Details for: RSC1A1

Gene ID: 6248

Symbol: RSC1A1

Ensembl ID: ENSG00000215695

Description: regulator of solute carriers 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 7.7537
    Cell Significance Index: -3.1500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3012
    Cell Significance Index: 15.6900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.2106
    Cell Significance Index: 2.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.1026
    Cell Significance Index: 57.8800
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.0832
    Cell Significance Index: 1.0100
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.0522
    Cell Significance Index: 0.4600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.0499
    Cell Significance Index: 1.0200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0470
    Cell Significance Index: 0.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0233
    Cell Significance Index: 4.6800
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.0193
    Cell Significance Index: 0.2300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0148
    Cell Significance Index: 0.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0048
    Cell Significance Index: 3.5600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.0035
    Cell Significance Index: 0.7300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0007
    Cell Significance Index: -0.0100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0007
    Cell Significance Index: -0.0100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0018
    Cell Significance Index: -0.0200
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0018
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0029
    Cell Significance Index: -1.8100
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0061
    Cell Significance Index: -0.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0062
    Cell Significance Index: -1.7900
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0088
    Cell Significance Index: -0.0900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0147
    Cell Significance Index: -0.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0151
    Cell Significance Index: -1.7300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0190
    Cell Significance Index: -0.2400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0198
    Cell Significance Index: -0.5300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0223
    Cell Significance Index: -0.4400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0279
    Cell Significance Index: -0.8900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0281
    Cell Significance Index: -0.6800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0302
    Cell Significance Index: -0.6400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0313
    Cell Significance Index: -0.3800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0317
    Cell Significance Index: -0.6200
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0322
    Cell Significance Index: -0.3000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0337
    Cell Significance Index: -1.1800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0354
    Cell Significance Index: -1.1600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0381
    Cell Significance Index: -0.9500
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.0408
    Cell Significance Index: -0.4500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0495
    Cell Significance Index: -1.0700
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0502
    Cell Significance Index: -0.6300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0502
    Cell Significance Index: -0.5300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0549
    Cell Significance Index: -0.5200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0582
    Cell Significance Index: -1.1600
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0617
    Cell Significance Index: -0.7700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0627
    Cell Significance Index: -0.6600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0648
    Cell Significance Index: -1.3000
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0651
    Cell Significance Index: -0.6100
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0686
    Cell Significance Index: -0.6000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0719
    Cell Significance Index: -1.5000
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0727
    Cell Significance Index: -0.6000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0782
    Cell Significance Index: -1.5400
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0809
    Cell Significance Index: -0.9000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0832
    Cell Significance Index: -0.6400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0840
    Cell Significance Index: -2.1400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0868
    Cell Significance Index: -1.5000
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0914
    Cell Significance Index: -0.6800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0974
    Cell Significance Index: -1.1500
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.1015
    Cell Significance Index: -1.3000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1073
    Cell Significance Index: -2.3500
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1104
    Cell Significance Index: -1.4900
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.1132
    Cell Significance Index: -1.3500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1171
    Cell Significance Index: -1.9700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1242
    Cell Significance Index: -1.4600
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.1287
    Cell Significance Index: -1.4700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1292
    Cell Significance Index: -1.6600
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.1296
    Cell Significance Index: -1.6400
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.1353
    Cell Significance Index: -1.7000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1464
    Cell Significance Index: -1.5700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1498
    Cell Significance Index: -1.9900
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1544
    Cell Significance Index: -2.0200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.1577
    Cell Significance Index: -0.9800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1625
    Cell Significance Index: -1.8600
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.1656
    Cell Significance Index: -2.0800
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.1717
    Cell Significance Index: -1.8900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1760
    Cell Significance Index: -2.0800
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1762
    Cell Significance Index: -2.4200
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.1773
    Cell Significance Index: -2.4900
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1790
    Cell Significance Index: -2.0800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1902
    Cell Significance Index: -3.2300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1917
    Cell Significance Index: -1.6200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1919
    Cell Significance Index: -2.3000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1945
    Cell Significance Index: -3.1500
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.2021
    Cell Significance Index: -1.9200
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.2024
    Cell Significance Index: -1.8400
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2065
    Cell Significance Index: -2.1100
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.2076
    Cell Significance Index: -1.4400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2096
    Cell Significance Index: -2.1400
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.2117
    Cell Significance Index: -2.5000
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.2151
    Cell Significance Index: -2.4800
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.2159
    Cell Significance Index: -2.5100
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.2242
    Cell Significance Index: -2.4700
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.2292
    Cell Significance Index: -2.4900
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: -0.2294
    Cell Significance Index: -2.6800
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.2328
    Cell Significance Index: -2.7700
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.2331
    Cell Significance Index: -2.4600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2359
    Cell Significance Index: -2.9000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.2375
    Cell Significance Index: -2.6300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2379
    Cell Significance Index: -3.1100
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.2380
    Cell Significance Index: -2.9300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.2427
    Cell Significance Index: -2.9100
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.2444
    Cell Significance Index: -2.9400
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.2509
    Cell Significance Index: -2.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The RSC1A1 gene is characterized by its involvement in various cellular processes, including: 1. **Regulation of solute carriers**: RSC1A1 regulates the activity of solute carrier 1, which is involved in the transport of solutes across cell membranes. 2. **Negative regulation of transport**: RSC1A1 acts as a negative regulator of transport processes, ensuring that solute transport is tightly controlled. 3. **Cell-type specific expression**: RSC1A1 is significantly expressed in various cell types, including pancreatic cells, erythroid lineage cells, cardiac muscle cells, and endothelial cells. 4. **Interactions with other transport mechanisms**: RSC1A1 interacts with other transport mechanisms, such as the Golgi apparatus and plasma membrane transport processes. **Pathways and Functions:** The RSC1A1 protein is involved in various cellular pathways, including: 1. **Cell junction**: RSC1A1 regulates the activity of solute carrier 1, which is involved in cell junction processes. 2. **Digestion and absorption**: RSC1A1 regulates the transport of nutrients and solutes in the intestine, ensuring proper digestion and absorption. 3. **Golgi apparatus**: RSC1A1 regulates the transport of proteins and solutes from the Golgi apparatus to the plasma membrane. 4. **Intestinal absorption**: RSC1A1 regulates the transport of glucose, amino acids, and other solutes in the intestine. 5. **Nucleoplasm**: RSC1A1 regulates the transport of nucleosides and other molecules in the nucleoplasm. **Clinical Significance:** The RSC1A1 gene has significant implications in various diseases, including: 1. **Diabetes**: Dysregulation of solute carrier 1 has been implicated in diabetes, and RSC1A1 may play a role in regulating glucose transport. 2. **Cardiovascular disease**: RSC1A1's role in regulating sodium channel activity and transport of bile salts and organic acids may be relevant to cardiovascular disease. 3. **Cancer**: RSC1A1's role in regulating protein localization to the plasma membrane and nucleoplasm may be relevant to cancer cell behavior. 4. **Neurological disorders**: RSC1A1's role in regulating nucleoside transport and protein localization to the plasma membrane may be relevant to neurological disorders. In conclusion, the RSC1A1 gene plays a critical role in regulating solute carrier 1 and other transport mechanisms, with implications in various cellular processes and diseases. Further research is needed to fully understand the functional significance of RSC1A1 and its potential as a therapeutic target for various diseases.

Genular Protein ID: 3599999819

Symbol: RSCA1_HUMAN

Name: Regulatory solute carrier protein family 1 member 1

UniProtKB Accession Codes:

Q92681 B2RBP5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 10 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8836035

Title: The human gene of a protein that modifies Na(+)-D-glucose co-transport.

PubMed ID: 8836035

DOI: 10.1089/dna.1996.15.769

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 14724758

Title: Downregulation of the Na(+)- D-glucose cotransporter SGLT1 by protein RS1 (RSC1A1) is dependent on dynamin and protein kinase C.

PubMed ID: 14724758

DOI: 10.1007/s00232-003-0626-y

PubMed ID: 16788147

Title: Transporter regulator RS1 (RSC1A1) coats the trans-Golgi network and migrates into the nucleus.

PubMed ID: 16788147

DOI: 10.1152/ajprenal.00067.2006

PubMed ID: 16788146

Title: RS1 (RSC1A1) regulates the exocytotic pathway of Na+-D-glucose cotransporter SGLT1.

PubMed ID: 16788146

DOI: 10.1152/ajprenal.00068.2006

PubMed ID: 17686765

Title: Tripeptides of RS1 (RSC1A1) inhibit a monosaccharide-dependent exocytotic pathway of Na+-D-glucose cotransporter SGLT1 with high affinity.

PubMed ID: 17686765

DOI: 10.1074/jbc.m705416200

Sequence Information:

  • Length: 617
  • Mass: 66790
  • Checksum: AAF1D6B5F3F5F27D
  • Sequence:
    • MSSLPTSDGF NHPARSSGQS PDVGNPMSLA RSVSASVCPI KPSDSDRIEP KAVKALKASA 
EFQLNSEKKE HLSLQDLSDH ASSADHAPTD QSPAMPMQNS SEEITVAGNL EKSAERSTQG 
LKFHLHTRQE ASLSVTSTRM HEPQMFLGEK DWHPENQNLS QVSDPQQHEE PGNEQYEVAQ 
QKASHDQEYL CNIGDLELPE ERQQNQHKIV DLEATMKGNG LPQNVDPPSA KKSIPSSECS 
GCSNSETFME IDTAQQSLVT LLNSTGRQNA NVKNIGALDL TLDNPLMEVE TSKCNPSSEI 
LNDSISTQDL QPPETNVEIP GTNKEYGHYS SPSLCGSCQP SVESAEESCP SITAALKELH 
ELLVVSSKPA SENTSEEVIC QSETIAEGQT SIKDLSERWT QNEHLTQNEQ CPQVSFHQAI 
SVSVETEKLT GTSSDTGREA VENVNFRSLG DGLSTDKEGV PKSRESINKN RSVTVTSAKT 
SNQLHCTLGV EISPKLLAGE EDALNQTSEQ TKSLSSNFIL VKDLGQGIQN SVTDRPETRE 
NVCPDASRPL LEYEPPTSHP SSSPAILPPL IFPATDIDRI LRAGFTLQEA LGALHRVGGN 
ADLALLVLLA KNIVVPT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.