Details for: UBA6 DT

Gene ID: 550112

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: UBA6 DT

Ensembl ID: ENSG00000248049

Description: UBA6 divergent transcript

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • pvalb GABAergic cortical interneuron CL4023018
    CSI 39.49
    rCSI 49.13%
    PRS 76.66
  • VIP GABAergic cortical interneuron CL4023016
    CSI 32.3
    rCSI 38.58%
    PRS 78.89
  • sst GABAergic cortical interneuron CL4023017
    CSI 28.78
    rCSI 37.11%
    PRS 79.92
  • retinal ganglion cell CL0000740
    CSI 21.44
    rCSI 47.37%
    PRS 81.18
  • retinal rod cell CL0000604
    CSI 19.06
    rCSI 33.59%
    PRS 87.26
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 16.15
    rCSI 27.1%
    PRS 78.85
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 15.75
    rCSI 27.82%
    PRS 78.26
  • sncg GABAergic cortical interneuron CL4023015
    CSI 15.14
    rCSI 24.35%
    PRS 79.73
  • lung ciliated cell CL1000271
    CSI 14.01
    rCSI 16.2%
    PRS 85.89
  • glioblast CL0000030
    CSI 13.37
    rCSI 21.32%
    PRS 83.93
  • neural crest cell CL0011012
    CSI 12.83
    rCSI 10.14%
    PRS 84.57
  • GABAergic amacrine cell CL4030027
    CSI 12.67
    rCSI 43.4%
    PRS 79.13
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 12.38
    rCSI 22.49%
    PRS 85.08
  • alveolar adventitial fibroblast CL4028006
    CSI 11.98
    rCSI 18.92%
    PRS 91.93
  • peripheral nervous system neuron CL2000032
    CSI 11.45
    rCSI 15.61%
    PRS 85.17
  • rod bipolar cell CL0000751
    CSI 11.36
    rCSI 20.4%
    PRS 86.48
  • neuron CL0000540
    CSI 10.99
    rCSI 29.27%
    PRS 79.68
  • Mueller cell CL0000636
    CSI 10.63
    rCSI 24.26%
    PRS 84.97
  • pulmonary alveolar type 2 cell CL0002063
    CSI 10.54
    rCSI 16.35%
    PRS 91.75
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 10.52
    rCSI 32.89%
    PRS 81.81
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 10.1
    rCSI 12.96%
    PRS 87.56
  • mesothelial cell CL0000077
    CSI 10.05
    rCSI 39.31%
    PRS 75.14
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 9.71
    rCSI 34.96%
    PRS 76.87
  • melanocyte CL0000148
    CSI 9.71
    rCSI 7.19%
    PRS 87.69
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 9.44
    rCSI 10.9%
    PRS 83.99
  • adipocyte CL0000136
    CSI 9.08
    rCSI 11.66%
    PRS 83.43
  • L6b glutamatergic cortical neuron CL4023038
    CSI 8.68
    rCSI 27.12%
    PRS 80.15
  • radial glial cell CL0000681
    CSI 8.58
    rCSI 11.92%
    PRS 89.53
  • retinal bipolar neuron CL0000748
    CSI 8.57
    rCSI 16.04%
    PRS 83.23
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 8.5
    rCSI 32.14%
    PRS 79.03
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 8.43
    rCSI 18.28%
    PRS 80.59
  • renal alpha-intercalated cell CL0005011
    CSI 7.14
    rCSI 9.55%
    PRS 93.97
  • epithelial cell of proximal tubule CL0002306
    CSI 6.81
    rCSI 16.63%
    PRS 84.82
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 6.46
    rCSI 15.45%
    PRS 81.29
  • Bergmann glial cell CL0000644
    CSI 6.45
    rCSI 8.83%
    PRS 83.99
  • H2 horizontal cell CL0004218
    CSI 6.45
    rCSI 32.05%
    PRS 86.05
  • amacrine cell CL0000561
    CSI 6.36
    rCSI 18.42%
    PRS 83.22
  • Kupffer cell CL0000091
    CSI 6.35
    rCSI 14.51%
    PRS 91.99
  • chondrocyte CL0000138
    CSI 6.04
    rCSI 9.6%
    PRS 86.66
  • fibroblast of lung CL0002553
    CSI 6
    rCSI 5.58%
    PRS 92.39
  • conjunctival epithelial cell CL1000432
    CSI 5.98
    rCSI 9.13%
    PRS 90.14
  • inhibitory interneuron CL0000498
    CSI 5.96
    rCSI 13.75%
    PRS 82.42
  • cerebral cortex neuron CL0010012
    CSI 5.79
    rCSI 23.6%
    PRS 84.24
  • contractile cell CL0000183
    CSI 5.55
    rCSI 16.37%
    PRS 90.31
  • lung secretory cell CL1000272
    CSI 5.52
    rCSI 13.67%
    PRS 91.68
  • cerebral cortex endothelial cell CL1001602
    CSI 5.45
    rCSI 9.42%
    PRS 86.04
  • vascular leptomeningeal cell CL4023051
    CSI 5.22
    rCSI 9.15%
    PRS 87.74
  • hepatic stellate cell CL0000632
    CSI 5.21
    rCSI 19.51%
    PRS 86.81
  • alveolar type 1 fibroblast cell CL4028004
    CSI 5.06
    rCSI 5.54%
    PRS 92.49
  • renal principal cell CL0005009
    CSI 4.97
    rCSI 12.91%
    PRS 90.41
  • kidney connecting tubule epithelial cell CL1000768
    CSI 4.85
    rCSI 12.29%
    PRS 85.25
  • blood vessel endothelial cell CL0000071
    CSI 4.81
    rCSI 9.97%
    PRS 89.56
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 4.73
    rCSI 6.71%
    PRS 88.97
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 4.59
    rCSI 27%
    PRS 79.29
  • glutamatergic neuron CL0000679
    CSI 4.58
    rCSI 9.41%
    PRS 80.02
  • interneuron CL0000099
    CSI 4.56
    rCSI 9.15%
    PRS 85.31
  • parietal epithelial cell CL1000452
    CSI 4.44
    rCSI 11.87%
    PRS 86.05
  • retina horizontal cell CL0000745
    CSI 4.39
    rCSI 6.69%
    PRS 88.1
  • cerebral cortex pyramidal neuron CL4023111
    CSI 4.24
    rCSI 26.11%
    PRS 91.77
  • choroid plexus epithelial cell CL0000706
    CSI 4.23
    rCSI 6.92%
    PRS 84.52
  • cardiac neuron CL0010022
    CSI 4.14
    rCSI 13.26%
    PRS 89.78
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 4.13
    rCSI 10.75%
    PRS 92.42
  • ON parasol ganglion cell CL4033052
    CSI 3.97
    rCSI 56.29%
    PRS 84.01
  • GABAergic neuron CL0000617
    CSI 3.94
    rCSI 13.2%
    PRS 78.37
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 3.84
    rCSI 12.62%
    PRS 80.2
  • cardiac muscle cell CL0000746
    CSI 3.76
    rCSI 5.4%
    PRS 83.58
  • renal interstitial pericyte CL1001318
    CSI 3.74
    rCSI 10.31%
    PRS 88.55
  • endocardial cell CL0002350
    CSI 3.74
    rCSI 17.9%
    PRS 87.69
  • glial cell CL0000125
    CSI 3.73
    rCSI 14.21%
    PRS 84.95
  • fibroblast of cardiac tissue CL0002548
    CSI 3.67
    rCSI 17.57%
    PRS 91.87
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 3.66
    rCSI 9.46%
    PRS 88.52
  • Schwann cell CL0002573
    CSI 3.61
    rCSI 10.26%
    PRS 87.69
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 3.56
    rCSI 8.64%
    PRS 76.7
  • cerebellar granule cell CL0001031
    CSI 3.53
    rCSI 5.18%
    PRS 86.33
  • mature astrocyte CL0002627
    CSI 3.48
    rCSI 14.78%
    PRS 84.62
  • retinal cone cell CL0000573
    CSI 3.36
    rCSI 5.4%
    PRS 83.75
  • periportal region hepatocyte CL0019026
    CSI 3.35
    rCSI 13.03%
    PRS 87.92
  • neural progenitor cell CL0011020
    CSI 3.31
    rCSI 14.56%
    PRS 80.87
  • epithelial cell of lower respiratory tract CL0002632
    CSI 3.27
    rCSI 2.54%
    PRS 93.3
  • diffuse bipolar 3b cell CL4033030
    CSI 3.26
    rCSI 21.67%
    PRS 85.6
  • astrocyte of the cerebral cortex CL0002605
    CSI 3.24
    rCSI 7.26%
    PRS 79.21
  • pulmonary alveolar type 1 cell CL0002062
    CSI 3.15
    rCSI 18.15%
    PRS 88.37
  • regular ventricular cardiac myocyte CL0002131
    CSI 3.1
    rCSI 19.38%
    PRS 85.25
  • kidney loop of Henle thick ascending limb epithelial cell CL1001106
    CSI 3.04
    rCSI 26.27%
    PRS 85.9
  • renal beta-intercalated cell CL0002201
    CSI 3.03
    rCSI 7.23%
    PRS 91.18
  • airway submucosal gland duct basal cell CL4033024
    CSI 3
    rCSI 19.2%
    PRS 92.5
  • corneal epithelial cell CL0000575
    CSI 2.91
    rCSI 8.34%
    PRS 92.62
  • podocyte CL0000653
    CSI 2.84
    rCSI 12.6%
    PRS 91.42
  • glycinergic amacrine cell CL4030028
    CSI 2.77
    rCSI 7.21%
    PRS 85.52
  • ON midget ganglion cell CL4033046
    CSI 2.74
    rCSI 55.73%
    PRS 82.96
  • OFF midget ganglion cell CL4033047
    CSI 2.73
    rCSI 55.54%
    PRS 83.58
  • lung neuroendocrine cell CL1000223
    CSI 2.71
    rCSI 4.01%
    PRS 92.53
  • direct pathway medium spiny neuron CL4023026
    CSI 2.26
    rCSI 54.11%
    PRS 76.66
  • indirect pathway medium spiny neuron CL4023029
    CSI 2.23
    rCSI 53.7%
    PRS 76.79
  • H1 horizontal cell CL0004217
    CSI 2.16
    rCSI 8.55%
    PRS 85.06
  • invaginating midget bipolar cell CL4033034
    CSI 2.14
    rCSI 12.65%
    PRS 82.75
  • retinal pigment epithelial cell CL0002586
    CSI 2.1
    rCSI 4.16%
    PRS 87.82
  • hepatocyte CL0000182
    CSI 1.81
    rCSI 3.24%
    PRS 89.58
  • macroglial cell CL0000126
    CSI 1.73
    rCSI 4.46%
    PRS 87.55
  • regular atrial cardiac myocyte CL0002129
    CSI 1.7
    rCSI 5.49%
    PRS 87.75
  • diffuse bipolar 4 cell CL4033031
    CSI 0.9
    rCSI 10.0%
    PRS 79.3%
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 0.9
    rCSI 9.8%
    PRS 87.4%
  • blood vessel smooth muscle cell CL0019018
    CSI 1.0
    rCSI 8.3%
    PRS 88.6%
  • midbrain dopaminergic neuron CL2000097
    CSI 1.1
    rCSI 6.9%
    PRS 85.5%
  • diffuse bipolar 3a cell CL4033029
    CSI 1.2
    rCSI 8.4%
    PRS 83.5%
  • starburst amacrine cell CL0004232
    CSI 1.3
    rCSI 10.6%
    PRS 78.4%
  • flat midget bipolar cell CL4033033
    CSI 1.3
    rCSI 9.3%
    PRS 82.2%
  • mesangial cell CL0000650
    CSI 1.4
    rCSI 5.6%
    PRS 95.2%
  • S cone cell CL0003050
    CSI 1.5
    rCSI 6.6%
    PRS 86.7%
  • diffuse bipolar 1 cell CL4033027
    CSI 1.5
    rCSI 11.3%
    PRS 80.9%
  • epicardial adipocyte CL1000309
    CSI 1.5
    rCSI 5.0%
    PRS 88.5%
  • OFFx cell CL4033036
    CSI 1.6
    rCSI 7.5%
    PRS 81.9%
  • kidney collecting duct intercalated cell CL1001432
    CSI 1.6
    rCSI 11.4%
    PRS 87.4%
  • diffuse bipolar 6 cell CL4033032
    CSI 1.6
    rCSI 8.5%
    PRS 81.8%
  • diffuse bipolar 2 cell CL4033028
    CSI 1.6
    rCSI 12.7%
    PRS 84.3%
  • regular atrial cardiac myocyte CL0002129
    CSI 1.7
    rCSI 5.5%
    PRS 87.8%
  • macroglial cell CL0000126
    CSI 1.7
    rCSI 4.5%
    PRS 87.6%
  • hepatocyte CL0000182
    CSI 1.8
    rCSI 3.2%
    PRS 89.6%
  • retinal pigment epithelial cell CL0002586
    CSI 2.1
    rCSI 4.2%
    PRS 87.8%
  • invaginating midget bipolar cell CL4033034
    CSI 2.1
    rCSI 12.7%
    PRS 82.8%
  • H1 horizontal cell CL0004217
    CSI 2.2
    rCSI 8.6%
    PRS 85.1%
  • indirect pathway medium spiny neuron CL4023029
    CSI 2.2
    rCSI 53.7%
    PRS 76.8%
  • direct pathway medium spiny neuron CL4023026
    CSI 2.3
    rCSI 54.1%
    PRS 76.7%
  • lung neuroendocrine cell CL1000223
    CSI 2.7
    rCSI 4.0%
    PRS 92.5%
  • OFF midget ganglion cell CL4033047
    CSI 2.7
    rCSI 55.5%
    PRS 83.6%
  • ON midget ganglion cell CL4033046
    CSI 2.7
    rCSI 55.7%
    PRS 83.0%
  • glycinergic amacrine cell CL4030028
    CSI 2.8
    rCSI 7.2%
    PRS 85.5%
  • podocyte CL0000653
    CSI 2.8
    rCSI 12.6%
    PRS 91.4%
  • corneal epithelial cell CL0000575
    CSI 2.9
    rCSI 8.3%
    PRS 92.6%
  • airway submucosal gland duct basal cell CL4033024
    CSI 3.0
    rCSI 19.2%
    PRS 92.5%
  • renal beta-intercalated cell CL0002201
    CSI 3.0
    rCSI 7.2%
    PRS 91.2%
  • kidney loop of Henle thick ascending limb epithelial cell CL1001106
    CSI 3.0
    rCSI 26.3%
    PRS 85.9%
  • regular ventricular cardiac myocyte CL0002131
    CSI 3.1
    rCSI 19.4%
    PRS 85.3%
  • pulmonary alveolar type 1 cell CL0002062
    CSI 3.2
    rCSI 18.2%
    PRS 88.4%
  • astrocyte of the cerebral cortex CL0002605
    CSI 3.2
    rCSI 7.3%
    PRS 79.2%
  • diffuse bipolar 3b cell CL4033030
    CSI 3.3
    rCSI 21.7%
    PRS 85.6%
  • epithelial cell of lower respiratory tract CL0002632
    CSI 3.3
    rCSI 2.5%
    PRS 93.3%
  • neural progenitor cell CL0011020
    CSI 3.3
    rCSI 14.6%
    PRS 80.9%
  • periportal region hepatocyte CL0019026
    CSI 3.4
    rCSI 13.0%
    PRS 87.9%
  • retinal cone cell CL0000573
    CSI 3.4
    rCSI 5.4%
    PRS 83.8%
  • mature astrocyte CL0002627
    CSI 3.5
    rCSI 14.8%
    PRS 84.6%
  • cerebellar granule cell CL0001031
    CSI 3.5
    rCSI 5.2%
    PRS 86.3%
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 3.6
    rCSI 8.6%
    PRS 76.7%
  • Schwann cell CL0002573
    CSI 3.6
    rCSI 10.3%
    PRS 87.7%
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 3.7
    rCSI 9.5%
    PRS 88.5%
  • fibroblast of cardiac tissue CL0002548
    CSI 3.7
    rCSI 17.6%
    PRS 91.9%
  • glial cell CL0000125
    CSI 3.7
    rCSI 14.2%
    PRS 85.0%
  • endocardial cell CL0002350
    CSI 3.7
    rCSI 17.9%
    PRS 87.7%
  • renal interstitial pericyte CL1001318
    CSI 3.7
    rCSI 10.3%
    PRS 88.6%
  • cardiac muscle cell CL0000746
    CSI 3.8
    rCSI 5.4%
    PRS 83.6%
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 3.8
    rCSI 12.6%
    PRS 80.2%
  • GABAergic neuron CL0000617
    CSI 3.9
    rCSI 13.2%
    PRS 78.4%
  • ON parasol ganglion cell CL4033052
    CSI 4.0
    rCSI 56.3%
    PRS 84.0%
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 4.1
    rCSI 10.8%
    PRS 92.4%
  • cardiac neuron CL0010022
    CSI 4.1
    rCSI 13.3%
    PRS 89.8%
  • choroid plexus epithelial cell CL0000706
    CSI 4.2
    rCSI 6.9%
    PRS 84.5%
  • cerebral cortex pyramidal neuron CL4023111
    CSI 4.2
    rCSI 26.1%
    PRS 91.8%
  • retina horizontal cell CL0000745
    CSI 4.4
    rCSI 6.7%
    PRS 88.1%
  • parietal epithelial cell CL1000452
    CSI 4.4
    rCSI 11.9%
    PRS 86.1%
  • interneuron CL0000099
    CSI 4.6
    rCSI 9.2%
    PRS 85.3%
  • glutamatergic neuron CL0000679
    CSI 4.6
    rCSI 9.4%
    PRS 80.0%
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 4.6
    rCSI 27.0%
    PRS 79.3%
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 4.7
    rCSI 6.7%
    PRS 89.0%
  • blood vessel endothelial cell CL0000071
    CSI 4.8
    rCSI 10.0%
    PRS 89.6%
  • kidney connecting tubule epithelial cell CL1000768
    CSI 4.9
    rCSI 12.3%
    PRS 85.3%
  • renal principal cell CL0005009
    CSI 5.0
    rCSI 12.9%
    PRS 90.4%
  • alveolar type 1 fibroblast cell CL4028004
    CSI 5.1
    rCSI 5.5%
    PRS 92.5%
  • hepatic stellate cell CL0000632
    CSI 5.2
    rCSI 19.5%
    PRS 86.8%
  • vascular leptomeningeal cell CL4023051
    CSI 5.2
    rCSI 9.2%
    PRS 87.7%
  • cerebral cortex endothelial cell CL1001602
    CSI 5.5
    rCSI 9.4%
    PRS 86.0%
  • lung secretory cell CL1000272
    CSI 5.5
    rCSI 13.7%
    PRS 91.7%
  • contractile cell CL0000183
    CSI 5.6
    rCSI 16.4%
    PRS 90.3%
  • cerebral cortex neuron CL0010012
    CSI 5.8
    rCSI 23.6%
    PRS 84.2%
  • inhibitory interneuron CL0000498
    CSI 6.0
    rCSI 13.8%
    PRS 82.4%
  • conjunctival epithelial cell CL1000432
    CSI 6.0
    rCSI 9.1%
    PRS 90.1%
  • fibroblast of lung CL0002553
    CSI 6.0
    rCSI 5.6%
    PRS 92.4%
  • chondrocyte CL0000138
    CSI 6.0
    rCSI 9.6%
    PRS 86.7%
  • Kupffer cell CL0000091
    CSI 6.4
    rCSI 14.5%
    PRS 92.0%
  • amacrine cell CL0000561
    CSI 6.4
    rCSI 18.4%
    PRS 83.2%
  • H2 horizontal cell CL0004218
    CSI 6.5
    rCSI 32.1%
    PRS 86.1%
  • Bergmann glial cell CL0000644
    CSI 6.5
    rCSI 8.8%
    PRS 84.0%
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 6.5
    rCSI 15.5%
    PRS 81.3%
  • epithelial cell of proximal tubule CL0002306
    CSI 6.8
    rCSI 16.6%
    PRS 84.8%
  • renal alpha-intercalated cell CL0005011
    CSI 7.1
    rCSI 9.6%
    PRS 94.0%
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 8.4
    rCSI 18.3%
    PRS 80.6%
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 8.5
    rCSI 32.1%
    PRS 79.0%
  • retinal bipolar neuron CL0000748
    CSI 8.6
    rCSI 16.0%
    PRS 83.2%
  • radial glial cell CL0000681
    CSI 8.6
    rCSI 11.9%
    PRS 89.5%
  • L6b glutamatergic cortical neuron CL4023038
    CSI 8.7
    rCSI 27.1%
    PRS 80.2%
  • adipocyte CL0000136
    CSI 9.1
    rCSI 11.7%
    PRS 83.4%
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 9.4
    rCSI 10.9%
    PRS 84.0%
  • melanocyte CL0000148
    CSI 9.7
    rCSI 7.2%
    PRS 87.7%
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 9.7
    rCSI 35.0%
    PRS 76.9%
  • mesothelial cell CL0000077
    CSI 10.1
    rCSI 39.3%
    PRS 75.1%
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 10.1
    rCSI 13.0%
    PRS 87.6%
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 10.5
    rCSI 32.9%
    PRS 81.8%
  • pulmonary alveolar type 2 cell CL0002063
    CSI 10.5
    rCSI 16.4%
    PRS 91.8%
  • Mueller cell CL0000636
    CSI 10.6
    rCSI 24.3%
    PRS 85.0%
  • neuron CL0000540
    CSI 11.0
    rCSI 29.3%
    PRS 79.7%
  • rod bipolar cell CL0000751
    CSI 11.4
    rCSI 20.4%
    PRS 86.5%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [UBA6 DT](/details-gene/550112) is a non-coding RNA (ncRNA) located on chromosome 4q13.2. As its name suggests, it is a divergent transcript originating from the locus of the *UBA6* gene. **Overall**, expression data reveals that [UBA6 DT](/details-gene/550112) is a highly specific marker for various neuronal subtypes within the central nervous system. Its most significant expression is observed in distinct classes of inhibitory interneurons in the cerebral cortex and in multiple cell types within the retina, suggesting a specialized role in neural circuit function and visual processing. ## Cellular Roles and Expression Landscape The expression profile of [UBA6 DT](/details-gene/550112) strongly indicates a primary function within the nervous system. The gene shows its highest significance in several subtypes of GABAergic cortical interneurons, including [pvalb GABAergic cortical interneuron](/details-cell/CL4023018) (CSI: 39.49), [VIP GABAergic cortical interneuron](/details-cell/CL4023016) (CSI: 32.30), and [sst GABAergic cortical interneuron](/details-cell/CL4023017) (CSI: 28.78). This pattern suggests a potential role in regulating the development, maintenance, or function of inhibitory circuits in the cortex. Beyond cortical interneurons, [UBA6 DT](/details-gene/550112) is also a significant marker in retinal cells, including [retinal ganglion cell](/details-cell/CL0000740) (CSI: 21.44), [retinal rod cell](/details-cell/CL0000604) (CSI: 19.06), and [GABAergic amacrine cell](/details-cell/CL4030027) (CSI: 12.67), implicating it in the complex processes of photoreception and visual signal transmission. Moderate significance is also noted in other neural lineage cells such as [differentiation-committed oligodendrocyte precursor](/details-cell/CL4023059) (CSI: 12.38) and in the malignant brain tumor cell type [glioblast](/details-cell/CL0000030) (CSI: 13.37). Notably, significant expression is also found in [lung ciliated cell](/details-cell/CL1000271), suggesting its function is not exclusively confined to the nervous system. ## Pathways and Molecular Function As a non-coding RNA, the precise molecular function of [UBA6 DT](/details-gene/550112) is not yet well-defined. Functional annotations for this gene are limited. However, its genomic location as a divergent transcript from the *UBA6* gene locus is notable. *UBA6* encodes an E1 ubiquitin-activating enzyme, a key component of the ubiquitin-proteasome system. It is plausible that [UBA6 DT](/details--gene/550112) acts as a *cis*-regulatory element, modulating the expression or splicing of *UBA6* in the specific neuronal subtypes where it is highly expressed. This could provide a mechanism for cell-type-specific regulation of protein turnover and signaling. ## Research Directions The highly specific expression pattern of [UBA6 DT](/details-gene/550112) in neuronal subtypes offers several avenues for future research into its role in both normal physiology and neurological disease. **Proposed Hypotheses:** 1. Given its high expression across multiple inhibitory neuron classes, [UBA6 DT](/details-gene/550112) may function as a master regulator of GABAergic interneuron identity or synaptic function. Its dysregulation could contribute to the excitatory/inhibitory imbalance seen in disorders like epilepsy or schizophrenia. 2. As a divergent ncRNA, [UBA6 DT](/details-gene/550112) may regulate the transcription of the neighboring *UBA6* gene in a cell-type-specific manner, thereby controlling ubiquitin-mediated processes critical for neuronal homeostasis in the retina and cortex. 3. The expression of [UBA6 DT](/details-gene/550112) in [glioblast](/details-cell/CL0000030) suggests it may be co-opted in tumorigenesis, potentially by altering cell signaling or protein degradation pathways to promote cancer cell survival or proliferation. **Key Experiment:** To test the hypothesis that [UBA6 DT](/details-gene/550112) is critical for GABAergic interneuron function, a compelling experiment would involve the use of antisense oligonucleotides (ASOs) or an AAV-CRISPRi system to achieve targeted knockdown of this ncRNA specifically in cortical interneurons of a mouse model. The functional consequences could be assessed using a combination of slice electrophysiology to measure changes in neuronal firing properties and synaptic transmission, and single-cell RNA sequencing to map the downstream transcriptional changes resulting from its loss. **Therapeutic Potential:** As a non-coding RNA with a highly restricted expression pattern, [UBA6 DT](/details-gene/550112) presents an attractive therapeutic target. Its specificity for neuronal subtypes could minimize off-target effects. If its dysregulation is implicated in neurological or psychiatric disorders, ASO-based therapies designed to either inhibit (in the case of pathogenic overexpression) or stabilize (in the case of loss-of-function) the ncRNA could be a viable strategy. Similarly, if its role in glioblastoma is confirmed to be oncogenic, it could be a target for novel brain cancer therapies.