Details for: CLTCL1

Gene ID: 8218

Symbol: CLTCL1

Ensembl ID: ENSG00000070371

Description: clathrin heavy chain like 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.63
    Marker Score: 9087
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 3.61
    Marker Score: 48019
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.5
    Marker Score: 5494
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.28
    Marker Score: 8122
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.23
    Marker Score: 935
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.18
    Marker Score: 1275
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.8
    Marker Score: 2183
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.64
    Marker Score: 448
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169324
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.37
    Marker Score: 667
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.36
    Marker Score: 1831
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.35
    Marker Score: 730
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.34
    Marker Score: 8051
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 851
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.23
    Marker Score: 10545
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.17
    Marker Score: 18291
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.15
    Marker Score: 8798.5
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4811
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.11
    Marker Score: 2258
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.07
    Marker Score: 40792
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 792
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.01
    Marker Score: 15038
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71819
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48044
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.96
    Marker Score: 9164
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.92
    Marker Score: 3576
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5243
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.91
    Marker Score: 20443
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.9
    Marker Score: 286
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.86
    Marker Score: 3592
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.83
    Marker Score: 381
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.83
    Marker Score: 498
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.81
    Marker Score: 776
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.79
    Marker Score: 48279
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.78
    Marker Score: 370
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.77
    Marker Score: 16523
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.77
    Marker Score: 224
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.76
    Marker Score: 858
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.76
    Marker Score: 239
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 689
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.75
    Marker Score: 304
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.75
    Marker Score: 417
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.72
    Marker Score: 833
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.71
    Marker Score: 414
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.71
    Marker Score: 2625
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.66
    Marker Score: 145
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.66
    Marker Score: 1273
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.65
    Marker Score: 1525
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.65
    Marker Score: 1131
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.64
    Marker Score: 358
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.6
    Marker Score: 931
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.6
    Marker Score: 379
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.59
    Marker Score: 376
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.54
    Marker Score: 3495
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.54
    Marker Score: 315
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.54
    Marker Score: 672
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.54
    Marker Score: 173
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.53
    Marker Score: 587
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.52
    Marker Score: 194
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.52
    Marker Score: 200
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.49
    Marker Score: 153
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.48
    Marker Score: 1972
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.48
    Marker Score: 213
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.47
    Marker Score: 312
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.47
    Marker Score: 433
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.47
    Marker Score: 3131
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.47
    Marker Score: 767.5
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.47
    Marker Score: 122.5
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.46
    Marker Score: 357
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.46
    Marker Score: 121
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.45
    Marker Score: 4249
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.45
    Marker Score: 482
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.43
    Marker Score: 300
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.43
    Marker Score: 284
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.43
    Marker Score: 227
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.43
    Marker Score: 8487
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.4
    Marker Score: 1743
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.4
    Marker Score: 147
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.4
    Marker Score: 429
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.39
    Marker Score: 221
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.39
    Marker Score: 489
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.39
    Marker Score: 339
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.39
    Marker Score: 240
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.39
    Marker Score: 414
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.39
    Marker Score: 346
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.39
    Marker Score: 122.5
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.37
    Marker Score: 127
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.37
    Marker Score: 534

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Other Information

**Key Characteristics** CLTCL1 is a gene that encodes a protein with high sequence similarity to clathrin heavy chain 2 (CLH2_HUMAN). Clathrin is a structural protein that plays a critical role in the formation of clathrin-coated vesicles, which are essential for endocytosis, exocytosis, and intracellular trafficking of proteins and lipids. The CLTCL1 protein is likely involved in the regulation of membrane trafficking and cellular development, given its significant expression in various cell types. **Pathways and Functions** CLTCL1 is involved in several cellular pathways, including: 1. **Cargo recognition for clathrin-mediated endocytosis**: CLTCL1 is likely involved in the recognition of cargo molecules for clathrin-mediated endocytosis, a process that allows cells to internalize and recycle surface receptors and proteins. 2. **Clathrin-coated endocytic vesicle formation**: The CLTCL1 protein is involved in the formation of clathrin-coated endocytic vesicles, which are essential for the internalization of cargo molecules. 3. **Axon guidance**: CLTCL1 is also involved in axon guidance, a process that regulates the growth and navigation of axons during neuronal development. 4. **Cytosol organization**: The CLTCL1 protein is involved in the organization of the cytoskeleton, which is essential for maintaining cellular structure and function. **Clinical Significance** Dysregulation of CLTCL1 has been implicated in various diseases, including: 1. **Neurological disorders**: CLTCL1 mutations have been associated with neurological disorders, such as autism and schizophrenia. 2. **Cardiovascular disease**: CLTCL1 dysregulation has been linked to cardiovascular disease, including arrhythmias and cardiac dysfunction. 3. **Muscular dystrophy**: CLTCL1 mutations have been associated with muscular dystrophy, a group of genetic disorders that affect muscle strength and function. In conclusion, CLTCL1 is a gene that plays a critical role in membrane trafficking, cellular development, and maintenance of cellular structure. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and mechanisms of CLTCL1.

Genular Protein ID: 2300258341

Symbol: CLH2_HUMAN

Name: Clathrin heavy chain 2

UniProtKB Accession Codes:

P53675 B7Z7U5 Q14017 Q15808 Q15809

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 21 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 2 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8733128

Title: Isolation of a new clathrin heavy chain gene with muscle-specific expression from the region commonly deleted in velo-cardio-facial syndrome.

PubMed ID: 8733128

DOI: 10.1093/hmg/5.5.617

PubMed ID: 8733129

Title: Characterization of a second human clathrin heavy chain polypeptide gene (CLH-22) from chromosome 22q11.

PubMed ID: 8733129

DOI: 10.1093/hmg/5.5.625

PubMed ID: 8844170

Title: Cloning and characterization of a novel human clathrin heavy chain gene (CLTCL).

PubMed ID: 8844170

DOI: 10.1006/geno.1996.0386

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15758025

Title: The aftiphilin/p200/gamma-synergin complex.

PubMed ID: 15758025

DOI: 10.1091/mbc.e04-12-1077

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

Sequence Information:

  • Length: 1640
  • Mass: 187030
  • Checksum: C661E1AB989D8E7F
  • Sequence:
    • MAQILPVRFQ EHFQLQNLGI NPANIGFSTL TMESDKFICI REKVGEQAQV TIIDMSDPMA 
PIRRPISAES AIMNPASKVI ALKAGKTLQI FNIEMKSKMK AHTMAEEVIF WKWVSVNTVA 
LVTETAVYHW SMEGDSQPMK MFDRHTSLVG CQVIHYRTDE YQKWLLLVGI SAQQNRVVGA 
MQLYSVDRKV SQPIEGHAAA FAEFKMEGNA KPATLFCFAV RNPTGGKLHI IEVGQPAAGN 
QPFVKKAVDV FFPPEAQNDF PVAMQIGAKH GVIYLITKYG YLHLYDLESG VCICMNRISA 
DTIFVTAPHK PTSGIIGVNK KGQVLSVCVE EDNIVNYATN VLQNPDLGLR LAVRSNLAGA 
EKLFVRKFNT LFAQGSYAEA AKVAASAPKG ILRTRETVQK FQSIPAQSGQ ASPLLQYFGI 
LLDQGQLNKL ESLELCHLVL QQGRKQLLEK WLKEDKLECS EELGDLVKTT DPMLALSVYL 
RANVPSKVIQ CFAETGQFQK IVLYAKKVGY TPDWIFLLRG VMKISPEQGL QFSRMLVQDE 
EPLANISQIV DIFMENSLIQ QCTSFLLDAL KNNRPAEGLL QTWLLEMNLV HAPQVADAIL 
GNKMFTHYDR AHIAQLCEKA GLLQQALEHY TDLYDIKRAV VHTHLLNPEW LVNFFGSLSV 
EDSVECLHAM LSANIRQNLQ LCVQVASKYH EQLGTQALVE LFESFKSYKG LFYFLGSIVN 
FSQDPDVHLK YIQAACKTGQ IKEVERICRE SSCYNPERVK NFLKEAKLTD QLPLIIVCDR 
FGFVHDLVLY LYRNNLQRYI EIYVQKVNPS RTPAVIGGLL DVDCSEEVIK HLIMAVRGQF 
STDELVAEVE KRNRLKLLLP WLESQIQEGC EEPATHNALA KIYIDSNNSP ECFLRENAYY 
DSSVVGRYCE KRDPHLACVA YERGQCDLEL IKVCNENSLF KSEARYLVCR KDPELWAHVL 
EETNPSRRQL IDQVVQTALS ETRDPEEISV TVKAFMTADL PNELIELLEK IVLDNSVFSE 
HRNLQNLLIL TAIKADRTRV MEYISRLDNY DALDIASIAV SSALYEEAFT VFHKFDMNAS 
AIQVLIEHIG NLDRAYEFAE RCNEPAVWSQ LAQAQLQKDL VKEAINSYIR GDDPSSYLEV 
VQSASRSNNW EDLVKFLQMA RKKGRESYIE TELIFALAKT SRVSELEDFI NGPNNAHIQQ 
VGDRCYEEGM YEAAKLLYSN VSNFARLAST LVHLGEYQAA VDNSRKASST RTWKEVCFAC 
MDGQEFRFAQ LCGLHIVIHA DELEELMCYY QDRGYFEELI LLLEAALGLE RAHMGMFTEL 
AILYSKFKPQ KMLEHLELFW SRVNIPKVLR AAEQAHLWAE LVFLYDKYEE YDNAVLTMMS 
HPTEAWKEGQ FKDIITKVAN VELCYRALQF YLDYKPLLIN DLLLVLSPRL DHTWTVSFFS 
KAGQLPLVKP YLRSVQSHNN KSVNEALNHL LTEEEDYQGL RASIDAYDNF DNISLAQQLE 
KHQLMEFRCI AAYLYKGNNW WAQSVELCKK DHLYKDAMQH AAESRDAELA QKLLQWFLEE 
GKRECFAACL FTCYDLLRPD MVLELAWRHN LVDLAMPYFI QVMREYLSKV DKLDALESLR 
KQEEHVTEPA PLVFDFDGHE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.