Details for: ITGA9

Gene ID: 3680

Symbol: ITGA9

Ensembl ID: ENSG00000144668

Description: integrin subunit alpha 9

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.82
    Marker Score: 67783
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.83
    Marker Score: 3428
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.82
    Marker Score: 62912
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.68
    Marker Score: 1567
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.53
    Marker Score: 7273.5
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.32
    Marker Score: 8962
  • Cell Name: interneuron (CL0000099)
    Fold Change: 2.24
    Marker Score: 1023
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 2.07
    Marker Score: 649
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 2.01
    Marker Score: 758
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.98
    Marker Score: 2116.5
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.94
    Marker Score: 3260
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.81
    Marker Score: 26999
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.79
    Marker Score: 35598
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.69
    Marker Score: 62433
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.69
    Marker Score: 3431.5
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.64
    Marker Score: 925
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.63
    Marker Score: 6805
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1153
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.56
    Marker Score: 2098
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.47
    Marker Score: 12649
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168421
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.45
    Marker Score: 1806
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.44
    Marker Score: 13687
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.42
    Marker Score: 2740.5
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.42
    Marker Score: 1414
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.36
    Marker Score: 21353
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.36
    Marker Score: 3193.5
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.32
    Marker Score: 362.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.28
    Marker Score: 412
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.25
    Marker Score: 5196
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.24
    Marker Score: 5736
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.2
    Marker Score: 1478
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.19
    Marker Score: 9092
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.18
    Marker Score: 1816
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.18
    Marker Score: 774
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.17
    Marker Score: 423
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.16
    Marker Score: 487
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.14
    Marker Score: 11822
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4783
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.14
    Marker Score: 289
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.12
    Marker Score: 990
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.11
    Marker Score: 37622
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.09
    Marker Score: 677
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.08
    Marker Score: 3095
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.08
    Marker Score: 22975
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.06
    Marker Score: 592
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 1.04
    Marker Score: 791
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.01
    Marker Score: 4126
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1
    Marker Score: 274
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1
    Marker Score: 1210
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1
    Marker Score: 4144
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1
    Marker Score: 6002
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71781
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48005
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.99
    Marker Score: 263
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.98
    Marker Score: 9230
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.95
    Marker Score: 474
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.95
    Marker Score: 58343
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.94
    Marker Score: 941
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.93
    Marker Score: 560
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.93
    Marker Score: 427
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2731
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.91
    Marker Score: 434
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5149
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.9
    Marker Score: 364
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.87
    Marker Score: 13950
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.84
    Marker Score: 1528
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.84
    Marker Score: 3242
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.84
    Marker Score: 900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.83
    Marker Score: 263
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 629
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.82
    Marker Score: 213
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.82
    Marker Score: 3417
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.82
    Marker Score: 315
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.8
    Marker Score: 436
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.79
    Marker Score: 907
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.78
    Marker Score: 29586
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1246
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 505
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.76
    Marker Score: 1104
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 692
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.74
    Marker Score: 416
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.73
    Marker Score: 412
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.71
    Marker Score: 399
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.69
    Marker Score: 784
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.69
    Marker Score: 286
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.68
    Marker Score: 448
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.68
    Marker Score: 471
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.67
    Marker Score: 582.5
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.67
    Marker Score: 162
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.67
    Marker Score: 160

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Other Information

**Key characteristics:** * ITGA9 is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is a glycoprotein that is expressed in high levels on the cell surface. * ITGA9 is a member of the integrin family of cell adhesion molecules, which are crucial for cell-cell adhesion and cell migration. * ITGA9 is a key player in cell adhesion, as it is involved in the formation and maintenance of cell contacts with neighboring cells. **Pathways and functions:** * ITGA9 is involved in cell-cell adhesion through its interaction with extracellular matrix proteins. * It is essential for the assembly of cell-cell junctions, which are critical for tissue integrity and cell signaling. * ITGA9 is also involved in cell migration and cell crawling. * It plays a role in the regulation of vascular tone, as it is expressed in high levels in blood vessels and is involved in the regulation of blood flow. * ITGA9 is also involved in the development and maintenance of the nervous system, as it is expressed in neurons and neural cells. **Clinical significance:** * Mutations in ITGA9 have been linked to various human diseases, including hypertension, atherosclerosis, and cancer. * ITGA9 inhibitors are being investigated as potential therapeutic agents for these diseases. * Targeting ITGA9 signaling has been shown to be effective in inhibiting cell adhesion and migration, which may provide a novel therapeutic approach for treating cancer and other diseases characterized by excessive cell adhesion.

Genular Protein ID: 2482790631

Symbol: ITA9_HUMAN

Name: Integrin alpha-9

UniProtKB Accession Codes:

Q13797 Q14638

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CPTAC 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 15 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8290272

Title: Aberrant upregulation of a novel integrin alpha subunit gene at 3p21.3 in small cell lung cancer.

PubMed ID: 8290272

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 8245132

Title: Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle.

PubMed ID: 8245132

DOI: 10.1083/jcb.123.5.1289

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 22654117

Title: Polydom/SVEP1 is a ligand for integrin alpha9beta1.

PubMed ID: 22654117

DOI: 10.1074/jbc.m112.355016

PubMed ID: 35802072

Title: The integrin ligand SVEP1 regulates GPCR-mediated vasoconstriction via integrins alpha9beta1 and alpha4beta1.

PubMed ID: 35802072

DOI: 10.1111/bph.15921

Sequence Information:

  • Length: 1035
  • Mass: 114489
  • Checksum: B812EDA867A3E836
  • Sequence:
    • MGGPAAPRGA GRLRALLLAL VVAGIPAGAY NLDPQRPVHF QGPADSFFGY AVLEHFHDNT 
RWVLVGAPKA DSKYSPSVKS PGAVFKCRVH TNPDRRCTEL DMARGKNRGT SCGKTCREDR 
DDEWMGVSLA RQPKADGRVL ACAHRWKNIY YEADHILPHG FCYIIPSNLQ AKGRTLIPCY 
EEYKKKYGEE HGSCQAGIAG FFTEELVVMG APGSFYWAGT IKVLNLTDNT YLKLNDEVIM 
NRRYTYLGYA VTAGHFSHPS TIDVVGGAPQ DKGIGKVYIF RADRRSGTLI KIFQASGKKM 
GSYFGSSLCA VDLNGDGLSD LLVGAPMFSE IRDEGQVTVY INRGNGALEE QLALTGDGAY 
NAHFGESIAS LDDLDNDGFP DVAIGAPKED DFAGAVYIYH GDAGGIVPQY SMKLSGQKIN 
PVLRMFGQSI SGGIDMDGNG YPDVTVGAFM SDSVVLLRAR PVITVDVSIF LPGSINITAP 
QCHDGQQPVN CLNVTTCFSF HGKHVPGEIG LNYVLMADVA KKEKGQMPRV YFVLLGETMG 
QVTEKLQLTY MEETCRHYVA HVKRRVQDVI SPIVFEAAYS LSEHVTGEEE RELPPLTPVL 
RWKKGQKIAQ KNQTVFERNC RSEDCAADLQ LQGKLLLSSM DEKTLYLALG AVKNISLNIS 
ISNLGDDAYD ANVSFNVSRE LFFINMWQKE EMGISCELLE SDFLKCSVGF PFMRSKSKYE 
FSVIFDTSHL SGEEEVLSFI VTAQSGNTER SESLHDNTLV LMVPLMHEVD TSITGIMSPT 
SFVYGESVDA ANFIQLDDLE CHFQPINITL QVYNTGPSTL PGSSVSISFP NRLSSGGAEM 
FHVQEMVVGQ EKGNCSFQKN PTPCIIPQEQ ENIFHTIFAF FTKSGRKVLD CEKPGISCLT 
AHCNFSALAK EESRTIDIYM LLNTEILKKD SSSVIQFMSR AKVKVDPALR VVEIAHGNPE 
EVTVVFEALH NLEPRGYVVG WIIAISLLVG ILIFLLLAVL LWKMGFFRRR YKEIIEAEKN 
RKENEDSWDW VQKNQ

Genular Protein ID: 1004218684

Symbol: Q8N6H6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8N6H6

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 4 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 1 RuleBase 1 SMART 1 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 632
  • Mass: 69153
  • Checksum: 08D5BF66CC9A08C3
  • Sequence:
    • MGGPAAPRGA GRLRALLLAL VVAGIPAGAY NLDPQRPVHF QGPADSFFGY AVLEHFHDNT 
RWVLVGAPKA DSKYSPSVKS PGAVFKCRVH TNPDRRCTEL DMARGKNRGT SCGKTCREDR 
DDEWMGVSLA RQPKADGRVL ACAHRWKNIY YEADHILPHG FCYIIPSNLQ AKGRTLIPCY 
EEYKKKYGEE HGSCQAGIAG FFTEELVVMG APGSFYWAGT IKVLNLTDNT YLKLNDEVIM 
NRRYTYLGYA VTAGHFSHPS TIDVVGGAPQ DKGIGKVYIF RADRRSGTLI KIFQASGKKM 
GSYFGSSLCA VDLNGDGLSD LLVGAPMFSE IRDEGQVTVY INRGNGALEE QLALTGDGAY 
NAHFGESIAS LDDLDNDGFP DVAIGAPKED DFAGAVYIYH GDAGGIVPQY SMKLSGQKIN 
PVLRMFGQSI SGGIDMDGNG YPDVTVGAFM SDSVVLLRAR PVITVDVSIF LPGSINITAP 
QCHDGQQPVN CLNVTTCFSF HGKHVPEEIG LNYVLMADVA KKEKGQMPRV YFVLLGETMG 
QVTEKLQLTY MEETCRHYVA HVKRRVQDVI SPIVFEAAYS LSEHVTGEEE RELPPLTPVL 
RWKKGQKIAQ KNQVRTLKLI LSTQGGSCTE QK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.