Details for: MRFAP1L1

Gene ID: 114932

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: MRFAP1L1

Ensembl ID: ENSG00000178988

Description: Morf4 family associated protein 1 like 1

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • granulocyte CL0000094
    CSI 12.81
    rCSI 19.57%
    PRS 83.91
  • retina horizontal cell CL0000745
    CSI 11.93
    rCSI 18.18%
    PRS 72.44
  • pancreatic ductal cell CL0002079
    CSI 8.99
    rCSI 17.48%
    PRS 79.04
  • mesodermal cell CL0000222
    CSI 8.22
    rCSI 9.86%
    PRS 73.78
  • effector CD8-positive, alpha-beta T cell CL0001050
    CSI 7.03
    rCSI 5.35%
    PRS 88.24
  • common myeloid progenitor CL0000049
    CSI 6.29
    rCSI 5.09%
    PRS 78.04
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 5.37
    rCSI 3.62%
    PRS 88.5
  • retinal ganglion cell CL0000740
    CSI 5.08
    rCSI 11.22%
    PRS 61.17
  • activated CD4-positive, alpha-beta T cell CL0000896
    CSI 4.84
    rCSI 4.47%
    PRS 90.64
  • double negative thymocyte CL0002489
    CSI 4.84
    rCSI 3.36%
    PRS 86.97
  • mature alpha-beta T cell CL0000791
    CSI 4.81
    rCSI 17.43%
    PRS 91.48
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 4.78
    rCSI 8.44%
    PRS 56.31
  • myofibroblast cell CL0000186
    CSI 4.61
    rCSI 6.39%
    PRS 73.87
  • CD4-positive, alpha-beta thymocyte CL0000810
    CSI 4.61
    rCSI 3.69%
    PRS 90.49
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 4.09
    rCSI 5.79%
    PRS 72.16
  • goblet cell CL0000160
    CSI 4.07
    rCSI 3.85%
    PRS 74.8
  • extravillous trophoblast CL0008036
    CSI 3.88
    rCSI 4.8%
    PRS 73.38
  • pulmonary ionocyte CL0017000
    CSI 3.79
    rCSI 4.62%
    PRS 82.67
  • early lymphoid progenitor CL0000936
    CSI 3.66
    rCSI 3.22%
    PRS 81.02
  • alternatively activated macrophage CL0000890
    CSI 3.49
    rCSI 4.38%
    PRS 85.92
  • respiratory basal cell CL0002633
    CSI 3.46
    rCSI 3.58%
    PRS 80.54
  • CD4-positive, alpha-beta memory T cell CL0000897
    CSI 3.33
    rCSI 2.39%
    PRS 88.54
  • unswitched memory B cell CL0000970
    CSI 3.23
    rCSI 2.72%
    PRS 89.09
  • mature T cell CL0002419
    CSI 3.2
    rCSI 2.49%
    PRS 90.51
  • stem cell CL0000034
    CSI 3.18
    rCSI 3.06%
    PRS 68.3
  • naive T cell CL0000898
    CSI 3.12
    rCSI 2.17%
    PRS 89.61
  • ciliated cell CL0000064
    CSI 3.08
    rCSI 4.98%
    PRS 71.09
  • hematopoietic multipotent progenitor cell CL0000837
    CSI 3.01
    rCSI 7.25%
    PRS 89.58
  • fibroblast of lung CL0002553
    CSI 2.9
    rCSI 2.7%
    PRS 76.49
  • secretory cell CL0000151
    CSI 2.9
    rCSI 3.02%
    PRS 75.36
  • hepatocyte CL0000182
    CSI 2.86
    rCSI 5.12%
    PRS 75.01
  • ionocyte CL0005006
    CSI 2.84
    rCSI 3.04%
    PRS 76.62
  • interneuron CL0000099
    CSI 2.81
    rCSI 5.65%
    PRS 65.3
  • T-helper 17 cell CL0000899
    CSI 2.74
    rCSI 2.18%
    PRS 92.81
  • mesenchymal cell CL0008019
    CSI 2.7
    rCSI 6.86%
    PRS 69.35
  • activated type II NK T cell CL0000931
    CSI 2.69
    rCSI 3.03%
    PRS 89.32
  • CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792
    CSI 2.65
    rCSI 2.6%
    PRS 89.49
  • hematopoietic precursor cell CL0008001
    CSI 2.63
    rCSI 2.7%
    PRS 88.53
  • plasmacytoid dendritic cell, human CL0001058
    CSI 2.6
    rCSI 1.81%
    PRS 79.13
  • nasal mucosa goblet cell CL0002480
    CSI 2.59
    rCSI 3%
    PRS 80.47
  • radial glial cell CL0000681
    CSI 2.57
    rCSI 3.57%
    PRS 74.41
  • cerebral cortex GABAergic interneuron CL0010011
    CSI 2.57
    rCSI 7.58%
    PRS 77.13
  • plasmablast CL0000980
    CSI 2.56
    rCSI 2.02%
    PRS 81.7
  • lung ciliated cell CL1000271
    CSI 2.55
    rCSI 2.95%
    PRS 67.38
  • glioblast CL0000030
    CSI 2.55
    rCSI 4.07%
    PRS 67.41
  • group 3 innate lymphoid cell CL0001071
    CSI 2.54
    rCSI 1.91%
    PRS 81.76
  • neural crest cell CL0011012
    CSI 2.53
    rCSI 2%
    PRS 63.64
  • hematopoietic stem cell CL0000037
    CSI 2.52
    rCSI 1.67%
    PRS 78.62
  • rod bipolar cell CL0000751
    CSI 2.5
    rCSI 4.49%
    PRS 68.9
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 2.46
    rCSI 3.15%
    PRS 72.08
  • T follicular helper cell CL0002038
    CSI 2.45
    rCSI 1.84%
    PRS 88.67
  • ciliated epithelial cell CL0000067
    CSI 2.35
    rCSI 2.07%
    PRS 64.34
  • interstitial cell of Cajal CL0002088
    CSI 2.34
    rCSI 2.98%
    PRS 81.15
  • pro-B cell CL0000826
    CSI 2.31
    rCSI 1.91%
    PRS 78.26
  • epithelial cell of lower respiratory tract CL0002632
    CSI 2.3
    rCSI 1.78%
    PRS 79.22
  • duct epithelial cell CL0000068
    CSI 2.27
    rCSI 3.32%
    PRS 80.7
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 2.24
    rCSI 2.02%
    PRS 73.6
  • acinar cell CL0000622
    CSI 2.15
    rCSI 3.16%
    PRS 85.81
  • fallopian tube secretory epithelial cell CL4030006
    CSI 2.14
    rCSI 2.06%
    PRS 75.13
  • mononuclear phagocyte CL0000113
    CSI 2.05
    rCSI 4.51%
    PRS 79.86
  • CD8-positive, alpha-beta cytotoxic T cell CL0000794
    CSI 2.04
    rCSI 2.44%
    PRS 91
  • dendritic cell, human CL0001056
    CSI 2.02
    rCSI 3.11%
    PRS 84.79
  • bronchus fibroblast of lung CL2000093
    CSI 1.98
    rCSI 1.61%
    PRS 75.54
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 1.95
    rCSI 2.43%
    PRS 55.04
  • respiratory hillock cell CL4030023
    CSI 1.94
    rCSI 3.46%
    PRS 85.38
  • progenitor cell CL0011026
    CSI 1.93
    rCSI 4.1%
    PRS 70.64
  • effector CD4-positive, alpha-beta T cell CL0001044
    CSI 1.92
    rCSI 5.51%
    PRS 92.37
  • epithelial cell of lung CL0000082
    CSI 1.89
    rCSI 1.57%
    PRS 76.36
  • sst GABAergic cortical interneuron CL4023017
    CSI 1.87
    rCSI 2.41%
    PRS 58.34
  • helper T cell CL0000912
    CSI 1.85
    rCSI 2.62%
    PRS 76.25
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 1.85
    rCSI 2.13%
    PRS 67.82
  • double-positive, alpha-beta thymocyte CL0000809
    CSI 1.83
    rCSI 1.87%
    PRS 86.18
  • placental villous trophoblast CL2000060
    CSI 1.77
    rCSI 2.73%
    PRS 74.84
  • enteroendocrine cell CL0000164
    CSI 1.75
    rCSI 2.39%
    PRS 76.17
  • transit amplifying cell of colon CL0009011
    CSI 1.74
    rCSI 2.04%
    PRS 77.69
  • paneth cell CL0000510
    CSI 1.72
    rCSI 2.54%
    PRS 87.34
  • enteric smooth muscle cell CL0002504
    CSI 1.7
    rCSI 2.42%
    PRS 77.17
  • intestinal epithelial cell CL0002563
    CSI 1.68
    rCSI 1.76%
    PRS 73.48
  • endocrine cell CL0000163
    CSI 1.68
    rCSI 8.62%
    PRS 92.37
  • erythrocyte CL0000232
    CSI 1.66
    rCSI 3.78%
    PRS 77.19
  • club cell CL0000158
    CSI 1.61
    rCSI 2.36%
    PRS 70.48
  • vascular associated smooth muscle cell CL0000359
    CSI 1.61
    rCSI 5.21%
    PRS 74.15
  • OFF-bipolar cell CL0000750
    CSI 1.59
    rCSI 2.17%
    PRS 79.11
  • granulocyte monocyte progenitor cell CL0000557
    CSI 1.58
    rCSI 1.37%
    PRS 80.14
  • VIP GABAergic cortical interneuron CL4023016
    CSI 1.56
    rCSI 1.87%
    PRS 57.05
  • CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920
    CSI 1.54
    rCSI 3.07%
    PRS 88.68
  • common dendritic progenitor CL0001029
    CSI 1.51
    rCSI 1.89%
    PRS 85.08
  • intermediate monocyte CL0002393
    CSI 1.47
    rCSI 2.21%
    PRS 81.29
  • effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062
    CSI 1.46
    rCSI 7.33%
    PRS 87.61
  • peripheral nervous system neuron CL2000032
    CSI 1.45
    rCSI 1.98%
    PRS 67.11
  • colon epithelial cell CL0011108
    CSI 1.44
    rCSI 1.51%
    PRS 72.97
  • memory T cell CL0000813
    CSI 1.41
    rCSI 2.71%
    PRS 93.75
  • activated CD8-positive, alpha-beta T cell, human CL0001049
    CSI 1.41
    rCSI 2.41%
    PRS 89.6
  • retinal cone cell CL0000573
    CSI 1.39
    rCSI 2.24%
    PRS 65.45
  • multi-ciliated epithelial cell CL0005012
    CSI 1.36
    rCSI 1.35%
    PRS 69.44
  • basal cell of epidermis CL0002187
    CSI 1.25
    rCSI 2.21%
    PRS 45.71
  • lung resident memory CD8-positive, alpha-beta T cell CL4033039
    CSI 1.18
    rCSI 3.06%
    PRS 92.93
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 1.14
    rCSI 1.91%
    PRS 57.07
  • melanocyte of skin CL1000458
    CSI 1
    rCSI 1.37%
    PRS 42.9
  • chondrocyte CL0000138
    CSI 0.96
    rCSI 1.53%
    PRS 68.31
  • cytotoxic T cell CL0000910
    CSI 0.3
    rCSI 1.5%
    PRS 81.2%
  • L6b glutamatergic cortical neuron CL4023038
    CSI 0.4
    rCSI 1.3%
    PRS 58.8%
  • group 2 innate lymphoid cell CL0001069
    CSI 0.5
    rCSI 2.4%
    PRS 94.1%
  • Cajal-Retzius cell CL0000695
    CSI 0.5
    rCSI 3.5%
    PRS 82.5%
  • stromal cell of ovary CL0002132
    CSI 0.6
    rCSI 1.7%
    PRS 83.8%
  • forebrain radial glial cell CL0013000
    CSI 0.6
    rCSI 2.1%
    PRS 78.6%
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 0.7
    rCSI 1.5%
    PRS 70.0%
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 0.8
    rCSI 1.8%
    PRS 55.2%
  • primitive red blood cell CL0002355
    CSI 0.8
    rCSI 4.2%
    PRS 83.5%
  • erythroid progenitor cell CL0000038
    CSI 0.8
    rCSI 4.5%
    PRS 82.4%
  • microcirculation associated smooth muscle cell CL0008035
    CSI 0.9
    rCSI 2.7%
    PRS 75.9%
  • chondrocyte CL0000138
    CSI 1.0
    rCSI 1.5%
    PRS 68.3%
  • melanocyte of skin CL1000458
    CSI 1.0
    rCSI 1.4%
    PRS 42.9%
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 1.1
    rCSI 1.9%
    PRS 57.1%
  • lung resident memory CD8-positive, alpha-beta T cell CL4033039
    CSI 1.2
    rCSI 3.1%
    PRS 92.9%
  • basal cell of epidermis CL0002187
    CSI 1.3
    rCSI 2.2%
    PRS 45.7%
  • multi-ciliated epithelial cell CL0005012
    CSI 1.4
    rCSI 1.4%
    PRS 69.4%
  • retinal cone cell CL0000573
    CSI 1.4
    rCSI 2.2%
    PRS 65.5%
  • activated CD8-positive, alpha-beta T cell, human CL0001049
    CSI 1.4
    rCSI 2.4%
    PRS 89.6%
  • memory T cell CL0000813
    CSI 1.4
    rCSI 2.7%
    PRS 93.8%
  • colon epithelial cell CL0011108
    CSI 1.4
    rCSI 1.5%
    PRS 73.0%
  • peripheral nervous system neuron CL2000032
    CSI 1.5
    rCSI 2.0%
    PRS 67.1%
  • effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062
    CSI 1.5
    rCSI 7.3%
    PRS 87.6%
  • intermediate monocyte CL0002393
    CSI 1.5
    rCSI 2.2%
    PRS 81.3%
  • common dendritic progenitor CL0001029
    CSI 1.5
    rCSI 1.9%
    PRS 85.1%
  • CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920
    CSI 1.5
    rCSI 3.1%
    PRS 88.7%
  • VIP GABAergic cortical interneuron CL4023016
    CSI 1.6
    rCSI 1.9%
    PRS 57.1%
  • granulocyte monocyte progenitor cell CL0000557
    CSI 1.6
    rCSI 1.4%
    PRS 80.1%
  • OFF-bipolar cell CL0000750
    CSI 1.6
    rCSI 2.2%
    PRS 79.1%
  • vascular associated smooth muscle cell CL0000359
    CSI 1.6
    rCSI 5.2%
    PRS 74.2%
  • club cell CL0000158
    CSI 1.6
    rCSI 2.4%
    PRS 70.5%
  • erythrocyte CL0000232
    CSI 1.7
    rCSI 3.8%
    PRS 77.2%
  • endocrine cell CL0000163
    CSI 1.7
    rCSI 8.6%
    PRS 92.4%
  • intestinal epithelial cell CL0002563
    CSI 1.7
    rCSI 1.8%
    PRS 73.5%
  • enteric smooth muscle cell CL0002504
    CSI 1.7
    rCSI 2.4%
    PRS 77.2%
  • paneth cell CL0000510
    CSI 1.7
    rCSI 2.5%
    PRS 87.3%
  • transit amplifying cell of colon CL0009011
    CSI 1.7
    rCSI 2.0%
    PRS 77.7%
  • enteroendocrine cell CL0000164
    CSI 1.8
    rCSI 2.4%
    PRS 76.2%
  • placental villous trophoblast CL2000060
    CSI 1.8
    rCSI 2.7%
    PRS 74.8%
  • double-positive, alpha-beta thymocyte CL0000809
    CSI 1.8
    rCSI 1.9%
    PRS 86.2%
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 1.9
    rCSI 2.1%
    PRS 67.8%
  • helper T cell CL0000912
    CSI 1.9
    rCSI 2.6%
    PRS 76.3%
  • sst GABAergic cortical interneuron CL4023017
    CSI 1.9
    rCSI 2.4%
    PRS 58.3%
  • epithelial cell of lung CL0000082
    CSI 1.9
    rCSI 1.6%
    PRS 76.4%
  • effector CD4-positive, alpha-beta T cell CL0001044
    CSI 1.9
    rCSI 5.5%
    PRS 92.4%
  • progenitor cell CL0011026
    CSI 1.9
    rCSI 4.1%
    PRS 70.6%
  • respiratory hillock cell CL4030023
    CSI 1.9
    rCSI 3.5%
    PRS 85.4%
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 2.0
    rCSI 2.4%
    PRS 55.0%
  • bronchus fibroblast of lung CL2000093
    CSI 2.0
    rCSI 1.6%
    PRS 75.5%
  • dendritic cell, human CL0001056
    CSI 2.0
    rCSI 3.1%
    PRS 84.8%
  • CD8-positive, alpha-beta cytotoxic T cell CL0000794
    CSI 2.0
    rCSI 2.4%
    PRS 91.0%
  • mononuclear phagocyte CL0000113
    CSI 2.1
    rCSI 4.5%
    PRS 79.9%
  • fallopian tube secretory epithelial cell CL4030006
    CSI 2.1
    rCSI 2.1%
    PRS 75.1%
  • acinar cell CL0000622
    CSI 2.2
    rCSI 3.2%
    PRS 85.8%
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 2.2
    rCSI 2.0%
    PRS 73.6%
  • duct epithelial cell CL0000068
    CSI 2.3
    rCSI 3.3%
    PRS 80.7%
  • epithelial cell of lower respiratory tract CL0002632
    CSI 2.3
    rCSI 1.8%
    PRS 79.2%
  • pro-B cell CL0000826
    CSI 2.3
    rCSI 1.9%
    PRS 78.3%
  • interstitial cell of Cajal CL0002088
    CSI 2.3
    rCSI 3.0%
    PRS 81.2%
  • ciliated epithelial cell CL0000067
    CSI 2.4
    rCSI 2.1%
    PRS 64.3%
  • T follicular helper cell CL0002038
    CSI 2.5
    rCSI 1.8%
    PRS 88.7%
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 2.5
    rCSI 3.2%
    PRS 72.1%
  • rod bipolar cell CL0000751
    CSI 2.5
    rCSI 4.5%
    PRS 68.9%
  • hematopoietic stem cell CL0000037
    CSI 2.5
    rCSI 1.7%
    PRS 78.6%
  • neural crest cell CL0011012
    CSI 2.5
    rCSI 2.0%
    PRS 63.6%
  • group 3 innate lymphoid cell CL0001071
    CSI 2.5
    rCSI 1.9%
    PRS 81.8%
  • glioblast CL0000030
    CSI 2.6
    rCSI 4.1%
    PRS 67.4%
  • lung ciliated cell CL1000271
    CSI 2.6
    rCSI 3.0%
    PRS 67.4%
  • plasmablast CL0000980
    CSI 2.6
    rCSI 2.0%
    PRS 81.7%
  • cerebral cortex GABAergic interneuron CL0010011
    CSI 2.6
    rCSI 7.6%
    PRS 77.1%
  • radial glial cell CL0000681
    CSI 2.6
    rCSI 3.6%
    PRS 74.4%
  • nasal mucosa goblet cell CL0002480
    CSI 2.6
    rCSI 3.0%
    PRS 80.5%
  • plasmacytoid dendritic cell, human CL0001058
    CSI 2.6
    rCSI 1.8%
    PRS 79.1%
  • hematopoietic precursor cell CL0008001
    CSI 2.6
    rCSI 2.7%
    PRS 88.5%
  • CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792
    CSI 2.7
    rCSI 2.6%
    PRS 89.5%
  • activated type II NK T cell CL0000931
    CSI 2.7
    rCSI 3.0%
    PRS 89.3%
  • mesenchymal cell CL0008019
    CSI 2.7
    rCSI 6.9%
    PRS 69.4%
  • T-helper 17 cell CL0000899
    CSI 2.7
    rCSI 2.2%
    PRS 92.8%
  • interneuron CL0000099
    CSI 2.8
    rCSI 5.7%
    PRS 65.3%
  • ionocyte CL0005006
    CSI 2.8
    rCSI 3.0%
    PRS 76.6%
  • hepatocyte CL0000182
    CSI 2.9
    rCSI 5.1%
    PRS 75.0%
  • secretory cell CL0000151
    CSI 2.9
    rCSI 3.0%
    PRS 75.4%
  • fibroblast of lung CL0002553
    CSI 2.9
    rCSI 2.7%
    PRS 76.5%
  • hematopoietic multipotent progenitor cell CL0000837
    CSI 3.0
    rCSI 7.3%
    PRS 89.6%
  • ciliated cell CL0000064
    CSI 3.1
    rCSI 5.0%
    PRS 71.1%
  • naive T cell CL0000898
    CSI 3.1
    rCSI 2.2%
    PRS 89.6%
  • stem cell CL0000034
    CSI 3.2
    rCSI 3.1%
    PRS 68.3%
  • mature T cell CL0002419
    CSI 3.2
    rCSI 2.5%
    PRS 90.5%
  • unswitched memory B cell CL0000970
    CSI 3.2
    rCSI 2.7%
    PRS 89.1%
  • CD4-positive, alpha-beta memory T cell CL0000897
    CSI 3.3
    rCSI 2.4%
    PRS 88.5%
  • respiratory basal cell CL0002633
    CSI 3.5
    rCSI 3.6%
    PRS 80.5%
  • alternatively activated macrophage CL0000890
    CSI 3.5
    rCSI 4.4%
    PRS 85.9%
  • early lymphoid progenitor CL0000936
    CSI 3.7
    rCSI 3.2%
    PRS 81.0%
  • pulmonary ionocyte CL0017000
    CSI 3.8
    rCSI 4.6%
    PRS 82.7%
  • extravillous trophoblast CL0008036
    CSI 3.9
    rCSI 4.8%
    PRS 73.4%
  • goblet cell CL0000160
    CSI 4.1
    rCSI 3.9%
    PRS 74.8%
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 4.1
    rCSI 5.8%
    PRS 72.2%
  • CD4-positive, alpha-beta thymocyte CL0000810
    CSI 4.6
    rCSI 3.7%
    PRS 90.5%
  • myofibroblast cell CL0000186
    CSI 4.6
    rCSI 6.4%
    PRS 73.9%
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 4.8
    rCSI 8.4%
    PRS 56.3%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [MRFAP1L1](/details-gene/114932) (Morf4 family associated protein 1 like 1) is a protein-coding gene whose function is not well-characterized, though it is annotated as being involved in protein binding. Expression data suggests it plays significant, yet diverse, roles in distinct cellular contexts. **Overall**, it shows exceptionally high significance in both hematopoietic cells of the myeloid lineage, specifically [granulocytes](/details-cell/CL0000094), and in specialized neuronal populations of the eye, such as the [retina horizontal cell](/details-cell/CL0000745). It is also consistently expressed across various T-lymphocyte developmental and activation states, suggesting a broad role within the immune system. Its function likely involves acting as an adapter or scaffold protein within multi-protein complexes that are specific to these disparate cell types. ## Cellular Roles and Expression Landscape The expression profile of [MRFAP1L1](/details-gene/114932) reveals a dichotomous pattern, with high significance in both the immune system and the central nervous system. - **Immune System:** The gene's most significant expression is observed in [granulocytes](/details-cell/CL0000094) (CSI: 12.81), a key component of the innate immune system. Its importance in the myeloid lineage is further supported by significant expression in [common myeloid progenitors](/details-cell/CL0000049) (CSI: 6.29). In parallel, [MRFAP1L1](/details-gene/114932) demonstrates a consistent role within the adaptive immune system, with notable significance across the T-cell lineage, including [effector CD8-positive, alpha-beta T cells](/details-cell/CL0001050) (CSI: 7.03), [central memory CD8-positive, alpha-beta T cells](/details-cell/CL0000907) (CSI: 5.37), and various thymocyte populations such as [double negative thymocytes](/details-cell/CL0002489) (CSI: 4.84) and [CD4-positive, alpha-beta thymocytes](/details-cell/CL0000810) (CSI: 4.61). This broad expression suggests a fundamental role in both myeloid and lymphoid cell biology. - **Nervous System:** Independent of its immune role, [MRFAP1L1](/details-gene/114932) is a highly significant marker for specific neuronal subtypes in the retina. It has a very high CSI in [retina horizontal cells](/details-cell/CL0000745) (CSI: 11.93) and a notable CSI in [retinal ganglion cells](/details-cell/CL0000740) (CSI: 5.08). This highly localized expression pattern suggests a specialized function in retinal architecture or visual signal processing. - **Other Tissues:** The gene also shows relevance in other cell types, including [pancreatic ductal cells](/details-cell/CL0002079) (CSI: 8.99) and [myofibroblast cells](/details-cell/CL0000186) (CSI: 4.61), indicating its functional importance is not limited to the immune and nervous systems. ## Pathways and Molecular Function The known molecular function of [MRFAP1L1](/details-gene/114932) is currently limited, with Gene Ontology annotations pointing primarily to [protein binding](/details-gene/GO:0005515) and, more specifically, [identical protein binding](/details-gene/GO:0042802). This suggests that the MRFAP1L1 protein likely acts as a component of a larger protein complex, potentially forming homodimers or homo-oligomers, or serving as a scaffold to bring other proteins together. The specific composition and function of these complexes are likely to be highly context-dependent, differing between an immune cell like a [granulocyte](/details-cell/CL0000094) and a neuron like a [retina horizontal cell](/details-cell/CL0000745). Notably, the gene was identified in a large-scale screen for genes potentially related to cancer development, though its specific role was not further characterized [Link](https://doi.org/10.1073/pnas.0404089101). ## Research Directions Given that [MRFAP1L1](/details-gene/114932) is poorly characterized but shows a distinct and significant expression pattern, it represents a compelling target for further investigation. Future research should focus on elucidating its molecular interactions and context-specific functions. **Proposed Hypotheses:** 1. Given its high expression in both innate and adaptive immune cells and its protein-binding function, [MRFAP1L1](/details-gene/114932) may function as an essential adapter protein that assembles a signaling complex required for key effector functions, such as degranulation in [granulocytes](/details-cell/CL0000094) or cytokine production in activated T-cells. 2. Based on its highly specific expression in retinal neurons, [MRFAP1L1](/details-gene/114932) likely forms a protein complex critical for synaptic integrity, neurotransmitter release, or signal transduction within the neural circuitry of the retina, thereby contributing to visual processing. 3. Considering its identification in a cancer-related screen [Link](https://doi.org/10.1073/pnas.0404089101), dysregulation of [MRFAP1L1](/details-gene/114932) expression or function could contribute to tumorigenesis, particularly in hematopoietic malignancies or pancreatic cancer, where its expression is prominent. **Key Experimental Proposal:** To test the hypothesis that [MRFAP1L1](/details-gene/114932) functions as a scaffold in different immune contexts (Hypothesis 1), an unbiased proteomics approach could be employed. An affinity purification-mass spectrometry (AP-MS) experiment using tagged [MRFAP1L1](/details-gene/114932) expressed in a myeloid cell line (e.g., HL-60 differentiated into granulocyte-like cells) and a T-cell line (e.g., Jurkat) would identify its binding partners. Comparing the interactomes from these two cell types would reveal both shared and unique protein complexes, providing direct insight into its cell-specific molecular functions in innate versus adaptive immunity. **Therapeutic Potential:** The therapeutic potential of [MRFAP1L1](/details-gene/114932) is currently speculative. As a protein-scaffolding molecule, it may not be a straightforward target for small molecule inhibitors unless a key binding pocket is identified. However, if its interaction with a specific partner protein is shown to drive pathology (e.g., hyper-inflammation or cancer cell survival), developing therapeutics to disrupt this specific protein-protein interaction could be a viable strategy. Further research is required to validate its role in disease before it can be considered a druggable target. Any therapeutic strategy would need to carefully consider potential on-target, off-tissue effects, particularly concerning retinal function.

Genular Protein ID: 1670911862

Symbol: MR1L1_HUMAN

Name: MORF4 family-associated protein 1-like 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 127
  • Mass: 14808
  • Checksum: 6C914B0B4BEECAE5
  • Sequence:
  • MRPLDIDEVE APEEVEVLEP EEDFEQFLLP VINEMREDIA SLIREHGRAY LRTRSKLWEM 
    DNMLIQIKTQ VEASEESALN HVQHPSGEAD ERVSELCEKA EEKAKEIAKM AEMLVELVWR 
    IERSESS