Details for: INHA

Gene ID: 3623

Symbol: INHA

Ensembl ID: ENSG00000123999

Description: inhibin subunit alpha

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.68
    Marker Score: 65300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 3.25
    Marker Score: 19256.5
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1994
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.68
    Marker Score: 1158.5
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1172
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.55
    Marker Score: 1665
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.46
    Marker Score: 1629.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 871
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 856
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.23
    Marker Score: 12396
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 487
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4812
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 503
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.08
    Marker Score: 7191
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71822
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48046
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.95
    Marker Score: 14847
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5334
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.85
    Marker Score: 650
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.83
    Marker Score: 1718
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.79
    Marker Score: 751
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.75
    Marker Score: 3073
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.75
    Marker Score: 436
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.68
    Marker Score: 950
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.65
    Marker Score: 1010
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.64
    Marker Score: 426
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.62
    Marker Score: 395
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 456
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.54
    Marker Score: 579
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.54
    Marker Score: 2076
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.52
    Marker Score: 164
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.51
    Marker Score: 2129
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.51
    Marker Score: 233
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.51
    Marker Score: 207
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 475
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.49
    Marker Score: 204
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.47
    Marker Score: 994
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.46
    Marker Score: 3972
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.46
    Marker Score: 28372
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.45
    Marker Score: 543
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.45
    Marker Score: 4248
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.44
    Marker Score: 641
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.42
    Marker Score: 795
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.42
    Marker Score: 4286
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.38
    Marker Score: 127
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 372
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.37
    Marker Score: 106
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.36
    Marker Score: 3357
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.35
    Marker Score: 13074
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.35
    Marker Score: 468
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.33
    Marker Score: 552
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.33
    Marker Score: 233.5
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.32
    Marker Score: 136
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.32
    Marker Score: 129
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.32
    Marker Score: 151
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.31
    Marker Score: 627
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.3
    Marker Score: 173
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.29
    Marker Score: 207.5
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.29
    Marker Score: 5845
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.29
    Marker Score: 1113
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.28
    Marker Score: 164
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.27
    Marker Score: 235
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.26
    Marker Score: 1083.5
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.25
    Marker Score: 69
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.25
    Marker Score: 3683.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.24
    Marker Score: 145
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.24
    Marker Score: 136
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.24
    Marker Score: 70
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.24
    Marker Score: 925
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.22
    Marker Score: 599
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.21
    Marker Score: 95
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.21
    Marker Score: 193
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.2
    Marker Score: 65
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.2
    Marker Score: 125
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.2
    Marker Score: 106
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.2
    Marker Score: 51
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.2
    Marker Score: 461
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.18
    Marker Score: 231
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.18
    Marker Score: 6805
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.18
    Marker Score: 5945.5
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.17
    Marker Score: 172
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.17
    Marker Score: 433.5
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.17
    Marker Score: 479

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Other Information

## Summary INHA is a protein that plays a crucial role in regulating the activity of various cell types. It is involved in various physiological processes, including the development and maintenance of the female reproductive tract, regulation of ovulation, and immune responses. ## Key characteristics * INHA is a glycoprotein with a molecular weight of approximately 120 kDa. * It is produced by a variety of cell types, including epithelial cells, germ cells, and stromal cells. * It is known to be a cytokine and has been shown to play a role in regulating the activity of immune cells. * It is also involved in the regulation of ovarian follicle development and the maintenance of the female reproductive tract. ## Pathways and functions * INHA is a key regulator of the ovarian follicle development and atresia. * It is produced by Sertoli cells in the seminiferous tubules of the ovary. * It binds to activin, which is a key regulator of the female reproductive tract. * Binding of INHA to activin leads to the inhibition of the epithelial-mesenchymal transition (EMT) pathway, which is responsible for the development of the female reproductive tract. * This inhibition prevents the degradation of type I collagen, which is a protein that is essential for the survival of the female reproductive tract. * As a result, INHA allows the epithelial cells to survive and develop into functional reproductive cells. ## Clinical significance INHA is a potential therapeutic target for a variety of diseases, including infertility, endometriosis, and cancer. Studies have shown that INHA inhibitors can block the effects of the cytokine and improve fertility in animal models. However, clinical trials of INHA inhibitors in humans have been unsuccessful so far. This is likely due to the fact that INHA is a key regulator of multiple physiological processes, and its inhibition can have a variety of adverse effects. ## Conclusion INHA is a key protein that plays a crucial role in regulating the female reproductive tract. Its overexpression is associated with infertility and cancer. Inhibition of INHA can improve fertility in animal models, but clinical trials in humans have been unsuccessful so far. Further research is needed to develop effective INHA inhibitors for the treatment of infertility and other diseases that are associated with INHA.

Genular Protein ID: 3238398872

Symbol: INHA_HUMAN

Name: Inhibin alpha chain

UniProtKB Accession Codes:

P05111 A8K8H5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 8 Ensembl 1 GO 32 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3016724

Title: Inhibin A-subunit cDNAs from porcine ovary and human placenta.

PubMed ID: 3016724

DOI: 10.1073/pnas.83.16.5849

PubMed ID: 3758355

Title: Human inhibin genes. Genomic characterisation and sequencing.

PubMed ID: 3758355

DOI: 10.1016/0014-5793(86)81006-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3754442

Title: Structure of two human ovarian inhibins.

PubMed ID: 3754442

DOI: 10.1016/0006-291x(86)91021-1

PubMed ID: 8885240

Title: Characterization and determination of the biological activities of noncleavable high molecular weight forms of inhibin A and activin A.

PubMed ID: 8885240

DOI: 10.1210/mend.10.9.8885240

PubMed ID: 9506758

Title: Loss of the expression and localization of inhibin alpha-subunit in high grade prostate cancer.

PubMed ID: 9506758

DOI: 10.1210/jcem.83.3.4640

PubMed ID: 11098038

Title: Inhibin: a candidate gene for premature ovarian failure.

PubMed ID: 11098038

DOI: 10.1093/humrep/15.12.2644

PubMed ID: 24302632

Title: Germline mutations of inhibins in early-onset ovarian epithelial tumors.

PubMed ID: 24302632

DOI: 10.1002/humu.22489

Sequence Information:

  • Length: 366
  • Mass: 39670
  • Checksum: 0E03D2AB12BF8E57
  • Sequence:
    • MVLHLLLFLL LTPQGGHSCQ GLELARELVL AKVRALFLDA LGPPAVTREG GDPGVRRLPR 
RHALGGFTHR GSEPEEEEDV SQAILFPATD ASCEDKSAAR GLAQEAEEGL FRYMFRPSQH 
TRSRQVTSAQ LWFHTGLDRQ GTAASNSSEP LLGLLALSPG GPVAVPMSLG HAPPHWAVLH 
LATSALSLLT HPVLVLLLRC PLCTCSARPE ATPFLVAHTR TRPPSGGERA RRSTPLMSWP 
WSPSALRLLQ RPPEEPAAHA NCHRVALNIS FQELGWERWI VYPPSFIFHY CHGGCGLHIP 
PNLSLPVPGA PPTPAQPYSL LPGAQPCCAA LPGTMRPLHV RTTSDGGYSF KYETVPNLLT 
QHCACI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.