Details for: HSPA8P1

Gene ID: 3314

Symbol: HSPA8P1

Ensembl ID: ENSG00000234176

Description: heat shock protein family A (Hsp70) member 8 pseudogene 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.4299
    Cell Significance Index: 4.4500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.2920
    Cell Significance Index: 3.6900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.2401
    Cell Significance Index: 3.3300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0999
    Cell Significance Index: 1.4800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0997
    Cell Significance Index: 1.3600
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.0838
    Cell Significance Index: 1.0400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0516
    Cell Significance Index: 1.5200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0407
    Cell Significance Index: 1.0900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0348
    Cell Significance Index: 0.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0135
    Cell Significance Index: 2.3000
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.0090
    Cell Significance Index: 0.1200
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.0043
    Cell Significance Index: 0.0500
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.0018
    Cell Significance Index: 0.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0027
    Cell Significance Index: -0.5300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0028
    Cell Significance Index: -0.0300
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0032
    Cell Significance Index: -0.0400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0105
    Cell Significance Index: -0.2300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0128
    Cell Significance Index: -0.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0131
    Cell Significance Index: -0.6100
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0237
    Cell Significance Index: -0.3000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0239
    Cell Significance Index: -0.7800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0247
    Cell Significance Index: -0.7900
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0269
    Cell Significance Index: -0.3300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0291
    Cell Significance Index: -1.0700
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0318
    Cell Significance Index: -0.3100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0325
    Cell Significance Index: -0.7000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0357
    Cell Significance Index: -0.7200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0359
    Cell Significance Index: -0.7600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0363
    Cell Significance Index: -0.7100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0389
    Cell Significance Index: -0.8100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0392
    Cell Significance Index: -0.7700
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0394
    Cell Significance Index: -0.4700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0405
    Cell Significance Index: -0.8100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0456
    Cell Significance Index: -0.7900
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0482
    Cell Significance Index: -0.5600
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0493
    Cell Significance Index: -0.4500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0538
    Cell Significance Index: -0.7200
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0553
    Cell Significance Index: -0.8300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0603
    Cell Significance Index: -0.7900
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.0625
    Cell Significance Index: -0.6600
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0638
    Cell Significance Index: -0.5400
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0694
    Cell Significance Index: -0.8300
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0695
    Cell Significance Index: -0.7900
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0727
    Cell Significance Index: -0.6300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0800
    Cell Significance Index: -1.0100
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0801
    Cell Significance Index: -0.9600
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0808
    Cell Significance Index: -0.9200
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0817
    Cell Significance Index: -1.0700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0834
    Cell Significance Index: -0.8800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0836
    Cell Significance Index: -0.6900
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0867
    Cell Significance Index: -1.1900
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0880
    Cell Significance Index: -1.0700
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0881
    Cell Significance Index: -1.1000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0898
    Cell Significance Index: -1.0700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0909
    Cell Significance Index: -1.0400
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0914
    Cell Significance Index: -1.0000
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0916
    Cell Significance Index: -1.0400
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0920
    Cell Significance Index: -1.0000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0924
    Cell Significance Index: -1.5700
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0937
    Cell Significance Index: -0.9400
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0945
    Cell Significance Index: -1.1400
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0946
    Cell Significance Index: -1.0500
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.0951
    Cell Significance Index: -1.0100
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0955
    Cell Significance Index: -0.7900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0965
    Cell Significance Index: -1.2400
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.0976
    Cell Significance Index: -1.1300
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0976
    Cell Significance Index: -1.3500
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0994
    Cell Significance Index: -1.1100
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0998
    Cell Significance Index: -1.0200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0999
    Cell Significance Index: -1.1800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1003
    Cell Significance Index: -1.3100
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.1011
    Cell Significance Index: -1.1100
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.1018
    Cell Significance Index: -1.1500
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1024
    Cell Significance Index: -1.1900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1025
    Cell Significance Index: -1.3400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1049
    Cell Significance Index: -1.3800
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.1061
    Cell Significance Index: -1.1000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1066
    Cell Significance Index: -1.3100
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: -0.1067
    Cell Significance Index: -0.9900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1069
    Cell Significance Index: -1.2400
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.1082
    Cell Significance Index: -1.3600
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.1087
    Cell Significance Index: -1.1800
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.1088
    Cell Significance Index: -1.1400
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.1092
    Cell Significance Index: -1.3700
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1099
    Cell Significance Index: -1.1100
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: -0.1105
    Cell Significance Index: -1.0300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1129
    Cell Significance Index: -1.0600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1130
    Cell Significance Index: -1.3700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1143
    Cell Significance Index: -1.3600
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1151
    Cell Significance Index: -1.3600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1154
    Cell Significance Index: -1.9900
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.1169
    Cell Significance Index: -1.3400
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.1177
    Cell Significance Index: -1.2900
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.1180
    Cell Significance Index: -1.3000
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1191
    Cell Significance Index: -1.3700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1194
    Cell Significance Index: -1.4100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1219
    Cell Significance Index: -1.3500
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.1219
    Cell Significance Index: -1.3500
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.1224
    Cell Significance Index: -1.3600
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1227
    Cell Significance Index: -1.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HSPA8P1 is a pseudogene that belongs to the heat shock protein 70 (Hsp70) family. It is characterized by its high expression levels in various cell types, including adventitial cells, mesenchymal stem cells, embryonic stem cells, innate lymphoid cells, skeletal muscle satellite stem cells, B cells, endothelial cells, epithelial cells, pericytes, and capillary endothelial cells. The widespread expression of HSPA8P1 suggests its involvement in multiple biological processes, including cell survival, differentiation, and immune regulation. **Pathways and Functions:** HSPA8P1 is involved in various cellular pathways that regulate cell growth, survival, and differentiation. Some of the key pathways and functions associated with HSPA8P1 include: 1. **Cell Survival Pathway:** HSPA8P1 acts as a molecular chaperone, helping to maintain protein homeostasis and prevent protein misfolding, which can lead to cell death. 2. **Immune Regulation:** HSPA8P1 is expressed in immune cells, including B cells and innate lymphoid cells, and plays a role in regulating immune responses, including the activation of immune cells and the production of cytokines. 3. **Tissue Repair:** HSPA8P1 is involved in the regulation of tissue repair and regeneration, particularly in the context of vascular injury and inflammation. 4. **Cell Differentiation:** HSPA8P1 is required for the proper differentiation of various cell types, including skeletal muscle satellite stem cells and endothelial cells. **Clinical Significance:** The clinical significance of HSPA8P1 is multifaceted, and its dysregulation has been implicated in various diseases. Some of the diseases associated with HSPA8P1 dysregulation include: 1. **Vascular Diseases:** HSPA8P1 is involved in the regulation of vascular function and integrity, and its dysregulation has been implicated in the pathogenesis of vascular diseases, including atherosclerosis and hypertension. 2. **Immune-Mediated Diseases:** HSPA8P1 plays a role in regulating immune responses, and its dysregulation has been implicated in the pathogenesis of immune-mediated diseases, including autoimmune disorders and cancer. 3. **Tissue Repair and Regeneration:** HSPA8P1 is involved in the regulation of tissue repair and regeneration, and its dysregulation has been implicated in the pathogenesis of diseases characterized by impaired tissue repair, including fibrosis and wound healing disorders. In conclusion, HSPA8P1 is a pseudogene that plays a significant role in various biological processes, including cell survival, immune regulation, and tissue repair. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and clinical significance of HSPA8P1.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.