Details for: ARHGAP35

Gene ID: 2909

Symbol: ARHGAP35

Ensembl ID: ENSG00000160007

Description: Rho GTPase activating protein 35

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.68
    Marker Score: 57236
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.34
    Marker Score: 35023
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.31
    Marker Score: 46047
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.28
    Marker Score: 86626
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.26
    Marker Score: 9378
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.25
    Marker Score: 17262
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.24
    Marker Score: 82517
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.08
    Marker Score: 8030
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.99
    Marker Score: 18712
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.95
    Marker Score: 120121
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.92
    Marker Score: 2586
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.88
    Marker Score: 2279
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.84
    Marker Score: 9642
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.82
    Marker Score: 4365
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.82
    Marker Score: 4001.5
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.81
    Marker Score: 17151
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.8
    Marker Score: 2071
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.8
    Marker Score: 18536
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.78
    Marker Score: 8214
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.77
    Marker Score: 15232
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.74
    Marker Score: 1924
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.72
    Marker Score: 855
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.7
    Marker Score: 496
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.69
    Marker Score: 891
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.65
    Marker Score: 5404
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.61
    Marker Score: 54277
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.56
    Marker Score: 2402
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.52
    Marker Score: 6204
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.52
    Marker Score: 890
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.5
    Marker Score: 843
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.49
    Marker Score: 770
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.48
    Marker Score: 7960
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.48
    Marker Score: 990
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.46
    Marker Score: 4888
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.4
    Marker Score: 438
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.38
    Marker Score: 1188
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.36
    Marker Score: 941
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.35
    Marker Score: 5643
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.34
    Marker Score: 10129
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.34
    Marker Score: 561
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.32
    Marker Score: 3118
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.31
    Marker Score: 766
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.31
    Marker Score: 20436
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.29
    Marker Score: 1819
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.27
    Marker Score: 976
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.26
    Marker Score: 2416
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.25
    Marker Score: 5413
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.25
    Marker Score: 8052
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.24
    Marker Score: 22058
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.24
    Marker Score: 356
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.22
    Marker Score: 5099.5
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.21
    Marker Score: 466
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.2
    Marker Score: 1142
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.19
    Marker Score: 709
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.19
    Marker Score: 4949
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.18
    Marker Score: 688
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.18
    Marker Score: 2705
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.18
    Marker Score: 707
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.16
    Marker Score: 6213
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.14
    Marker Score: 18354
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.13
    Marker Score: 999
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.11
    Marker Score: 533
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.09
    Marker Score: 2209
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.08
    Marker Score: 536
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.08
    Marker Score: 1162
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.08
    Marker Score: 1219
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.06
    Marker Score: 2851
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.06
    Marker Score: 1780
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.05
    Marker Score: 693
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.04
    Marker Score: 1095
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.03
    Marker Score: 2358
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.03
    Marker Score: 3674
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.02
    Marker Score: 883
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.02
    Marker Score: 1779
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.01
    Marker Score: 2888
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.01
    Marker Score: 1218
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.01
    Marker Score: 1084
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1
    Marker Score: 405
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1
    Marker Score: 5991
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71708
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47933
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30392
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.98
    Marker Score: 457
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.98
    Marker Score: 267
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.98
    Marker Score: 1259
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.96
    Marker Score: 1192
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.95
    Marker Score: 344
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.95
    Marker Score: 21151
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2399
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 483
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.93
    Marker Score: 349
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.92
    Marker Score: 340
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.92
    Marker Score: 1490
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2708
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.89
    Marker Score: 1265
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.89
    Marker Score: 497
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.89
    Marker Score: 6642
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.88
    Marker Score: 3032

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Other Information

**Key characteristics:** - ARHGAP35 is a transmembrane protein that belongs to the Rho GTPase-activating protein family. - It is a key regulator of Rho GTPases, which are essential for various cellular processes, including cell migration, proliferation, and differentiation. - ARHGAP35 is localized to the plasma membrane and acts as a bridge between the Rho GTPases and the cytoskeleton. - It is also involved in the regulation of the Cdc42 gtpase cycle, a signaling pathway that is important for cell cycle regulation. **Pathways and functions:** - ARHGAP35 is involved in several cellular processes, including axon guidance and neuronal development. - It is essential for the guidance of migrating neurons along the developing optic nerve. - It also plays a role in the regulation of synaptic plasticity, a process by which the strength of synaptic connections between neurons is modified in response to experience. - ARHGAP35 is also involved in the regulation of neuronal survival and differentiation. **Clinical significance:** - Mutations in ARHGAP35 have been linked to several neurodevelopmental disorders, including autism, schizophrenia, and epilepsy. - These disorders are characterized by abnormal neuronal migration, synaptic plasticity, and neuronal survival. - Targeting ARHGAP35 has been explored as a therapeutic strategy for these disorders. **Additional information:** - The gene encoding ARHGAP35 is located on chromosome 17q21. - It is a highly conserved protein, with a similar gene found in mice and zebrafish. - ARHGAP35 is a promising target for therapeutic intervention in neurodevelopmental disorders.

Genular Protein ID: 2456673725

Symbol: RHG35_HUMAN

Name: Glucocorticoid receptor DNA-binding factor 1

UniProtKB Accession Codes:

Q9NRY4 A7E2A4 Q14452 Q9C0E1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 35 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 6 PRO 1 PROSITE 4 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 16 RefSeq 2 SAM 1 SASBDB 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11214970

Title: Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 11214970

DOI: 10.1093/dnares/7.6.347

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11054565

Title: p190-A, a human tumor suppressor gene, maps to the chromosomal region 19q13.3 that is reportedly deleted in some gliomas.

PubMed ID: 11054565

DOI: 10.1016/s0378-1119(00)00387-5

PubMed ID: 1894621

Title: Molecular cloning and characterization of a factor that binds the human glucocorticoid receptor gene and represses its expression.

PubMed ID: 1894621

DOI: 10.1016/s0021-9258(19)47378-x

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18829532

Title: Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion.

PubMed ID: 18829532

DOI: 10.1158/0008-5472.can-08-0997

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19673492

Title: Regulation of the substrate preference of p190RhoGAP by protein kinase C-mediated phosphorylation of a phospholipid binding site.

PubMed ID: 19673492

DOI: 10.1021/bi900667y

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20675588

Title: Neutrophil functions and autoimmune arthritis in the absence of p190RhoGAP: generation and analysis of a novel null mutation in mice.

PubMed ID: 20675588

DOI: 10.4049/jimmunol.0904163

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28894085

Title: p190RhoGAP proteins contain pseudoGTPase domains.

PubMed ID: 28894085

DOI: 10.1038/s41467-017-00483-x

PubMed ID: 19393245

Title: NMR structural studies on human p190-A RhoGAPFF1 revealed that domain phosphorylation by the PDGF-receptor alpha requires its previous unfolding.

PubMed ID: 19393245

DOI: 10.1016/j.jmb.2009.04.035

Sequence Information:

  • Length: 1499
  • Mass: 170514
  • Checksum: 8CCB493414A7E3E6
  • Sequence:
    • MMMARKQDVR IPTYNISVVG LSGTEKEKGQ CGIGKSCLCN RFVRPSADEF HLDHTSVLST 
SDFGGRVVNN DHFLYWGEVS RSLEDCVECK MHIVEQTEFI DDQTFQPHRS TALQPYIKRA 
AATKLASAEK LMYFCTDQLG LEQDFEQKQM PDGKLLVDGF LLGIDVSRGM NRNFDDQLKF 
VSNLYNQLAK TKKPIVVVLT KCDEGVERYI RDAHTFALSK KNLQVVETSA RSNVNVDLAF 
STLVQLIDKS RGKTKIIPYF EALKQQSQQI ATAKDKYEWL VSRIVKNHNE NWLSVSRKMQ 
ASPEYQDYVY LEGTQKAKKL FLQHIHRLKH EHIERRRKLY LAALPLAFEA LIPNLDEIDH 
LSCIKAKKLL ETKPEFLKWF VVLEETPWDA TSHIDNMENE RIPFDLMDTV PAEQLYEAHL 
EKLRNERKRV EMRRAFKENL ETSPFITPGK PWEEARSFIM NEDFYQWLEE SVYMDIYGKH 
QKQIIDKAKE EFQELLLEYS ELFYELELDA KPSKEKMGVI QDVLGEEQRF KALQKLQAER 
DALILKHIHF VYHPTKETCP SCPACVDAKI EHLISSRFIR PSDRNQKNSL SDPNIDRINL 
VILGKDGLAR ELANEIRALC TNDDKYVIDG KMYELSLRPI EGNVRLPVNS FQTPTFQPHG 
CLCLYNSKES LSYVVESIEK SRESTLGRRD NHLVHLPLTL ILVNKRGDTS GETLHSLIQQ 
GQQIASKLQC VFLDPASAGI GYGRNINEKQ ISQVLKGLLD SKRNLNLVSS TASIKDLADV 
DLRIVMCLMC GDPFSADDIL FPVLQSQTCK SSHCGSNNSV LLELPIGLHK KRIELSVLSY 
HSSFSIRKSR LVHGYIVFYS AKRKASLAML RAFLCEVQDI IPIQLVALTD GAVDVLDNDL 
SREQLTEGEE IAQEIDGRFT SIPCSQPQHK LEIFHPFFKD VVEKKNIIEA THMYDNAAEA 
CSTTEEVFNS PRAGSPLCNS NLQDSEEDIE PSYSLFREDT SLPSLSKDHS KLSMELEGND 
GLSFIMSNFE SKLNNKVPPP VKPKPPVHFE ITKGDLSYLD QGHRDGQRKS VSSSPWLPQD 
GFDPSDYAEP MDAVVKPRNE EENIYSVPHD STQGKIITIR NINKAQSNGS GNGSDSEMDT 
SSLERGRKVS IVSKPVLYRT RCTRLGRFAS YRTSFSVGSD DELGPIRKKE EDQASQGYKG 
DNAVIPYETD EDPRRRNILR SLRRNTKKPK PKPRPSITKA TWESNYFGVP LTTVVTPEKP 
IPIFIERCIE YIEATGLSTE GIYRVSGNKS EMESLQRQFD QDHNLDLAEK DFTVNTVAGA 
MKSFFSELPD PLVPYNMQID LVEAHKINDR EQKLHALKEV LKKFPKENHE VFKYVISHLN 
KVSHNNKVNL MTSENLSICF WPTLMRPDFS TMDALTATRT YQTIIELFIQ QCPFFFYNRP 
ITEPPGARPS SPSAVASTVP FLTSTPVTSQ PSPPQSPPPT PQSPMQPLLP SQLQAEHTL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.