Details for: GNRH1

Gene ID: 2796

Symbol: GNRH1

Ensembl ID: ENSG00000147437

Description: gonadotropin releasing hormone 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71829
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48054
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.94
    Marker Score: 14760
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5294
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.88
    Marker Score: 593
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8
    Marker Score: 3342
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 700
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.75
    Marker Score: 1421.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 559
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.65
    Marker Score: 1317
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.54
    Marker Score: 348
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.52
    Marker Score: 3114
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.51
    Marker Score: 307
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.51
    Marker Score: 224
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.49
    Marker Score: 452
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.33
    Marker Score: 158
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.33
    Marker Score: 377
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.28
    Marker Score: 353
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.24
    Marker Score: 363
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.23
    Marker Score: 154
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 62
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.22
    Marker Score: 109
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 72
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.2
    Marker Score: 345
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.18
    Marker Score: 47
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.17
    Marker Score: 209
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.16
    Marker Score: 68
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.16
    Marker Score: 97
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.15
    Marker Score: 49
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.15
    Marker Score: 186
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.15
    Marker Score: 433
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.15
    Marker Score: 204
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.15
    Marker Score: 8937
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.14
    Marker Score: 49
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.14
    Marker Score: 542
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.14
    Marker Score: 67
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.14
    Marker Score: 99
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.13
    Marker Score: 104
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.13
    Marker Score: 33
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.13
    Marker Score: 115
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.13
    Marker Score: 52
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.13
    Marker Score: 1304
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.12
    Marker Score: 1182
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.12
    Marker Score: 513
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.12
    Marker Score: 48
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.12
    Marker Score: 129
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.12
    Marker Score: 50
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.12
    Marker Score: 47
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.11
    Marker Score: 462
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.11
    Marker Score: 125
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.11
    Marker Score: 26
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.11
    Marker Score: 49
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.11
    Marker Score: 41
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.11
    Marker Score: 35
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.11
    Marker Score: 64
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.11
    Marker Score: 239
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.11
    Marker Score: 108.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.11
    Marker Score: 3965
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.11
    Marker Score: 45
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.11
    Marker Score: 96
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.11
    Marker Score: 31
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.1
    Marker Score: 2218
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.1
    Marker Score: 134
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.1
    Marker Score: 36
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.1
    Marker Score: 99
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.1
    Marker Score: 61
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1
    Marker Score: 58
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.1
    Marker Score: 150
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.1
    Marker Score: 104
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.1
    Marker Score: 21
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.1
    Marker Score: 119
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.1
    Marker Score: 112
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.09
    Marker Score: 811
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.09
    Marker Score: 91
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.09
    Marker Score: 183
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.09
    Marker Score: 53
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.09
    Marker Score: 131
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.09
    Marker Score: 65
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.09
    Marker Score: 92
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.09
    Marker Score: 20
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.09
    Marker Score: 166
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.09
    Marker Score: 67
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.09
    Marker Score: 44
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.09
    Marker Score: 96
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.09
    Marker Score: 275
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.09
    Marker Score: 20
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.09
    Marker Score: 59
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.09
    Marker Score: 23

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Other Information

**Key characteristics:** * GNRH1 is a glycoprotein that belongs to the G protein-coupled receptor (GPCR) family. * It is a cell-surface receptor that is expressed on a variety of cell types in the female reproductive tract. * GNRH1 is a key regulator of female reproductive function. * It is involved in the regulation of ovarian follicle development, ovulation, and reproductive behavior. * It is also involved in the regulation of the menstrual cycle. **Pathways and functions:** * GNRH1 is a receptor for gonadotropin-releasing hormone (GnRH). * It is expressed in the pituitary gland, which produces GnRH. * GnRH binds to GNRH1 on the surface of pituitary cells, triggering a cascade of intracellular events that lead to the release of GnRH from the pituitary gland. * GnRH then binds to its receptor, GNRH1, on the surface of target cells. * This binding activates GNRH1, which leads to the activation of downstream signaling pathways that regulate the function of target cells. **Clinical significance:** * Mutations in GNRH1 have been linked to polycystic ovary syndrome (PCOS), a genetic disorder characterized by the development of multiple ovarian cysts. * GNRH1 is a potential therapeutic target for the treatment of PCOS. * Studies have shown that blocking GNRH1 signaling can improve fertility in women with PCOS. **Additional notes:** * GNRH1 is a highly conserved protein, with similar sequences found in organisms from yeast to humans. * GNRH1 is a well-studied protein that has been extensively characterized in research. * GNRH1 is a key regulator of female reproductive function, and its dysfunction can lead to infertility and other reproductive problems.

Genular Protein ID: 1420019693

Symbol: GON1_HUMAN

Name: Progonadoliberin-1

UniProtKB Accession Codes:

P01148 A0AVP0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 GO 13 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 2671939

Title: The complete nucleotide sequence of the human gonadotropin-releasing hormone gene.

PubMed ID: 2671939

DOI: 10.1093/nar/17.15.6403

PubMed ID: 2867548

Title: Isolation of the gene and hypothalamic cDNA for the common precursor of gonadotropin-releasing hormone and prolactin release-inhibiting factor in human and rat.

PubMed ID: 2867548

DOI: 10.1073/pnas.83.1.179

PubMed ID: 6090951

Title: Characterization of cDNA for precursor of human luteinizing hormone releasing hormone.

PubMed ID: 6090951

DOI: 10.1038/311666a0

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6760865

Title: The chemical identity of the immunoreactive LHRH-like peptide biosynthesized in the human placenta.

PubMed ID: 6760865

DOI: 10.1016/0006-291x(82)92047-2

PubMed ID: 2983326

Title: Novel activity of human angiotensin I converting enzyme: release of the NH2- and COOH-terminal tripeptides from the luteinizing hormone-releasing hormone.

PubMed ID: 2983326

DOI: 10.1073/pnas.82.4.1025

PubMed ID: 10336644

Title: Hydrolysis by somatic angiotensin-I converting enzyme of basic dipeptides from a cholecystokinin/gastrin and a LH-RH peptide extended at the C-terminus with gly-Arg/Lys-arg, but not from diarginyl insulin.

PubMed ID: 10336644

DOI: 10.1046/j.1432-1327.1999.00419.x

PubMed ID: 7683654

Title: Differences in the properties and enzymatic specificities of the two active sites of angiotensin I-converting enzyme (kininase II). Studies with bradykinin and other natural peptides.

PubMed ID: 7683654

DOI: 10.1016/s0021-9258(18)98378-x

PubMed ID: 19535795

Title: Isolated familial hypogonadotropic hypogonadism and a GNRH1 mutation.

PubMed ID: 19535795

DOI: 10.1056/nejmoa0900136

PubMed ID: 26190377

Title: Atomic view of the histidine environment stabilizing higher-pH conformations of pH-dependent proteins.

PubMed ID: 26190377

DOI: 10.1038/ncomms8771

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

PubMed ID: 23643382

Title: Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism.

PubMed ID: 23643382

DOI: 10.1016/j.ajhg.2013.04.008

Sequence Information:

  • Length: 92
  • Mass: 10380
  • Checksum: 30A72221B076FA79
  • Sequence:
    • MKPIQKLLAG LILLTWCVEG CSSQHWSYGL RPGGKRDAEN LIDSFQEIVK EVGQLAETQR 
FECTTHQPRS PLRDLKGALE SLIEEETGQK KI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.