Details for: RNVU1 2A

Gene ID: 6063

Symbol: RNVU1 2A

Ensembl ID: ENSG00000278099

Description: RNA, variant U1 small nuclear 2A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.3117
    Cell Significance Index: 3.7600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.2447
    Cell Significance Index: 3.2000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.1840
    Cell Significance Index: 1.8800
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.0913
    Cell Significance Index: 1.1800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0737
    Cell Significance Index: 1.1700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0681
    Cell Significance Index: 1.0100
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.0270
    Cell Significance Index: 0.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0203
    Cell Significance Index: 2.3300
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.0025
    Cell Significance Index: 0.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0014
    Cell Significance Index: -0.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0016
    Cell Significance Index: -2.9100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0017
    Cell Significance Index: -3.1800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0019
    Cell Significance Index: -2.6300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0021
    Cell Significance Index: -3.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0040
    Cell Significance Index: -2.5100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0065
    Cell Significance Index: -2.9400
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0123
    Cell Significance Index: -0.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0150
    Cell Significance Index: -0.7800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0175
    Cell Significance Index: -2.5400
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0207
    Cell Significance Index: -0.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0214
    Cell Significance Index: -1.0000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0510
    Cell Significance Index: -2.3100
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0577
    Cell Significance Index: -0.6500
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0724
    Cell Significance Index: -0.7000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0863
    Cell Significance Index: -0.8700
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0868
    Cell Significance Index: -1.2000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0954
    Cell Significance Index: -2.4300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0990
    Cell Significance Index: -3.1300
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.1051
    Cell Significance Index: -1.0900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1106
    Cell Significance Index: -1.8900
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1207
    Cell Significance Index: -1.2100
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1245
    Cell Significance Index: -1.3500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1261
    Cell Significance Index: -1.6200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1273
    Cell Significance Index: -1.6700
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1292
    Cell Significance Index: -1.3700
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1297
    Cell Significance Index: -1.3800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1298
    Cell Significance Index: -1.8000
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.1301
    Cell Significance Index: -1.4400
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.1328
    Cell Significance Index: -1.2700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1348
    Cell Significance Index: -2.2900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1349
    Cell Significance Index: -1.8400
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.1374
    Cell Significance Index: -1.4400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1399
    Cell Significance Index: -1.5500
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1402
    Cell Significance Index: -1.1600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1430
    Cell Significance Index: -1.6900
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1436
    Cell Significance Index: -1.4000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1499
    Cell Significance Index: -1.9300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1507
    Cell Significance Index: -1.5900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1525
    Cell Significance Index: -1.8000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1588
    Cell Significance Index: -2.2600
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.1612
    Cell Significance Index: -1.6700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1710
    Cell Significance Index: -2.0500
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.1714
    Cell Significance Index: -2.1400
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1728
    Cell Significance Index: -1.5200
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.1773
    Cell Significance Index: -1.5500
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1785
    Cell Significance Index: -1.6700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1806
    Cell Significance Index: -2.4000
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1817
    Cell Significance Index: -2.2700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1837
    Cell Significance Index: -2.1600
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.1839
    Cell Significance Index: -1.6600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1847
    Cell Significance Index: -2.2700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1877
    Cell Significance Index: -1.9600
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1912
    Cell Significance Index: -2.0300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1914
    Cell Significance Index: -1.8200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1917
    Cell Significance Index: -2.1600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1977
    Cell Significance Index: -2.6900
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1990
    Cell Significance Index: -2.0100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1998
    Cell Significance Index: -2.0400
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.2003
    Cell Significance Index: -1.8400
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.2026
    Cell Significance Index: -1.7100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2051
    Cell Significance Index: -2.3600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2057
    Cell Significance Index: -1.9500
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.2077
    Cell Significance Index: -1.9500
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.2089
    Cell Significance Index: -2.2000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.2115
    Cell Significance Index: -2.7600
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.2159
    Cell Significance Index: -2.6100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.2208
    Cell Significance Index: -2.2400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.2226
    Cell Significance Index: -2.1400
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.2256
    Cell Significance Index: -2.7100
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.2268
    Cell Significance Index: -3.4500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.2270
    Cell Significance Index: -2.6000
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.2317
    Cell Significance Index: -2.7300
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.2359
    Cell Significance Index: -2.9600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2367
    Cell Significance Index: -3.2500
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.2406
    Cell Significance Index: -2.2400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2433
    Cell Significance Index: -2.9000
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.2439
    Cell Significance Index: -3.0600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2519
    Cell Significance Index: -3.1800
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.2532
    Cell Significance Index: -1.8400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.2537
    Cell Significance Index: -2.7200
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.2552
    Cell Significance Index: -2.7200
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.2562
    Cell Significance Index: -2.1200
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.2563
    Cell Significance Index: -2.3300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.2576
    Cell Significance Index: -2.9100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.2638
    Cell Significance Index: -3.0600
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.2639
    Cell Significance Index: -3.1400
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.2647
    Cell Significance Index: -3.2200
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.2730
    Cell Significance Index: -3.1300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2781
    Cell Significance Index: -1.6500
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.2781
    Cell Significance Index: -2.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **RNA variant:** RNVU1 2A is a variant of the U1 snRNA, which is a small nuclear RNA that plays a crucial role in the splicing of pre-mRNA. 2. **5'-splice site recognition:** RNVU1 2A is involved in the recognition of 5'-splice sites, which are essential for the proper splicing of pre-mRNA. 3. **Spliceosome complex:** RNVU1 2A is a component of the spliceosome complex, which is responsible for the recognition and removal of 5'-splice sites. 4. **Significant expression:** RNVU1 2A is significantly expressed in various cell types, including ependymal cells, B cells, and retinal cells. **Pathways and Functions:** 1. **mRNA 5'-splice site recognition:** RNVU1 2A plays a crucial role in the recognition of 5'-splice sites, which is essential for the proper splicing of pre-mRNA. 2. **Pre-mRNA 5'-splice site binding:** RNVU1 2A binds to pre-mRNA 5'-splice sites, facilitating the recognition and removal of these sites by the spliceosome complex. 3. **U1 snRNP:** RNVU1 2A is a component of the U1 snRNP (U1 small nuclear ribonucleoprotein), which is a complex that recognizes and binds to 5'-splice sites. 4. **Immune regulation:** RNVU1 2A has been implicated in the regulation of immune responses, particularly in the context of innate immunity and lymphoid cell development. **Clinical Significance:** 1. **Neurological disorders:** RNVU1 2A has been implicated in the pathogenesis of neurological disorders, such as multiple sclerosis and amyotrophic lateral sclerosis (ALS). 2. **Immune-mediated diseases:** RNVU1 2A has been linked to immune-mediated diseases, such as rheumatoid arthritis and lupus. 3. **Cancer:** RNVU1 2A has been identified as a potential biomarker for cancer diagnosis and prognosis. 4. **Gene therapy:** RNVU1 2A has been explored as a target for gene therapy, particularly in the context of immune system disorders. In conclusion, RNVU1 2A is a small nuclear RNA variant that plays a crucial role in the recognition and removal of 5'-splice sites from pre-mRNA. Its significant expression in various cell types and implication in immune regulation make it an important gene for further study and potential therapeutic applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.