Details for: GSTT2

Gene ID: 2953

Symbol: GSTT2

Ensembl ID: ENSG00000099984

Description: glutathione S-transferase theta 2 (gene/pseudogene)

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glial cell (CL0000125)
    Fold Change: 16.31
    Marker Score: 17936
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 10.07
    Marker Score: 32244
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 4.72
    Marker Score: 4525
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 4.09
    Marker Score: 34612.5
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.33
    Marker Score: 194
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.28
    Marker Score: 340
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.25
    Marker Score: 1045
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.21
    Marker Score: 73
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.18
    Marker Score: 104
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.17
    Marker Score: 223
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.16
    Marker Score: 64
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.11
    Marker Score: 33
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.11
    Marker Score: 116
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.1
    Marker Score: 312
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.1
    Marker Score: 189
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.1
    Marker Score: 41
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.09
    Marker Score: 32
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.09
    Marker Score: 27
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.08
    Marker Score: 1064
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.07
    Marker Score: 26
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.07
    Marker Score: 23
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.07
    Marker Score: 27
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.07
    Marker Score: 265
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.06
    Marker Score: 53
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.06
    Marker Score: 1062
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.06
    Marker Score: 72
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.06
    Marker Score: 125
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.05
    Marker Score: 63
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.05
    Marker Score: 61
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.05
    Marker Score: 10
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.04
    Marker Score: 37
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.04
    Marker Score: 50.5
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.04
    Marker Score: 9
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.04
    Marker Score: 9
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.04
    Marker Score: 44.5
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.03
    Marker Score: 52
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.03
    Marker Score: 32
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.03
    Marker Score: 15.5
  • Cell Name: follicular dendritic cell (CL0000442)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.03
    Marker Score: 29
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.03
    Marker Score: 166
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.03
    Marker Score: 262
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.02
    Marker Score: 29
  • Cell Name: type D enteroendocrine cell (CL0000502)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.02
    Marker Score: 26
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.02
    Marker Score: 23
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.02
    Marker Score: 25.5
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.02
    Marker Score: 20.5
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.02
    Marker Score: 29
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.02
    Marker Score: 28
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.01
    Marker Score: 42
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.01
    Marker Score: 23
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.01
    Marker Score: 41
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.01
    Marker Score: 34
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.01
    Marker Score: 27
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.01
    Marker Score: 28
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.01
    Marker Score: 48
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.01
    Marker Score: 29
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.01
    Marker Score: 86
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.01
    Marker Score: 7

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Other Information

**Key characteristics:** * Gene name: GSTT2 * Ensembl ID: ENSG00000099984 * Protein: GST2_HUMAN (Glutathione S-transferase theta-2) * Size: 2.1 kb * Location: Chromosome 19p13.3 * Expression: Significantly expressed in glial cell, amacrine cell, retina horizontal cell, retinal bipolar neuron, secondary lens fiber, lens epithelial cell, pigmented epithelial cell, Schwann cell, corneal endothelial cell, and anterior lens cell **Pathways and functions:** * GSTT2 gene is involved in multiple pathways related to glutathione metabolism, including: * Glutathione metabolic process * Glutathione transferase activity * Detoxification of ROS generated during inflammation and cell stress * It helps maintain cellular glutathione levels within a narrow range necessary for proper cellular function. * It plays a role in maintaining redox balance in the body, protecting cells from oxidative stress caused by ROS generated during inflammation, cell death, and aging. **Clinical significance:** * Mutations in the GSTT2 gene have been linked to several human diseases, including: * Alpha-1 antitrypsin deficiency, a genetic disorder characterized by a lack of a protein that helps digest an enzyme in the liver. * Retinoblastoma, a cancer of the eye. * Certain types of cancer, including lung cancer, breast cancer, and colon cancer. * Liver disease and other metabolic disorders. **Conclusion:** The GSTT2 gene is an essential regulator of glutathione metabolism, playing a crucial role in maintaining cellular health and preventing the accumulation of harmful ROS. Its mutations can lead to various diseases, underscoring its importance in human health.

Genular Protein ID: 4283528469

Symbol: GST2_HUMAN

Name: Glutathione S-transferase theta-2

UniProtKB Accession Codes:

P0CG29 O60665 P30712 Q6IPV7 Q9HD76

Database IDs:

AGR 1 AlphaFoldDB 1 BioGRID-ORCS 1 BioMuta 1 CDD 2 CTD 1 ChEBI 9 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EC 1 EMBL 2 Ensembl 1 GO 6 Gene3D 2 GeneCards 1 GenomeRNAi 1 HGNC 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PeptideAtlas 1 Pfam 2 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SFLD 2 SMR 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10975610

Title: Characterization of the glutathione S-transferase GSTT1 deletion: discrimination of all genotypes by polymerase chain reaction indicates a trimodular genotype-phenotype correlation.

PubMed ID: 10975610

DOI: 10.1097/00008571-200008000-00009

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 1417752

Title: Characterization of a human class-theta glutathione S-transferase with activity towards 1-menaphthyl sulphate.

PubMed ID: 1417752

DOI: 10.1042/bj2860929

PubMed ID: 8761485

Title: The distribution of theta-class glutathione S-transferases in the liver and lung of mouse, rat and human.

PubMed ID: 8761485

DOI: 10.1042/bj3180297

Sequence Information:

  • Length: 244
  • Mass: 27506
  • Checksum: DBA15D045262FFC3
  • Sequence:
    • MGLELFLDLV SQPSRAVYIF AKKNGIPLEL RTVDLVKGQH KSKEFLQINS LGKLPTLKDG 
DFILTESSAI LIYLSCKYQT PDHWYPSDLQ ARARVHEYLG WHADCIRGTF GIPLWVQVLG 
PLIGVQVPKE KVERNRTAMD QALQWLEDKF LGDRPFLAGQ QVTLADLMAL EELMQPVALG 
YELFEGRPRL AAWRGRVEAF LGAELCQEAH SIILSILEQA AKKTLPTPSP EAYQAMLLRI 
ARIP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.