Details for: GSTT2

Gene ID: 2953

Symbol: GSTT2

Ensembl ID: ENSG00000099984

Description: glutathione S-transferase theta 2 (gene/pseudogene)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.1798
    Cell Significance Index: 37.6900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.6386
    Cell Significance Index: 32.2500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.5925
    Cell Significance Index: 33.8000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.5497
    Cell Significance Index: 54.2900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.5064
    Cell Significance Index: 49.3200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.4384
    Cell Significance Index: 35.8800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 1.4347
    Cell Significance Index: 28.6100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.3079
    Cell Significance Index: 41.6600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.0774
    Cell Significance Index: 21.6300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.0217
    Cell Significance Index: 22.0800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9953
    Cell Significance Index: 26.6700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.8079
    Cell Significance Index: 15.9800
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.8004
    Cell Significance Index: 10.6700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.7264
    Cell Significance Index: 15.1600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.4522
    Cell Significance Index: 4.6800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.4398
    Cell Significance Index: 6.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1466
    Cell Significance Index: 29.4000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.1413
    Cell Significance Index: 1.8200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.1106
    Cell Significance Index: 2.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0949
    Cell Significance Index: 13.7900
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.0916
    Cell Significance Index: 1.3700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0155
    Cell Significance Index: 0.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0145
    Cell Significance Index: 22.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0128
    Cell Significance Index: 2.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0123
    Cell Significance Index: 23.1900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0119
    Cell Significance Index: 0.6200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0111
    Cell Significance Index: 15.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0072
    Cell Significance Index: 13.3100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0060
    Cell Significance Index: 3.8000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0040
    Cell Significance Index: 0.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0054
    Cell Significance Index: -2.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0086
    Cell Significance Index: -2.4700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0093
    Cell Significance Index: -0.4200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0095
    Cell Significance Index: -1.0900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0153
    Cell Significance Index: -0.1600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0167
    Cell Significance Index: -0.7800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0172
    Cell Significance Index: -0.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0237
    Cell Significance Index: -2.4200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0306
    Cell Significance Index: -3.1900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0323
    Cell Significance Index: -0.9500
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0537
    Cell Significance Index: -0.6800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0559
    Cell Significance Index: -1.7900
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0611
    Cell Significance Index: -0.7700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0870
    Cell Significance Index: -1.3800
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1050
    Cell Significance Index: -0.9300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1055
    Cell Significance Index: -1.2600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1062
    Cell Significance Index: -3.3600
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.1113
    Cell Significance Index: -1.3700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1177
    Cell Significance Index: -4.3200
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1229
    Cell Significance Index: -1.7000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1232
    Cell Significance Index: -3.5500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1234
    Cell Significance Index: -1.1700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1314
    Cell Significance Index: -2.2100
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1339
    Cell Significance Index: -1.7300
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.1345
    Cell Significance Index: -1.6700
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1346
    Cell Significance Index: -1.0900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1376
    Cell Significance Index: -4.0400
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1380
    Cell Significance Index: -1.5100
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1526
    Cell Significance Index: -1.9600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1534
    Cell Significance Index: -1.8600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1592
    Cell Significance Index: -2.3900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1650
    Cell Significance Index: -2.8200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1690
    Cell Significance Index: -3.7000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1718
    Cell Significance Index: -2.0200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1750
    Cell Significance Index: -4.3700
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1768
    Cell Significance Index: -2.0800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1842
    Cell Significance Index: -3.9900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1846
    Cell Significance Index: -3.8300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1849
    Cell Significance Index: -2.6600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1860
    Cell Significance Index: -2.7200
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.1919
    Cell Significance Index: -2.9200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1928
    Cell Significance Index: -3.7700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1951
    Cell Significance Index: -2.8800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.2067
    Cell Significance Index: -2.7000
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.2140
    Cell Significance Index: -2.6800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2159
    Cell Significance Index: -3.1000
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.2193
    Cell Significance Index: -2.6500
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.2201
    Cell Significance Index: -1.8600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2271
    Cell Significance Index: -3.8000
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.2311
    Cell Significance Index: -2.2000
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.2315
    Cell Significance Index: -2.6900
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.2316
    Cell Significance Index: -2.5100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2324
    Cell Significance Index: -3.0500
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.2354
    Cell Significance Index: -2.5700
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.2368
    Cell Significance Index: -2.8200
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.2385
    Cell Significance Index: -2.5000
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.2408
    Cell Significance Index: -2.3300
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.2409
    Cell Significance Index: -2.1900
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2418
    Cell Significance Index: -3.3200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2426
    Cell Significance Index: -3.9300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2427
    Cell Significance Index: -2.5600
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.2441
    Cell Significance Index: -2.6500
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.2465
    Cell Significance Index: -2.8000
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.2492
    Cell Significance Index: -3.5000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2517
    Cell Significance Index: -3.1800
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.2524
    Cell Significance Index: -2.6600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.2578
    Cell Significance Index: -2.9500
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.2580
    Cell Significance Index: -2.7400
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.2588
    Cell Significance Index: -2.6700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.2596
    Cell Significance Index: -2.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GSTT2 is a member of the glutathione S-transferase (GST) family, which plays a crucial role in protecting cells from oxidative stress and carcinogenic compounds. GSTT2 is a pseudogene, meaning it lacks a functional gene and is not capable of producing a protein. Despite this, GSTT2 is significantly expressed in various tissues, including glial cells, neurons, and epithelial cells. Its expression is often linked to the presence of other GST genes, suggesting a functional role in cellular processes. **Pathways and Functions:** GSTT2 is involved in several key pathways, including: 1. **Glutathione metabolic process**: GSTT2 is thought to play a role in the regulation of glutathione levels, which is essential for maintaining cellular redox balance and preventing oxidative stress. 2. **Glutathione transferase activity**: Although GSTT2 is a pseudogene, it shares a common functional domain with other GST enzymes, suggesting a conserved mechanism for glutathione transferase activity. 3. **Cytosol and nucleus**: GSTT2 is expressed in both cytosolic and nuclear compartments, indicating its involvement in various cellular processes, including transcriptional regulation and signaling pathways. **Clinical Significance:** GSTT2 has been implicated in several human diseases, including: 1. **Cancer**: GSTT2 has been shown to be overexpressed in various types of cancer, including breast, lung, and colon cancer. Its expression is often associated with poor prognosis and reduced survival rates. 2. **Neurodegenerative diseases**: GSTT2 has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's, where its expression is often altered in affected tissues. 3. **Ocular diseases**: GSTT2 is expressed in the retina and lens, and its expression has been linked to ocular diseases, such as age-related macular degeneration (AMD) and cataracts. In conclusion, GSTT2 is a pseudogene with a complex and multifaceted role in human biology. Its expression in various tissues and its involvement in key pathways suggest a functional role in cellular processes. Further research is needed to fully elucidate the clinical significance of GSTT2 and its potential as a biomarker for human disease. **Recommendations:** 1. **Further research**: Investigate the functional role of GSTT2 in human tissues and its relationship to various diseases. 2. **Biomarker development**: Explore the potential of GSTT2 as a biomarker for human disease, particularly in cancer and neurodegenerative diseases. 3. **Therapeutic applications**: Investigate the therapeutic potential of GSTT2 in preventing or treating diseases related to its expression and function.

Genular Protein ID: 4283528469

Symbol: GST2_HUMAN

Name: Glutathione S-transferase theta-2

UniProtKB Accession Codes:

P0CG29 O60665 P30712 Q6IPV7 Q9HD76

Database IDs:

AGR 1 AlphaFoldDB 1 BioGRID-ORCS 1 BioMuta 1 CDD 2 CTD 1 ChEBI 9 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 EC 1 EMBL 2 Ensembl 1 EvolutionaryTrace 1 GO 6 Gene3D 2 GeneCards 1 GenomeRNAi 1 HGNC 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PeptideAtlas 1 Pfam 2 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SFLD 2 SMR 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10975610

Title: Characterization of the glutathione S-transferase GSTT1 deletion: discrimination of all genotypes by polymerase chain reaction indicates a trimodular genotype-phenotype correlation.

PubMed ID: 10975610

DOI: 10.1097/00008571-200008000-00009

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 1417752

Title: Characterization of a human class-theta glutathione S-transferase with activity towards 1-menaphthyl sulphate.

PubMed ID: 1417752

DOI: 10.1042/bj2860929

PubMed ID: 8761485

Title: The distribution of theta-class glutathione S-transferases in the liver and lung of mouse, rat and human.

PubMed ID: 8761485

DOI: 10.1042/bj3180297

Sequence Information:

  • Length: 244
  • Mass: 27506
  • Checksum: DBA15D045262FFC3
  • Sequence:
    • MGLELFLDLV SQPSRAVYIF AKKNGIPLEL RTVDLVKGQH KSKEFLQINS LGKLPTLKDG 
DFILTESSAI LIYLSCKYQT PDHWYPSDLQ ARARVHEYLG WHADCIRGTF GIPLWVQVLG 
PLIGVQVPKE KVERNRTAMD QALQWLEDKF LGDRPFLAGQ QVTLADLMAL EELMQPVALG 
YELFEGRPRL AAWRGRVEAF LGAELCQEAH SIILSILEQA AKKTLPTPSP EAYQAMLLRI 
ARIP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.