YTGDKCELDQ CWEHCRNGGT CAASPSGMPT CRCPTGFTGP KCTQQVCAGY CANNSTCTVN 
QGNQPQCRCL PGFLGDRCQY RQCSGYCENF GTCQMAADGS RQCRCTAYFE GSRCEVNKCS 
RCLEGACVVN KQSGDVTCNC TDGRVAPSCL TCVGHCSNGG SCTMNSKMMP ECQCPPHMTG 
PRCEEHVFSQ QQPGHIASIL IPLLLLLLLV LVAGVVFWYK RRVQGAKGFQ HQRMTNGAMN 
VEIGNPTYKM YEGGEPDDVG GLLDADFALD PDKPTNFTNP VYATLYMGGH GSRHSLASTD 
EKRELLGRGP EDEIGDPLA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.