Details for: HLA DPB2

Gene ID: 3116

Symbol: HLA DPB2

Ensembl ID: ENSG00000224557

Description: major histocompatibility complex, class II, DP beta 2 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 5.6557
    Cell Significance Index: 111.8300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 5.0569
    Cell Significance Index: 99.5300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 4.8039
    Cell Significance Index: 119.8300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 4.7340
    Cell Significance Index: 94.4000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 4.6373
    Cell Significance Index: 93.1000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 4.2516
    Cell Significance Index: 135.4100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 3.8983
    Cell Significance Index: 127.6300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 3.5033
    Cell Significance Index: 75.6900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 2.4983
    Cell Significance Index: 87.5200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.6435
    Cell Significance Index: 14.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3643
    Cell Significance Index: 73.0800
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.3216
    Cell Significance Index: 3.5600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.2213
    Cell Significance Index: 2.8500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.0701
    Cell Significance Index: 0.8500
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.0411
    Cell Significance Index: 0.3900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0333
    Cell Significance Index: 2.0400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.0263
    Cell Significance Index: 0.2800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0187
    Cell Significance Index: 0.5500
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.0087
    Cell Significance Index: 0.0900
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: 0.0074
    Cell Significance Index: 0.0800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0018
    Cell Significance Index: -0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0018
    Cell Significance Index: -3.3700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0022
    Cell Significance Index: -3.9800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0027
    Cell Significance Index: -4.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0041
    Cell Significance Index: -5.5100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0068
    Cell Significance Index: -0.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0084
    Cell Significance Index: -5.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0116
    Cell Significance Index: -5.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0238
    Cell Significance Index: -4.0700
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0261
    Cell Significance Index: -0.3900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0314
    Cell Significance Index: -4.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0359
    Cell Significance Index: -4.1100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0458
    Cell Significance Index: -4.7700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0499
    Cell Significance Index: -2.5900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1116
    Cell Significance Index: -5.0600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1361
    Cell Significance Index: -2.8400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1440
    Cell Significance Index: -2.4900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1449
    Cell Significance Index: -5.3200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1805
    Cell Significance Index: -1.9000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1840
    Cell Significance Index: -5.8200
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1857
    Cell Significance Index: -2.5500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1959
    Cell Significance Index: -4.9900
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.2219
    Cell Significance Index: -2.7000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2246
    Cell Significance Index: -3.8400
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.2375
    Cell Significance Index: -2.8700
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.2556
    Cell Significance Index: -2.1100
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.2645
    Cell Significance Index: -3.0900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2897
    Cell Significance Index: -3.8500
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.2906
    Cell Significance Index: -3.6400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2956
    Cell Significance Index: -5.0200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2958
    Cell Significance Index: -3.8000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.2987
    Cell Significance Index: -3.5300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3007
    Cell Significance Index: -4.4400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.3011
    Cell Significance Index: -5.1900
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.3057
    Cell Significance Index: -3.8500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3146
    Cell Significance Index: -3.9700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.3180
    Cell Significance Index: -4.4100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3222
    Cell Significance Index: -3.5100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3294
    Cell Significance Index: -4.9400
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: -0.3321
    Cell Significance Index: -2.8100
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.3322
    Cell Significance Index: -4.0900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.3371
    Cell Significance Index: -3.9100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.3433
    Cell Significance Index: -4.6700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.3437
    Cell Significance Index: -4.0900
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.3444
    Cell Significance Index: -4.3000
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.3463
    Cell Significance Index: -3.7600
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.3506
    Cell Significance Index: -3.8200
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.3510
    Cell Significance Index: -5.3400
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.3523
    Cell Significance Index: -3.9800
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.3558
    Cell Significance Index: -3.4200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3572
    Cell Significance Index: -4.1100
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.3574
    Cell Significance Index: -4.0600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3602
    Cell Significance Index: -5.1800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.3624
    Cell Significance Index: -4.4600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.3627
    Cell Significance Index: -4.7600
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.3639
    Cell Significance Index: -3.3900
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.3670
    Cell Significance Index: -4.6100
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.3682
    Cell Significance Index: -3.7200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3716
    Cell Significance Index: -5.2900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.3746
    Cell Significance Index: -4.9300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.3776
    Cell Significance Index: -4.9300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.3785
    Cell Significance Index: -4.4500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3825
    Cell Significance Index: -4.5600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3855
    Cell Significance Index: -5.2600
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.3912
    Cell Significance Index: -4.4900
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.3925
    Cell Significance Index: -4.6700
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.3966
    Cell Significance Index: -4.1800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.4016
    Cell Significance Index: -4.1000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.4030
    Cell Significance Index: -5.2600
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.4089
    Cell Significance Index: -4.0000
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.4093
    Cell Significance Index: -3.9900
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.4128
    Cell Significance Index: -4.9500
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.4131
    Cell Significance Index: -3.6400
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: -0.4144
    Cell Significance Index: -3.8500
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.4157
    Cell Significance Index: -4.8300
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.4166
    Cell Significance Index: -3.6700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.4178
    Cell Significance Index: -6.0000
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.4243
    Cell Significance Index: -5.0000
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.4276
    Cell Significance Index: -3.8600
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.4323
    Cell Significance Index: -4.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HLA DPB2 is a member of the MHC class II family, which plays a critical role in the immune system by presenting antigens to CD4+ T cells. However, unlike its functional counterparts, HLA DPB2 is a pseudogene, meaning it lacks a functional coding sequence. Despite this, it is significantly expressed in numerous cell types, suggesting alternative roles or functional redundancy. The gene is also highly conserved across species, indicating its evolutionary importance. **Pathways and Functions:** The expression of HLA DPB2 in various cell types has led to the proposal of multiple functional roles. In the immune system, HLA DPB2 may participate in the regulation of immune responses, potentially influencing the activation and differentiation of T cells. Its expression in leukocytes, a type of white blood cell, further supports this hypothesis. In addition to its immune-related functions, HLA DPB2 may also play a role in the regulation of neuronal activity, given its expression in neurons and glial cells. The gene's involvement in the development and maintenance of the nervous system has been suggested, with potential implications for neurodegenerative diseases. **Clinical Significance:** The clinical significance of HLA DPB2 is multifaceted and warrants further investigation. In the context of immune-related disorders, HLA DPB2 may serve as a biomarker or therapeutic target. For instance, its expression in leukocytes could be used to monitor immune responses in patients with autoimmune diseases. Moreover, the gene's involvement in the nervous system raises the possibility of its role in neurodegenerative diseases, such as multiple sclerosis or Alzheimer's disease. Further research is needed to elucidate the functional significance of HLA DPB2 and its potential applications in human disease. In conclusion, the HLA DPB2 gene is a complex and multifaceted molecule with significant implications for our understanding of the immune system and beyond. Further investigation into its pathways and functions will be crucial in unraveling its role in human disease and developing novel therapeutic strategies. **Implications and Future Directions:** 1. **Biomarker development:** HLA DPB2 could serve as a biomarker for immune-related disorders, allowing for more accurate diagnosis and monitoring of disease progression. 2. **Therapeutic targeting:** The gene's involvement in the immune system and nervous system raises the possibility of its use as a therapeutic target for autoimmune and neurodegenerative diseases. 3. **Gene therapy:** Further research into HLA DPB2's functional significance could inform the development of gene therapy strategies for immune-related disorders and neurodegenerative diseases. 4. **Basic research:** Elucidating the gene's pathways and functions will provide valuable insights into the mechanisms underlying immune regulation and nervous system development, with potential implications for our understanding of human disease. In summary, HLA DPB2 is a gene with significant implications for our understanding of the immune system and beyond. Further research is needed to fully elucidate its functions and potential applications in human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.